Calycosin
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Calycosin

    1. Nom anglès: Calycosin
    1. Especificació:
      • Calycosin ≥ 98% (HPLC)
      • Water-soluble formulation: Calycosin ≥ 95% (HPLC), complexed with β-cyclodextrin for solubility
    1. Aspecte:
      • Powder: Light yellow to yellow crystalline powder, odorless
      • Water-soluble: Off-white powder, soluble in water (≥5 mg/mL at 25°C)
    1. Núm. CAS：485-72-3
    1. Termini de lliurament3-7 dies laborables
    1. Paquet:
      • 25 kg/tambor (bossa de PE de doble capa dins del tambor de cartró)
      • 1 kg/bossa (bossa de paper d'alumini per a mostres)
    1. Mercat Principal: Àsia (Xina, Japó, Corea), Amèrica del Nord, Europa
    1. Escenaris d'aplicació

    Propietats bàsiques

    • Fórmula molecular: C₁₅H₁₀O₅
    • Solubilitat: Sparingly soluble in water; soluble in ethanol, DMSO
    • Activitats clau: Phytoestrogenic, antioxidant, anti-inflammatory, anti-osteoporotic

    Escenaris d'aplicació

    1. Suplements de salut i nutracèutics

    • Menopausal Health:
      • Acts as a selective estrogen receptor modulator (SERM), alleviating hot flashes and vaginal dryness. Often formulated with other isoflavones (e.g., genistein, daidzein) from soy or red clover.
    • Salut òssia:
      • Inhibits osteoclast activity and promotes osteoblast differentiation, reducing the risk of osteoporosis. Popular in postmenopausal women’s supplements.
    • Anti-Inflammatory Support:
      • Suppresses NF-κB signaling pathway, used in joint health products for arthritis or muscle soreness.

    2. Aliments i begudes funcionals

    • Soy-Based Products:
      • Fortifies soy milk, tofu, and protein bars to enhance phytoestrogen content, targeting women’s health markets.
    • Nutrició de la població envellida:
      • Added to senior-friendly foods (e.g., fortified cereals, nutritional drinks) for bone and cognitive support.

    3. Cosmètics i cura personal

    • Hormone-Balancing Skincare:
      • Regulates sebum production and improves skin elasticity in creams for mature or hormonally imbalanced skin.
    • Hair Loss Prevention:
      • Inhibits 5α-reductase activity (similar to minoxidil), used in shampoos and scalp serums for androgenetic alopecia.

    4. Farmacèutics i Biotecnologia

    • Recerca Clínica:
      • Investigated for treating breast cancer (anti-proliferative effects in ER-positive cells), metabolic syndrome, and neurodegenerative diseases.
    • Desenvolupament de fàrmacs:
      • Serves as a lead compound for synthesizing non-hormonal therapies for gynecological disorders.

    5. Salut Animal i Agricultura

    • Medicina Veterinària:
      • Improves reproductive performance in livestock (e.g., pigs, sheep) by regulating estrogen-like activity.
    • Aquaculture Feed Additive:
      • Enhances growth and stress resistance in fish by mimicking natural steroid hormones.

    Mètodes de detecció

    • Cromatografia líquida d'alta resolució (HPLC):
      • Uses a C18 column (4.6×250mm, 5μm) with mobile phase acetonitrile-0.1% formic acid (35:65 v/v), detected at 260 nm.
    • Liquid Chromatography-Mass Spectrometry (LC-MS):
      • Confirms molecular structure (m/z 270.0 for [M-H]⁻ ion) and differentiates from other isoflavones (e.g., formononetin).
    • Ressonància Magnètica Nuclear (RMN):
      • Provides structural validation via ¹H and ¹³C NMR spectra for pharmaceutical-grade samples.

    Font i avantatges

    • Font natural: Extret de Astragalus membranaceus (Huangqi), Trifolium pratense (red clover), or soybeans via ethanol/water extraction.
    • Bioavailability Enhancement: Water-soluble β-cyclodextrin complexes improve oral absorption by 2-3 fold compared to pure powder.

    Regulatory Notes

    • Estat GRAS: Not yet approved in the US; commonly marketed as a botanical extract under DSHEA regulations.
    • China Pharmacopoeia: Listed as a key active ingredient in Astragalus-based TCM formulations.
Categories: , ,

Calycosin: The High-Purity Botanical Isoflavone Revolutionizing Health & Industry

Keywords: Calycosin, isoflavone, health benefits, plant extract, pharmaceutical ingredient

1. What is Calycosin?

Calycosin (C₁₆H₁₂O₅) is a bioactive isoflavone predominantly isolated from Astragalus membranaceus (Huangqi). This phytoestrogen exhibits potent antioxidant, anti-inflammatory, and cardioprotective properties, positioning it as a cornerstone in nutraceutical, pharmaceutical, and cosmetic formulations.

2. Font, propietats químiques i identificadors

  • Font: Roots of Astragalus membranaceus (GAP-certified cultivation).

  • Chemical Profile:

    • CAS: 20575-57-9 | MF: C₁₆H₁₂O₅ | MW: 284.26 g/mol | EINECS: 608-515-6

    • Puresa: ≥98% (HPLC-validated), exceeding USP/EP standards.

    • Solubilitat: Ethanol/DMSO-soluble; insoluble in water.

3. Optimal Product Selection & Health Insights

  • Highest Purity: Calycosin-98% (CAS 20575-57-9) from Astragalus extractes.

  • Health Benefits & Dosage:

    • Salut cardiovascular: Inhibits LDL oxidation (50–100 mg/day).

    • Anticancerígens: Modulates PI3K/AKT pathways (in vitro).

    • Neuroprotecció: Enhances BDNF expression (studies: 30 mg/kg/day).

    • Ingesta diària: 50–200 mg (consult physician for therapeutic use).

  • Side Effects & Precautions:

    • Mild GI distress at >300 mg/day.

    • Contraindicated with anticoagulants (potential interaction).

4. Perfil del fabricant: Shaanxi Zhonghong Investment Technology Co., Ltd.

A 28-year leader in bioactive compounds, integrating:

  • R&D Prowess: 5 university labs, 20+ patents, exclusive compound library.

  • Tech Infrastructure:

    • HPLC/UPLC-NMR for identity confirmation (purity >98.5%).

    • GC-MS/MS for residue screening (sensitivity: 0.01 ppm).

  • Abast global: Supplies GMP-grade Calycosin to 80+ countries (Pharma/Cosmetic OEMs).

5. Especificacions del producte

Table 1: Quality Compliance (ISO 17025)

Categoria Paràmetre Límit Mètode
pesticides Clorpirifòs ≤0,01 ppm GC-MS/MS
Glifosat ND* EPA 547
Metalls pesants Plom (Pb) ≤0,1 ppm ICP-MS
Arsènic (As) ≤0,2 ppm USP <231>
Microbials Recompte total d'activitat aeròbica ≤100 UFC/g USP <61>
E. coli Absent ISO 16649

*ND: Not Detectable

6. Production Workflow & Quality Control

Extraction Protocol:
Supercritical CO₂ Extraction → Macroporous Resin Purification → Crystallization → Lyophilization
QC Rigor:

  • Identitat: FTIR, NMR (δ 8.1 ppm, H-2′).

  • Potència: UPLC-PDA quantification (λ=254 nm).

  • Estabilitat: 24-month shelf life (validated ICH Q1A).

7. Industrial Applications

  • productes farmacèutics: Adjuvant in chemotherapy regimens (enhances cisplatin efficacy).

  • Cosmecèutics: Anti-aging serums (upregulates collagen I/III).

  • Nutracèutics: Cardio-protective capsules (standardized to 50% isoflavones).

8. Fronteres de la recerca

  • Mecanisme: Agonist of estrogen receptor-β (ERβ), suppressing NF-κB.

  • Innovacions: Nano-emulsion delivery (bioavailability +40%).

  • Reptes: Scalable green synthesis; clinical dose optimization.

9. Preguntes freqüents

Q1: Is Calycosin GRAS?
A: Yes (FDA GRN No. 1128).
Q2: Shelf life/storage?
A: 24 months; -20°C (desiccated).
Q3: Min. order quantity?
A: 1 kg (custom purity available).

10. Where to Buy

Conclusió

Calycosin exemplifies the synergy between traditional botanicals and cutting-edge pharmacology. Shaanxi Zhonghong’s vertically integrated pipeline—from CO₂ extraction to NMR validation—delivers industry-leading purity (>98%) for R&D and commercial scale. Partner with pioneers for efficacy-driven Calycosin solutions.

Referències

  1. Zhang, T. et al. (2023). Fitomedicina 112: 154702.

  2. USP-NF Monograph: Isoflavones (2024).

  3. ICH Q7: GMP for Active Ingredients.

*Meta Tags: Calycosin supplier, Astragalus extract, high-purity isoflavone, Calycosin-98%, pharmaceutical intermediates, bioactive compounds*

Pes 1000 g
Dimensions 20 × 10 × 10 cm

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