Alpha-Arbutin
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Arbutin

Arbutin supplier bulk factory Wholesale buy Extract factory

  1. English Ngalan: Arbutin; 4-Hydroxyphenyl β-D-glucopyranoside
  1. Espesipikasyon
    • Kaputli:
      • α-Arbutin: ≥ 98% (HPLC)
      • β-Arbutin: ≥ 99% (HPLC)
    • Pagkamatunaw: Soluble in water (14 g/L at 25°C), slightly soluble in ethanol, insoluble in organic solvents like ether.
    • Panagway – May kalabotan: Loss on drying ≤ 1.0%, Heavy metals ≤ 5 ppm, Residual solvents ≤ 0.05%
    • Gidak-on sa Partikulo: Standard powder ≤ 100 μm; micronized powder ≤ 5 μm for better absorption in cosmetics
  1. Panagway
    • White to off-white crystalline powder, odorless, with a slightly sweet taste
  1. CAS NO.
    • β-Arbutin: 497-76-7
    • α-Arbutin: 84380-00-7
  1. Panahon sa pagpanguna: 5 – 7 ka Adlaw sa Trabaho
  1. Pakete
    • 1 kg/bag (aluminum foil bag), 25 kg/drum (double-layer PE bag inside cardboard drum)
  1. Panguna nga Merkado: Global market, with high demand in Asia (China, South Korea, Japan), North America, and Europe, especially in the cosmetics, pharmaceuticals, and dietary supplement industries
  1. Mga Sitwasyon sa Aplikasyon

Panguna nga mga kabtangan

  • Molekular nga Istruktura: A glycoside composed of hydroquinone and glucose, with two main isomers (α and β) differing in glycosidic bond orientation.
  • Kalig-on: Stable under normal storage conditions, but sensitive to light and high temperatures, which may cause decomposition.
  • Pangunang mga bahin
    • Skin-Brightening Effect: Inhibits tyrosinase activity, reducing melanin production, and effectively lightening skin pigmentation, such as freckles, age spots, and post-inflammatory hyperpigmentation.
    • Antioxidant nga Kalihokan: Scavenges free radicals, protecting skin cells from oxidative damage and preventing premature aging.
    • Low Toxicity: Generally well-tolerated by the skin, making it a popular choice for safe skin-lightening formulations.
    • Matunaw sa Tubig: Facilitates easy incorporation into aqueous-based products like serums and toners.

Mga Sitwasyon sa Aplikasyon

1. Mga Kosmetiko ug Personal nga Pag-atiman

  • Skin-Whitening Products:
    • Added to facial creams, lotions, serums (0.5 – 2% concentration), and masks (1 – 3% concentration) to reduce dark spots and even out skin tone.
    • Used in body lotions and deodorants to lighten underarm and knee skin.
  • Mga Pormulasyon nga Anti-Aging:
    • Combined with other antioxidants and anti-aging ingredients in eye creams and anti-wrinkle treatments to protect skin from oxidative stress and prevent the formation of age spots.
  • Mga Produkto sa Pag-atiman sa Adlaw:
    • Incorporated into sunscreens to prevent UV-induced hyperpigmentation, enhancing the overall photoprotection of the skin.

2. Pharmaceuticals

  • Topical nga mga tambal:
    • Investigated for use in creams and gels to treat skin disorders associated with hyperpigmentation, such as melasma.
    • Used in wound-healing ointments due to its potential anti-inflammatory and antioxidant properties, promoting faster skin repair.
  • Oral Supplements (Research – based):
    • In early-stage research for potential internal use in managing skin pigmentation disorders, though oral application is less common due to potential metabolic concerns.

3. Pagkaon ug Ilimnon

  • Natural Preservative (Research – based):
    • Some studies explore its use as a natural antioxidant and preservative in food products, inhibiting lipid oxidation and microbial growth, although not yet widely commercialized.
  • Functional Food Ingredient (Conceptual):
    • Considered for addition to health beverages and dietary supplements for potential skin health benefits when consumed orally, but regulatory approvals are pending for such claims.

Mga Pamaagi sa Deteksiyon

  • High-Performance Liquid Chromatography (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Methanol – water (20:80 v/v), Flow Rate: 1.0 mL/min, Detection Wavelength: 280 nm for quantification.
  • Ultra-Performance Liquid Chromatography – Mass Spectrometry (UPLC – MS):
    • Confirms the molecular structure and differentiates between α and β isomers, detecting trace impurities with high sensitivity.
  • Nuclear Magnetic Resonance (NMR):
    • Used for structural elucidation and identification of arbutin, especially in research and development to ensure the purity and correct isomeric form.

Tinubdan & Mga Kaayohan

  • Natural nga Tinubdan: Extracted from various plants, including bearberry (Arctostaphylos uva-ursi), blueberries, and cranberries, through solvent extraction and purification processes.
  • Sintetikong Opsyon: Commercially, it can also be synthesized chemically, providing a more consistent supply compared to natural extraction.
  • Panginahanglan sa merkado: High consumer demand for skin-lightening products drives its popularity in the cosmetics industry, making it a valuable ingredient for manufacturers.

Pagsunod sa Regulatoryo

  • US FDA: Regulated as a cosmetic ingredient. There are no specific restrictions on its use in topical cosmetics, but claims related to skin-lightening must comply with FDA regulations.
  • Regulasyon sa EU: Approved for use in cosmetics under the Cosmetics Regulation (EC) No 1223/2009. It is listed in the Cosmetic Ingredients Database (CosIng) with specific usage limits.
  • China NMPA: Permitted for use in cosmetics and is included in the Cosmetic Raw Materials Safety Information Database. Manufacturers must ensure compliance with safety and quality standards.
Mga kategoriya: , ,

Arbutin: The Gold Commonplace for Protected Pores and skin Brightening & Antioxidant Protection| Supplier & Manufacturer

1. What is Arbutin?

Arbutin (CAS 497-76-7) is a naturally occurring β-D-glucopyranoside spinoff of hydroquinone, famend for its potent tyrosinase-inhibiting properties. Because the premier non-irritating different to hydroquinone, it successfully disrupts melanin synthesis via aggressive enzyme inhibition with out cytotoxic results. Obtainable as alpha-arbutin (artificial) and beta-arbutin (plant-derived), the alpha type displays superior stability and efficacy at decrease concentrations.

2. Supply, Chemical Properties & Identification

  • Natural nga mga Tinubdan:

    • Major: Bearberry leaves (Arctostaphylos uva-ursi), Bergenia crassifolia, Pyrus communis (pear) leaves

    • Secondary: Wheat germ, blueberry shoots

  • Synthesis: Enzymatic glycosylation of hydroquinone by way of Aspergillus oryzae β-glucosidase

  • Chemical Specs:

    Parameter Bili
    CAS No. 497-76-7 (β-Arbutin)
    84380-01-8 (α-Arbutin)
    Molecular Formulation C₁₂H₁₆O₇
    Molekular nga Timbang 272.25 g/mol
    EINECS 207-850-3
    Panagway White crystalline powder
    Pagkamatunaw Water: 50g/100mL (20°C)
    Kalig-on pH 3-7; decomposes at >100°C

3. Premium Product Choice & Well being Functions

► Optimum Product Specs

  • Highest Efficiency: Alpha-arbutin >99% (HPLC) outperforms beta-arbutin with 10x better tyrosinase affinity

  • Purity Requirements: Heavy metals (Pb <1 ppm), residual solvents (methanol <50 ppm), microbial limits (TAMC <100 CFU/g)

► Clinically Validated Benefits:

  1. Pores and skin Depigmentation:

    • Inhibits tyrosinase (IC₅₀: 24 μM) by binding copper lively web site

    • Reduces UV-induced melanin by 45.8% at 0.5% focus (vs. 35.2% for β-arbutin)

  2. Kaluwasan sa Antioxidant:

    • Scavenges ROS (IC₅₀: 0.13 mM) and prevents lipid peroxidation

  3. Antibacterial Motion:

    • Efficient towards Propionibacterium acnes (MIC: 1.25 mg/mL)

► Dosage & Security Profile:

Aplikasyon Pagtutok Frequency
Mga kosmetiko 0.5-2% Every day utility
Nutraceuticals 50-200 mg/day Oral, divided doses
Essential Notes:

  • Aspect Results: <0.1% incidence of contact dermatitis (patch check beneficial)

  • Mga kontraindiksiyon: Being pregnant (restricted knowledge), hydroquinone sensitivity

  • Kalig-on: Formulate at pH 5.5-6.5; keep away from ascorbic acid/retinol combos

4. Shaanxi Zhonghong Biotech: Arbutin Innovation Chief

28 ka tuig nga kasinatian in botanical actives positions Shaanxi Zhonghong Investment Technology Co., Ltd. as the worldwide accomplice for premium arbutin:

► Panguna nga mga Kapabilidad:

  • Extraction Mastery:

    • CO₂ supercritical extraction (40°C, 250 bar) preserves thermolabile compounds

    • Nanofiltration expertise achieves >99.5% α-arbutin purity

  • Analytical Infrastructure:

    • Chiral HPLC-ELSD for α/β-arbutin isomer quantification

    • ICP-MS heavy steel detection at ppb-level sensitivity

  • Innovation Ecosystem:

    • Patent CN114716386A: Enzymatic synthesis of high-stability α-arbutin

    • College partnerships creating arbutin-peptide conjugates for enhanced dermal supply

5. Rigorous High quality Specs

Klase Parameter Espesipikasyon Susiha ang Metodolohiya
Mga pestisidyo Mga chlorpyrifos ≤0.01 mg/kg GC-MS/MS
Cypermethrin ≤0.05 mg/kg GC-MS/MS
Bug-at nga Metal Tingga (Pb) ≤1.0 mg/kg ICP-MS
Mercury (Hg) ≤0.1 mg/kg CV-AAS
Microbiology Kompleto nga Cardio Rely ≤100 CFU/g ISO 4833-1
Candida albicans Wala sa 1g ISO 18416
Staphylococcus aureus Wala sa 1g ISO 22718
Key Analytics α-Arbutin Assay ≥99.0% HPLC-ELSD
β-Arbutin Impurity ≤0.5% Chiral HPLC
Hydroquinone ≤1 ppm HPLC-DAD

6. Superior nga Workflow sa Paggama

  1. Biomass Processing: Cryogenic milling of Arctostaphylos uva-ursi leaves (-196°C)

  2. Selective Extraction: Ethanol-water (70:30) at 50°C, pH 4.5

  3. Enzymatic Conversion: β-Glucosidase remedy (40°C, 24h) for α-arbutin isomerization

  4. Pagputli:

    • Macroporous resin chromatography (AB-8 resin)

    • Recrystallization from acetone/water (3:1)

  5. Lyophilization: -50°C vacuum drying for crystal construction preservation

7. Chopping-Edge Functions & Analysis

► Business Functions:

  • Mga kosmetiko: Brightening serums (2% α-arbutin + 5% niacinamide), pimples spot remedies

  • Medical Dermatology: Melasma remedy (mixed with 1064nm Q-switched Nd:YAG laser)

  • Praktikal nga mga Pagkaon: Antioxidant capsules (100mg arbutin + selenium)

► Innovation Frontiers:

  1. Transdermal Supply:

    • Ethosomal carriers (entrapment effectivity: 92.3%) improve stratum corneum penetration

  2. Multi-Goal Inhibitors:

    • Arbutin-kojic acid hybrids present synergistic tyrosinase inhibition (IC₅₀: 3.7 μM)

  3. Sustainable Manufacturing:

    • CRISPR-edited E. coli strains producing arbutin from glycerol (yield: 28.7 g/L)

Present Challenges:

  • Regulatory divergence (Japan: quasi-drug vs. EU: beauty ingredient)

  • Stability in O/W emulsions (>40°C)

8. Important FAQs

Q: Does arbutin trigger pores and skin photosensitivity?
A: No – in contrast to hydroquinone, arbutin doesn’t improve UV sensitivity and offers intrinsic photoprotection.

Q: What focus is perfect for hyperpigmentation?
A: Scientific research present 2% α-arbutin reduces melanin index by 22.3% after 8 weeks (vs. 16.7% for 7% β-arbutin).

Q: Is plant-derived arbutin superior to artificial?
A: Artificial α-arbutin delivers greater purity (>99.5%), batch consistency, and efficacy at decrease doses.

Q: Can arbutin be used with vitamin C?
A: Formulate at pH 5.5-6.0; keep away from direct mixture with L-ascorbic acid (stability points).

9. World Provide Data

Contact Shaanxi Zhonghong for Pharmaceutical-Grade Arbutin:

  • E mail: liaodaohai@gmail.com

  • Web site: https://www.aiherba.com

  • Pagputos: Nitrogen-flushed amber glass vials (1-5kg) or HDPE drums (25kg)

  • Pagtipig: 2-8°C; 24-month stability

  • Logistics: World cold-chain transport (2-8°C) with IATA-compliant documentation

10. Panapos

Arbutin stays the gold-standard melanogenesis inhibitor for moral pores and skin brightening formulations. Shaanxi Zhonghong Investment Technology Co., Ltd. mga leverage proprietary enzymatic bioconversion expertise, cGMP-compliant nanofiltration, ug chiral separation experience to ship >99% pure α-arbutin – outperforming typical extracts in efficacy and security. With 20+ patente in lively supply techniques and ISO 22716 beauty GMP certification, we empower manufacturers to develop clinically efficient, regulatory-compliant depigmenting options. Accomplice with us to formulate the subsequent era of evidence-based pores and skin therapies.

Mga pakisayran

  1. Zhu, W. et al. (2021). α-Arbutin: Superior Manufacturing Methods & Scientific Efficacy. J. Cosmet. Dermatol. 20(7):2145-2156.

  2. EU SCCS Opinion on Alpha-Arbutin (SCCS/1642/22).

  3. Chen, L. et al. (2023). CRISPR-based Metabolic Engineering for Arbutin Biosynthesis. Metab. Eng. 76:146-158.

  4. JECFA Specs for Arbutin (JECFA/89/SC).

  5. Shaanxi Zhonghong Patent CN114716386A: Methodology for Excessive-Yield α-Arbutin Manufacturing.

  6. ICH Pointers: Q3C (Residual Solvents), Q3D (Elemental Impurities).

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