কোয়ারসেটিন সম্পূরক

Quercetin Dietary supplements​: The Premier Flavonoid Powerhouse – Final Information & Premium Supply| Supplier & Manufacturer

১. কোয়ারসেটিন কী?
কোয়ারসেটিন হলো একটি খাদ্যতালিকাগত ফ্ল্যাভোনল belonging to the polyphenolic compounds subclass. As a potent plant pigment, it serves vital roles in UV safety and stress response in botanicals. In human physiology, it displays multifunctional bioactivity, appearing as a grasp antioxidant, anti-inflammatory agent, এবং mobile signaling modulator. Its distinctive catechol construction এবং α,β-unsaturated carbonyl group allow distinctive free radical scavenging and metallic chelation capabilities.

2. সরবরাহ, রাসায়নিক বৈশিষ্ট্য এবং সনাক্তকরণ

• Main Natural Sources (Highest Concentrations):

  • Sophora japonica Buds: Richest supply (as much as 20% dry weight)

  • Onion Skins (Allium cepa): Significantly purple onions (1-1.5%)

  • Ginkgo biloba Leaves: Standardized extracts (22-26%)

  • Apple Peel (Malus domestica): Key supply of quercetin glycosides

  • Different Sources: Capers, lovage, elderberries, buckwheat, tea

• রাসায়নিক বৈশিষ্ট্য:

  • সিএএস পরিমাণ: 117-39-5

  • আণবিক উপাদান: সি₁₅এইচ₁₀ও₇

  • আণবিক ওজন: ৩০২.২৪ গ্রাম/মোল

  • EINECS পরিমাণ: 204-187-1

  • চেহারা: হলুদ স্ফটিক পাউডার

  • দ্রাব্যতা: Insoluble in water; soluble in ethanol, DMSO, lipids (when complexed)

  • স্থিতিশীলতা: Delicate to UV mild and alkaline circumstances; degrades above 160°C

3. Benefits, Efficacy, Dosage & Security

• Optimum Sources & Bioavailability: Sophora japonica extracts ship the very best pure concentrations (95-98% purity). Bioavailability is enhanced by phospholipid complexation (Quercetin Phytosome®) or liposomal encapsulation, growing absorption by 5-20x vs. commonplace powder.

• Validated Well being Benefits & Mechanisms:

  • Systemic Antioxidant Protection: মডিউল করে Nrf2/ARE পথ, upregulating glutathione synthesis এবং superoxide dismutase (SOD)

  • প্রদাহ-বিরোধী গতি: বাধা দেয় COX-2, LOX, এবং NF-κB signaling pathways, decreasing pro-inflammatory cytokines (TNF-α, IL-6)

  • ইমিউন মডুলেশন: Stabilizes mast cells, reduces histamine launch through cAMP phosphodiesterase inhibition

  • Cardiometabolic Assist: Improves endothelial perform by eNOS activation, inhibits LDL oxidation

  • Viral Protection: Demonstrated 3CL protease inhibition in opposition to coronaviruses in vitro

• Medical Dosage:

  সূত্র	Each day Dose	দৈর্ঘ্য
  Commonplace Powder	500-1000 mg	৮-১২ সপ্তাহ
  Phytosome®	250-500 mg	স্থির
  Acute Immune Assist	As much as 3000 mg	≤5 days

• Security Profile:

  • GRAS standing (FDA)

  • Keep away from concomitant use with CYP3A4 substrates (cyclosporine, warfarin)

  • Potential renal toxicity at >5g/day

  • Being pregnant Class C

4. Shaanxi Zhonghong: Quercetin Excellence
লিভারেজিং 28 years in bioactive phytochemistry, Shaanxi Zhonghong Investment Technology Co., Ltd. pioneers quercetin manufacturing by:

• Core Improvements:

  • Glycoside-to-Aglycone Conversion: Patented enzymatic hydrolysis for >98% aglycone purity

  • Nanocrystallization Know-how: 200nm particle measurement for enhanced solubility

  • Phytosome® Manufacturing: Validated complexation with sunflower phospholipids

• উচ্চমানের অবকাঠামো:

  • UPLC-QTOF-MS সম্পর্কে for isomer profiling

  • সিজিএমপি এবং ISO 22000 licensed amenities

  • Batch traceability through blockchain expertise

5. Product Specification (Pharmaceutical Grade)

৬. সুপিরিয়র ম্যানুফ্যাকচারিং ওয়ার্কফ্লো

1. বোটানিক্যাল সোর্সিং: DNA-authenticated Sophora japonica buds

2. Multistage Extraction: Ethanol/water (70:30) at 45°C with microwave help

3. Macroporous Resin Chromatography: AB-8 resin for flavonoid isolation

4. Enzymatic Bioconversion: β-glucosidase remedy (45°C, pH 5.0)

5. Crystallization Management: Anti-solvent precipitation at 4°C

6. Nanomilling: Moist-milling to D90 < 250nm

7. Phospholipid Complexation (Optionally available): 1:1 ratio with phosphatidylcholine

8. লাইওফিলাইজেশন: -40°C main drying

৭. অ্যাপ্লিকেশন ম্যাট্রিক্স

8. Mechanism & Medical Proof

• মাইটোকন্ড্রিয়াল জৈবজেনেসিস: প্রম্পট SIRT1/PGC-1α পথ (5-15% improve in ATP manufacturing)

• Senescence Modulation: কমায় p16INK4a expression in human fibroblasts

• Viral Inhibition: IC₅₀ = 7.6 μM in opposition to SARS-CoV-2 3CL protease

• Cardiometabolic Results: 12% LDL discount in hyperlipidemic sufferers (500mg/day, 8 weeks)

9. Technological Frontiers

• Bioavailability Options:

  • Quercetin-β-cyclodextrin complexes (water solubility: 35 mg/mL)

  • Strong lipid nanoparticles (90% oral bioavailability)

• অনভিজ্ঞ রসায়ন:

  • সাবক্রিটিক্যাল জল নিষ্কাশন (SWE) at 120°C/50 bar

  • Enzyme-assisted deep eutectic solvent techniques

10. Analysis Challenges

• Pharmacokinetics: Quick plasma half-life (3-4 hours)

• চিকিৎসা অনুবাদ: Restricted Part III trials for immune claims

• নিয়ন্ত্রক অবস্থান: Novel Meals authorization required in EU

১১. প্রায়শই জিজ্ঞাসিত প্রশ্নাবলী

1. Q: Why select Sophora japonica-derived quercetin?
   ক: Superior focus profile (98% vs. 70% in onion extracts) and decrease pesticide danger.

2. Q: The best way to overcome bioavailability limitations?
   ক: Our phytosome expertise achieves Cₘₐₓ 4.3x greater than commonplace powder.

3. Q: Validated immune help dosage?
   ক: 500-1000mg/day prophylactic; 3000mg/day acute part (max 5 days).

4. প্রশ্ন: সূত্রের স্থিতিশীলতা?
   ক: Nanoencapsulated type retains >90% efficiency at 25°C/60% RH for twenty-four months.

5. Q: GMP compliance?
   ক: Manufactured underneath ICH Q7 pointers with ISO 17025 accredited QC.

12. Procurement Info

• Technical Dossiers: liaodaohai@gmail.com

• Order Portal: aiherba.com/quercetin

• MOQ: 1kg (R&D), 10kg (business)

• সরবরাহ: -20°C validated chilly chain transport

১৩. উপসংহার
কোয়ারসেটিন প্রতিনিধিত্ব করে apex of flavonoid bioactivity with clinically validated impacts on immune competence, বিপাকীয় সুস্থতা, এবং oxidative resilience. Shaanxi Zhonghong’s উল্লম্বভাবে নির্মিত উৎপাদন—from DNA-verified Sophora japonica থেকে nanoparticle-enhanced supply techniques—ensures unprecedented purity (≥98%) and bioavailability. Our patented enzymatic conversion expertise and সিজিএমপি-সম্মত উৎপাদন ship benchmark materials compliant with USP, EP, and JP monographs. Accomplice with our ২৮ বছরের অভিজ্ঞতা for quercetin options powering next-generation nutraceuticals, prescription drugs, and useful meals.

১৪. তথ্যসূত্র

1. Li Y, et al. (2021). অণু. 26(9):2507. [Bioavailability]

2. Colunga Biancatelli RML, et al. (2020). Entrance Immunol. 11:1451. [Antiviral]

3. EFSA Panel (2020). EFSA জার্নাল. 18(1):e05993.

4. Anand David AV, et al. (2016). J Meals Sci. 81(10):R2501. [Metabolism]

5. Zhonghong Technical File QRC-2024. aiherba.com/docs/QRC-Spec