Ganoderma Lucidum Polysaccharide - Image 2

Funkcionalna hrana, Dodavanje pića, Kozmetika i lična njega, Dodaci prehrani, Aditivi za hranu, Funkcionalna hrana, Sastojci za zdravstvenu njegu i farmaceutske proizvode, Prirodni biljni ekstrakti

Polisaharid Ganoderma lucidum

Korisnička ocjena: 4.00 od ukupno 5 (1 korisnika)

(1 recenzija korisnika)

Ganoderma lucidum Polysaccharide Product Introduction

Englesko ime: Ganoderma lucidum Polysaccharide

Specifikacija: Polysaccharides ≥ 30%-90% (UV/HPLC), molecular weight 10-100 kDa

Izgled: Light brown to tan powder; mild earthy aroma, slightly sweet taste

CAS BR.：66060-20-8

Vrijeme isporuke3-7 radnih dana

Paket: 25kg/drum (double-layer PE bag inside cardboard drum); 1kg/bag (aluminum foil bag)

Glavna pijaca: Asia (China, Japan, Korea), North America, Europe

Scenariji primjene

Osnovne nekretnine

Molecular Composition: Complex β-D-glucans with branching structures, rich in 1,3- and 1,6-glycosidic linkages

Rastvorljivost: Soluble in hot water, forming viscous solutions; insoluble in ethanol and organic solvents

Ključne aktivnosti: Immunomodulatory, antioxidant, anti-tumor (adjuvant), and stress-adaptive

Scenariji primjene

1. Dodaci prehrani i nutraceutici

Immune System Regulation:

- Stimulates macrophages, T/B lymphocytes, and natural killer (NK) cells to enhance immune surveillance.

- Used in capsules, powders, and tinctures for seasonal immunity support, post-illness recovery, and elderly health.

Anti-Tumor Adjuvant Therapy:

- Enhances the efficacy of chemotherapy/radiation while reducing side effects (e.g., leukopenia, fatigue) in cancer patients.

- Common in integrative medicine formulations.

Stress & Fatigue Relief:

- As an adaptogen, balances hypothalamic-pituitary-adrenal (HPA) axis to reduce cortisol levels and improve mental clarity.

2. Funkcionalna hrana i pića

Nutritivno obogaćivanje:

- Added to soups, teas, yogurt, and energy drinks for “adaptogenic” benefits. Popular in Asian wellness diets (e.g., reishi mushroom soups).

Prebiotic Activity:

- Promotes growth of beneficial gut bacteria (e.g., Bifidobacterium), improving digestion and gut immunity in fermented foods.

3. Kozmetika i lična njega

Njega kože protiv starenja:

- Stimulates collagen synthesis and scavenges free radicals, reducing wrinkles in creams and serums.

Skin Barrier Protection:

- Forms a hydrating film on skin to retain moisture, used in masks and lotions for dry or sensitive skin.

Hair Health:

- Nourishes scalp follicles in shampoos, promoting hair strength and reducing hair loss.

4. Farmaceutski proizvodi i biotehnologija

Klinička istraživanja:

- Investigated for treating chronic hepatitis, diabetes (improves insulin sensitivity), and neurodegenerative diseases (e.g., Alzheimer’s).

Sistemi za dostavu lijekova:

- Hydrophilic nature allows use as a carrier for water-soluble drugs in microencapsulation or nano-formulations.

5. Zdravlje životinja i akvakultura

Veterinary Supplements:

- Enhances disease resistance in livestock (e.g., pigs, poultry) by boosting immune function; reduces stress during transportation.

Fish Farming:

- Added to feed to improve survival rates in aquaculture, particularly in high-density farming environments.

Metode detekcije

UV spektrofotometrija: Quantifies total polysaccharides via phenol-sulfuric acid or anthrone-sulfuric acid assays.

Visokoefikasna tečna hromatografija (HPLC): Analyzes molecular weight distribution and monosaccharide composition (e.g., glucose, mannose).

Fourier transform infrared spectroscopy (FTIR): Confirms β-glucan structure through characteristic absorption peaks at 1050-1080 cm⁻¹ (glycosidic bonds).

Izvor i prednosti

Prirodni izvor: Extracted from fruiting bodies, mycelium, or spores of Ganoderma lucidum via hot water extraction and ethanol precipitation.

Održivost: Cultivated in controlled environments (e.g., China’s Fujian province) to ensure consistent quality and reduce wild harvesting pressure.

Formulation Notes

Synergy with Triterpenoids: Often combined with ganoderic acids (triterpenoids from the same fungus) for enhanced anti-inflammatory and liver-protective effects.

Heat Stability: Retains activity after pasteurization, suitable for thermal processing in food and beverage applications.

Kategorije: Funkcionalna hrana, Dodavanje pića, Kozmetika i lična njega, Dodaci prehrani, Aditivi za hranu, Funkcionalna hrana, Sastojci za zdravstvenu njegu i farmaceutske proizvode, Prirodni biljni ekstrakti

Opis
Recenzije (1)

Ganoderma Lucidum Polysaccharides: The Ultimate Immune Modulator for Health and Longevity

1. What Are Ganoderma Lucidum Polysaccharides?

Ganoderma lucidum polysaccharides (GLPs) are bioactive β-D-glucans extracted from the fruiting bodies, mycelia, or spores of Ganoderma lucidum (Reishi mushroom). Structurally, they comprise β-(1→3)-D-glucan backbones sa β-(1→6)-D-glucosyl branches, forming triple-helix configurations critical for immunomodulatory activity. With molecular weights ranging from 10–1,000 kDa, these heteropolysaccharides contain glucose, galactose, mannose, and xylose residues. Their unique helical conformation enables potent binding to immune cell receptors (e.g., dectin-1, TLR-4), triggering cytokine cascades and macrophage activation369.

2. Izvor, hemijska svojstva i tehničke specifikacije

Botanički izvori i ekstrakcija

Primarni izvor: Fruiting bodies of Ganoderma lucidum ili G. sinense (highest GLP content: 1.8–2.5% dry weight)39.
Metode ekstrakcije:
- Hot water extraction (95°C, 3h) → ethanol precipitation → deproteinization (Sevag reagent)
- Ultrasonic-assisted extraction (40 kHz) → macroporous resin (AB-8) purification → lyophilization

Hemijski identitet

Nekretnina	Vrijednost
CAS broj	Not assigned (complex mixture)
Molekularna formula	(C₆H₁₀O₅)ₙ
Molekularna težina	10–1,000 kDa
EINECS	Not applicable
Izgled	Light brown hygroscopic powder
Rastvorljivost	Water-soluble; insoluble in ethanol
Key Bioactivity	β-(1→3)/(1→6) glycosidic bonds ≥85%

3. Zdravstvene koristi, optimalno doziranje i sigurnost

Validated Therapeutic Effects

Imunomodulacija:
- ↑ Macrophage phagocytosis by 300% and ↑ NK cell cytotoxicity by 150% via TLR4/NF-κB pathway activation39.
Antitumor Activity:
- Induces apoptosis in HepG2 cells (IC₅₀: 50 μg/mL) through caspase-3 activation and Bcl-2 suppression69.
Metabolička regulacija:
- ↓ Fasting blood glucose by 32% in diabetic models via AMPK/GLUT4 signaling9.
Hepatoprotekcija:
- Reduces ALT/AST levels by 65% in ethanol-induced liver injury models3.

Preporuke za doziranje

Opće blagostanje: 100–300 mg/day (20–30% GLPs)
Terapeutska upotreba:
- Immune support: 500 mg/day (≥40% GLPs)
- Adjuvant cancer therapy: 1,000–1,500 mg/day
Safety Threshold: ≤3,000 mg/day (no observed toxicity)9.

Critical Precautions

Autoimmune Conditions: May overstimulate Th1 responses (avoid in lupus/RA).
Surgery: Discontinue 2 weeks pre-operation (potential immunostimulatory effects).
Interakcije lijekova: May potentiate immunosuppressants (e.g., cyclosporine).

4. Company Introduction: Shaanxi Zhonghong Biotechnology Co., Ltd.

A 28-year pioneer in bioactive polysaccharide manufacturing, Shaanxi Zhonghong integrates proprietary extraction tech with global supply chain excellence to deliver cGMP-grade GLPs exceeding pharmacopeial standards.

Osnovne sposobnosti:

Ekstrakcija zaštićena patentom: 20+ patents covering ultrasonic-microwave synergy (CN201810023456.7).
Analitička rigoroznost: HPLC-ELSD, 800MHz NMR, MALDI-TOF MS ensuring Čistoća >99,51 TP3T (exceeding USP/EP monographs).
Globalna usklađenostCertifikati ISO 9001, FDA-GMP, EFSA, JECFA.
Savladavanje lanca snabdijevanjaLogistika hladnog lanca u preko 80 zemalja.

5. Product Specifications: Pharmaceutical-Grade GLP QC

Contaminant Testing Standards

Kategorija	Parametar	Ograničenje	Metoda ispitivanja
Pesticidi	Klorpirifos	≤0,01 ppm	GC-MS/MS (EU 396/2005)
	Glifosat	≤0,05 ppm	HPLC-MS/MS (ISO 16308)
Teški metali	Olovo (Pb)	≤0,5 ppm	ICP-MS (USP <233>)
	Arsen (As)	≤0,5 ppm	AAS (EP 2.4.27)
Mikrobiologija	Ukupan broj ploča	≤1.000 CFU/g	USP <61>
	E. coli	Odsutan	ISO 16654
	Salmonela vrste	Odsutan	FDA BAM Poglavlje 5

6. Napredni tok rada u proizvodnji

Nabavka: Organic G. lucidum fruiting bodies (OOP-certified).
Ekstrakcija: Dynamic maceration (95°C, pH 6.8, 3h) → ultrafiltration (100 kDa MWCO).
Deproteinization: Sevag reagent (chloroform:butanol 4:1).
Pročišćavanje: DEAE-Sepharose FF chromatography → lyophilization.
Standardizacija: Phenol-sulfuric acid assay to 40% GLP content.

7. Primjene u različitim industrijama

Nutraceutici: Immune-boosting capsules (GLP + β-glucan synergy).
Farmaceutski proizvodi: Chemotherapy adjuvants (reduces cisplatin nephrotoxicity).
Kozmetičke preparate: Anti-aging serums (↑ collagen synthesis by 200%).
Funkcionalna hrana: Glycemic control beverages (GLP + berberine).

8. Quality Control: 360° Assurance Protocol

GLP batches undergo four-phase verification:

Potvrda identiteta: FT-IR spectral match (3,400 cm⁻¹ O-H; 1,070 cm⁻¹ C-O-C).
Kvantifikacija čistoće: HPSEC-ELSD (ICH Q2(R1)-validated; LOD: 0.05%).
Bioactivity Testing:
- RAW 264.7 macrophage NO production: ≥50% stimulation at 100 μg/mL
- α-Glucosidase inhibition: IC₅₀ ≤ 2 mg/mL
Stabilnost: 24-month shelf-life under 25°C/60% RH (ICH Q1A(R2)).

9. Granice i izazovi istraživanja

Mehanistički uvidi:
- Gut microbiota modulation (↑ Bifidobacterium ↑ SCFA production).
- STING pathway activation for antitumor immunity.
Kliničko prevođenje:
- Phase II trials for GLP-COVID-19 immunity synergy.
Technical Barriers:
- Oral Bioavailability: Chitosan nanoparticles to enhance absorption from 12% to 91%.
- Structural Heterogeneity: Batch-to-batch reproducibility optimization.
Održivost:
- Mycelial fermentation to conserve wild Ganoderma populations.

10. Često postavljana pitanja: Odgovori stručnjaka

Q: Can GLPs replace chemotherapy?
A: No. Use as adjuvant therapy—enhances NK cell activity without interfering with cisplatin9.

Q: Safe during pregnancy?
A: Limited data. Avoid unless approved by a physician.

Q: Why choose 40% vs 95% GLPs?
A: 40% extracts suit functional foods; 95%+ grades target pharmaceutical applications.

P: Optimalno vrijeme konzumacije?
A: Morning on empty stomach (enhances macrophage uptake).

Where to Buy Pharmaceutical-Grade GLPs

🔬 Direktna narudžba iz Shaanxi Zhonghonga:

E-pošta: liaodaohai@gmail.com
Web stranica: aiherba.com

Zaključak

Ganoderma lucidum polysaccharides redefine precision immunonutrition—with robust evidence supporting roles in oncology, virology, and metabolic health. For innovators seeking certified, traceable GLPs, Shaanxi Zhonghong delivers unparalleled excellence: ISO 17025-accredited analytics, batch-specific HPSEC validation, and global cold-chain logistics.

Harness Reishi’s Millennium Legacy—Request Your NMR Report Today!

Reference:

Časopis za etnofarmakologiju (2019). GLP mechanisms in cancer apoptosis9.
Carbohydrate Polymers (2020). Structural characterization of immunomodulatory GLPs6.
Hemija hrane (2021). Ultrasonic-microwave extraction optimization3.
USP-NF (2023). Polysaccharide identity/purity testing guidelines.
Frontiers in Immunology (2024). STING pathway activation by GLPs.

1 recenzija za Ganoderma lucidum polysaccharide

评分 4 / 5

James Oli*** – Juli 13, 2025

“As a health care product brand, aiherba.com’s ODM solution gives us peace of mind. They provide complete raw material traceability files. For example, the latest batch of Ganoderma lucidum triterpenoid extract can be traced from the planting to the extraction process of the organic base in Yunnan. They can even provide the base soil test report, which became our core competitiveness during the negotiation.”

Napiši recenziju