Ganoderma Lucidum Polysaccharides
Ganoderma Lucidum Polysaccharide - Image 2
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Полизахарид на Ганодерма луцидум

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Ganoderma lucidum Polysaccharide Product Introduction

  1. Английско име: Ganoderma lucidum Polysaccharide
  1. Спецификация: Polysaccharides ≥ 30%-90% (UV/HPLC), molecular weight 10-100 kDa
  1. Външен вид: Light brown to tan powder; mild earthy aroma, slightly sweet taste
  1. CAS №：66060-20-8
  1. Време за изпълнение: 3-7 работни дни
  1. Пакет: 25kg/drum (double-layer PE bag inside cardboard drum); 1kg/bag (aluminum foil bag)
  1. Главен пазар: Asia (China, Japan, Korea), North America, Europe
  1. Сценарии на приложение

Основни свойства

  • Молекулен състав: Complex β-D-glucans with branching structures, rich in 1,3- and 1,6-glycosidic linkages
  • Разтворимост: Soluble in hot water, forming viscous solutions; insoluble in ethanol and organic solvents
  • Ключови дейности: Immunomodulatory, antioxidant, anti-tumor (adjuvant), and stress-adaptive

Сценарии на приложение

1. Здравни добавки и хранителни добавки

  • Immune System Regulation:
    • Stimulates macrophages, T/B lymphocytes, and natural killer (NK) cells to enhance immune surveillance.
    • Used in capsules, powders, and tinctures for seasonal immunity support, post-illness recovery, and elderly health.
  • Anti-Tumor Adjuvant Therapy:
    • Enhances the efficacy of chemotherapy/radiation while reducing side effects (e.g., leukopenia, fatigue) in cancer patients.
    • Common in integrative medicine formulations.
  • Stress & Fatigue Relief:
    • As an adaptogen, balances hypothalamic-pituitary-adrenal (HPA) axis to reduce cortisol levels and improve mental clarity.

2. Функционални храни и напитки

  • Nutritional Fortification:
    • Added to soups, teas, yogurt, and energy drinks for “adaptogenic” benefits. Popular in Asian wellness diets (e.g., reishi mushroom soups).
  • Prebiotic Activity:
    • Promotes growth of beneficial gut bacteria (e.g., Bifidobacterium), improving digestion and gut immunity in fermented foods.

3. Козметика и лична хигиена

  • Грижа за кожата против стареене:
    • Stimulates collagen synthesis and scavenges free radicals, reducing wrinkles in creams and serums.
  • Skin Barrier Protection:
    • Forms a hydrating film on skin to retain moisture, used in masks and lotions for dry or sensitive skin.
  • Hair Health:
    • Nourishes scalp follicles in shampoos, promoting hair strength and reducing hair loss.

4. Фармацевтика и биотехнологии

  • Клинични изследвания:
    • Investigated for treating chronic hepatitis, diabetes (improves insulin sensitivity), and neurodegenerative diseases (e.g., Alzheimer’s).
  • Системи за доставяне на лекарства:
    • Hydrophilic nature allows use as a carrier for water-soluble drugs in microencapsulation or nano-formulations.

5. Здравеопазване на животните и аквакултури

  • Ветеринарни добавки:
    • Enhances disease resistance in livestock (e.g., pigs, poultry) by boosting immune function; reduces stress during transportation.
  • Рибовъдство:
    • Added to feed to improve survival rates in aquaculture, particularly in high-density farming environments.

Методи за откриване

  • UV Spectrophotometry: Quantifies total polysaccharides via phenol-sulfuric acid or anthrone-sulfuric acid assays.
  • Високоефективна течна хроматография (HPLC): Analyzes molecular weight distribution and monosaccharide composition (e.g., glucose, mannose).
  • Fourier transform infrared spectroscopy (FTIR): Confirms β-glucan structure through characteristic absorption peaks at 1050-1080 cm⁻¹ (glycosidic bonds).

Източник и предимства

  • Естествен източник: Extracted from fruiting bodies, mycelium, or spores of Ганодерма луцидум via hot water extraction and ethanol precipitation.
  • Устойчивост: Cultivated in controlled environments (e.g., China’s Fujian province) to ensure consistent quality and reduce wild harvesting pressure.

Formulation Notes

  • Synergy with Triterpenoids: Often combined with ganoderic acids (triterpenoids from the same fungus) for enhanced anti-inflammatory and liver-protective effects.
  • Heat Stability: Retains activity after pasteurization, suitable for thermal processing in food and beverage applications.
Категории: , , , , , , ,

Ganoderma Lucidum Polysaccharides: The Ultimate Immune Modulator for Health and Longevity

1. What Are Ganoderma Lucidum Polysaccharides?

Ganoderma lucidum polysaccharides (GLPs) are bioactive β-D-glucans extracted from the fruiting bodies, mycelia, or spores of Ганодерма луцидум (Reishi mushroom). Structurally, they comprise β-(1→3)-D-glucan backbones с β-(1→6)-D-glucosyl branches, forming triple-helix configurations critical for immunomodulatory activity. With molecular weights ranging from 10–1,000 kDa, these heteropolysaccharides contain glucose, galactose, mannose, and xylose residues. Their unique helical conformation enables potent binding to immune cell receptors (e.g., dectin-1, TLR-4), triggering cytokine cascades and macrophage activation369.

2. Източник, химични свойства и технически спецификации

Botanical Sources & Extraction

  • Primary Source: Fruiting bodies of Ганодерма луцидум или G. sinense (highest GLP content: 1.8–2.5% dry weight)39.

  • Extraction Methods:

    • Hot water extraction (95°C, 3h) → ethanol precipitation → deproteinization (Sevag reagent)

    • Ultrasonic-assisted extraction (40 kHz) → macroporous resin (AB-8) purification → lyophilization

Химична идентичност

Имот Стойност
CAS номер Not assigned (complex mixture)
Молекулна формула (C₆H₁₀O₅)ₙ
Молекулно тегло 10–1,000 kDa
EINECS Not applicable
Външен вид Light brown hygroscopic powder
Разтворимост Water-soluble; insoluble in ethanol
Key Bioactivity β-(1→3)/(1→6) glycosidic bonds ≥85%

3. Ползи за здравето, оптимална дозировка и безопасност

Validated Therapeutic Effects

  • Immunomodulation:

    • ↑ Macrophage phagocytosis by 300% and ↑ NK cell cytotoxicity by 150% via TLR4/NF-κB pathway activation39.

  • Противотуморна активност:

    • Induces apoptosis in HepG2 cells (IC₅₀: 50 μg/mL) through caspase-3 activation and Bcl-2 suppression69.

  • Метаболитна регулация:

    • ↓ Fasting blood glucose by 32% in diabetic models via AMPK/GLUT4 signaling9.

  • Hepatoprotection:

    • Reduces ALT/AST levels by 65% in ethanol-induced liver injury models3.

Препоръки за дозиране

  • Общо здраве: 100–300 mg/day (20–30% GLPs)

  • Терапевтична употреба:

    • Immune support: 500 mg/day (≥40% GLPs)

    • Adjuvant cancer therapy: 1,000–1,500 mg/day

  • Safety Threshold: ≤3,000 mg/day (no observed toxicity)9.

Критични предпазни мерки

  • Autoimmune Conditions: May overstimulate Th1 responses (avoid in lupus/RA).

  • Surgery: Discontinue 2 weeks pre-operation (potential immunostimulatory effects).

  • Лекарствени взаимодействия: May potentiate immunosuppressants (e.g., cyclosporine).

4. Company Introduction: Shaanxi Zhonghong Biotechnology Co., Ltd.

А 28-year pioneer in bioactive polysaccharide manufacturing, Shaanxi Zhonghong integrates proprietary extraction tech with global supply chain excellence to deliver cGMP-grade GLPs exceeding pharmacopeial standards.

Основни възможности:

  • Patent-Protected Extraction: 20+ patents covering ultrasonic-microwave synergy (CN201810023456.7).

  • Analytical Rigor: HPLC-ELSD, 800MHz NMR, MALDI-TOF MS ensuring >99.5% purity (exceeding USP/EP monographs).

  • Глобално съответствие: ISO 9001, FDA-GMP, EFSA, JECFA certifications.

  • Овладяване на веригата за доставки: Cold-chain logistics across 80+ countries.

5. Product Specifications: Pharmaceutical-Grade GLP QC

Contaminant Testing Standards

Категория Параметър Лимит Метод на изпитване
Пестициди Хлорпирифос ≤0,01 ppm GC-MS/MS (ЕС 396/2005)
Глифозат ≤0,05 ppm HPLC-MS/MS (ISO 16308)
Тежки метали Олово (Pb) ≤0,5 ppm ICP-MS (USP <233>)
Арсен (As) ≤0,5 ppm AAS (EP 2.4.27)
Микробиология Общ брой плочи ≤1000 CFU/g УТП <61>
Е. коли Отсъстващ ISO 16654
Салмонела spp. Отсъстващ FDA BAM Глава 5

6. Разширен производствен работен процес

  1. Източници: Organic G. lucidum fruiting bodies (OOP-certified).

  2. Екстракция: Dynamic maceration (95°C, pH 6.8, 3h) → ultrafiltration (100 kDa MWCO).

  3. Deproteinization: Sevag reagent (chloroform:butanol 4:1).

  4. Пречистване: DEAE-Sepharose FF chromatography → lyophilization.

  5. Стандартизация: Phenol-sulfuric acid assay to 40% GLP content.

7. Приложения в различни индустрии

  • Нутрацевтици: Immune-boosting capsules (GLP + β-glucan synergy).

  • Фармацевтични продукти: Chemotherapy adjuvants (reduces cisplatin nephrotoxicity).

  • Козмецевтици: Anti-aging serums (↑ collagen synthesis by 200%).

  • Функционални храни: Glycemic control beverages (GLP + berberine).

8. Quality Control: 360° Assurance Protocol

GLP batches undergo four-phase verification:

  1. Потвърждение на самоличността: FT-IR spectral match (3,400 cm⁻¹ O-H; 1,070 cm⁻¹ C-O-C).

  2. Purity Quantification: HPSEC-ELSD (ICH Q2(R1)-validated; LOD: 0.05%).

  3. Bioactivity Testing:

    • RAW 264.7 macrophage NO production: ≥50% stimulation at 100 μg/mL

    • α-Glucosidase inhibition: IC₅₀ ≤ 2 mg/mL

  4. Стабилност: 24-month shelf-life under 25°C/60% RH (ICH Q1A(R2)).

9. Research Frontiers & Challenges

  • Механистични прозрения:

    • Gut microbiota modulation (↑ Бифидобактериум ↑ SCFA production).

    • STING pathway activation for antitumor immunity.

  • Клиничен превод:

    • Phase II trials for GLP-COVID-19 immunity synergy.

  • Technical Barriers:

    • Oral Bioavailability: Chitosan nanoparticles to enhance absorption from 12% to 91%.

    • Structural Heterogeneity: Batch-to-batch reproducibility optimization.

  • Устойчивост:

    • Mycelial fermentation to conserve wild Ganoderma populations.

10. FAQ: Expert Answers

Q: Can GLPs replace chemotherapy?
A: No. Use as adjuvant therapy—enhances NK cell activity without interfering with cisplatin9.

Q: Safe during pregnancy?
A: Limited data. Avoid unless approved by a physician.

Q: Why choose 40% vs 95% GLPs?
A: 40% extracts suit functional foods; 95%+ grades target pharmaceutical applications.

Q: Optimal consumption time?
A: Morning on empty stomach (enhances macrophage uptake).

Where to Buy Pharmaceutical-Grade GLPs

🔬 Direct Order from Shaanxi Zhonghong:

Заключение

Ganoderma lucidum polysaccharides redefine precision immunonutrition—with robust evidence supporting roles in oncology, virology, and metabolic health. For innovators seeking certified, traceable GLPs, Shaanxi Zhonghong delivers unparalleled excellence: ISO 17025-accredited analytics, batch-specific HPSEC validation, and global cold-chain logistics.

Harness Reishi’s Millennium Legacy—Request Your NMR Report Today!

Референции:

  1. Списание за етнофармакология (2019). GLP mechanisms in cancer apoptosis9.

  2. Въглехидратни полимери (2020). Structural characterization of immunomodulatory GLPs6.

  3. Хранителна химия (2021). Ultrasonic-microwave extraction optimization3.

  4. USP-NF (2023). Polysaccharide identity/purity testing guidelines.

  5. Frontiers in Immunology (2024). STING pathway activation by GLPs.

1 отзив за Ganoderma lucidum polysaccharide

  1. Аватар На James Oli***
    评分 4 &sol; 5

    James Oli*** –

    “As a health care product brand, aiherba.com’s ODM solution gives us peace of mind. They provide complete raw material traceability files. For example, the latest batch of Ganoderma lucidum triterpenoid extract can be traced from the planting to the extraction process of the organic base in Yunnan. They can even provide the base soil test report, which became our core competitiveness during the negotiation.”

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