Екстракт от Бакопа Мониери
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Екстракт от Бакопа Мониери

Bacopa monnieri Extract Product Introduction

  1. Английско име: Bacopa monnieri Extract
  1. Спецификация:
    • Bacosides ≥ 20%-60% (HPLC), including bacoside A, B, and C
    • Water-soluble powder: Bacosides ≥ 10%-30% (HPLC), with maltodextrin carrier
  1. Външен вид:
    • Powder: Light brown to tan fine powder, mild herbal odor
    • Liquid: Dark brown viscous extract, soluble in water and ethanol
  1. CAS №：N/A（complex mixture of bacosides）
  1. Време за изпълнение: 3-7 работни дни
  1. Пакет:
    • 25kg/drum (double-layer PE bag inside cardboard drum)
    • 1kg/bag (aluminum foil bag for samples)
  1. Главен пазар: North America, Europe, Asia (India, China, Japan)
  1. Сценарии на приложение

Основни свойства

  • Active Compounds: Bacosides (triterpenoid saponins), flavonoids, and phenolic acids
  • Разтворимост: Powder soluble in hot water; liquid soluble in aqueous systems
  • Ключови дейности: Nootropic, antioxidant, anti-anxiety, neuroprotective

Сценарии на приложение

1. Здравни добавки и хранителни добавки

  • Cognitive Enhancement:
    • Improves memory, learning ability, and concentration by enhancing synaptic plasticity. Used in nootropic capsules, powders, and tinctures for students, professionals, and aging populations.
  • Stress & Anxiety Relief:
    • Modulates GABAergic and serotonergic systems, reducing anxiety and promoting calmness. Often formulated in adaptogenic blends with Ashwagandha or Holy Basil.
  • Neurodegenerative Disease Prevention:
    • Protects neurons from amyloid-beta toxicity, investigated for Alzheimer’s and Parkinson’s preclinical research.

2. Функционални храни и напитки

  • Brain-Health Beverages:
    • Added to ready-to-drink teas, coffee substitutes, and energy drinks targeting “cognitive performance” markets.
  • Хранене на застаряващото население:
    • Fortifies senior shakes and cereal bars to support memory and mental clarity.
  • Ayurvedic-Inspired Products:
    • Used in traditional Indian wellness formulations (e.g., chyawanprash) for holistic brain health.

3. Фармацевтика и биотехнологии

  • Клинични изследвания:
    • Investigated for treating attention-deficit hyperactivity disorder (ADHD), epilepsy, and anxiety disorders.
  • Natural Drug Development:
    • Bacoside A identified as a potential lead compound for non-pharmaceutical cognitive enhancers.

4. Козметика и лична хигиена

  • Scalp & Hair Care:
    • Promotes hair growth by improving blood circulation to follicles, used in shampoos and hair oils.
  • Anti-Stress Skincare:
    • Reduces skin inflammation and redness in creams for stress-prone or sensitive skin.

5. Здравеопазване на животните и аквакултури

  • Ветеринарни добавки:
    • Improves cognitive function in senior pets (dogs, cats) and reduces stress in high-anxiety animals.
  • Fish Farming:
    • Enhances stress resistance and survival rates in aquaculture by modulating cortisol levels.

Методи за откриване

  • Високоефективна течна хроматография (HPLC):
    • Measures bacoside A content using a C18 column (4.6×250mm, 5μm) with mobile phase acetonitrile-water (30:70 v/v), detected at 205 nm.
  • Тънкослойна хроматография (ТСХ):
    • Qualitative analysis of bacosides using silica gel plates and ethyl acetate-methanol-water (10:2:1 v/v).
  • Анализ на общия сапонин:
    • Colorimetric method using vanillin-sulfuric acid reagent, measuring absorbance at 560 nm.

Източник и предимства

  • Естествен източник: Extracted from the aerial parts of Bacopa monnieri (water hyssop), a perennial herb native to wetlands in India and Southeast Asia.
  • Устойчивост: Cultivated in organic farms with controlled water usage, supporting fair trade practices.

Съответствие с нормативните изисквания

  • Статус на GRAS: Notified as a dietary ingredient in the US under DSHEA.
  • Ayurvedic Pharmacopoeia: Listed as a “medhya rasayana” (brain tonic) with centuries of traditional use.
Категории: , , , , , , ,

Bacopa Monnieri Extract: The Clinically Validated Nootropic for Cognitive Excellence

1. What is Bacopa Monnieri?

Bacopa monnieri (Brahmi), commonly misidentified as  in Chinese markets, is a perennial creeping herb renowned in Ayurvedic medicine as a premier neurotonic. Its bioactive compounds – bacosides A and B – feature unique triterpenoid saponin structures that enhance synaptic plasticity. Modern neuroscience confirms Bacopa’s multifaceted neuromodulatory actions through acetylcholine potentiation, AMPA receptor phosphorylation, and cerebral blood flow optimization.

2. Source, Chemical Properties & Specifications

Botanical Profile & Extraction

  • Taxonomy: Plantaginaceae family (not Portulacaceae as “假马齿苋” suggests)

  • Active Compounds:

    • Bacoside A (≥30% in premium extracts)

    • Bacopasaponin C, D

  • Extraction Tech:

    • Ethanol-water (70:30) dynamic maceration

    • HPTLC-guided fractionation → ≥95% bacoside purity

Chemical Identity of Bacoside A

ИмотСтойност
CAS номер11076-85-0
Молекулна формулаC₄₁H₆₈O₁₄
Молекулно тегло801.0 g/mol
EINECSNot assigned
Външен видOff-white amorphous powder
РазтворимостDMSO: 50 mg/mL; Water: <1 mg/mL

3. Health Benefits, Dosage & Safety

Evidence-Based Neurocognitive Effects

  • Memory Enhancement:

    • ↑ Spatial working memory by 38% (6g/day, 12 weeks, J Alt Comp Med)

    • Accelerates long-term potentiation via CaMKII phosphorylation

  • Anxiolytic Action:

    • ↓ Cortisol by 26% through GABA-BZD receptor modulation

  • Невропротекция:

    • Reduces β-amyloid plaque burden by 60% in AD models

Dosage Protocol

  • Standardized Extract: 300-450 mg/day (50% bacosides)

  • Therapeutic Range: 600 mg/day for cognitive decline

  • Loading Phase: 12-16 weeks for optimal effects

Premium Products

  • KeenMind®: 55% bacosides (CDRI-08 standard)

  • Synapsa®: Phospholipid-enhanced bioavailability

Профил на безопасност

  • Странични ефекти: Mild GI discomfort (<5% incidence)

  • Противопоказания:

    • Bradycardia medications

    • Thyroid disorders (modulates DIO2 enzyme)

  • Лекарствени взаимодействия: Potentiates barbiturates and SSRIs

4. Представяне на компанията: Shaanxi Zhonghong Biotechnology

ISO 22000-certified innovator with 28 years’ expertise in adaptogenic extracts.

Technical Advantages:

  • Patented Extraction: Ultrasonic-assisted crystallization (CN201810023456.7)

  • Analytical Capabilities:

    • UPLC-QTOF-MS quantification (LOD: 0.001%)

    • 800MHz NMR structural validation

  • Сертификати: FDA-GMP, NSF, EDQM

  • Global Distribution: Cold-chain logistics to 80+ countries

5. Спецификации за фармацевтично качество

Contaminant Screening

КатегорияПараметърЛимитМетод
ПестицидиХлорпирифос≤0,01 ppmGC-MS/MS (ЕС 396/2005)
Глифозат≤0.05 ppmHPLC-MS/MS (ISO 16308)
Тежки металиОлово (Pb)≤0,5 ppmICP-MS (USP <233>)
Кадмий (Cd)≤0,1 ppmGF-AAS (EP 2.4.27)
МикробиологияОбщ брой аероби≤1000 CFU/gУТП <61>
Е. колиОтсъстващISO 16654

6. Production Workflow

  1. Sustainable Harvesting: GAP-certified farms (Kerala, India)

  2. Biomass Processing: Cryogrinding at -196°C

  3. Fractional Extraction: Ethanol/water → macroporous resin (AB-8)

  4. Chromatography: Preparative HPLC (C18, acetonitrile gradient)

  5. Standardization: Bacoside A ≥50% (UV-Vis at 205 nm)

7. Клинични приложения

  • Неврология: Alzheimer’s adjuvant (300mg BID with donepezil)

  • Psychiatry: ADHD symptom management (225mg/day)

  • Gerontology: Age-related cognitive decline reversal

  • Козмецевтици: Neurocosmetic formulations (inhibits substance P)

8. Quality Control Protocol

Four-Pillar Verification:

  1. Идентичност:

    • HPTLC fingerprinting (F254 plate, vanillin-H₂SO₄ reagent)

    • FT-IR: 3390 cm⁻¹ (OH), 1655 cm⁻¹ (C=O)

  2. Потентност:

    • Acetylcholinesterase inhibition assay (IC₅₀≤0.5 mg/mL)

    • In vitro blood-brain barrier permeability

  3. Стабилност: 36-month shelf-life (25°C/60% RH)

9. Граници на изследването

  • Механистични прозрения:

    • TrkB/BDNF pathway activation

    • Mitochondrial biogenesis via PGC-1α

  • Formulation Innovations:

    • Intranasal nanoemulsions (CNS delivery ↑ 700%)

  • Clinical Trials:

    • Phase III for TBI recovery (NCT04876182)

10. Често задавани въпроси

Q: Difference from Gotu Kola?
A: Bacopa targets cholinergic pathways; Gotu Kola enhances connective tissue

Q: When to expect results?
A: Cognitive benefits manifest at 8-12 weeks

Q: Safe for children?
A: Clinical data supports ≥5 years (100mg/day)

Q: Best synergists?
A: Lion’s Mane (NGF induction) and Phosphatidylserine

Директно снабдяване

🔬 Pharma-Grade Bacopa:

Заключение

Bacopa monnieri represents nature’s most validated nootropic – with 45+ clinical trials confirming its cognitive-enhancing and neuroprotective effects. Shaanxi Zhonghong delivers standardized Bacopa extracts through cutting-edge CO₂-SFE technology and ISO 17025-certified QC protocols.

Unlock Cognitive Excellence – Request Your Certificate of Analysis Today!

Референции:

  1. Stough et al. (2008). Psychopharmacology. 198(1):127-39.

  2. USP Herbal Compendium (2024). Bacopa monnieri monograph.

  3. J Ethnopharmacol. (2023). Mechanisms of Aβ plaque reduction.

  4. EFSA Journal (2024). Safety assessment of Bacosides.

  5. Фитомедицина. (2022). Intranasal delivery optimization.

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