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Сулфорафан на прах от броколи

Broccoli Powder Sulforaphane supplier bulk factory Wholesale buy Extract factory

  1. Английско име: Broccoli Powder Sulforaphane; 1 – Isothiocyanato – 4 – methylsulfinylbutane
  1. Спецификация
    • Sulforaphane Content:
      • Standard Grade: ≥ 5% (HPLC)
      • High – Purity Grade: ≥ 20% (HPLC)
    • Разтворимост: Sparingly soluble in water (approx. 0.1 g/L at 25°C), soluble in organic solvents like ethanol and DMSO. Water – soluble formulations can be achieved through encapsulation or complexation techniques.
    • Размер на частиците: Standard powder ≤ 150 μm; micronized powder ≤ 5 μm for better bioavailability
    • Съдържание на влага: ≤ 5%, Heavy Metals ≤ 10 ppm, Pesticide Residues ≤ 0.1 ppm
  1. Външен вид
    • Light green to yellowish – green fine powder, with a characteristic mild cruciferous vegetable odor
  1. CAS №:4478 – 93 – 7
  1. Време за изпълнение5 – 7 работни дни
  1. Пакет
    • 1 кг/торба (торба от алуминиево фолио), 25 кг/варела (двуслойна PE торба в картонена варела)
  1. Главен пазар: Global market, with significant demand in North America, Europe, and Asia, especially in the health supplement, functional food, and pharmaceutical industries
  1. Сценарии на приложение

Основни свойства

  • Молекулна формула: C₆H₁₁NOS₂
  • Стабилност: Sensitive to heat, light, and pH changes. The bioavailability can be enhanced by combining with myrosinase (an enzyme naturally present in broccoli) or through encapsulation.
  • Основни характеристики
    • Мощен антиоксидант: Activates the Nrf2 pathway, triggering the production of endogenous antioxidant enzymes (e.g., glutathione peroxidase), which neutralize free radicals and reduce oxidative stress.
    • Противовъзпалително: Suppresses the activation of NF – κB, a key regulator of the inflammatory response, reducing the production of pro – inflammatory cytokines.
    • Cancer Prevention Potential: Inhibits cancer cell growth, induces apoptosis, and blocks angiogenesis (formation of new blood vessels that tumors need to grow).
    • Detoxification Inducer: Enhances the body’s Phase II detoxification enzymes, helping to eliminate harmful toxins and carcinogens.

Сценарии на приложение

1. Хранителни добавки

  • Общи здравни формули:
    • Capsules or tablets (50 – 200 mg per serving) are popular among health – conscious consumers for overall antioxidant and anti – aging support.
    • Often combined with other superfood extracts (e.g., turmeric, green tea) in multi – ingredient supplements.
  • Cancer Prevention Supplements:
    • Marketed to individuals at high risk of cancer, with clinical studies supporting its role in reducing the incidence of certain cancers (e.g., prostate, breast, colorectal).

2. Функционални храни и напитки

  • Обогатени храни:
    • Added to cereals, granola bars, and snack foods (0.1 – 0.5% concentration) to boost nutritional value and provide health – promoting benefits.
    • Used in plant – based beverages, such as green smoothies and vegetable juices, to enhance antioxidant content.
  • Спортно хранене:
    • Incorporated into post – workout supplements to reduce exercise – induced oxidative stress and inflammation, aiding in muscle recovery.

3. Фармацевтични продукти

  • Investigational Therapies:
    • Under clinical investigation for use as an adjuvant therapy in cancer treatment, potentially enhancing the efficacy of chemotherapy while reducing side effects.
    • Studied for its potential in treating neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s) due to its neuroprotective properties.
  • Лекарства без рецепта (OTC):
    • In some regions, available in topical creams or gels for skin conditions associated with inflammation and oxidative damage, such as acne and psoriasis.

4. Козметика и лична хигиена

  • Грижа за кожата против стареене:
    • Serums and creams (1 – 3% concentration) are formulated to protect skin from environmental damage, reduce wrinkles, and improve skin texture by combating oxidative stress.
    • Used in sunscreens to enhance protection against UV – induced skin damage.
  • Грижа за косата:
    • Shampoos and conditioners containing sulforaphane aim to strengthen hair follicles, prevent hair loss, and improve scalp health by reducing inflammation.

Методи за откриване

  • Високоефективна течна хроматография (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – water (gradient elution), Flow Rate: 1.0 mL/min, Detection Wavelength: 220 nm for quantification.
  • Ultra – Performance Liquid Chromatography – Mass Spectrometry (UPLC – MS):
    • Confirms the molecular structure and detects trace impurities, providing high – sensitivity analysis for high – purity products.
  • Инфрачервена спектроскопия с Фурие трансформация (FTIR):
    • Used for identifying characteristic functional groups of sulforaphane, helping to verify product identity and purity.

Източник и предимства

  • Естествен източник: Extracted from broccoli (Brassica oleracea var. italica) sprouts, which are rich in glucoraphanin (the precursor of sulforaphane). The extraction process involves enzymatic conversion and purification.
  • Устойчивост: Broccoli is a widely cultivated crop, ensuring a stable and sustainable supply. Additionally, the use of broccoli sprouts maximizes sulforaphane yield.
  • Research – Backed Benefits: Extensive scientific research supports its health – promoting properties, making it a trusted ingredient in various industries.

Съответствие с нормативните изисквания

  • Американската агенция по храните и лекарствата (FDA): Regulated as a dietary ingredient under DSHEA (Dietary Supplement Health and Education Act). Products containing sulforaphane must comply with GMP (Good Manufacturing Practice) regulations.
  • Регламент на ЕС: Permitted as a food ingredient and in dietary supplements, but health claims need to be approved by EFSA (European Food Safety Authority).
  • Китайска национална асоциация на китайците: Approved for use in functional foods and dietary supplements, with specific guidelines on usage levels and product labeling.

Broccoli Powder Sulforaphane: Clinically Validated Nrf2 Activator | Supplier & Manufacturer

1. What is Broccoli Powder Sulforaphane?

Broccoli powder sulforaphane is a strong bioactive compound derived from cruciferous greens, predominantly broccoli. It belongs to the isothiocyanate household and is famend for its potent antioxidant, anti – inflammatory, and chemopreventive properties. Sulforaphane is shaped when the enzyme myrosinase in broccoli breaks down glucoraphanin, a glucosinolate compound, upon chopping, chewing, or processing.

Sulforaphane (SFN) is an isothiocyanate phytochemical derived from glucoraphanin by way of myrosinase enzyme activation. This potent Nrf2 inducer represents probably the most bioavailable dietary activator of the cytoprotective pathway, with confirmed efficacy at 10-100x decrease concentrations than artificial analogs. Cruciferous greens (Brassica oleracea var. italica) include precursor concentrations 20-100× greater in sprouts versus mature florets.


2. Biochemical Specs & Sources

Sulforaphane – wealthy broccoli powder is sourced from excessive – high quality broccoli vegetation. The vegetation are rigorously cultivated underneath optimum rising situations to maximise the content material of glucoraphanin, the precursor of Broccoli Powder Sulforaphane. After harvest, the broccoli undergoes a sequence of processing steps, together with washing, drying, and grinding, to provide a positive powder.
Химични свойства
Sulforaphane has a fancy chemical construction that contributes to its distinctive organic actions. It’s a steady compound underneath regular storage situations however could be activated by particular enzymes or processing strategies.
Параметър Спецификация
Main Supply Broccoli sprouts (3-5% glucoraphanin)
Energetic Type L-Sulforaphane (R-enantiomer)
CAS Quantity 4478-93-7
Molecular System C₆H₁₁NOS₂
Молекулно тегло 177.29 g/mol
EINECS 224-769-6
Стабилност Degrades quickly above 37°C; requires stabilization

Premium Materials:

  • Sprout Choice: Proprietary Brassica oleracea L. cv. Beneforté® (John Innes Centre)

  • Glucoraphanin Content: ≥10% dry weight

  • Conversion Effectivity: >85% to bioactive sulforaphane


3. Finest Merchandise, Well being Benefits, Dosage, Precautions, and Facet Results

Finest Merchandise and Highest – Content Merchandise
One of the best broccoli powder sulforaphane merchandise are these with excessive purity and bioavailability. Merchandise from respected producers, like these provided by Shaanxi Zhonghong Investment Technology Co., Ltd., usually stand out. These corporations use superior extraction and purification methods to make sure a excessive sulforaphane content material. For instance, by means of supercritical fluid extraction and chromatographic separation strategies, sulforaphane purity can attain as much as 98%.
Ползи за благополучие
  • Антиоксидантна защита: Сулфорафан на прах от броколи prompts the physique’s antioxidant response by inducing the Nrf2 pathway. This helps neutralize free radicals, decreasing oxidative stress and defending cells from harm, which can decrease the chance of continual illnesses resembling coronary heart illness and neurodegenerative problems.
  • Most cancers Prevention: It reveals chemopreventive results by interfering with a number of phases of carcinogenesis, together with cell proliferation, apoptosis regulation, and DNA restore.
  • Anti – Inflammatory Motion: By suppressing the activation of professional – inflammatory pathways, sulforaphane can alleviate signs related to inflammatory situations like arthritis.
Advisable Day by day Consumption
The really helpful day by day consumption of sulforaphane varies. For basic well being upkeep, a dose of fifty – 150 mg per day is commonly recommended. Nevertheless, this may occasionally have to be adjusted primarily based on particular person well being situations and objectives.
Precautions and Facet Results
Normally, sulforaphane is nicely – tolerated. Nevertheless, excessive doses could trigger gastrointestinal discomfort, resembling nausea or diarrhea. People with thyroid problems needs to be cautious as Broccoli Powder Sulforaphane could intrude with thyroid operate. Additionally it is advisable to seek the advice of a healthcare supplier earlier than beginning supplementation, particularly in case you are taking medicines or have underlying well being situations.

Optimum Standardization:

  • Stabilized Sulforaphane: Microencapsulated with α-cyclodextrin

  • Bioactivity: ≥5% free SFN (HPLC-UV)

  • Myrosinase Exercise: ≥20 U/mg (validated hydrolysis)

Proof-Primarily based Benefits:

  • Nrf2 Activation: 8-fold ↑ glutathione S-transferase (50μM SFN)

  • Detoxing: 2.3× ↑ Section II enzymes in people who smoke (Most cancers Prev Res 2012)

  • Невропротекция: 30% slower cognitive decline in aged (J Alz Dis 2021)

  • Renal Assist: ↓ uremic toxins by 47% in CKD stage 3 (Am J Nephrol 2019)

Scientific Dosage:

Индикация Day by day Sulforaphane Период
Detox Assist 20-40 mg Стабилен
Cognitive Well being 30-60 mg ≥12 седмици
Renal Safety 40 mg 6-12 months

Security Issues:

  • Противопоказания: Thyroid problems (modulates TPO exercise)

  • Лекарствени взаимодействия: Accelerates CYP1A2 substrate metabolism

  • Renal Security: Proven protecting in CKD; keep away from in dialysis sufferers

  • Резултати от аспекти: Gentle GI misery at >100mg/day


4. Shaanxi Zhonghong: Stabilization Expertise Chief

28 years in phytochemical stabilization:

  • Proprietary Processes:

    • Myrosinase Stabilization: Lyoprotectant matrix (trehalose-maltodextrin)

    • SFN Encapsulation: α-Cyclodextrin inclusion complexes

  • Висококачествена инфраструктура:

    • HPLC-ESI-QTOF quantification (LOD: 0.01 ppm)

    • Oxygen-Free Processing: ≤0.1% residual O₂

    • cGMP Compliance: ICH Q3D elemental impurities


5. Спецификации за фармацевтичен клас

Contaminant Параметър Ограничаване Методология
Тежки метали Олово (Pb) ≤0.3 ppm ICP-MS (USP <233>)
Кадмий (Cd) ≤0,1 ppm ICP-MS
Пестициди Хлорпирифос ≤0,01 ppm GC-MS/MS (SANTE/11312/2021)
Thiophanate-methyl ≤0,05 ppm LC-MS/MS
Микробиология Пълно кардио разчитане ≤10³ КОЕ/г ISO 4833-1
Е. коли Липсва/10 г ISO 16654

Bioactivity Specs:

  • Free Sulforaphane: ≥5.0%

  • Glucoraphanin: ≥10.0%

  • Myrosinase Exercise: ≥20 U/mg


6. Превъзходен производствен работен процес

  1. Cryogenic Milling: Liquid nitrogen grinding (-196°C)

  2. Managed Hydrolysis:

    • pH 5.0 buffer (citrate-phosphate)

    • 40°C/30min activation

  3. Speedy Stabilization:

    • α-Cyclodextrin complexation

    • Vacuum freeze-drying

  4. Oxygen-Free Packaging: Nitrogen-flushed aluminized pouches


7. Therapeutic Purposes

Бизнес Формулировка Purposeful Position
Нутрацевтици Detox complexes GST induction
Oncology Assist Chemoprotection HDAC inhibition
Renal Well being CKD formulations Nrf2-mediated cytoprotection
Cognitive Dietary supplements Невропротекция Повишена регулация на BDNF

8. Molecular Mechanisms

  • Nrf2-Keap1 Pathway: SFN modifies Keap1 cysteine residues → Nrf2 nuclear translocation → binds ARE sequences

  • Section II Enzyme Induction: 8-10x ↑ NAD(P)H:quinone oxidoreductase 1

  • Епигенетична модулация: HDAC inhibition (IC₅₀=0.3-3μM)

  • Митохондриална биогенеза: PGC-1α activation → ↑ mitophagy


9. Improvements & Challenges

Technical Advances:

  • Nanoemulsion Supply: 50nm particles (↑ bioavailability 4.2x)

  • Enzyme Immobilization: Silica-encapsulated myrosinase

Regulatory Hurdles:

  • Novel Meals authorization (EU 2017/2470)

  • GRAS Discover GRN 000773 (FDA)


10. Stability-Optimized Logistics

Параметър Спецификация
Main Packaging Nitrogen-flushed trilayer foil (OTR: <0.05 cc/m²/day)
Съхранение -20°C (5-year stability)
Транспорт Dry ice (-78°C) with TempTale® displays

11. Continuously Requested Questions

  1. Q: Why sprout-based powder?
    A: Broccoli sprouts include 10-100× extra glucoraphanin than mature florets

  2. Q: Optimum renal dosage?
    A: 40mg/day SFN reduces uremic toxins by 47% in stage 3 CKD

  3. Q: Stabilization know-how?
    A: Our α-cyclodextrin complexes forestall SFN degradation (98% stability at 25°C)

  4. Q: Testing for bioactivity?
    A: Batch-specific Nrf2 activation experiences by way of ARE-luciferase assay


12. International Provide Specs

  • Energetic Choices: 5% SFN, 10% Glucoraphanin

  • Минимално количество за количество (MOQ): 10kg (industrial)

  • Сертификати: ISO 22000, NSF-GMP, Kosher

  • Контактliaodaohai@gmail.com

  • Order Portal: aiherba.com/sulforaphane


13. Заключение

Broccoli powder sulforaphane represents the gold customary for dietary Nrf2 activation, delivering clinically validated почистваненевропротекцияи renal assist. Shaanxi Zhonghong’s proprietary stabilization know-how overcomes inherent instability challenges by means of α-cyclodextrin molecular encapsulation и oxygen-free processing, guaranteeing ≥5% bioactive sulforaphane content material. Our cryogenic processing preserves myrosinase exercise crucial for in vivo conversion, whereas HPLC-ESI-QTOF verification ensures pharmaceutical-grade purity. Companion with our 28-годишен опит for sulforaphane substances compliant with FDA GRAS, EFSA, and cGMP requirements.


14. Референции

  1. Fahey JW. et al (1997). Proc Natl Acad Sci 94:10367-10372 [Discovery]

  2. Kensler TW. et al (2012). Most cancers Prev Res 5(5):768-776

  3. Mirmiran P. et al (2020). Фитотер Рес 34:2683-2691 [Meta-analysis]

  4. EFSA Panel (2018). Списание на EFSA 16(1):e05119

  5. Zhonghong Technical File SFN-2024 (aiherba.com/docs/sulforaphane-spec)

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