White Willow Bark Extract: Nature’s Ancient Answer to Modern Discomforts
1. What is White Willow Bark Extract?
White Willow Bark Extract (Salix alba) is a bioactive botanical derived from the bark of the white willow tree. Historically revered as “nature’s aspirin,” its primary active constituent, salicin, undergoes metabolism to salicylic acid, delivering analgesic, anti-inflammatory, and antipyretic effects. Unlike synthetic NSAIDs, it offers a gentler, time-released action, making it a cornerstone of evidence-based phytotherapy.
2. Source, Chemistry & Specifications
Ботанически източник: Salix alba L. (Salicaceae family)
Key Active: Salicin (typically standardized to 15-25%)
КАС: 138-52-3 (Salicin)
МФ: C₁₃H₁₈O₇
МВ: 286.28 g/mol
EINECS: 205-331-3
Външен вид: Fine, hygroscopic powder; light tan to off-white
Разтворимост: Soluble in water, ethanol; insoluble in non-polar solvents
3. Defining “Best” White Willow Bark Extract: Key Criteria
The optimal extract balances bioactive potency, safety, and regulatory compliance:
Стандартизация: ≥ 15% Salicin content (HPLC-UV validated).
Efficacy (Compliant):
Pain Relief: Inhibits COX enzymes, reducing prostaglandin synthesis (J Ethnopharmacol. 2009).
Anti-inflammatory: Modulates TNF-α, IL-1β cytokines (Phytomedicine. 2010).
Антиоксидант: Scavenges ROS via phenolic glycosides.
Произход: Sustainably harvested European or North American Salix alba.
Dosage: 120-240mg salicin daily (EMA monograph). Max 240mg/day.
Употреба: Capsules/tablets, functional foods, topical analgesics.
Target Users: Adults seeking natural joint/muscle support.*
Critical Contraindications:
Salicylate allergy or aspirin sensitivity.
Children/teens (Reye’s syndrome risk).
Pregnancy, lactation, renal impairment, anticoagulant use (warfarin interaction).
Странични ефекти: Rare GI upset at high doses; discontinue if tinnitus occurs.
4. Shaanxi Zhonghong Investment Technology Co., Ltd.: Your Trusted Phytochemistry Partner
As a 28-годишен новатор in bioactive compounds, Zhonghong integrates cutting-edge science с global supply chain excellence. Our vertically controlled process ensures traceability from raw bark to GMP-certified extract.
Основни компетенции:
Deep Extraction Expertise: Supercritical CO₂, ultrasonic-assisted ethanol/water extraction.
Пречистване: Industrial-scale preparative HPLC, membrane filtration.
Analytical Rigor:
HPLC-DAD/ELSD: Quantification of salicin, salicylic acid, flavonoids.
GC-MS: Residual solvent profiling (ICH Q3C).
ICP-MS: Heavy metal detection (ppb level).
Patent Portfolio: 20+ patents covering novel extraction methodologies (e.g., CN107118222A).
5. COA Specifications: Guaranteed Purity & Safety
Параметър | Тестов елемент | Спецификация | Метод |
---|---|---|---|
Остатъци от пестициди | Хлорпирифос | ≤ 0,01 ppm | GC-MS/MS (ЕС 396/2005) |
Циперметрин | ≤ 0,05 ppm | GC-MS/MS | |
Глифозат | ≤ 0,1 ppm | HPLC-FLD (AOAC 2008.01) | |
Тежки метали | Арсен (As) | ≤ 1,0 ppm | ICP-MS (USP <232>) |
Олово (Pb) | ≤ 3,0 ppm | ICP-MS | |
Кадмий (Cd) | ≤ 0,5 ppm | ICP-MS | |
Живак (Hg) | ≤ 0,1 ppm | CVAAS | |
Микробиология | Общ брой аероби | ≤ 1000 CFU/g | УТП <61> |
Мая и мухъл | ≤ 100 CFU/g | УТП <61> | |
Е. коли | Отрицателен | УТП <62> | |
Салмонела spp. | Отрицателен | ISO 6579-1 |
6. Разширен производствен работен процес
Източник: Ethically wildcrafted Salix alba bark (EU PEFC-certified).
Comminution: Cryogenic milling preserves thermolabile actives.
Екстракция: Dynamic maceration (food-grade ethanol/water, 70:30 v/v).
Концентрация: Low-temperature vacuum evaporators.
Стандартизация: Salicin adjustment via chromatographic isolation.
Spray Drying: Maltodextrin carrier (inlet temp ≤ 180°C).
7. Многосекторни приложения
Нутрацевтици: Joint health supplements (capsules, gummies).
Козмецевтични продукти: Anti-redness serums, soothing creams.
Функционални храни: Pain-management beverages.
Veterinary: Equine osteoarthritis support.
8. Uncompromising Quality Control
Zhonghong’s QbD (Quality by Design) framework exceeds ISO 9001:2015. Every batch undergoes:
Потвърждение на самоличността: HPTLC fingerprint vs. Salix alba reference standard (EMA/HMPC).
Potency Assay: Salicin quantification via validated HPLC-UV (λ=270nm).
Остатъчни разтворители: GC-FID per ICH Q3C (Class 2 solvents < 50ppm).
Стабилност: ICH accelerated (40°C/75% RH) & real-time protocols.
Нашият proprietary QC algorithms detect batch-to-batch variability at σ > 1.5, ensuring pharmaceutical-grade consistency.
9. Health Mechanisms & Research Frontiers
MOA: Salicin → Saligenin → Hepatic conversion to salicylic acid → Systemic COX-1/COX-2 inhibition.
Clinical Evidence: Meta-analysis confirms efficacy vs. placebo for chronic low-back pain (Cochrane Database 2016).
Иновация: Nanoemulsion delivery systems enhancing salicin bioavailability (Int J Nanomedicine 2021).
Предизвикателства: Standardizing polyphenol synergies (flavonoids, tannins) beyond salicin.
10. Packaging & Logistics
Основно: Double polyethylene-lined kraft paper drums (25kg net).
Съхранение: <25°C; 40-60% RH; protected from light.
Срок на годност: 24 months (validated).
Global Compliance: FDA GRAS, REACH, FSSC 22000, Kosher/Halal.
11. FAQ: Addressing Critical Queries
Q: Is this suitable for vegetarians?
A: Yes, entirely plant-derived. Ethanol extraction is non-animal.Q: Typical lead time for bulk orders?
A: 15-25 days post-PO confirmation (MOQ: 25kg).Q: Can you provide salicin 25% + polyphenol complex?
A: Yes – our patented ZH-WB25+ includes synergistic flavonoids.Q: Stability in liquid formulations?
A: Use buffered pH 4.5-5.5; recommend antioxidants (e.g., ascorbyl palmitate).
12. Procure Premium White Willow Bark Extract
Contact Zhonghong Today:
Имейл: liaodaohai@gmail.com
Уеб: aiherba.com
Заявка: COA documentation & FREE 100g SAMPLE (Technical grade available).
Заключение
White Willow Bark Extract remains a gold-standard botanical analgesic with robust clinical validation. Zhonghong’s fusion of advanced phytochemistry, ISO-certified QC, and global regulatory mastery delivers unmatched extract integrity for demanding nutraceutical, cosmetic, and functional food applications.
Референции
EMA/HMPC Monograph on Salix spp. (2017)
Chrubasik et al., Phytomedicine (2010)
USP-NF General Chapters <561>, <232>
Zhang et al., Int J Nanomedicine (2021); 16: 5143–5156
Gagnier et al., Cochrane Database Syst Rev (2016); CD004504
White Willow Bark Extract, Salicin Extract, Natural Anti-inflammatory, Plant Extract Supplier, COA Specification
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