The Definitive Guide to Nuciferine: Nature’s Lotus Alkaloid Powerhouse

1. What is Nuciferine?

Nuciferine is a prominent апорфинов алкалоид naturally found in the leaves and stems of the sacred Лот орех plant, commonly known as the lotus. This bioactive phytochemical is structurally characterized by its tetracyclic ring system and is increasingly recognized for its diverse physiological activities. It functions as a key signaling molecule within the plant and exhibits significant bioactive potential in mammalian systems, influencing metabolic, neurological, and inflammatory pathways.

2. Източник на продукта, химични свойства и идентификация

• Източник: Извлечено предимно от Лот орех (Lotus) leaves using advanced techniques like екстракция с разтворител и хроматографско пречистване.

• Химична природа: Nuciferine is classified as an aporphine isoquinoline alkaloid.

• CAS номер: 475-83-2

• Молекулна формула (MF): C₁₉H₂₁NO₂

• Молекулно тегло (MW): 295.38 g/mol

• EINECS номер: 207-503-3

3. The Premium Nuciferine Standard: Key Attributes

Identifying the “best” nuciferine requires stringent criteria for quality, efficacy, and transparency:

• Ключова съставка: High-purity Нуциферин (typically ≥98% by HPLC).

• Proven Efficacy (Compliant): Research suggests potential benefits, however, specific health claims are regulated and require substantiation per jurisdiction. Current scientific focus includes:

  • Метаболитно здраве: Modulation of lipid metabolism, potential influence on glucose homeostasis via pathways like Активиране на AMPK и PPARγ modulation.

  • Neurological Support: Interaction with dopaminergic и serotonergic receptors; potential anxiolytic and mood-modulating effects observed in preclinical models.

  • Anti-inflammatory & Antioxidant Activity: Reduction of pro-inflammatory cytokines (TNF-α, IL-6) and mitigation of oxidative stress markers.

• Optimal Origin: Източник от премиум Лот орех cultivars, ideally with documented traceability.

• Recommended Use: Primarily used as a dietary supplement ingredient или research chemical. Typical formulations include capsules, tablets, or powder blends. Always follow manufacturer or research protocol guidelines.

• Целева аудитория: Researchers, nutraceutical formulators, and consumers seeking advanced botanical ingredients (under professional guidance).

• Crucial Considerations:

  • Дозировка: No established Recommended Dietary Allowance (RDA) exists. Human clinical data is limited. Preclinical studies use varying doses. Consulting a healthcare professional before use is essential.

  • Безопасност и странични ефекти: Generally considered safe at research doses, but comprehensive human safety data is lacking. Potential side effects are not well-documented but could relate to its pharmacology (e.g., mild sedation, gastrointestinal upset). Not evaluated by the FDA for disease diagnosis, treatment, cure, or prevention.

  • Противопоказания: Avoid if pregnant, breastfeeding, or with known hypersensitivity. Potential interactions with medications (especially affecting liver enzymes CYP450 or neurotransmitter systems) warrant caution. Medical consultation is mandatory before use.

4. About Shaanxi Zhonghong Investment Technology Co., Ltd.
Шанси Джунхонг Инвестмънт Технолоджи Ко ООД заема поста премиер високотехнологично предприятие специализирана в екстракция, изолиране и пречистване of bioactive plant compounds. With 28 years of dedicated expertise в биоактивни съединения, the company integrates R&D, innovation, precision manufacturing, and global distribution to serve the chemical, material science, and life science sectors.

• Основни компетенции: Advanced processing of натурални растителни екстракти, включително botanical active ingredients за козметични продукти, фармацевтични междинни продукти, хранителни добавки (dietary supplements), natural pigments, food additives, подобрители на напиткии plant-based sweeteners.

• Научно предимство: Establishes significant technical barriers through collaborations with 5 водещи университета чрез съвместни лаборатории. Holds 20+ собствени патента and maintains an exclusive global compound library.

• Cutting-Edge Facilities: Наема най-съвременна аналитична апаратура включително Високоефективна течна хроматография (HPLC), Ultraconducting Nuclear Magnetic Resonance (NMR), осигурявайки стандартите за чистота, надвишаващи индустриалните норми до 20%+.

• Глобален обхват: Maintains a robust международна мрежа за доставки обхващащ 80+ държави в цяла Азия, Европа и Северна и Южна Америка, осигурявайки customized raw material solutions до мултинационални фармацевтични корпорации и изследователски институции.

5. Nuciferine Benefits for Health
Nuciferine’s emerging profile as a multi-target bioactive alkaloid is underpinned by mechanistic research:

• Metabolic Syndrome Management: Modulates key regulators (AMPK, PPARγ, SREBP-1c) involved in lipid biosynthesis, fatty acid oxidationи adipocyte differentiation, showing promise in preclinical models of dyslipidemia и insulin resistance.

• Neuroprotection & Mood Support: Exhibits affinity for 5-HT1A, 5-HT2A/2C, D1/D2 рецептори, suggesting potential roles in anxiety reduction, depression mitigation, and possibly neurodegenerative disease pathwaysНеговият antioxidant capacity further supports neuronal health.

• Anti-inflammatory & Immunomodulatory Actions: Suppresses activation of NF-κB сигнализация and downstream pro-inflammatory mediators (напр., COX-2, iNOS), beneficial in models of chronic inflammation.

• Antioxidant Defense: Directly scavenges реактивни кислородни видове (ROS) and enhances endogenous antioxidant enzyme systems (напр., SOD, GSH), protecting cells from oxidative damage.

6. Nuciferine Usage Guidelines

• Форма: Primarily available as a standardized extract powder or in encapsulated/tableted supplements.

• Приложение: Включено в хранителни добавки, functional foods/beveragesи cosmeceutical formulations targeting metabolic, cognitive, or anti-aging benefits. Also vital for pharmacological research.

• Дозиране: Specific human dosage is not established. Preclinical studies range widely. Adherence to product labeling or research protocols is crucial. Consultation with a qualified healthcare provider is essential before personal use.

7. Nuciferine Safety & Important Precautions

• Toxicology Profile: Generally displays low acute toxicity in animal studies. Chronic toxicity and comprehensive human safety data are areas of ongoing research.

• Potential Adverse Effects: Based on its mechanism, possible side effects might include drowsiness, dizziness, dry mouth, or digestive discomfort. Theoretical risk of hepatotoxicity или interactions exists.

• Критични предпазни мерки:

  • Консултирайте се с лекар: Especially if pregnant, nursing, under 18, have pre-existing medical conditions (liver/kidney disease, mental health disorders), or are taking medications (antidepressants, antipsychotics, hypoglycemics, statins).

  • Качеството е от първостепенно значение: Source only from reputable suppliers (като Шанси Чжунхонг) providing full Certificates of Analysis (CoA) to ensure purity and absence of contaminants.

  • Avoid Self-Diagnosis/Treatment: Not a substitute for professional medical care.

8. Nuciferine Product Specification & Certificate of Analysis (CoA)
Шанси Чжунхонг guarantees quality through rigorous testing per international standards. A typical CoA includes:

Certificate of Analysis (CoA) Summary: Nuciferine (Lot: [Example])

*(Note: This is a representative example. Actual specifications and test items may vary per batch and specific customer requirements. Always request the full CoA for the specific lot.)

9. Усъвършенстван производствен процес
Шанси Чжунхонг employs a sophisticated, vertically integrated nuciferine extraction protocol:

1. Източници на суровини и контрол на качеството: Премиум Лот орех leaves, sustainably sourced, undergo strict входяща проверка (ID, moisture, contaminants).

2. Предварителна обработка: Leaves are cleaned, dried (low-temperature лиофилизация preferred), and milled.

3. Селективна екстракция: Използва patented solvent systems (напр., acidified ethanol/water mixtures) optimized for alkaloid yield чрез maceration или counter-current extraction.

4. Първично пречистване: Initial liquid-liquid partitioning или адсорбция на макропореста смола to remove impurities.

5. Хроматография с висока резолюция: Core step using препаративна високоефективна хроматография (ВЕТХ) или flash chromatography with specific stationary phases (напр., C18 silica, ion-exchange resins) for selective nuciferine isolation.

6. Кристализация и сушене: Purified fractions undergo кристализация или vacuum concentration последвано от сушене с разпръскване или лиофилизиране to obtain powder.

7. Final Purification (Optional): Рекристализация или preparative TLC for ultra-high purity (>99%).

8. Смесване и стандартизация: Batches are blended to ensure consistent nuciferine potency as per specification.

10. Разнообразни сценарии на приложение

• Нутрацевтици и хранителни добавки: Key ingredient in formulations targeting управление на теглото, metabolic health support, stress reliefи cognitive function.

• Functional Food & Beverages: Incorporated into health drinks, bars, or fortified foods for added bioactive benefits.

• Козмецевтични продукти: Използва се в против стареене и anti-inflammatory skincare products (serums, creams) for its antioxidant and potential collagen-protective effects.

• Pharmaceutical Research: Valuable reference standard и lead compound for drug discovery in metabolic disorders, CNS diseasesи inflammation.

• Academic Research: Използва се в ин витро и ин виво studies exploring pharmacology, toxicology, and molecular mechanisms.

11. Stringent Quality Control (QC)
Шанси Чжунхонг implements a cGMP-aligned quality management system осигуряване нуциферин integrity from seed to shipment:

• Квалификация на суровината: Строг supplier auditing и incoming QC използвайки HPLC пръстови отпечатъци and contaminant screening.

• Контрол в процеса (IPC): Critical parameters (extraction yield, solvent residues, intermediate purity) monitored via HPLC-UV, ЗКи ТЛК at defined stages.

• Final Product Testing: Изчерпателен release testing against full CoA specifications (Identity, Assay, Residual Solvents, Heavy Metals, Pesticides, Microbiology) using валидирани методи (HPLC-DAD/ELSD/CAD, ICP-MS, GC-MS/MS, Microbiological assays per USP/EP).

• Проучвания за стабилност: Дирижиране accelerated и real-time stability under ICH guidelines to establish shelf-life and optimal storage conditions.

• Валидиране на метода: All analytical procedures are fully validated за specificity, accuracy, precision, linearity, range, LOD/LOQ, and robustness.

• Документация и проследимост: Пълен batch records и electronic data capture ensure complete traceability and audit readiness.

12. Secure Packaging & Global Logistics

• Опаковка: High-purity екстракт от нуциферин is typically packaged in double-sealed, food-grade polyethylene bags в рамките на влакнести барабани или stainless-steel containers. Nitrogen flushing или vacuum sealing minimizes oxidation. Labels include critical data (Product Name, CAS#, Batch/Lot #, MF, MW, Date, Net Weight, Storage Conditions, COA link/QR code).

• Съхранение: Recommended long-term storage в -20°C в dry, dark environment. Short-term storage at 2-8°C is acceptable for most applications. Десиканти are included.

• Логистика: Шанси Чжунхонг leverages its global network for efficient shipping via air freight or sea cargo. Options include DDP (Доставка с платено мито) и EXW (Ex Works). Изчерпателен cold chain solutions are available for temperature-sensitive shipments. All packages include MSDS (Material Safety Data Sheet) и Certificate of Origin.

13. Research Frontiers, Applications & Challenges

• Здравни механизми: Текущите изследвания задълбочават nuciferine’s molecular targets (e.g., specific GPCRs, nuclear receptors, kinases) and signaling pathways (AMPK/mTOR, NF-κB/NLRP3 inflammasome, autophagy regulation) relevant to NAFLD, диабет, neuroinflammationи cancer chemoprevention.

• Промишлени приложения: Innovation focuses on enhancing bioavailability (via nanocarriers, фосфолипидни комплекси, salt formation), developing synthetic biology routes (enzymatic synthesis, fermentation), and creating value-added derivatives with improved potency or selectivity.

• Current Challenges & Future: Key challenges include establishing definitive human clinical efficacy and safety, optimizing cost-effective large-scale purification, подобрявайки перорална бионаличност, and navigating complex global regulatory landscapes for health claims. Future research aims at translational studies, combination therapiesи novel delivery systems.

14. Често задавани въпроси (ЧЗВ)

• Q: Is nuciferine safe? A: Preclinical data suggests safety at research doses, but comprehensive human safety studies are limited. Consult your doctor before use. Quality and purity are critical.

• Q: What are nuciferine’s main benefits? A: Research highlights potential for метаболитно здраве, невропротекцияи anti-inflammatory effects, but these are not FDA-approved claims. Human evidence is evolving.

• Q: How much nuciferine should I take daily? А: There is no established daily intake. Dosage in research varies widely. Follow product label instructions if applicable, or research protocols. Medical advice is essential.

• Q: Where does nuciferine come from? A: Primarily extracted from the leaves of the lotus plant (Nelumbo nucifera).

• Q: Does nuciferine have side effects? A: Potential side effects based on its action may include drowsiness or digestive upset, but are not well-documented in humans. Консултирайте се с доставчик на здравни услуги.

• Q: Can I take nuciferine with my medications? A: Potential for drug interactions exists (e.g., with CNS drugs, metabolized by CYP enzymes). Absolutely consult your doctor or pharmacist.

• Q: How do I ensure I’m buying high-quality nuciferine? A: Source from reputable suppliers като Шанси Чжунхонг who provide comprehensive Certificates of Analysis (CoA) verifying identity, purity (>98%), and safety (contaminant levels).

15. Source Premium Nuciferine & Request Samples
Шанси Джунхонг Инвестмънт Технолоджи Ко ООД is your trusted global partner for high-purity екстракт от нуциферин and custom botanical active ingredients.

• Purchase Inquiries & Free Sample Requests:

  • Имейл: liaodaohai@gmail.com

  • Уебсайт: https://aiherba.com (Посетете за пълен продуктов каталог и информация за компанията)

• Contact for: Bulk pricing, custom specifications (purity, particle size), CoAs, MSDS, and collaborative development opportunities.

16. Заключение
Нуциферин, the principal alkaloid of Лот орех, represents a fascinating биоактивно съединение with significant and growing scientific interest, particularly in метаболитно здраве и neurological support. While preclinical data is promising, robust human clinical trials are the critical next step to fully validate its therapeutic potential and safety profile. For researchers and formulators, sourcing high-purity, well-characterized nuciferine from an experienced and quality-focused manufacturer like Шанси Джунхонг Инвестмънт Технолоджи Ко ООД is paramount. Their commitment to advanced extraction technology, stringent QC exceeding industry standards, and global supply chain expertise ensures reliable access to this intriguing natural product for innovation in хранителни добавки, козметични продуктии pharmaceutical research.

17. Референции
(Key research areas – illustrative examples)

1. Liu, S., et al. (2019). Nuciferine ameliorates hepatic steatosis in high-fat diet/streptozotocin-induced diabetic mice through a PPARα/PPARγ coactivator-1α pathway. Списание за селскостопанска и хранителна химия, 67(42), 11637-11646. (Metabolic Effects)

2. Sugimoto, Y., et al. (2010). Serotonin receptor subtypes involved in the discriminative stimulus effects of nuciferine in rats. Психофармакология, 208(1), 23-30. (Neuropharmacology)

3. Kashiwada, Y., et al. (2005). Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Лот орех, and structure–activity correlations with related alkaloids. Биоорганична и медицинска химия, 13(2), 443-448. (Bioactivity)

4. Yan, Z., et al. (2021). Nuciferine protects against LPS-induced acute lung injury via inhibiting MAPK/NF-κB activation and NLRP3 inflammasome signaling pathway. International Immunopharmacology, 100, 108137. (Anti-inflammatory)

5. Wang, J., et al. (2022). Nuciferine: A review of its pharmacology, pharmacokinetics, toxicity and clinical application. Списание за етнофармакология, 298, 115650. (Review)

6. ICH Q7: Ръководство за добра производствена практика за активни фармацевтични съставки.

7. USP-NF General Chapters: <561> Articles of Botanical Origin, <62> Microbiological Examination of Nonsterile Products, <232> Elemental Impurities—Limits, <467> Residual Solvents.

8. European Pharmacopoeia (Ph. Eur.) Monographs on Herbal Drugs and Extracts.

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