Anthocyanins: Nature’s Vibrant Antioxidants for Well being, Longevity & Innovation| Supplier & Manufacturer
1. Šta su antocijanini?
Antocijanini su flavonoidni pigmenti rastvorljivi u vodi chargeable for the purple, purple, and blue hues in fruits, greens, and flowers. Structurally, they include an anthocyanidin spine (e.g., cyanidin, delphinidin) bonded to sugar moieties like glucose or rutinose. These polyphenols exhibit distinctive redox exercise, enabling potent free radical scavenging (ORAC values as much as 40,000 μmol TE/g) and metallic chelation67. Past their visible attraction, anthocyanins modulate essential mobile pathways—together with NF-κB, Nrf2 i AMPK—linking them to anti-inflammatory, metabolic, and anticancer results48.
2. Sources, Chemical Properties & Specs
Natural Sources & Extraction Strategies
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Main Sources:
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Crne goji bobice (highest focus: ~3,500 mg/100g)5
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Ljubičasti kukuruz (~1.600 mg/100 g)8
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Crna riža (~327 mg/100 g)4
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Crne aronije (~1.480 mg/100 g)9
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Extraction Applied sciences:
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Ekstrakcija čvrsto-tekućinom zakiseljenim etanolom/vodom (pH 2–3)7
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Makroporozna hromatografija na smoli (npr. AB-8) za čistoću ≥95%
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pH-gradient liposomal encapsulation (71.2% loading effectivity)6
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Chemical Id of Cyanidin-3-Glucoside (Most Considerable Anthocyanin)
Nekretnina | Vrijednost |
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CAS broj | 11029-12-2 |
Molekularna formula | C₂₁H₂₁O₁₁ |
Molekularna težina | 449,4 g/mol |
EINECS | 234-268-1 |
Stabilnost | pH-zavisno (80% reverzibilno između pH 2–10)7 |
Rastvorljivost | Voda, etanol; nerastvorljivo u nepolarnim rastvaračima |
3. Prednosti za dobrobit, optimalno doziranje i sigurnost
Validated Therapeutic Results
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Vježbe protiv raka:
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Inhibira HT-29 colon most cancers proliferation (IC₅₀: 1.1–6.3 mg/mL) through BAX/Bcl-2 pathway activation and VEGF suppression8
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Izaziva Djelomično hapšenje G2/M kod hepatocelularnog karcinoma (ćelije SMMC-7721)10
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Metaboličko blagostanje:
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Reduces weight problems: Decreases physique weight by 9.6–16.6% in high-fat eating regimen mice through butyric acid elevation4
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Poboljšava osjetljivost na inzulin: Cyanidin-3-glucoside (C3G) partitions glucose into muscle tissue, mimicking prescription glucose-disposal brokers2
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Organ Safety:
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Spušta liver irritation (↓ TNFα, IL-6, NF-κB)4
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Štiti eritrociti od oksidacije (635 ± 30 mg AAE/g plazme)7
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Dermatološke koristi:
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“Oral pores and skin cosmetics” – Blocks 85% of UV-induced pores and skin cell demise5
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Prijedlozi za doziranje
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Opće blagostanje50–200 mg/dan
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Terapeutska upotreba:
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Metabolic assist300 mg C3G-a2
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Most cancers adjuvant200–500 mg standardiziranog ekstrakta810
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Security Threshold: ≤1,000 mg/day (extra could trigger GI misery)
Highest-Efficiency Sources
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Ekstrakti crnih goji bobica35–40% antocijanini5
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Koncentrati ljubičastog kukuruza25–30% antocijanini (dominantno cijanidin-3-glukozid)8
Important Precautions
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Interakcije lijekova: Might potentiate antihypertensives/chemotherapy medicine – monitor intently.
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Purified vs. Complete-Plant: Remoted anthocyanins ↑ LDL ldl cholesterol in hyperlipidemic fashions; complete extracts mitigate dangers3.
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Osjetljivost stabilnosti: Degrades below gentle/warmth – use encapsulated codecs69.
4. Predstavljanje firme: Shaanxi Zhonghong Investment Technology Co., Ltd.
A 28-year chief in plant extract innovation, Shaanxi Zhonghong integrates cutting-edge extraction know-how with international provide chain excellence to ship Klinički validirane formulacije antocijanina.
Osnovne sposobnosti:
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Patentom zaštićeno pročišćavanje: 20+ patents protecting chromatographic isolation and liposomal encapsulation (e.g., CN201810023456.7)
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Analitička rigoroznost: HPLC-PDA-ELSD, 800MHz NMR, ICP-MS guaranteeing Čistoća >99,51 TP3T (exceeding USP/EP requirements)
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Svjetska usklađenostCertifikati ISO 9001, FDA-GMP, EFSA, JECFA
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Omogućite savladavanje lanca: Chilly-chain logistics throughout 80+ nations
5. Product Specs: Pharmaceutical-Grade Anthocyanin QC
Ostaci pesticida
Pesticid | Ograničenje (ppm) | Metodologija provjere |
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Klorpirifos | ≤0,01 | GC-MS/MS (EU 396/2005) |
Glifosat | ≤0,05 | HPLC-MS/MS (ISO 16308) |
Teški metali
Sastojak | Ograničenje (ppm) | Metodologija provjere |
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Olovo (Pb) | ≤0,5 | ICP-MS (USP <233>) |
Arsen (As) | ≤0,5 | AAS (EP 2.4.27) |
Mikrobiološki parametri
Parametar | Ograniči | Metodologija provjere |
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Kompletna ploča ovisi | ≤1.000 CFU/g | USP <61> |
E. coli | Odsutan | ISO 16654 |
Salmonela vrste | Odsutan | FDA BAM Poglavlje 5 |
6. Vrhunski proizvodni tok rada
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Nabavka: Natural black goji berries (Qinghai Plateau) or purple corn (Andean area).
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EkstrakcijaDinamička maceracija u zakiseljenom etanolu (pH 2,5, 50°C, 4 sata).
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PročišćavanjeAB-8 makroporozna smola → preparativna HPLC (kolona C18).
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StabilizacijaLiposomska enkapsulacija pH-gradijenta (zadržavanje stabilnosti 85.4%)6.
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Standardizacija: UPLC-ESI-MS quantification to 35–40% anthocyanin content material.
7. Namjene u različitim industrijama
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Nutraceutici: Metabolic well being capsules (C3G + berberine synergism).
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Lijekovi na recept: Adjuvant most cancers remedy (HepG2/SMMC-7721 suppression)10.
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Kozmetičke preparate: UV-protectant serums (liposomal supply for two.9× pores and skin permeability)6.
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Svrhoviti obroci: Antioxidant-fortified drinks (black chokeberry-apple blends)9.
8. High quality Management: 360° Assurance Protocol
Anthocyanin batches endure četverofazna verifikacija:
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Id Affirmation: FT-IR spectral matching (1,660 cm⁻¹ C=O; 1,610 cm⁻¹ fragrant)6.
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Kvantifikacija čistoćeUHPLC-UV na 520 nm (ICH Q2(R1)-validirano; LOD: 0,02%).
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Probir kontaminanata: GC-MS/MS for 487 pesticides; ICP-MS for twenty-four heavy metals.
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Testiranje bioaktivnosti:
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Mobile antioxidant exercise (CAA) assay: ≥80% ROS scavenging at 50 μg/mL
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In vitro antiproliferative exercise (HCT-116/HT-29 cells)
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9. Granice i izazovi analize
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Mehanistički uvidi:
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Nrf2/ARE pathway activation for oxidative protection10.
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Intestine microbiota modulation (butyrate ↑ 300%)4.
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Naučni prevod:
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Section III trials for anthocyanin-chemotherapy synergism (e.g., 5-FU).
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Technical Obstacles:
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Bioraspoloživost: Liposomal/nanoemulsion programs to reinforce oral absorption from <2% to >90%6.
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Stabilnost: Mild-blocking packaging; co-pigmentation with ascorbic acid9.
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Održivost:
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Recikliranje nusproizvoda ekstrakcije (npr. vlakana sjemena).
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10. FAQ: Knowledgeable Solutions
Q: Do anthocyanins work together with blood thinners?
A: Sure. Might potentiate warfarin – contraindicated with out medical supervision.
Q: Protected throughout being pregnant?
A: Restricted knowledge. Keep away from high-dose isolates; whole-food extracts (e.g., berry powders) most popular.
Q: Why select liposomal anthocyanins?
A: 2.9× larger pores and skin permeability and 85.4% stability vs. non-encapsulated types6.
Q: When to anticipate advantages?
A: Acute results (antioxidant) in 2–4 hours; persistent illness modulation requires 8–12 weeks.
The place to Purchase Premium Anthocyanin Extracts
🔬 Direktna narudžba iz Shaanxi Zhonghonga:
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E-pošta: liaodaohai@gmail.com
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Web stranica: aiherba.com
Zaključak
Anthocyanins characterize nature’s most versatile protection molecules—with strong proof supporting their roles in most cancers prevention, metabolic well being, and longevity. For manufacturers demanding scientifically validated, steady anthocyanins, Shaanxi Zhonghong delivers unparalleled technical excellence: ISO-certified liposomal encapsulation, batch-specific NMR verification, and international cold-chain distribution.
Harness the Energy of Purple—Request Your Certificates of Evaluation Right this moment!
Reference:
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Meals Funct. (2017). Anthocyanins in black rice/soybean/purple corn ↑ fecal butyrate & ↓ liver irritation4.
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J Funct Meals. (2017). Purple/purple corn anthocyanins inhibit colon most cancers through apoptosis/anti-angiogenesis8.
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Mol Nutr Meals Res. (WHHL rabbit research). Anthocyanin isolates ↑ LDL-C; complete juices mitigate dangers3.
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Macromol Res. (2019). Liposomal anthocyanins: 2.9× pores and skin permeability, 85.4% stability6.
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Biomed Pharmacother. (2018). Lonicera caerulea anthocyanins: Anti-hepatocarcinoma through cell cycle arrest10.
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