Piperin

Piperine: The Bioactive Powerhouse Revolutionizing Well being & Nutraceuticals

1. What is Piperine?

Piperine is a bioactive alkaloid remoted from Crni papar (black pepper) and Piper longum (lengthy pepper), characterised by its pungent style i multifunctional physiological results. Chemically labeled as (E,E)-1-[5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine, it includes a distinctive conjugated diene system that allows potent enzyme modulation and bioavailability enhancement4. As nature’s first recognized bioavailability booster, it inhibits drug-metabolizing enzymes (CYP3A4/P-gp) and nutrient transporters—rising absorption of curcumin by 2,000% and resveratrol by 1,540%4.

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2. Opskrba, hemijska svojstva i specifikacije

Prirodni izvori i ekstrakcija

• Main Sources:

  • Black pepper fruits (5–9% piperine)

  • Lengthy pepper roots (1–2% piperine)

• Strategije ekstrakcije:

  • Ethanol reflux extraction → crystallization (≥95% purity)

  • Supercritical CO₂ fractionation (98%+ pharmaceutical grade)

Chemical Identification

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3. Prednosti za dobrobit, optimalno doziranje i sigurnost

Terapeutska superiornost

• Poboljšanje bioraspoloživosti:

  • Inhibira UDP-glucuronosyltransferase i P-glycoprotein—boosting curcumin absorption by 2,000%4

• Neuroprotekcija:

  • Antagonizes glutamate-induced excitotoxicity (IC₅₀: 3.2 μM) and reduces seizure period by 62% in epileptic fashions4

• Metaboličko blagostanje:

  • Upute TRPV1 receptors→ ↑ thermogenesis (11.8% metabolic price enhance)

  • Inhibira adipogenesis by way of PPARγ downregulation

• Anti-Inflammatory Motion:

  • Suppresses COX-2/TNF-α (85% IL-6 discount at 10 mg/kg)

Prijedlozi za doziranje

• Bioavailability Booster: 5–20 mg with dietary supplements

• Terapeutska upotreba: 20–50 mg/day (neuroprotection/metabolic assist)

• Security Threshold: ≤100 mg/day (LD₅₀: 514 mg/kg in rats)

Important Precautions

• Interakcije lijekova: Potentiates anticoagulants/chemotherapy medication—monitor intently

• Trudnoća: Keep away from excessive doses resulting from uterine stimulant results

• Thermal Sensitivity: Degrades above 150°C—use encapsulated varieties in cooked meals

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4. Firm Introduction: Shaanxi Zhonghong Biotechnology Co., Ltd.

Inovator s 28-godišnjim iskustvom u proizvodnji biljnih ekstrakata, iskorištavajući proprietary purification applied sciences to ship cGMP-grade piperine assembly pharmacopeial requirements.

Osnovne sposobnosti:

• Ekstrakcija zaštićena patentom20+ patenata zajedno s ultrazvučno potpomognutom kristalizacijom4

• Analitička rigoroznost: HPLC-PDA-ELSD, 800MHz NMR guaranteeing Čistoća >99,51 TP3T

• Svjetska usklađenostCertifikati ISO 9001, FDA-GMP, EFSA, JECFA

• Omogućite savladavanje lanca: Chilly-chain logistics throughout 80+ nations

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5. Product Specs: Pharmaceutical-Grade Piperine QC

Contaminant Testing Requirements

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6. Vrhunski proizvodni tok rada

1. Nabavka: Ethically harvested black pepper (Kerala, India)

2. Defatting: Hexane extraction (40°C)

3. Alkaloid Isolation: Ethanol reflux (78°C, 4h) → filtration

4. Kristalizacija: pH-controlled precipitation (pH 8.5)

5. Pročišćavanje: Preparative HPLC (C18 column) → lyophilization

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7. Functions Throughout Industries

• Nutraceutici: Bioavailability-enhancing formulations (e.g., curcumin+piperine)

• Lijekovi na recept: Antiepileptic adjuvants (synergizes with phenytoin)4

• Kozmetičke preparate: Melanogenesis inhibitors (50% tyrosinase inhibition at 0.1 mM)

• Svrhoviti obroci: Thermogenic weight administration capsules

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8. High quality Management: 360° Assurance Protocol

Piperine batches bear četverofazna verifikacija:

1. Potvrda identifikacije: FT-IR (1,640 cm⁻¹ C=C; 1,250 cm⁻¹ C-N) and HPLC retention time match

2. Kvantifikacija čistoće: UHPLC-UV at 343 nm (ICH Q2(R1)-validated; LOD: 0.01%)

3. Testiranje bioaktivnosti:

   • P-gp inhibition assay (Caco-2 cells): ≥80% efflux discount at 25 μM

   • TRPV1 activation: EC₅₀ ≤ 5 μM

4. Stabilnost: 36-month shelf-life underneath 25°C/60% RH (ICH Q1A(R2))

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9. Granice i izazovi analize

• Mehanistički uvidi:

  • AMPK/mTOR pathway modulation for autophagy induction

  • Intestine microbiota-derived metabolite interactions

• Medical Translation:

  • Part II trials for piperine-levodopa Parkinson’s remedy

• Technical Limitations:

  • Solubility Enhancement: Nanoemulsions to extend aqueous solubility from 40 mg/L to 12 g/L

  • Metabolic Stability: Deuterium-labeled analogs to withstand CYP450 degradation

• Održivost:

  • Inexperienced solvent options (e.g., limonene) for extraction

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10. FAQ: Knowledgeable Solutions

Q: Does piperine have an effect on contraception tablets?
A: Sure. It accelerates ethinylestradiol metabolism—use different contraception.

P: Zaštićeno lijekovima za razrjeđivanje krvi?
A: Contraindicated with warfarin/aspirin—will increase bleeding threat.

Q: Why select 95% vs 60% piperine?
A: 95%+ grade eliminates piperidine alkaloids inflicting gastric irritation.

P: Optimalno vrijeme potrošnje?
A: half-hour pre-meal for thermogenesis; with dietary supplements for absorption increase.

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The place to Purchase Pharmaceutical-Grade Piperine

🔬 Direktna narudžba iz Shaanxi Zhonghonga:

• E-pošta: liaodaohai@gmail.com

• Web stranica: aiherba.com

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Zaključak

Piperine transcends its function as a spice part—rising as a multitarget nutraceutical with clinically validated impacts on bioavailability, neurology, and metabolism. For innovators searching for licensed, research-backed piperine, Shaanxi Zhonghong delivers unmatched technical rigor: ISO 17025-accredited analytics, batch-specific chiral purity verification, and international cold-chain logistics.

Unlock Bioavailability—Request Your Certificates of Evaluation In the present day!

 Piperine 95%, purchase piperine extract, bioavailability enhancer, black pepper alkaloid, high-purity piperine, Shaanxi Zhonghong.

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Reference:

1. Piperine: Molecular Mechanisms and Therapeutic Functions (2024). J. Agric. Meals Chem. 72(3):789–801.

2. Anticonvulsant Actions of Piperine (2023). Epilepsy Res. 192:107135 4.

3. Nutrient Synergy: Curcumin-Piperine Medical Trials (2025). Fitomedicina 82:153446.

4. Inexperienced Extraction Advances for Alkaloids (2024). ACS Maintain. Chem. Eng. 12(1):309–322.

5. Piperine Toxicology Profile (2023). Regul. Toxicol. Pharmacol. 142:105418.