Bisabolol

Unlocking the Energy of Bisabolol: Nature’s Soothing Elixir from AIHerba | Supplier & Manufacturer

1. Què és el bisabolol?
Bisabolol, que es presenta principalment com a (-)-α-bisabolol, is a naturally occurring monocyclic sesquiterpene alcohol famend for its distinctive skin-soothing, anti-irritant, and anti inflammatory properties. This bioactive compound is a prized beauty and pharmaceutical ingredient, providing a delicate but potent resolution for delicate pores and skin and numerous inflammatory circumstances. Its delicate floral aroma additional enhances its enchantment in perfumery.

2. Subministrament de productes, propietats químiques i identificació

• Major Natural Supply: Camamilla alemanya (Matricaria chamomilla/recutita), particularly its important oil, is the richest pure supply of (-)-α-bisabolol. Additionally present in smaller portions in Candeia arbre (Vanillosmopsis species) oil and different vegetation.

• Propietats químiques:

  • Quantitat CAS: 515-69-5 (Usually refers back to the racemic combination; pure (-)-α-Bisabolol is 23089-26-1)

  • MF (Formulació Molecular): C₁₅H₂₆O

  • MW (Pes Molecular): 222,37 g/mol

  • EINECS: 207-454-3

  • Aspecte: Líquid viscós d'incolor a groc pàl·lid.

  • Solubilitat: Soluble en alcohols i olis, insoluble en aigua.

  • Optical Exercise: Natural (-)-α-Bisabolol is levorotatory. Artificial variations could also be racemic.

• AIHerba Supply & Benefit: AIHerba makes use of premium German Chamomile flowers, using extracció supercrítica de CO2 i destil·lació molecular patentades methods to yield (-)-α-Bisabolol with unparalleled purity (>98%) and stereochemical integrity, maximizing its bioactivity.

3. What is the Finest Bisabolol? Efficacy, Security & Utilization

• “Finest” Outlined: El màxima eficàcia is constantly attributed to pure (-)-α-Bisabolol resulting from its particular stereochemistry. AIHerba’s concentrate on ultra-high purity pure (-)-α-Bisabolol ensures superior efficiency.

• Highest Content Supply: German Chamomile important oil usually comprises the very best pure focus (as much as ~50%, although AIHerba isolates it to >98%).

• Well being & Pores and skin Benefits:

  • Potent antiinflamatori: Inhibeix la COX-2, la LOX i les citocines inflamatòries (TNF-α, IL-6).

  • Calmant i antiirritant: Quickly calms pores and skin irritation (e.g., from surfactants, UV, chemical peels).

  • Antioxidant: Scavenges free radicals, defending pores and skin cells.

  • Wound Therapeutic & Regenerative: Stimulates fibroblast migration and promotes tissue restore.

  • Antimicrobià: Displays exercise towards sure micro organism and fungi.

  • Penetració millorada: Can enhance pores and skin absorption of different actives.

  • Ajuda amb la barrera cutània: Contributes to a more healthy pores and skin barrier operate.

• Day by day Consumption: El bisabolol s'utilitza principalment tòpicament (cosmetics, skincare). Oral consumption shouldn’t be frequent for bisabolol itself; security ranges depend upon the particular software (beauty, complement, pharmaceutical). Beauty use is usually thought to be secure at typical concentrations (0.2% – 2.0%).

• Wants Consideration:

  • Sensibilitat: Whereas usually well-tolerated, patch testing new merchandise is at all times beneficial.

  • Oxidació: Pure bisabolol can oxidize over time; formulations ought to embrace antioxidants and use acceptable packaging (e.g., airless containers, nitrogen flushing).

• Resultats d'aspecte: Uncommon. Potential for gentle pores and skin irritation or allergic response in extremely delicate people. Natural (-)-α-Bisabolol has a wonderful security profile.

4. Introducing AIHerba: Your Trusted Bisabolol Companion
Shaanxi Zhonghong Investment Technology Co., Ltd. (AIHerba) és un primer ministre empresa d'alta tecnologia integrating agile R&D, collaborative innovation, built-in manufacturing, and international advertising. For over 28 anys, we have specialised in serving the chemical, supplies, and life sciences sectors, with core experience within the extraction, isolation, purification, and industrial software of bioactive plant constituents.

• Destresa científica: 5+ strategic college joint labs, 20+ patented applied sciences, and a globally distinctive biblioteca de compostos propietària.

• Chopping-Edge High quality: HPLC (cromatografia líquida d'excessiva eficiència), GC-MS (cromatografia de gasolina-espectrometria de masses), i RMN superconductora (ressonància magnètica nuclear) guarantee purity requirements exceeding trade norms by 20%+.

• Assoliment del món: Servint Més de 80 països a tota Àsia, Europa i Amèrica, oferint custom-made pure ingredient options to main multinational pharmaceutical corporations, analysis establishments, and beauty giants.

5. Product Specs: Rigorous High quality Management
AIHerba’s (-)-α-Bisabolol adheres to the strictest high quality requirements. Key specs embrace:

Desk 1: Pesticide Residue Evaluation

Desk 2: Heavy Metals Evaluation

Desk 3: Microbial Evaluation

6. Superior Manufacturing Move
AIHerba’s (-)-α-Bisabolol manufacturing exemplifies cutting-edge phytochemistry:

1. Aprovisionament: Premium German Chamomile flowers from licensed sustainable farms.

2. Major Extraction: Extracció supercrítica de CO2 (SFE) – Makes use of tunable strain/temperature for selective, solvent-free isolation of volatiles, preserving delicate actives.

3. Enfocament: Removing of waxes and non-target compounds.

4. Aïllament i purificació: Preparative HPLC and/or Excessive-Vacuum Fractional Distillation – Achieves focused separation of (-)-α-Bisabolol from different terpenes.

5. Crystallization (Non-obligatory): For attaining highest purity grades (>99%).

6. Estabilització: Addició d'antioxidants sinèrgics (per exemple, tocoferol).

7. Control de qualitat estricte: HPLC-DAD/ELSD, GC/HPLC quiral, GC-MS, RMN for identification, purity (>98%), enantiomeric extra, and residual solvent evaluation. ICP-MS per a metalls pesants. Proves microbiològiques segons la farmacopea.

8. Embalatge: Underneath inert environment (Nitrogen) in light-protected, food-grade HDPE or glass containers.

7. Diversos escenaris d'aplicació

• Cosmètica i cura de la pell: Calming serums, delicate pores and skin lotions, after-sun merchandise, anti-redness remedies, child care, post-procedure formulations (laser, peels), zits remedies (mitigates irritation), pure deodorants.

• Medicaments amb recepta: Topical anti-inflammatory and wound therapeutic ointments/gels, mucoadhesive formulations, dental care merchandise (anti-gingivitis).

• Perfumeria: Gives a tender, candy, floral notice with fixative properties.

• Nutracèutics: Included into topical wellness merchandise (e.g., muscle soothing balms).

8. Complete High quality Management (QC)
AIHerba’s QC paradigm is constructed on Pharmaceutical cGMP ideas i aprofitaments instrumentació analítica d'última generació. Identification affirmation makes use of FTIR (Fourier Remodel Infrared Spectroscopy) empremtes dactilars i Cromatografia quiral to confirm the (-)-enantiomer. Purity is quantified by way of validated HPLC-UV/ELSD strategies calibrated towards licensed reference requirements, constantly guaranteeing >98% (-)-α-Bisabolol content material. Residual Solvent Evaluation (Headspace GC-MS) ensures compliance with ICH Q3C tips. Recerca d'estabilitat (ICH Q1A) underneath accelerated and long-term circumstances decide shelf-life and optimum storage parameters. Each batch undergoes full spectroscopic (NMR for structural elucidation if wanted), chromatographic, and microbiological testing, documentat en un Certificates of Evaluation (CoA) traceable to worldwide requirements (USP, EP, CP). Our Certificació ISO 9001 high quality administration system ensures traceability and steady enchancment.

9. Embalatge segur i logística mundial

• Embalatge: Ampolles de HDPE de grau alimentari d'1 kg i 5 kg; bidons de HDPE de 25 kg. Tot nitrogen rentat i folrat amb bossa d'alumini for max oxidation safety. Customized packaging obtainable.

• Emmagatzematge: Retailer tightly sealed in unique packaging, shielded from mild and moisture at 2-8 °C (refrigerat) for long-term stability. Quick-term (<6 months) at <25°C acceptable.

• Logística: Shipped globally by way of logística amb temperatura controlada (chilly chain the place required). Compliant with all worldwide rules (REACH, FDA, COSMOS and so on.). Complete documentation offered.

10. Deep Dive: Well being Mechanisms, Purposes & Innovation

• Mecanisme de moviment: (-)-α-Bisabolol exerts results by way of a number of pathways:

  • Modulates NF-κB and MAPK signaling cascades, suppressing pro-inflammatory cytokine manufacturing.

  • Inhibeix enzims clau: ciclooxigenasa-2 (COX-2), 5-lipoxigenasa (5-LOX).

  • Demonstrates antioxidant exercise by quenching ROS/RNS.

  • Enhances penetration by way of lipid bilayer interplay.

  • Promou la reepitelització i la formació de teixit de granulació en ferides.

• Industrial Purposes & AIHerba Innovation: Past cosmetics, bisabolol enhances transdermal drug supply programs. AIHerba innovates by way of vies de síntesi enantioselectives (per a l'isòmer (-) ultrapur), noves formulacions de cocristalls per a una major estabilitat/solubilitat, i sustained-release supply programs (e.g., lipid nanoparticles) built-in with our biblioteca de compostos propietària screening for synergistic combos.

• Anàlisi de fronteres i reptes:

  • Fronteres: Explorant l'eficàcia en neuroinflammatory circumstances, gastroprotective results, anti-cancer adjunct remedy (enhancing chemo efficacy/lowering negative effects), superior biomaterials (recobriments antiinflamatoris per a implants).

  • Reptes: Scaling sustainable cultivation of high-bisabolol chamomile strains, cost-effective large-scale chiral purification, definitive medical dose-response research for particular therapeutic endpoints, long-term stability optimization in advanced formulations.

11. Preguntes freqüents (FAQ)

• Q: Is pure (-)-α-Bisabolol higher than artificial?

  • A: Sure, quite a few research point out pure (-)-α-Bisabolol possesses superior eficàcia antiinflamatòria i calmant de la pell in comparison with artificial racemic mixtures or different isomers resulting from its particular stereochemistry.

• Q: What focus of Bisabolol is efficient in cosmetics?

  • A: Typical efficient concentrations vary from 0,2% a 2,0%. Efficacy relies on the formulation and desired impact; AIHerba gives software assist.

• Q: Is Bisabolol secure for delicate pores and skin?

  • A: Completely. Natural (-)-α-Bisabolol is famend for its distinctive tolerance and efficacy in calming delicate, irritated, and reactive pores and skin.

• Q: Does Bisabolol have any identified drug interactions?

  • A: Topical use has no vital reported interactions. Seek the advice of a doctor for potential interactions with oral medicines if used systemically (uncommon).

• Q: How ought to I retailer AIHerba Bisabolol?

  • A: For optimum long-term stability and to stop oxidation, retailer tightly sealed, shielded from mild, and refrigerated (2-8°C). See CoA for particular batch suggestions.

• Q: Is AIHerba Bisabolol compliant with worldwide requirements?

  • A: Sure. Our product meets or exceeds specs outlined in related USP/EP monographs (the place relevant), COSMOS, ISO, and is REACH/FDA compliant. Certificates obtainable.

12. The place to Purchase Premium (-)-α-Bisabolol
Supply the very best purity, naturally derived (-)-α-Bisabolol straight from the producer:

• Lloc web: www.aiherba.com

• Contacte: Sr Liao Daohai

• Correu electrònic: liaodaohai@gmail.com

• Consulta per: Bulk pricing, samples, technical knowledge sheets (TDS), certificates of research (CoA), and formulation assist.

13. Conclusió
(-)-α-Bisabolol stands as a cornerstone bioactive ingredient for light but highly effective soothing and anti inflammatory efficacy. AIHerba, aprofitant 28 years of experience in phytochemistry and superior purification applied sciences, lliura ultra-pure (>98%) pure (-)-α-Bisabolol. De fonts sostenibles i validades per RMN superconductora, HPLC i ICP-MS, our ingredient meets the stringent calls for of worldwide beauty, pharmaceutical, and analysis markets. Select AIHerba for unparalleled high quality, scientific assist, and a dedication to innovation in pure actives.

14. Referències

1. Kamatou, G. P. P., & Viljoen, A. M. (2010). A evaluation of the applying and pharmacological properties of α-bisabolol and α-bisabolol-rich oils. Revista de la Societat Americana de Químics del Petroli, 87(1), 1-7.

2. European Medicines Company (EMA) Evaluation Report on Matricaria recutita L., flos. (2015).

3. Cavalieri, E., et al. (2004). Professional-apoptotic exercise of α-bisabolol in preclinical fashions of major human acute leukemia cells. The Journal of Medical Investigation, 114(3).

4. Worldwide Group for Standardization (ISO). ISO 16128 – Tips on technical definitions and standards for pure and organic beauty substances.

5. United States Pharmacopeia (USP) Normal Chapters: <561> Articles of Botanical Origin, <2023> Microbiological Examination of Nonsterile Merchandise.

6. European Pharmacopoeia (Ph. Eur.) Monographs: 2.8.12 Microbiological examination of non-sterile merchandise, 2.4.8 Heavy Metals.

7. Current Analysis (e.g., search PubMed.gov for “alpha-bisabolol mechanism”, “bisabolol pores and skin”, “bisabolol wound therapeutic” – 2023/2024 publications). AIHerba Inner Analysis & Stability Information.