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Alpha-Arbutin

α-Arbutin supplier bulk factory Wholesale Extract factory

  1. English Ngalan: α-Arbutin,Alpha-Arbutin
  1. Espesipikasyon
    • General Powder: α-Arbutin ≥ 99% (HPLC), optical purity ≥ 98%
    • Water-soluble Powder: α-Arbutin ≥ 98% (HPLC), with a water-soluble tighatag (e.g., cyclodextrin), solubility ≥ 100 g/L at 25°C
  1. Panagway
    • General Powder: White crystalline powder, odorless
    • Water-soluble Powder: Off-white free-flowing powder
  1. CAS NO.:84380-01-8
  1. Panahon sa pagpanguna: 3 – 7 ka Adlaw sa Trabaho
  1. Pakete
    • 1 kg/bag (aluminum foil bag), 25 kg/drum (double-layer PE bag inside cardboard drum)
  1. Panguna nga Merkado: Asia (ilabina sa Okay ra-beauty and J-beauty markets), North America, Europe
  1. Mga Sitwasyon sa Aplikasyon

Panguna nga mga kabtangan

  • Molekular Formula: C₁₂H₁₆O₇
  • Pagkamatunaw: Soluble in water, ethanol, and propylene glycol; the water-soluble formulation exhibits enhanced dissolution katulin
  • yawe Mga kapilian:
    • Potent tyrosinase inhibitor, blocking melanin synthesis dugang malampuson than β-Arbutin (IC₅₀ = 0.2 mM)
    • Antioxidant properties, pagdepensa pores ug panit from UV-induced oxidative stress
    • Lig-on sa acidic mga sitwasyon (labing maayo pH 4 – 6), bisan pa niana degrades in alkaline environments or at sobra temperatures (> 60°C)

Mga Sitwasyon sa Aplikasyon

1. Mga kosmetiko & Pribado Pag-atiman

  • Mga pores ug panit Lightening Mga baligya:
    • Serums and Essences: Generally formulated at 2 – 5% focus, pagpaubos itom spots, melasma, and post-inflammatory hyperpigmentation. Medikal panukiduki presente a 30% diskwento in pigmentation after 8 weeks of use.
    • Mga sunscreen: Added at 1 – 2% sa paghatag matag usa solar kaluwasan and anti-pigmentation mga bentaha, paghunong UV-induced melanin paghimo.
    • Whitening Mga lotion: Gisagol uban sa lainlain buhi mga substansiya like niacinamide and hyaluronic acid, nagtutok sa heneral pores ug panit brightening and hydration.
  • kontra-Nagkatigulang na Mga pormulasyon:
    • Inhibits collagen degradation gidala sa free radicals, pagpaubos ang hitsura sa mapuslanon mga strain and wrinkles when included in anti-aging masks and mga lotion.

2. Gireseta nga mga tambal

  • Dermatological Therapies:
    • Gigamit sa prescription-strength mga lotion (kutob sa 4% focus in some mga lugar) for treating grabe pigmentation mga problema nagpahinumdom sa melasma and freckles.
    • Submit-surgical and post-peel mga gimbuhaton to forestall o timbangan balik post-treatment hyperpigmentation, kasagaran gisagol with vitamin E.

3. May katuyoan Mga pagkaon & Mga ilimnon

  • Oral Mga suplemento sa pagkaon:
    • Capsules or tablets containing 500 mg of α-Arbutin, kasagaran paired with vitamin C sa pagpausbaw collagen synthesis and promote pores ug panit kaayohan gikan sa sulod.
  • Magnificence Mga ilimnon:
    • Added to low-calorie mga ilimnon at 0.5 – 1% focus, marketed as “beauty-from-within” baligya kay heneral pores ug panit brightening.

4. Industrial Mga katuyoan

  • Textile Dyeing:
    • Ingon sa usa ka putli mordant, α-Arbutin mahimong gamiton to repair dyes on mga materyales, producing malumo ug makanunayon pagkolor hues uban sa gawas naggamit harsh kemikal nga mga compound.
  • Mga biopestisidyo:
    • Aqueous mga kapilian of α-Arbutin (0.1 – 0.5%) presente antifungal properties, making it angay nga gamiton in eco-friendly agricultural pest pagdumala.

Deteksiyon Mga estratehiya

  • SobraEpisyente Liquid Chromatography (HPLC):
    • Kolum: C18 (250 × 4.6 mm, 5 μm), Cellular Seksyon: Acetonitrile – Water (15:85, v/v), Stream Maningil: 1.0 mL/min, Detection Wavelength: 280 nm
  • Mass Spectrometry (MS):
    • Gigamit sa pag-verify the molecular pagtukod and purity, ilabina for pharmaceutical-grade α-Arbutin baligya.
  • Differential Scanning Calorimetry (DSC):
    • Determines the melting level (195 – 198°C for α-Arbutin), nagsilbi sa sa kompirma produkto taas nga kalidad and authenticity.

Suplay & Mga kaayohan

  • Paggama: Sa panguna synthesized pinaagi sa enzymatic or chemical processes, paghatag mas dako purity and consistency kon itandi sa putli pagkuha mga estratehiya.
  • Pagka-epektibo: Kini lig-on pagpugong epekto on tyrosinase nagtanyag paspas and visual matapos sa pores ug panit lightening, making it a labing ganahan ingredient for high-end kahalangdon baligya.
  • Seguridad: Kasagaran well-tolerated by most pores ug panit matang, with a pagkunhod hulga of irritation kon itandi sa lain 美白 mga broker.

Pagsunod sa Regulatoryo

  • China NMPA: Permitted as a katahom ingredient with a kadaghanan focus sa duha% (requiring seguridad ebalwasyon kay mas dako mga han-ay).
  • EU Katahom Regulation (EC 1223/2009): Accredited nga gamiton in cosmetics, with a pugong of three% in leave-on baligya.
  • US FDA: Tentatively labeled as an OTC ingredient for pores ug panit lightening, with focus limits sa ilawom pagtasa.

Alpha-Arbutin: The Gold Normal in Pores and skin Lightening and Antioxidant Safety| Supplier & Manufacturer

1. What is Alpha-Arbutin?

Alpha-arbutin is a glycosylated hydroquinone spinoff famend for its potent pores and skin – lightening properties. In contrast to its counterpart, beta – arbutin, alpha – arbutin displays a better affinity for tyrosinase, the important thing enzyme concerned in melanin synthesis. This makes it simpler at decreasing hyperpigmentation, comparable to age spots, freckles, and melasma, with out inflicting important pores and skin irritation. Extensively used within the cosmetics business, alpha – arbutin has additionally proven antioxidant and anti – inflammatory results, positioning it as a multifunctional bioactive ingredient.

Alpha-Arbutin Applications
Alpha-Arbutin Purposes

2. Gigikanan sa Produkto ug Mga Kinaiya sa Kemikal

2.1 Suplay

Alpha-arbutin could be extracted from varied crops, together with bearberry (Arctostaphylos uva-ursi), blueberries (Vaccinium spp.), and cranberries (Vaccinium macrocarpon). Nevertheless, as a result of low pure content material in crops, most business alpha – arbutin is produced by way of biocatalysis or chemical synthesis. At Shaanxi Zhonghong Investment Technology Co., Ltd., we make the most of superior biocatalytic processes to make sure excessive – purity, sustainable manufacturing with minimal environmental influence.

2.2 Kemikal nga Profile

  • Gidaghanon sa CAS: 84380 – 01 – 8
  • Molecular Formula (MF): C₁₂H₁₆O₇
  • Molekular nga Timbang (MW): 272.25 g/mol
  • EINECS: 282 – 776 – 3
  • Estado sa Lawas: Puti hangtod sa puti – puti nga kristal nga powder
  • Pagkamatunaw: Soluble in water (5 – 10 g/L at 25°C), barely soluble in ethanol

3. Optimum Product, Well being Benefits, Dosage, Precautions and Aspect Results

3.1 Finest Merchandise and Content

The best – high quality alpha – arbutin merchandise sometimes have a purity of 98% or increased. Our firm leverages state – of – the – artwork purification methods, comparable to excessive – efficiency liquid chromatography (HPLC) and crystallization processes, to realize a purity stage 20% above the business common. This ensures most efficacy in pores and skin – lightening purposes and minimizes the danger of impurities inflicting antagonistic reactions.

3.2 Well being Benefits

3.2.1 Pores and skin Lightening

Alpha-arbutin inhibits tyrosinase exercise, blocking the conversion of tyrosine to melanin. By decreasing melanin manufacturing, it successfully lightens current darkish spots and prevents new pigmentation, resulting in a extra even pores and skin tone.

3.2.2 Antioxidant Safety

It acts as a free – radical scavenger, neutralizing reactive oxygen species (ROS) comparable to hydroxyl and superoxide radicals. This antioxidant property helps defend pores and skin cells from oxidative harm, which is related to untimely ageing, effective strains, and wrinkles.

3.2.3 Anti – Inflammatory Results

Alpha-arbutin can cut back the manufacturing of professional – inflammatory cytokines, soothing irritated pores and skin and selling a more healthy pores and skin barrier perform. This makes it appropriate for delicate pores and skin sorts vulnerable to irritation.

3.3 Beneficial Dosage

In beauty formulations, the standard focus of alpha – arbutin ranges from 0.5% to 2%. For direct software merchandise like serums or lotions, making use of a pea – sized quantity (roughly 1 – 2 grams) containing the suitable focus to the affected pores and skin areas a couple of times every day is widespread. Nevertheless, it is vital to comply with product – particular directions.

3.4 Precautions and Aspect Results

Alpha-arbutin is mostly nicely – tolerated. Nevertheless, in uncommon instances, it might trigger delicate pores and skin irritation, comparable to redness or itching, particularly in people with extremely delicate pores and skin. Extended publicity to daylight can cut back its effectiveness and enhance the danger of pores and skin harm, so sunscreen use is advisable when utilizing alpha – arbutin merchandise. Keep away from contact with eyes, and if unintended ingestion happens, search medical recommendation instantly.

4. Firm Introduction

With 28 years of expertise within the bioactive compound business, Shaanxi Zhonghong Investment Technology Co., Ltd. is a number one excessive – tech enterprise. Our operations span agile analysis and improvement, collaborative innovation, built-in manufacturing, and international advertising and marketing, serving the chemical, supplies, and life science sectors.
  • Analysis Edge: Our partnerships with 5 prime – tier universities by way of joint laboratories, together with over 20 patented applied sciences and a singular international compound library, drive steady innovation in alpha – arbutin manufacturing and software.
  • Technological Superiority: Outfitted with state – of – the – artwork services, together with excessive – efficiency liquid chromatography (HPLC) and superconducting nuclear magnetic resonance spectrometers, we guarantee product purity requirements 20% increased than the business common.
  • Pagkab-ot sa Kalibutan: Our intensive community covers greater than 80 nations throughout Asia, Europe, and the Americas. We provide custom-made uncooked materials options for multinational pharmaceutical firms, analysis establishments, and beauty producers.

5. Product Specs

Venture
Ngalan
Timailhan
Pamaagi sa Detection
Mga Salin sa Pestisidyo
Mga chlorpyrifos
<0.01 ppm
Gasoline Chromatography – Mass Spectrometry (GC – MS)
Cypermethrin
<0.02 ppm
GC - MS
Carbendazim
<0.05 ppm
Sobra – Episyente nga Liquid Chromatography – Mass Spectrometry (HPLC – MS/MS)
Bug-at nga Metal
Tingga (Pb)
<0.5 ppm
Inductively Coupled Plasma – Mass Spectrometry (ICP – MS)
Mercury (Hg)
<0.01 ppm
Chilly Vapor Atomic Absorption Spectroscopy (CVAAS)
Cadmium (Cd)
<0.05 ppm
ICP - MS
Kontaminasyon sa Mikrobyo
Whole viable depend
<100 CFU/g
Normal microbiological plating methods
Escherichia coli
Absent
Polymerase Chain Response (PCR) ug plating
Salmonella
Absent
PCR ug plating
Listeria monocytogenes
Absent
PCR ug plating

6. Kurso sa Paggama sa

  1. Uncooked Materials Preparation: For biocatalytic manufacturing, choose excessive – high quality enzymes or microorganisms with excessive exercise for alpha – arbutin synthesis. Guarantee correct cultivation and activation of those organic catalysts.
  1. Biocatalysis or Chemical Synthesis: In biocatalysis, use enzymes to catalyze the response between hydroquinone and glucose to kind alpha – arbutin. In chemical synthesis, rigorously management response situations comparable to temperature, pH, and response time to advertise the formation of alpha – arbutin whereas minimizing by – product technology.
  1. Pagputli: Make use of a number of purification steps, together with filtration, extraction, and chromatography. HPLC is used to separate alpha – arbutin from impurities, guaranteeing excessive – purity product. Crystallization processes might also be utilized to additional refine the product.
  1. Pagpauga ug Pagporma: Dry the purified alpha – arbutin beneath managed situations to take away moisture. Then, formulate it into completely different varieties in keeping with buyer necessities, comparable to effective powders, granules, or pre – blended options for cosmetics.
  1. High quality Inspection: Conduct complete high quality testing on the completed product, together with purity willpower, identification, and inspection of pesticide residues, heavy metals, and microbial contamination.

7. Mga Sitwasyon sa Paggamit

7.1 Cosmetics

  • Pores and skin – Lightening Merchandise: Alpha-arbutin is a key ingredient in serums, lotions, masks, and lotions designed to cut back hyperpigmentation and obtain a brighter, extra even complexion.
  • Anti – Growing old Formulations: Mixed with different antioxidants and anti – ageing substances, it helps fight oxidative stress and enhance pores and skin texture, decreasing the looks of effective strains and wrinkles.
  • Sunscreen and After – Solar Care: Its antioxidant properties make it appropriate for inclusion in sunscreens to boost UV safety and in after – solar merchandise to appease solar – broken pores and skin.

7.2 Prescribed drugs (Analysis – based mostly)

At the moment, alpha – arbutin is beneath investigation for potential purposes in treating pores and skin illnesses associated to irregular pigmentation, comparable to melasma and publish – inflammatory hyperpigmentation. Its anti – inflammatory and antioxidant results might also contribute to wound – therapeutic analysis.

8. Taas nga kalidad nga Pagdumala

High quality management is the cornerstone of our alpha – arbutin manufacturing. On the uncooked materials stage, we conduct strict inspections on enzymes, microorganisms, or chemical precursors, verifying their purity and exercise by way of biochemical assays and spectroscopic evaluation. Through the manufacturing course of, actual – time monitoring of response parameters (temperature, pH, response time) ensures constant product high quality. Within the purification part, HPLC is used for exact separation and purity willpower, with every batch of merchandise present process a number of rounds of study to make sure the absence of impurities. For ultimate product inspection, we carry out complete exams on chemical purity, microbial security, and heavy metallic content material, adhering to strict worldwide requirements. Our high quality management laboratory is licensed to ISO 9001 and follows Good Manufacturing Follow (GMP) pointers. By implementing a multi – step high quality management system, we assure that each batch of alpha – arbutin meets the very best high quality and security necessities, offering dependable merchandise to our prospects worldwide.

9. Packaging ug Logistics

  • Pagputos: Our alpha – arbutin merchandise are packaged in air – tight, moisture – resistant containers. For small orders, we use aluminum foil luggage or amber glass bottles, whereas for bulk orders, fiber drums are utilized. Every bundle is labeled with detailed data, together with product identify, batch quantity, purity, expiration date, and storage directions.
  • Pagtipig: Retailer in a cool, dry place, away from direct daylight, at temperatures between 2 – 8°C. Below correct storage situations, the shelf lifetime of our alpha – arbutin merchandise can attain as much as 36 months.
  • Transportasyon: We accomplice with dependable worldwide logistics suppliers to make sure quick and safe supply. Samples could be shipped through specific providers like DHL or FedEx inside 3 – 5 enterprise days, whereas bulk orders are transported by sea or air freight in keeping with buyer necessities.

10. Well being Efficacy Analysis, Industrial Application Innovation, and Challenges

10.1 Pagtuki sa mga utlanan

  • Nano – Supply Techniques: Scientists are exploring nanoencapsulation methods to enhance the steadiness and bioavailability of alpha – arbutin, enabling higher penetration into the pores and skin and extra focused supply.
  • Mga Sagol nga Therapy: Analysis is underway to research the synergistic results of alpha – arbutin when mixed with different pores and skin – lively substances, comparable to vitamin C and niacinamide, for enhanced pores and skin – lightening and anti – ageing outcomes.

10.2 Mga Hagit

  • Kalig-on: Alpha-arbutin could be unstable beneath sure situations, comparable to excessive temperature or publicity to gentle. Creating extra secure formulations with out compromising its efficacy stays a problem.
  • Pagsunod sa Regulatoryo: As a beauty ingredient, alpha – arbutin should adjust to varied worldwide rules relating to security, labeling, and efficacy claims. Guaranteeing constant compliance throughout completely different markets is essential for its widespread adoption.

11. FAQ

11.1 The place can I purchase Alpha-Arbutin?

  • We provide quite a lot of alpha – arbutin merchandise with completely different purity ranges and packaging choices to satisfy various buyer wants.

11.2 Is Alpha-Arbutin secure for all pores and skin sorts?

Alpha-arbutin is mostly secure for many pores and skin sorts. Nevertheless, people with extremely delicate pores and skin could expertise delicate irritation. It is advisable to carry out a patch check earlier than utilizing new merchandise containing alpha – arbutin.

11.3 Can Alpha-Arbutin be used throughout being pregnant?

There may be restricted analysis on the security of alpha – arbutin throughout being pregnant. Pregnant or nursing girls ought to seek the advice of a health care provider earlier than utilizing merchandise containing alpha – arbutin.

11.4 How lengthy does it take to see outcomes?

Seen pores and skin – lightening outcomes could take 4 – 8 weeks of constant use, because the pores and skin’s pure renewal cycle wants time to exchange pigmented cells with new, lighter – coloured ones.

12. Panapos

Alpha-arbutin stands as a revolutionary ingredient within the magnificence and skincare business, providing efficient pores and skin – lightening, antioxidant, and anti – inflammatory advantages. As a number one producer, Shaanxi Zhonghong Investment Technology Co., Ltd. is dedicated to offering excessive – high quality alpha – arbutin merchandise, backed by superior expertise, strict high quality management, and intensive international attain. Whether or not for creating modern beauty merchandise or advancing dermatological analysis, our alpha – arbutin choices set the usual for excellence.

13. Mga pakisayran

  1. Kameyama, Okay., et al. (1995). Alpha – arbutin: A novel reversible tyrosinase inhibitor from the leaves of Vaccinium ashei. Journal of Agricultural and Meals Chemistry, 43(11), 2807 – 2810.
  1. Wang, Y., et al. (2018). Advances within the manufacturing and software of arbutin. Mga molekula, 23(6), 1461.
  1. European Fee. (2019). Beauty Substances Database (CosIng). Retrieved from [CosIng official website]

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