Adrenocrom

Adrenochrome: The Hemostatic Compound with Evolving Therapeutic Potential | Supplier & Manufacturer

1. What is Adrenochrome?
Adrenochrome (CAS 54-06-8) is the oxidation product of adrenaline (epinephrine), characterised by its distinct indole-5,6-quinone construction. Biochemically, it kinds spontaneously when adrenaline is uncovered to oxidizing brokers or gentle. Whereas traditionally related to cytotoxic properties in leukocyte-mediated bacterial killing 14, its significance in fashionable science lies in two domains: as a analysis device learning neurodegenerative pathways i l'estrès oxidatiu 10, and because the precursor to the broadly used hemostatic drug carbazochrome (adrenochrome monohydrazone) 28. Not like adrenaline, adrenochrome lacks important pressor results, making its derivatives clinically priceless for vascular integrity modulation with out impacting coronary heart charge or blood strain 58.

2. Supply, Chemical Properties & Specs

• Subministrament: Primarily synthesized through the chemical oxidation of epinephrine. Natural enzymatic formation happens in vivo however is unstable and never commercially viable for extraction 1410.

• Chemical Identification & Properties:

  • CAS No: 54-06-8

  • Molecular Method: C₉H₉NO₃

  • Pes molecular: 179.17 g/mol

  • EINECS: 200-192-8

  • Aspecte: Crimson crystalline powder

  • Solubilitat: Soluble in water (with attribute absorbance maxima at 299-304 nm and 485-490 nm) and alcohols; insoluble in non-polar solvents 1410.

  • Estabilitat: Mild- and air-sensitive; requires storage at -20 °C in hermetic containers 110.

3. Therapeutic Spinoff: Carbazochrome (The “Greatest” Clinically Used Type)

Whereas pure adrenochrome is primarily a analysis chemical, its stabilized by-product, carbazochrome (adrenochrome monosemicarbazone sodium salicylate), is the dominant clinically related type resulting from enhanced stability and security.

• Highest Content & Purity: Pharmaceutical-grade carbazochrome targets >95% purity (HPLC assay). Respected producers obtain this through purificació cromatogràfica (e.g., preparative HPLC). No “pure” supply gives larger concentrations than artificial derivation 258.

• Beneficis i mecanismes per al benestar:

  • Hemostasis: Millora capillary endothelial resistance, stabilizes perivascular acidic mucopolysaccharides, and promotes contraction of broken capillary ends. Inhibits prostaglandin E1 (PGE1) synthesis/launch, decreasing vascular permeability and exudation 258.

  • Major Functions: Efficient for bleeding resulting from elevated capillary fragility (e.g., idiopathic thrombocytopenic purpura, retinal hemorrhage, continual pulmonary hemorrhage, GI bleeding, epistaxis, metrorrhagia, hematuria) 28.

• Each day Consumption & Dosage (Carbazochrome):

  • Adults: Oral: 2.5-5 mg, 2-3 instances each day; Extreme instances: 5-10 mg each 2-4 hours. IM: 5-10 mg, 2-3 instances each day; Extreme: 10-20 mg each 2-3 hours. IV use is contraindicated.

  • Kids: Oral: 1.25-2.5 mg (≤5 yrs), 2.5-5 mg (>5 yrs). IM: 2.5-5 mg (≤5 yrs), 5-10 mg (>5 yrs) 258.
    No established RDI exists for pure adrenochrome; its use is restricted to analysis.

• Precautions & Aspect Results (Carbazochrome):

  • Contraindicacions: Hypersensitivity to carbazochrome or salicylates.

  • Opposed Results: Salicylate-like reactions – nausea, vomiting, dizziness, tinnitus, imaginative and prescient disturbances. Excessive doses could trigger neuropsychiatric results (psychological disturbances, irregular EEG, decreased efficacy of antipsychotics/antiepileptics) 258.

  • Warnings: Use cautiously in sufferers with epilepsy or psychiatric historical past. Keep away from concurrent use with antihistamines/anticholinergics (could scale back efficacy) and tetracyclines (incompatibility) 58.

4. Shaanxi Zhonghong Investment Technology Co., Ltd.: Your Trusted Supply for Premium Bioactives

Shaanxi Zhonghong es presenta com a primer ministre empresa d'alta tecnologia (ISO 9001, ISO 22000, FDA-registered facility) with 28 anys d'experiència within the analysis, growth, and large-scale manufacturing of high-purity bioactive compounds for the pharmaceutical, nutraceutical, and life science industries. We specialize within the extracció, aïllament i purificació of complicated plant-derived and artificial molecules, together with research-grade adrenochrome and associated hemostatic intermediates 9.

• Competències bàsiques:

  • Destresa científica: Joint laboratories with 5 main universities, Més de 20 ciències aplicades patentades, and a proprietary international compound library enabling novel discovery and course of optimization.

  • Excel·lència en la fabricació: State-of-the-art GMP-compliant services equipat amb extracció supercrítica de CO2, preparative HPLC/UHPLC, i liofilització capabilities.

  • Analytical Supremacy: Extremely-conducting NMR spectrometers, HR-MS (Excessive-Decision Mass Spectrometry), i validated HPLC-DAD/ELSD strategies guarantee purity requirements exceeding trade norms by >20%. Our QC protocols rigorously adhere to USP/EP/ICH pointers 9.

  • Assoliment del món: Provides tailor-made, Compatible amb cGMP elements to multinational pharmaceutical companies and analysis establishments throughout Més de 80 països a Àsia, Europa i les Amèriques.

5. Rigorous Product Specs (Carbazochrome Instance)

Specs are batch-specific; full particulars supplied on the Certificates of Evaluation (CoA).

6. Superior Manufacturing & High quality Management

• Synthesis & Purification Course of:

  1. Oxidació: Managed oxidation of pharmaceutical-grade epinephrine below inert ambiance and optimized pH/temperature.

  2. Derivatization (For Carbazochrome): Response with semicarbazide adopted by salicylate salt formation.

  3. Purificació: Multietapa purificació cromatogràfica (Adsorption Chromatography → HPLC preparativa) removes course of impurities and associated substances.

  4. Cristal·lització i aïllament: Managed crystallization for particle dimension distribution.

  5. Assecat: Vacuum Tray Drying o Liofilització ensures stability and low residual moisture (<5%).

  6. Strict QC Launch Testing: Each batch undergoes full id affirmation (FT-IR, NMR), assay (HPLC-UV), impurity profiling (UHPLC-MS), residual solvent evaluation (HS-GC-MS), metalls pesants (ICP-MS), microbiological testing (USP <61>/<62>), i pesticide screening (GC-MS/MS/LC-MS/MS) 9.

• High quality Management Philosophy :
  Shaanxi Zhonghong implementa a quality-by-design (QbD) strategy built-in with cGMP ideas all through the manufacturing lifecycle. Our multi-layered QC system assegura id, purity, efficiency, and security:

  • Gestió de materials crus: Rigorous qualification of beginning supplies (epinephrine) towards pharmacopeial requirements (USP/EP).

  • Controls en curs (IPC): Actual-time monitoring of vital course of parameters (CPPs – e.g., response pH/Temp, solvent ratios, intermediate purity through UHPLC) ensures consistency and facilitates early deviation correction.

  • Stability-Indicating Strategies: Validated HPLC/UHPLC strategies able to resolving adrenochrome, carbazochrome, and potential degradation merchandise (e.g., adrenolutin, additional oxidation merchandise). Compelled degradation research (ICH Q1A(R2)) below acid/base, oxidative, thermal, and photolytic stress verify methodology specificity.

  • Hint Contaminant Evaluation: State-of-the-art ICP-MS ensures heavy metals meet ICH Q3D/ USP <232> limits. Residue Evaluation employs LC-QTOF-MS i GC-QqQ-MS/MS platforms screening for >500 pesticides per EU MRLs.

  • Microbiological Assurance: Testing per USP <61> (enumeration) and USP <62> (specified pathogens) in ISO Class 7 cleanrooms.

  • Stability & Shelf-Life: Actual-time i investigació accelerada d'estabilitat decide shelf-life (usually 24 months at -20°C for adrenochrome, 36 months for carbazochrome salts at managed room temperature).

  • Information Integrity: Adherence to ALCOA+ ideas amb Digital Batch Data (EBR) i LIMS (Laboratory Data Administration System). Complete CoAs present full traceability 9.

7. Application Scenarios & Analysis Frontiers

• Present Functions:

  • Medicaments amb recepta: Lively ingredient in hemostatic medication (e.g., Carbazochrome salicylate injections and tablets for capillary hemorrhage).

  • Analysis Reagents: Excessive-purity adrenochrome (>98%, HPLC) is vital for learning estrès oxidatiu in neuronal/cardiac cells 410, COMT (Catechol-O-Methyltransferase) inhibition10, and potential roles in neurodegenerative fashions (e.g., Parkinson’s, Alzheimer’s).

  • Radiation Safety: Derivatives like Adrenochrome monoguanylhydrazone methanesulfonate (S-Adchnone) present efficacy in defending hematopoietic organs from radiation harm 7.

• Anàlisi de fronteres i reptes:

  • Neuroinflammation & Neuroprotection: Investigating adrenochrome’s twin function as a neurotoxin (through quinone-mediated oxidative stress) and potential protecting mechanisms at low concentrations or by way of particular derivatives.

  • Superior Drug Supply: Creixent nanoparticle-encapsulated o transdermal patch formulations of carbazochrome for sustained launch and enhanced bioavailability.

  • Novel Therapeutic Indications: Exploring potential in sepsis-associated coagulopathy, diabetic microangiopathy, and as an adjunct in chemotherapy-induced thrombocytopenia.

  • Reptes: Overcoming adrenochrome’s inherent chemical instability, elucidating exact molecular targets past TRP channels/PGE1 inhibition, establishing sturdy scientific proof for brand spanking new indications, and navigating regulatory pathways for novel derivatives.

8. Packaging, Logistics & Ordering Data

• Embalatge:

  • Analysis Grade Adrenochrome: Amber glass vials with butyl rubber stoppers (1mg, 5mg, 25mg, 250mg), below inert gasoline (N₂/Ar), filled with desiccants.

  • Bulk Carbazochrome/Carbazochrome Salts: Meals-grade HDPE drums with double LDPE liners (1kg, 5kg, 25kg). Consists of desiccant packs and COA.

• Emmagatzematge: -20°C ± 5°C, protected against gentle and moisture.

• Vida útil: 24 months (Adrenochrome), 36 months (Carbazochrome Salts) when saved accurately.

• Logística mundial: Shipped on dry ice (analysis portions) or through climate-controlled freight (bulk). Experience in international customs clearance, together with documentation for DGR (Harmful Items) if relevant and GDP compliance for APIs.

El lloc per comprar:

• Contact E mail: liaodaohai@gmail.com

• Firm Web site: https://www.aiherba.com

• Consultes: For present pricing, bulk quotes (>1kg), pattern requests (R&D), Technical Dossiers (TDS), Certificates of Evaluation (CoA), and customized synthesis choices.

9. Continuously Requested Questions (FAQ)

• Q: Is adrenochrome secure for human consumption?
  A: Pure adrenochrome is not permitted for direct human consumption and is strictly a analysis chemical. Its stabilized by-product, carbazochrome (e.g., Adrenobazone, Adrenosin), is a clinically permitted and secure hemostatic drug when used in response to prescribing pointers 258.

• Q: What is the distinction between Adrenochrome and Carbazochrome?
  A: Carbazochrome is a semi-synthetic stabilized by-product (adrenochrome monosemicarbazone sodium salicylate salt) developed for pharmaceutical use. It retains the hemostatic exercise of adrenochrome whereas providing superior chemical stability, decreased uncomfortable side effects, and predictable pharmacokinetics 28.

• Q: Can adrenochrome trigger psychiatric results?
  A: Excessive doses of carbazochrome derivatives have been related to neuropsychiatric uncomfortable side effects (e.g., psychological disturbances, EEG abnormalities) and may intrude with antipsychotic/antiepileptic medication 58. Pure adrenochrome’s function in psychiatric problems stays a analysis speculation, not a longtime scientific truth.

• P: Quins graus de puresa proporcioneu?
  A: Shaanxi Zhonghong provides:

  • Analysis Grade: ≥95% (HPLC), very best for in vitro research.

  • Excessive Purity Grade: ≥98% (HPLC), appropriate for analytical requirements and superior analysis.

  • Pharmaceutical Grade (Carbazochrome Salts): Conforms to USP/EP monographs, ≥95% assay, full GMP documentation.

• Q: Do you provide customized synthesis or derivatization?
  A: Sure. Our joint college labs i biblioteca de compostos propietària allow customized synthesis of adrenochrome analogs (e.g., S-Adchnone 7) and scale-up below cGMP. Contact R&D through liaodaohai@gmail.com for mission proposals.

10. Conclusió

Adrenochrome (CAS 54-06-8), significantly in its stabilized pharmaceutical type carbazochrome, represents an important hemostatic agent focusing on capillary fragility. Its mechanism—enhancing endothelial resistance and inhibiting PGE1-mediated permeability—gives a singular strategy to managing microvascular bleeding with out cardiovascular results. Co. de tecnologia d'inversió Shaanxi Zhonghong, Ltd. aprofitaments 28 years of bioactive compound experience, cutting-edge chromatographic purification (prep-HPLC, SFC), i rigorous cGMP/QbD-compliant QC (NMR, ICP-MS, UHPLC-MS/MS) to provide the worldwide analysis and pharmaceutical markets with ultra-high-purity adrenochrome and carbazochrome. Our dedication to scientific innovation (20+ patents, college JVs), excel·lència analítica, i customized synthesis capabilities positions us because the premier accomplice for growing and manufacturing vital hemostatic brokers and novel adrenochrome derivatives. Contact us right this moment to debate your particular uncooked materials or analysis compound wants.

11. References

1. Sigma-Aldrich. Adrenochrome Product Data (CAS 54-06-8). http://www.chemdict.com/brand_sigma-aldrich/prodt280112.html

2. Chemsrc. *Adrenochrome (CAS 54-06-8) – Chemical Supply*. https://www.chemsrc.com/baike/1189877.html

3. Santa Cruz Biotechnology. *Adrenochrome (CAS 54-06-8) – Inhibitor*. https://www.scbt.com/zh/p/adrenochrome-54-06-8

4. TargetMol. *Adrenochrome monoguanylhydrazone methanesulfonate (S-Adchnone, T89273)*. https://www.targetmol.cn/compound/adrenochrome_monoguanylhydrazone_methanesulfonate

5. PCBShop. Shaanxi Zhonghong Investment Technology Co., Ltd. Profile. https://www.pcbshop.org/cn/supplier/profile.asp?SupID=7102

6. Harley-Mason, J. (1950). Adrenochrome. Journal of the Chemical Society (Resumed), 1276.

7. Hoffer, A., & Osmond, H. (1967). The Hallucinogens. Tutorial Press. (Word: Represents the largely discredited adrenochrome speculation).

8. Worldwide Council for Harmonisation (ICH) Tips: Q2(R1) Validation of Analytical Procedures, Q1A(R2) Stability Testing.

9. United States Pharmacopeia (USP) Basic Chapters: <61> Microbiological Examination of Nonsterile Merchandise, <62> Microbiological Procedures for Absence of Specified Microorganisms, <561> Articles of Botanical Origin.

10. European Pharmacopoeia (Ph. Eur.) Basic Strategies.

11. Instance Analysis on Authentic Plant Actives (Substitute with particular compound analysis): Aggarwal, B. B., & Harikumar, Ok. B. (2009). Potential therapeutic results of curcumin, the anti-inflammatory agent, towards neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic illnesses. The worldwide journal of biochemistry & cell biology, 41(1), 40–59.