Quercetin Dietary supplements: The Premier Flavonoid Powerhouse – Final Information & Premium Supply| Supplier & Manufacturer
1. Quercetin nədir?
Quercetin a pəhriz flavonol belonging to the polyphenolic compounds subclass. As a potent plant pigment, it serves vital roles in UV safety and stress response in botanicals. In human physiology, it displays multifunctional bioactivity, appearing as a grasp antioxidant, anti-inflammatory agent, və mobile signaling modulator. Its distinctive catechol construction və α,β-unsaturated carbonyl group allow distinctive free radical scavenging and metallic chelation capabilities.
2. Təchizat, Kimyəvi Xüsusiyyətlər və İdentifikasiya
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Main Natural Sources (Highest Concentrations):
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Sophora japonica Buds: Richest supply (as much as 20% dry weight)
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Onion Skins (Allium cepa): Significantly purple onions (1-1.5%)
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Ginkgo biloba Leaves: Standardized extracts (22-26%)
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Apple Peel (Malus domestica): Key supply of quercetin glycosides
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Different Sources: Capers, lovage, elderberries, buckwheat, tea
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Kimyəvi xassələri:
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CAS Miqdarı: 117-39-5
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Molekulyar komponentlər: C₁₅H₁₀O₇
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Molekulyar Çəki: 302,24 q/mol
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EINECS Miqdarı: 204-187-1
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Görünüş: Sarı kristal toz
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Həlletmə qabiliyyəti: Insoluble in water; soluble in ethanol, DMSO, lipids (when complexed)
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Sabitlik: Delicate to UV mild and alkaline circumstances; degrades above 160°C
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3. Benefits, Efficacy, Dosage & Security
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Optimum Sources & Bioavailability: Sophora japonica extracts ship the very best pure concentrations (95-98% purity). Bioavailability is enhanced by phospholipid complexation (Quercetin Phytosome®) or liposomal encapsulation, growing absorption by 5-20x vs. commonplace powder.
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Validated Well being Benefits & Mechanisms:
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Systemic Antioxidant Protection: Modulyasiya edir Nrf2/ARE yolu, upregulating glutathione synthesis və superoxide dismutase (SOD)
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Anti-Inflammatory Motion: Mane olur COX-2, LOX, və NF-κB signaling pathways, decreasing pro-inflammatory cytokines (TNF-α, IL-6)
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İmmun modulyasiya: Stabilizes mast cells, reduces histamine launch through cAMP phosphodiesterase inhibition
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Cardiometabolic Assist: Improves endothelial perform by eNOS activation, inhibits LDL oxidation
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Viral Protection: Demonstrated 3CL protease inhibition in opposition to coronaviruses in vitro
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Medical Dosage:
Formulyasiya Hər gün doza Uzunluq Commonplace Powder 500-1000 mg 8-12 həftə Phytosome® 250-500 mg Sabit Acute Immune Assist As much as 3000 mg ≤5 days -
Security Profile:
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GRAS standing (FDA)
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Keep away from concomitant use with CYP3A4 substrates (cyclosporine, warfarin)
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Potential renal toxicity at >5g/day
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Being pregnant Class C
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4. Shaanxi Zhonghong: Quercetin Excellence
İstifadə etmək 28 years in bioactive phytochemistry, Shaanxi Zhonghong Investment Technology Co., Ltd. pioneers quercetin manufacturing by:
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Core Improvements:
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Glycoside-to-Aglycone Conversion: Patented enzymatic hydrolysis for >98% aglycone purity
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Nanocrystallization Know-how: 200nm particle measurement for enhanced solubility
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Phytosome® Manufacturing: Validated complexation with sunflower phospholipids
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Yüksək keyfiyyətli infrastruktur:
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UPLC-QTOF-MS for isomer profiling
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cGMP və ISO 22000 licensed amenities
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Batch traceability through blockchain expertise
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5. Product Specification (Pharmaceutical Grade)
Sinif | Parametr | Spesifikasiya | Texnikanı yoxlayın |
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Saflıq | Quercetin Aglycone | ≥98.0% | HPLC-DAD (EP 10.0) |
Ağır metallar | Qurğuşun (Pb) | ≤1,0 ppm | ICP-MS (USP <233>) |
Kadmium (Cd) | ≤0,5 ppm | ICP-MS | |
Arsen (As) | ≤1,0 ppm | ICP-MS | |
Pestisidlər | Xlorpirifos | ≤0,01 ppm | GC-MS/MS |
Sipermetrin | ≤0,02 ppm | GC-MS/MS | |
Complete 186 Pesticides | Detrimental | EU SANTE/11813/2017 | |
Mikrobiologiya | Tam Kardiodan asılıdır | ≤1000 KFU/q | USP <61> |
Maya və Küf | ≤100 KFU/q | USP <61> | |
Enterobacteriaceae | Yoxdur/10q | ISO 21528-2 |
6. Üstün İstehsalat İş Akışı
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Botanical Sourcing: DNA-authenticated Sophora japonica buds
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Multistage Extraction: Ethanol/water (70:30) at 45°C with microwave help
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Macroporous Resin Chromatography: AB-8 resin for flavonoid isolation
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Enzymatic Bioconversion: β-glucosidase remedy (45°C, pH 5.0)
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Crystallization Management: Anti-solvent precipitation at 4°C
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Nanomilling: Moist-milling to D90 < 250nm
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Phospholipid Complexation (Optionally available): 1:1 ratio with phosphatidylcholine
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Liyofilizasiya: -40°C main drying
7. Application Matrix
Biznes | Formulation Examples | Useful Position |
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Nutraceuticals | Immune complexes, sports activities formulation | Oxidative stress discount |
Reçeteli dərmanlar | Antiviral adjuvants, cardioprotectives | Endothelial perform modulation |
Kosmetiklər | Anti-pollution serums, UV protectants | MMP inhibition |
Useful Meals | Stability-enhanced drinks | Shelf-life extension |
8. Mechanism & Medical Proof
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Mitoxondrial biogenez: Təkliflər SIRT1/PGC-1α yolu (5-15% improve in ATP manufacturing)
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Senescence Modulation: azaldır p16INK4a expression in human fibroblasts
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Viral Inhibition: IC₅₀ = 7.6 μM in opposition to SARS-CoV-2 3CL protease
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Cardiometabolic Results: 12% LDL discount in hyperlipidemic sufferers (500mg/day, 8 weeks)
9. Technological Frontiers
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Bioavailability Options:
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Quercetin-β-cyclodextrin complexes (water solubility: 35 mg/mL)
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Strong lipid nanoparticles (90% oral bioavailability)
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Təcrübəsiz Kimya:
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Kritikaltı suyun çıxarılması (SWE) at 120°C/50 bar
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Enzyme-assisted deep eutectic solvent texnikalar
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10. Analysis Challenges
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Pharmacokinetics: Quick plasma half-life (3-4 hours)
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Tibbi Tərcümə: Restricted Part III trials for immune claims
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Regulatory Standing: Novel Meals authorization required in EU
11. Tez-tez verilən suallar
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Q: Why select Sophora japonica-derived quercetin?
A: Superior focus profile (98% vs. 70% in onion extracts) and decrease pesticide danger. -
Q: The best way to overcome bioavailability limitations?
A: Our phytosome expertise achieves Cₘₐₓ 4.3x greater than commonplace powder. -
Q: Validated immune help dosage?
A: 500-1000mg/day prophylactic; 3000mg/day acute part (max 5 days). -
S: Tərkiblərdə sabitlik?
A: Nanoencapsulated type retains >90% efficiency at 25°C/60% RH for twenty-four months. -
Q: GMP compliance?
A: Manufactured underneath ICH Q7 pointers with ISO 17025 accredited QC.
12. Procurement Info
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Technical Dossiers: liaodaohai@gmail.com
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Order Portal: aiherba.com/quercetin
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MOQ: 1kg (R&D), 10kg (business)
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Logistika: -20°C validated chilly chain transport
13. Nəticə
Quercetin təmsil edir apex of flavonoid bioactivity with clinically validated impacts on immune competence, metabolik yaxşılıq, və oxidative resilience. Shaanxi Zhonghong's şaquli quraşdırılmış istehsal—from DNA-verified Sophora japonica üçün nanoparticle-enhanced supply techniques—ensures unprecedented purity (≥98%) and bioavailability. Our patented enzymatic conversion expertise and cGMP-yə uyğun istehsal ship benchmark materials compliant with USP, EP, and JP monographs. Accomplice with our 28 illik təcrübə for quercetin options powering next-generation nutraceuticals, prescription drugs, and useful meals.
14. İstinadlar
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Li Y, et al. (2021). Molekullar. 26(9):2507. [Bioavailability]
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Colunga Biancatelli RML, et al. (2020). Giriş immunol. 11:1451. [Antiviral]
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EFSA Panel (2020). EFSA jurnalı. 18(1):e05993.
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Anand David AV, et al. (2016). J Meals Sci. 81(10):R2501. [Metabolism]
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Zhonghong Technical File QRC-2024. aiherba.com/docs/QRC-Spec
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