Hydroxybenzoates (Parabens): Complete Information from AIHerba | Supplier & Manufacturer

1. Hidroksibenzoatlar nədir?

Hydroxybenzoates, generally referred to as parabens, are a gaggle of artificial or naturally derived esters of para-hydroxybenzoic acid. They perform primarily as extremely efficient geniş spektrli konservantlar in cosmetics, prescribed drugs, meals, and drinks. Their efficacy lies in inhibiting microbial progress (micro organism, fungi, yeasts) by disrupting cell membrane integrity and enzyme exercise. Widespread sorts embody Methylparaben (Methyl 4-hydroxybenzoate), Ethylparaben, Propylparaben, and Butylparaben, differing by their alkyl chain size (methyl, ethyl, propyl, butyl).

2. Məhsul Təchizatı, Kimyəvi Xüsusiyyətlər və İdentifikatorlar

• Təchizat: Whereas synthetically produced for industrial scale and consistency, the core para-hydroxybenzoic acid construction may be naturally present in some fruits (e.g., blueberries, cloudberries). AIHerba provides each artificial and bitki mənşəli hidroksibenzoatlar utilizing superior extraction and esterification methods.

• Kimyəvi xassələri:

  • Görünüş: Sometimes white crystalline powders.

  • Həlletmə qabiliyyəti: Low solubility in water; increased solubility in alcohols, ethers, and acetone.

  • Sabitlik: Steady below regular processing circumstances (warmth, pH vary 3-8). Efficient at low concentrations (usually 0.01%-0.3%).

  • Mode of Motion: Penetrates microbial cell partitions/membranes, interfering with membrane transport and inhibiting key metabolic enzymes.

• Açar identifikatorlar:

  • CAS: Varies by sort (e.g., Methylparaben: 99-76-3; Propylparaben: 94-13-3)

  • MF (Molecular Method): Dəyişir (məsələn, Metilparaben: C8H8O3; Propilparaben: C10H12O3)

  • MW (Molekulyar Çəki): Dəyişir (məsələn, Metilparaben: 152,15 q/mol; Propilparaben: 180,20 q/mol)

  • EINECS: Dəyişir (məsələn, Metilparaben: 202-785-7; Propilparaben: 202-307-7)

3. Efficacy, Well being Affect & Security

• “Finest” Kind & Focus: There is not any single “greatest” paraben; efficacy is determined by software pH, required spectrum, and formulation compatibility. Usually, blends (e.g., Methyl and Propylparaben) are used synergistically for broader safety. AIHerba provides high-purity grades (>99.5%) exceeding business requirements.

• Well being Benefits (Operate): Their major profit is məhsulun qorunması, stopping spoilage and potential infections from contaminated merchandise. That is essential for client security. Claims of direct içəridə well being advantages for parabens are inaccurate and unsupported.

• Day by day Consumption & Security: Regulatory our bodies globally (FDA, EFSA, SCCS) set up strict Acceptable Day by day Consumption (ADI) ranges based mostly on intensive toxicology. For instance, the ADI for Methylparaben is 0-10 mg/kg physique weight/day. Precise publicity from correctly preserved merchandise is often far beneath ADI limits.

• Ehtiyat tədbirləri və Aspekt Nəticələr:

  • Allergik reaksiyalar: Uncommon, however attainable pores and skin sensitization (contact dermatitis) can happen in prone people, particularly with increased concentrations or compromised pores and skin boundaries.

  • Endocrine Disruption Issues: Debate exists relating to potential weak estrogenic exercise in vitro and at very excessive doses in vivo. Nevertheless, present scientific consensus, backed by regulatory critiques (e.g., SCCS Opinion 2021), concludes that parabens (particularly methyl- and ethyl-) are protected at licensed concentrations in cosmetics (usually max 0.4% for single ester, 0.8% whole for mixtures). AIHerba adheres strictly to international regulatory limits.

  • İstifadə edin: Observe beneficial utilization ranges for particular functions. Patch testing new beauty formulations is prudent.

4. Shaanxi Zhonghong Investment Technology Co., Ltd tərəfindən AIHerba.
AIHerba, the flagship model of Shaanxi Zhonghong Investment Technology Co., Ltd., premyerdir yüksək texnologiyalı müəssisə integrating agile R&D, collaborative innovation, built-in manufacturing, and international advertising. We concentrate on serving the chemical, materials, and həyat elmi sənayeləri, with core experience within the extraction, isolation, purification, and software of bioaktiv bitki komponentləri.

• Elmi şücaət: 28 years of deep area experience in bioaktiv birləşmələr. Options 5 kollec birgə laboratoriyası və tutur 20+ mülkiyyət patenti. Saxlayır a globally distinctive compound library.

• Azaldıcı İnfrastruktur: İşə götürür HPLC (Həddindən artıq Effektiv Maye Xromatoqrafiyası), NMR (Nüvə Maqnit Rezonans Spektroskopiyası), və fərqli superior analytical methods guaranteeing purity requirements exceeding business norms by 20%+.

• Dünya əldə etmək: təmin edir fərdiləşdirilmiş tərkib variantları çoxmillətli əczaçılıq firmalarına, analiz müəssisələrinə və istehsalçılara 80+ beynəlxalq məkan Asiyada, Avropada və Amerikada.

• Məhsul portfeli: Sources premium uncooked supplies globally to provide standartlaşdırılmış botanika ekstraktları, gözəllik aktivləri, qidalandırıcı/ əczaçılıq vasitələri, pure pigments (colors), və bitki əsaslı tatlandırıcılar.

5. AIHerba Hydroxybenzoate Specs: Rigorous High quality Management

• Identification & Purity: Confirmed by way of FTIR, NMR, HPLC (>99.5%).

• Qalıq həlledicilər: Monitored per ICH Q3C tips utilizing GC.

6. İstehsalat kursu
AIHerba-da a çox mərhələli təmizləmə protokolu:

1. Mənbə: Collection of premium uncooked supplies (benzoic acid derivatives or chosen botanicals).

2. Esterləşdirmə: Managed chemical response (e.g., acid-catalyzed esterification of 4-hydroxybenzoic acid with the respective alcohol).

3. Kristallaşma: Purification by recrystallization utilizing pharma-grade solvents.

4. Superior Filtration: Elimination of particulate matter by way of nanofiltrasiya.

5. Qurutma: Liyofilizasiya (dondurularaq qurutma) or vacuum drying to attain exact moisture content material.

6. Mikronizasiya: Particle dimension discount for optimum solubility/formulation (if required).

7. QC Launch: Rigorous testing towards specs (HPLC, GC, ICP-MS, Micro).

7. Tətbiq Ssenariləri

• Kosmetika və Şəxsi Qulluq: Lotions, lotions, shampoos, conditioners, make-up (major preservative system).

• Reçeteli dərmanlar: Topical lotions/ointments, oral suspensions, parenteral formulations (excipient/preservative).

• Yemək və İçki: Juices, smooth drinks, baked items, processed meats, sauces (preservative – verify native rules).

• Sənaye Məqsədləri: Adhesives, paints, reducing fluids (biocide).

8. Yüksək keyfiyyətli İdarəetmə 
AIHerba-nın Yüksək keyfiyyətli İdarəetmə Sistemi (QMS) edir cGMP/ISO 9001 uyğunlaşdırılmışdır, guaranteeing traceability from uncooked materials to completed product. Sabitlik tədqiqatı (ICH tips) decide shelf-life below numerous circumstances (temp, humidity). Batch-specific Certificates of Evaluation (CoA) doc compliance with all launch specs. Our ən müasir analitik dəst consists of UHPLC-DAD for exact quantification and impurity profiling (<0.1% detection), GC-FID/MS for residual solvents and unstable impurities, and ICP-MS for ultra-trace heavy steel evaluation. Mikrobioloji sınaq istifadə edir təsdiqlənmiş membran filtrasiyası və biokimyəvi identifikasiya strategies. Ciddi dəyişiklik idarəetməsi və methodology validation (ICH Q2) underpin knowledge integrity. Ətraf mühitin monitorinqi of cleanrooms (ISO Class 7) ensures product security. Provider qualification packages assure uncooked materials high quality. This multi-layered QC method ensures AIHerba hydroxybenzoates meet the highest pharmacopeial requirements (USP, EP, JP) and customer-specific necessities for consistency, security, and efficacy in demanding functions.

9. Qablaşdırma və Logistika

• Major: Meals-grade polyethylene-lined multi-wall kraft paper baggage (25 kg web).

• Options: HDPE barabanları (50 kq, 100 kq) və ya double-sealed foil baggage for enhanced moisture safety.

• Etiketləmə: Compliant with GHS requirements; consists of batch quantity, expiry date, CoA QR code.

• Yaddaş: Cool (<25°C), dry circumstances, away from robust oxidizing brokers. Shelf life: 24 months unopened.

• Logistika: World delivery by way of air/sea freight. Experience in dealing with təhlükəli materialların sənədləri (if relevant) and chilly chain logistics for delicate compounds.

10. Analysis & Innovation

• Well being & Mechanism: Ongoing analysis explores structure-activity relationships (SAR) for optimizing antimicrobial efficacy whereas minimizing potential estrogenicity. Research deal with metabolik yollar (hidroliz, konjuqasiya) və dəriyə nüfuzetmə kinetikası utilizing Franz cell diffusion.

• Business Purposes & Tech: AIHerba yeniliklər edir inexperienced chemistry synthesis marşrutlar (enzimatik esterləşmə), co-kristal mühəndisliyi for enhanced solubility/stability, and creating sinergetik qoruyucu qarışıqlar with pure extracts (e.g., glyceryl caprylate, radish root ferment) to scale back general paraben load. Exploring mikrokapsulyasiya for managed launch.

• Sərhədlər və Çağırışlar: Key challenges embody addressing client notion points regardless of sturdy security knowledge and creating broad-spectrum, globally authorized, “paraben-free” alternate options matching parabens’ cost-effectiveness and stability. Analysis frontiers contain QSAR modelləşdirmə yeni ester dizaynı üçün və superior supply methods.

11. Tez-tez verilən suallar – Hidroksibenzoatlar (Parabens)

• Q: Are parabens protected? A: Main international regulatory our bodies (FDA, EFSA, SCCS) deem methylparaben and ethylparaben protected at present licensed ranges in cosmetics and meals based mostly on intensive scientific evaluate.

• Q: Do parabens trigger most cancers? A: No credible scientific proof hyperlinks parabens at typical publicity ranges to most cancers improvement in people. The weak estrogenic exercise noticed in lab research happens at doses vastly increased than human publicity.

• Q: Why are parabens used if there are considerations? A: They’re extremely efficient, broad-spectrum, steady, and cost-effective preservatives with a protracted security observe document. Options typically require increased concentrations, could also be much less steady, or have their very own security/regulatory challenges.

• Q: What does “paraben-free” imply? A: It signifies the product doesn’t include any members of the hydroxybenzoate ester household as preservatives. It does yox inherently imply the product is safer or higher preserved.

• Q: Are AIHerba parabens pure? A: AIHerba provides each artificial and bitki mənşəli hidroksibenzoatlar produced by way of extraction and esterification of pure precursors. The ultimate molecule is chemically similar, no matter origin.

• S: Raf ömrü nədir? A: Sometimes 24 months when saved unopened in a cool, dry place (<25°C).

12. The place to Purchase
Supply premium Hidroksibenzoatlar (Parabens) immediately from the producer, AIHerba:

• Elektron poçt: liaodaohai@gmail.com

• Veb sayt: https://www.aiherba.com

• Əlaqə: Go to our web site for detailed product inquiries, technical knowledge sheets (TDS), and pattern requests.

13. Nəticə
Hydroxybenzoates stay a cornerstone of contemporary product preservation as a consequence of their bənzərsiz effektivlik profili və sturdy security document when used inside established regulatory limits. AIHerba, yararlanmaq 28 years of bioactive compound experience və qabaqcıl nou-hau, offers the worldwide market with yüksək təmizlikli hidroksibenzoatlar – each artificial and bitki mənşəli – manufactured below stringent cGMP circumstances. Our dedication to superior analytical management (HPLC, NMR), rigorous QC exceeding pharmacopeial requirements, və revolutionary R&D ensures prospects obtain probably the most dependable and efficient preservative options for cosmetics, prescribed drugs, meals, and industrial functions. Belief AIHerba for high quality, consistency, and scientific excellence in preservation know-how.

14. İstinadlar

• Beauty Ingredient Overview (CIR) Professional Panel. (2008). Remaining amended report on the protection evaluation of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as utilized in beauty merchandise. Worldwide Journal of Toxicology, *27*(Əlavə 4), 1–82.

• Scientific Committee on Client Security (SCCS). (2021). Opinion on Parabens (Remaining Opinion). SCCS/1624/20.

• U.S. Meals and Drug Administration (FDA). (2022, Might 19). Parabens in Cosmetics. https://www.fda.gov/cosmetics/cosmetic-ingredients/parabens-cosmetics

• European Meals Security Authority (EFSA) Panel on Meals Components and Nutrient Sources added to Meals (ANS). (2004). Opinion of the Scientific Panel on Meals Components, Flavourings, Processing Aids and Supplies in Contact with Meals (AFC) on a request from the Fee associated to para hydroxybenzoates (E 214-219). EFSA jurnalı, 83, 1–26.

• ICH Harmonised Tripartite Guideline. Validation of Analytical Procedures: Textual content and Methodology Q2(R2) (Present Step 4 model, 2022).

• United States Pharmacopeia (USP) Basic Chapters: <61> Microbiological Examination of Nonsterile Merchandise: Microbial Enumeration Checks, <62> Microbiological Examination of Nonsterile Merchandise: Checks for Specified Microorganisms, <467> Residual Solvents.

• European Pharmacopoeia (Ph. Eur.) Basic Chapters: 2.6.12. Microbiological examination of non-sterile merchandise: microbial enumeration exams, 2.6.13. Microbiological examination of non-sterile merchandise: take a look at for specified microorganisms.