Zeaxanthin: The Visionary Antioxidant Powering Subsequent-Gen Well being Improvements | Supplier & Manufacturer
1. Šta je zeaksantin?
Zeaksantin je dijetalni ksantofil karotenoid characterised by its karakterističan žuto-narandžasti pigment and potent redox exercise. Structurally categorised as a *3,3′-dihydroxy-β-carotene* spinoff, it options 11 konjugiranih dvostrukih veza i ionone ring hydroxyl teams that allow distinctive free radical scavenging capability (ORAC worth: 40,000 μmol TE/g)15. As one among solely two carotenoids (alongside lutein) concentrated within the human macula, it contains as much as 90% of the central retinal pigment epithelium—serving as nature’s “inner sun shades” towards high-energy blue mild210.
2. Opskrba, hemijska svojstva i specifikacije
Prirodni izvori i ekstrakcija
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Glavni izvori:
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Žuti kukuruz (highest focus: 0.5–2.5 mg/100g)610
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Narandžaste paprike (1,3–3,5 mg/100 g)
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Žumanjci (0,3–0,5 mg/100 g)
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Goji bobice (0,8–1,3 mg/100 g)
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Strategije ekstrakcije:
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Superkritična CO₂ ekstrakcija (45°C, 250 bara) za izolaciju osjetljivu na toplinu
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Kristalizacija rastvaračem etil acetata → hromatografsko prečišćavanje (čistoća ≥95%)9
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Hemijski identifikacijski broj
Nekretnina | Vrijednost |
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CAS broj | 144-68-3 |
Molekularna formula | C₄₀H₅₆O₂ |
Molekularna težina | 568,87 g/mol |
EINECS | 205-636-4 |
Nivo topljenja | 203–205°C |
Rastvorljivost | Rastvorljiv u lipidima; nerastvorljiv u vodi19 |
Stabilnost | Gentle/temperature-sensitive; degrades above 120°C9 |
3. Prednosti za dobrobit, optimalno doziranje i sigurnost
Terapeutska superiornost
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Macular Safety:
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Filters 90% of blue mild (400–460 nm) and reduces AMD threat by 43% by way of Aktivacija Nrf2 puta210
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Antioksidativna zaštita:
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Quenches singlet oxygen (¹O₂) 2.5x quicker than β-carotene; protects retinal lipids from peroxidation
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Onkološka vježba:
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Izaziva Apoptoza posredovana Bax/Bcl-2 u HepG2 ćelijama (IC₅₀: 1,2 mg/mL)1
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Kognitivno poboljšanje:
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Crosses blood-brain barrier; reduces hippocampal oxidative stress by 65% in Alzheimer’s fashions
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Prijedlozi za doziranje
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General Eye Well being2–6 mg/dan2
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Terapeutska upotreba:
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Prevencija AMD-a: 10–12 mg/dan (s luteinom)
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Submit-cataract restoration: 8–10 mg/day
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Security Threshold: ≤20 mg/day (extra could trigger carotenodermia)2
Highest-Efficiency Sources
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Ekstrakti cvijeta nevena5–10% zeaksantin
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Oleoresini paprike: 3–8% zeaxanthin (esterified type)
Crucial Precautions
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Interakcije lijekovaPojačava antikoagulanse (npr. varfarin) - pratiti PT/INR
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Termička degradacija: Keep away from cooking above 120°C; use encapsulated varieties for baked items
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Pojačivači apsorpcije: Devour with wholesome fat (e.g., avocado, olive oil) for 300% bioavailability improve
Zeaxanthin Meals
4. Firm Introduction: Shaanxi Zhonghong Biotechnology Co., Ltd.
Inovator s 28-godišnjim iskustvom u proizvodnji biljnih ekstrakata, iskorištavajući proprietary purification applied sciences to ship cGMP-grade zeaxanthin assembly pharmacopeial requirements.
Osnovne sposobnosti:
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Ekstrakcija zaštićena patentom: 20+ patents together with ultrasonic-assisted crystallization (CN201810023456.7)
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Analitička rigoroznost: HPLC-PDA-ELSD, 800MHz NMR making certain Čistoća >99,51 TP3T (prevazilazi monografije USP/EP)
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Međunarodna usklađenostCertifikati ISO 9001, FDA-GMP, EFSA, JECFA
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Omogućite savladavanje lanca: Chilly-chain logistics throughout 80+ nations
5. Product Specs: Pharmaceutical-Grade Zeaxanthin QC
Ostaci pesticida
Pesticid | Ograničenje (ppm) | Metodologija provjere |
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Klorpirifos | ≤0,01 | GC-MS/MS (EU 396/2005) |
Glifosat | ≤0,05 | HPLC-MS/MS (ISO 16308) |
Teški metali
Sastojak | Ograničenje (ppm) | Metodologija provjere |
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Olovo (Pb) | ≤0,5 | ICP-MS (USP <233>) |
Arsen (As) | ≤0,5 | AAS (EP 2.4.27) |
Mikrobiološki parametri
Parametar | Ograniči | Metodologija provjere |
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Kompletna ploča ovisi | ≤1.000 CFU/g | USP <61> |
E. coli | Odsutan | ISO 16654 |
Salmonela vrste | Odsutan | FDA BAM Poglavlje 5 |
6. Vrhunski proizvodni tok rada
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Nabavka: Natural marigold petals (Tagetes erecta) ili paprika
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EkstrakcijaSuperkritični CO₂ (45°C, 250 bara) → saponifikacija
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PročišćavanjePreparativna HPLC sa C30 kolonama
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StabilizacijaKapsuliranje suncokretovog ulja (održavanje stabilnosti 85%)
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StandardizacijaUV-Vis na 452 nm (zeaksantin ≥95%)
7. Namjene u različitim industrijama
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Nutraceutici: Eye well being capsules (zeaxanthin:lutein = 1:2 ratio)
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Lijekovi na recept: Dry AMD adjuvant remedy (10 mg/day formulation)
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Kozmetičke preparate: Blue-light safety serums (liposomal supply)
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Korisni obroci: Fortified toddler formulation (DHA/zeaxanthin synergy)
8. High quality Management: 360° Assurance Protocol
Zeaxanthin batches bear četverofazna verifikacija:
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Id AffirmationFT-IR spektralno podudaranje (3.400 cm⁻¹ OH; 1.660 cm⁻¹ C=C)
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Kvantifikacija čistoćeUHPLC-UV na 452 nm (ICH Q2(R1)-validirano; LOD: 0,02%)
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Testiranje bioaktivnosti:
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In vitro ARPE-19 cell antioxidant assay: ≥80% ROS discount at 5 μM
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ABTS uklanjanje radikala: IC₅₀ ≤ 10 μM
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Stabilnost: 24-month shelf-life beneath 25°C/60% RH (ICH Q1A(R2))
9. Granice i izazovi analize
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Mehanistički uvidi:
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Nrf2/ARE pathway modulation for retinal pigment epithelial (RPE) safety
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Intestine microbiota-derived metabolites enhancing ocular bioavailability
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Medical Translation:
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Part III trials for zeaxanthin-glaucoma neuroprotection
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Technical Boundaries:
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Fotostabilnost: Microencapsulation with ethyl cellulose to stop UV degradation
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Oralna apsorpcija: Self-emulsifying drug supply techniques (SEDDS) to spice up bioavailability from 12% to 90%
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Održivost:
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Recikliranje biomase nevena u biorazgradivu ambalažu
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10. FAQ: Professional Solutions
Q: Can zeaxanthin reverse current macular degeneration?
A: No. It slows development however can not regenerate broken RPE cells—early intervention is important2.
Q: Protected for diabetics?
A: Sure. Improves retinal microcirculation with out affecting HbA1c10.
Q: Why select esterified vs. free zeaxanthin?
A: Esterified varieties (e.g., paprika extracts) resist gastric degradation; free varieties higher for sublingual supply.
P: Optimalno vrijeme potrošnje?
A: Jutro s obrocima bogatim omega-3 masnim kiselinama (sinergistička apsorpcija).
The place to Purchase Pharmaceutical-Grade Zeaxanthin
🔬 Direktna narudžba iz Shaanxi Zhonghonga:
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Elektronska pošta: liaodaohai@gmail.com
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Web stranica: aiherba.com
Zaključak
Zeaksantin predstavlja nature’s final ocular defend—with clinically validated roles in imaginative and prescient preservation, cognitive well being, and oxidative protection. For innovators searching for licensed, traceable zeaxanthin, Shaanxi Zhonghong delivers unparalleled excellence: ISO 17025-accredited analytics, batch-specific chiral purity verification, and international cold-chain logistics.
Defend Your Imaginative and prescient—Request HPLC Chromatograms At this time!
Reference:
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Hemijska knjiga. (2024). Zeaxanthin Properties & Purposes 1.
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BBS.HCBBS. (2023). Zeaxanthin Dosage & Security Pointers 2.
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Časopis za očnu farmakologiju. (2024). Mehanizmi puta zeaksantina Nrf2.
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Hemija obroka. (2025). Optimizacija stabilnosti enkapsuliranog zeaksantina.
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Investigative Ophthalmology & Visible Science. (2024). ARPE-19 Cell Safety Information.
Recenzije
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