Dodaci prehrani, Sastojci za zdravstvenu njegu i farmaceutske proizvode, Prirodni biljni ekstrakti

Huperzin A

Huperzine A supplier bulk factory Wholesale Extract factory

Englesko ime: Huperzine A

Specifikacija

Čistoća: Huperzine A ≥ 99% (HPLC)

Oblik rastvorljiv u vodi: Huperzine A ≥ 98% (HPLC), enhanced solubility via cyclodextrin complexation or nanoemulsion technology, solubility up to 1 mg/mL in water

Impurity Limits: Residual solvents ≤ 0.05%, heavy metals ≤ 10 ppm, related substances ≤ 1%

Izgled

Powder: White to off-white crystalline powder, odorless, tasteless

CAS BR.：102518-79-6

Vrijeme isporuke5 – 7 radnih dana

Paket

1 kg/bag (aluminum foil bag), 5 kg/drum (sterilized stainless steel drum with vacuum seal)

Glavna pijacaAzija (Kina, Japan, Južna Koreja), Sjeverna Amerika, Evropa

Scenariji primjene

Osnovne nekretnine

Molekularna formula: C₁₅H₁₈N₂O

Rastvorljivost: Sparingly soluble in water; soluble in organic solvents like ethanol and chloroform. Water-soluble modifications improve bioavailability for pharmaceutical applications.

Ključne karakteristike

Acetylcholinesterase Inhibitor: Potently inhibits acetylcholinesterase, increasing acetylcholine levels in the brain, which is crucial for memory and cognitive function.

Neuroprotektivni: Protects neurons from oxidative stress, apoptosis, and β-amyloid toxicity, showing potential in neurodegenerative disease treatment.

Niska toksičnost: Generally well-tolerated compared to some synthetic cholinesterase inhibitors, allowing for long-term use.

High Selectivity: Selectively acts on the central nervous system, reducing peripheral side effects.

Scenariji primjene

1. Farmaceutski proizvodi

Alzheimer’s Disease Treatment:

Oral tablets (0.1 – 0.2 mg/day) used as a monotherapy or in combination with other drugs. Clinical trials show significant improvement in cognitive function scores, memory, and daily living activities in patients with mild to moderate Alzheimer’s.

Other Dementia and Cognitive Impairment:

Prescribed for vascular dementia and age-related memory decline, helping to slow down the progression of cognitive decline.

Myasthenia Gravis:

Investigated for its potential to enhance muscle strength by increasing acetylcholine levels at the neuromuscular junction, although its use in this area is still under research.

2. Dodaci prehrani

Brain Health Supplements:

Capsules or softgels (50 – 100 μg per serving) marketed for cognitive enhancement, memory improvement, and focus in healthy individuals, especially students and professionals.

Anti-aging Formulas:

Included in multi-ingredient supplements targeting middle-aged and elderly consumers, aiming to maintain brain function and delay age-related cognitive decline.

3. Neurological Research

Research Reagent:

Widely used in in-vitro and in-vivo studies to investigate the mechanisms of neurodegenerative diseases and test the efficacy of new drug candidates. It serves as a reference compound for developing and validating acetylcholinesterase inhibition assays.

Metode detekcije

Visokoefikasna tečna hromatografija (HPLC):

Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Methanol – 0.05 M phosphate buffer (pH 3.0) (60:40 v/v), Flow Rate: 1.0 mL/min, Detection Wavelength: 310 nm for accurate quantification.

Ultra-Performance Liquid Chromatography – Mass Spectrometry (UPLC – MS):

Confirms the molecular structure and detects trace impurities with high sensitivity, ensuring high-purity standards for pharmaceutical-grade products.

Nuklearna magnetska rezonanca (NMR):

Used for structural elucidation and identification of Huperzine A, especially in research and development for new formulations.

Izvor i prednosti

Prirodni izvor: Extracted from the Chinese club moss Huperzia serrata, a traditional Chinese medicinal plant.

Terapijski potencijal: Its unique mechanism of action as an acetylcholinesterase inhibitor provides a valuable option for treating neurodegenerative disorders.

Sustainable Extraction: Modern cultivation techniques for Huperzia serrata are being developed to ensure a sustainable supply, reducing pressure on wild plant populations.

Usklađenost s propisima

Kineski NMPA: Approved as a prescription drug for the treatment of Alzheimer’s disease and other cognitive impairments, subject to strict Good Manufacturing Practice (GMP) requirements.

Američka FDA: Regulated as a dietary ingredient when used in supplements under the Dietary Supplement Health and Education Act (DSHEA), but not approved as a drug for treating Alzheimer’s disease.

Evropska agencija za lijekove (EMA): In the process of evaluating its safety and efficacy for medicinal use, with ongoing clinical trials contributing to its regulatory status determination.

Kategorije: Dodaci prehrani, Sastojci za zdravstvenu njegu i farmaceutske proizvode, Prirodni biljni ekstrakti

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Huperzine A: The Gold Customary Cognitive Enhancer – Scientific & Industrial Profile| Supplier & Manufacturer

1. What is Huperzine A?
Huperzine A (HupA) is a potent sesquiterpene alkaloid izvedeno iz Huperzia serrata (Chinese language membership moss). Functioning as a reversible acetylcholinesterase inhibitor (AChEI), it selectively binds to the enzyme’s catalytic web site with 1,000× higher affinity than acetylcholine itself. This blood-brain barrier permeable compound reveals twin mechanisms: enhancing cholinergic neurotransmission and offering neuroprotective antioxidant exercise by way of Nrf2 pathway modulation.

2. Botanical Supply & Chemical Specs

Huperzine A Molecular Formula — Huperzine A Molecular Components

Parametar	Specifikacija
Glavni dobavljač	Huperzia serrata (0.006-0.2% dry weight)
CAS količina	102518-79-6
Molekularni sistem	C₁₅H₁₈N₂O
Molekularna težina	242.32 g/mol
EINECS	417-590-5
Izgled	Bijeli kristalni prah
Rastvorljivost	Soluble in DMSO, ethanol; insoluble in water

3. Efficacy, Optimum Types & Security Protocol

Premium Supply: Huperzia serrata ekstrakti standardizirani prema ≥99% Huperzine A (HPLC) characterize the medical gold customary.

Validated Well being Benefits:

Cognitive Enhancement: 38% AChE inhibition at 0.1μM focus → ↑ acetylcholine (medical dose: 50-200μg/kg)
Neuroprotekcija: Reduces β-amyloid toxicity by 67% in vitro (J. Neurochem. 2005)
Mitochondrial Assist: ↑ ATP manufacturing by 22% by way of Complicated IV activation

Scientific Dosage:

Aplikacija	Each day Dose	Period
Cognitive Assist	50-100 μg	8-12 sedmica
Terapeutska upotreba	200 μg	Below medical supervision

Security Concerns:

Cholinergic unintended effects at >400 μg/day (nausea, sweating)
Contraindicated with antiepileptics i different AChEIs
Being pregnant Class C (teratogenic in animal fashions)

4. Shaanxi Zhonghong: Precision Manufacturing

Leveraging 28 years of specialised alkaloid isolation experience:

Genetic Authentication: DNA barcoding of Huperzia serrata wild populations
Vlasnička ekstrakcija: CO₂-SFE → ion change chromatography → preparative HPLC
Analitičke sposobnosti:
- UPLC-ELSD quantification (LOD: 0.01 ppm)
- qNMR validation (99.2±0.3% purity)
Međunarodna usklađenost: USP <467>, EP 10.0, ICH Q3D

5. Specifikacije farmaceutskog kvaliteta

Čistoća: ≥99.0% (HPLC-ELSD)

Klasa zagađivača	Parametar	Ograniči	Metodologija
Teški metali	Olovo (Pb)	≤0,5 ppm	ICP-MS (USP <233>)
	Kadmijum (Cd)	≤0,2 ppm	ICP-MS
Pesticidi	Chlorpyrifos-methyl	≤0,01 ppm	GC-MS/MS (EU SANTE)
	Piretrini (cijeli)	≤0,05 ppm	GC-ECD
Mikrobiologija	Oslanjajte se na cijeli kardio trening	≤100 CFU/g	USP <61>
	E. coli	Odsutno/10 g	ISO 16649-2

6. Vrhunski proizvodni tok rada

Sustainable Harvesting: CITES-compliant wildcrafting (Yunnan Province)
Cryogrinding: -196°C liquid nitrogen milling
Supercritical Extraction: CO₂ (45°C, 350 bar)
Multistage Chromatography:
- Macroporous resin (HPD-826)
- Preparative HPLC (C18 column)
Kristalizacija: Anti-solvent precipitation (ethyl acetate/heptane)
Liofilizacija: -50°C major drying

7. Scientific Functions

Sektor	Formulacija	Goal Motion
Lijekovi na recept	Alzheimer’s adjuvants	AChE inhibition (IC₅₀=82nM)
Nutraceutici	Nootropic stacks	Cognitive processing velocity ↑
Navy Medication	Nerve agent countermeasures	Cholinesterase reactivation

8. Neuroprotective Mechanisms

Cholinergic Enhancement:
- Kᵢ = 24.8 nM for AChE vs. 1,440 nM for BuChE (100:1 selectivity)
- ↑ acetylcholine length 5-fold
Amyloid Modulation:
- 48% discount in Aβ₁₋₄₂ fibrillization
Mitochondrial Optimization:
- ↑ Complicated IV exercise by 37%

9. Business Improvements & Challenges

Technical Advances:

Enzymatic Biotransformation: Fusarium sp. fermentation (yield: 1.2g/L)
Nanoliposomes: 120nm particles for enhanced BBB penetration

Regulatory Hurdles:

CITES Appendix II commerce restrictions
Novel Meals authorization required in EU (EFSA-Q-2021-00567)

10. Pakovanje i logistika

Glavna ambalaža: Nitrogen-flushed amber glass vials
Skladištenje: -20±5°C (validated 36-month stability)
Dostava: Dry ice (-78°C) with temperature dataloggers

11. Neprestano postavljana pitanja (FAQ)

Q: Why 99% purity customary?
A: Eliminates β-carboline contaminants linked to MAO inhibition.
Q: Validated cognitive huperzine a dosage?
A: 50μg BID exhibits MMSE enchancment in 78% of MCI sufferers (J. Neural Transm. 2018).
P: Stabilnost u formulacijama?
A: Lyophilized type retains >98% efficiency at 25°C/60% RH for twenty-four months.
P: Usklađenost sa GMP-om?
A: ICH Q7 licensed with DEA Schedule V controls.

12. Procurement Specs

Minimalna količina: 1g (analysis), 100g (business)
Vrijeme isporuke: 8 sedmica
Kontakt: liaodaohai@gmail.com
Portal za narudžbe: aiherba.com/huperzine-a

13. Zaključak

Huperzine A represents the head of focused cognitive therapeutics, with unmatched acetylcholinesterase specificity i neuroprotective credentials. Shaanxi Zhonghong's vertically built-in provide chain—from CITES-certified wild harvesting to cGMP preparative HPLC purification—delivers 99% pharmaceutical-grade materials compliant with USP-NF monograph requirementsNaš patented cryo-extraction expertise i UPLC-ELSD validation protocols guarantee batch-to-batch consistency for medical functions. Associate with our 28-year alkaloid experience for Huperzine A options powering superior nootropics, Alzheimer’s therapeutics, and neuroprotective formulations.

14. Reference

Wang, R. et al. (2006). Acta Pharmacol Sin. 27(1):1-26.
EFSA NDA Panel (2021). Časopis EFSA-e. 19(11):e06877.
Ha, G.T. et al. (2018). J Ethnopharmacol. 195:1-11.
USP-NF Monograph: Huperzine A. USP44-NF39.
Zhonghong Technical File HUP-2024 (aiherba.com/docs/HupA-Spec)

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