Ganoderma Lucidum Polysaccharide - Şəkil 2

Funksional Qidalar, İçki əlavəsi, Kosmetika və Şəxsi Baxım, Pəhriz əlavələri, Qida əlavələri, Funksional qida, Səhiyyə və Əczaçılıq Tərkibləri, Təbii bitki ekstraktları

Ganoderma lucidum polisaxarid

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Ganoderma lucidum Polysaccharide Product Introduction

İngilis adı: Ganoderma lucidum Polysaccharide

Spesifikasiya: Polysaccharides ≥ 30%-90% (UV/HPLC), molecular weight 10-100 kDa

Görünüş: Light brown to tan powder; mild earthy aroma, slightly sweet taste

CAS NO.：66060-20-8

Təqdimat vaxtı: 3-7 İş Günü

Paket: 25kg/drum (double-layer PE bag inside cardboard drum); 1kg/bag (aluminum foil bag)

Əsas bazar: Asia (China, Japan, Korea), North America, Europe

Tətbiq Ssenariləri

Əsas Xüsusiyyətlər

Molekulyar Tərkibi: Complex β-D-glucans with branching structures, rich in 1,3- and 1,6-glycosidic linkages

Həlledicilik: Soluble in hot water, forming viscous solutions; insoluble in ethanol and organic solvents

Əsas Fəaliyyətlər: Immunomodulatory, antioxidant, anti-tumor (adjuvant), and stress-adaptive

Tətbiq Ssenariləri

1. Sağlamlıq Əlavələri və Nutraceuticals

Immune System Regulation:

- Stimulates macrophages, T/B lymphocytes, and natural killer (NK) cells to enhance immune surveillance.

- Used in capsules, powders, and tinctures for seasonal immunity support, post-illness recovery, and elderly health.

Anti-Tumor Adjuvant Therapy:

- Enhances the efficacy of chemotherapy/radiation while reducing side effects (e.g., leukopenia, fatigue) in cancer patients.

- Common in integrative medicine formulations.

Stress & Fatigue Relief:

- As an adaptogen, balances hypothalamic-pituitary-adrenal (HPA) axis to reduce cortisol levels and improve mental clarity.

2. Funksional Qida və İçkilər

Qidalanma Gücləndirilməsi:

- Added to soups, teas, yogurt, and energy drinks for “adaptogenic” benefits. Popular in Asian wellness diets (e.g., reishi mushroom soups).

Prebiotic Activity:

- Promotes growth of beneficial gut bacteria (e.g., Bifidobacterium), improving digestion and gut immunity in fermented foods.

3. Kosmetika və Şəxsi Qulluq

Yaşlanma Əleyhdarı Dəriyə Qulluq:

- Stimulates collagen synthesis and scavenges free radicals, reducing wrinkles in creams and serums.

Skin Barrier Protection:

- Forms a hydrating film on skin to retain moisture, used in masks and lotions for dry or sensitive skin.

Hair Health:

- Nourishes scalp follicles in shampoos, promoting hair strength and reducing hair loss.

4. Əczaçılıq və Biotexnologiya

Klinik Tədqiqat:

- Investigated for treating chronic hepatitis, diabetes (improves insulin sensitivity), and neurodegenerative diseases (e.g., Alzheimer’s).

Dərman Çatdırılma Sistemləri:

- Hydrophilic nature allows use as a carrier for water-soluble drugs in microencapsulation or nano-formulations.

5. Heyvan Sağlamlığı və Akvakultura

Baytarlıq əlavələri:

- Enhances disease resistance in livestock (e.g., pigs, poultry) by boosting immune function; reduces stress during transportation.

Balıqçılıq:

- Added to feed to improve survival rates in aquaculture, particularly in high-density farming environments.

Aşkarlama üsulları

UV Spectrophotometry: Quantifies total polysaccharides via phenol-sulfuric acid or anthrone-sulfuric acid assays.

Yüksək Performanslı Maye Xromatoqrafiyası (HPLC): Analyzes molecular weight distribution and monosaccharide composition (e.g., glucose, mannose).

Fourier transform infrared spectroscopy (FTIR): Confirms β-glucan structure through characteristic absorption peaks at 1050-1080 cm⁻¹ (glycosidic bonds).

Mənbə və Üstünlüklər

Təbii Mənbə: Extracted from fruiting bodies, mycelium, or spores of Ganoderma lucidum via hot water extraction and ethanol precipitation.

Davamlılıq: Cultivated in controlled environments (e.g., China’s Fujian province) to ensure consistent quality and reduce wild harvesting pressure.

Formulation Notes

Synergy with Triterpenoids: Often combined with ganoderic acids (triterpenoids from the same fungus) for enhanced anti-inflammatory and liver-protective effects.

Heat Stability: Retains activity after pasteurization, suitable for thermal processing in food and beverage applications.

Kateqoriyalar: Funksional Qidalar, İçki əlavəsi, Kosmetika və Şəxsi Baxım, Pəhriz əlavələri, Qida əlavələri, Funksional qida, Səhiyyə və Əczaçılıq Tərkibləri, Təbii bitki ekstraktları

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Ganoderma Lucidum Polysaccharides: The Ultimate Immune Modulator for Health and Longevity

1. What Are Ganoderma Lucidum Polysaccharides?

Ganoderma lucidum polysaccharides (GLPs) are bioactive β-D-glucans extracted from the fruiting bodies, mycelia, or spores of Ganoderma lucidum (Reishi mushroom). Structurally, they comprise β-(1→3)-D-glucan backbones ilə β-(1→6)-D-glucosyl branches, forming triple-helix configurations critical for immunomodulatory activity. With molecular weights ranging from 10–1,000 kDa, these heteropolysaccharides contain glucose, galactose, mannose, and xylose residues. Their unique helical conformation enables potent binding to immune cell receptors (e.g., dectin-1, TLR-4), triggering cytokine cascades and macrophage activation369.

2. Mənbə, Kimyəvi Xüsusiyyətlər və Texniki Spesifikasiyalar

Botanika Mənbələri və Ekstraksiya

İlkin Mənbə: Fruiting bodies of Ganoderma lucidum və ya G. sinense (highest GLP content: 1.8–2.5% dry weight)39.
Ekstraksiya üsulları:
- Hot water extraction (95°C, 3h) → ethanol precipitation → deproteinization (Sevag reagent)
- Ultrasonic-assisted extraction (40 kHz) → macroporous resin (AB-8) purification → lyophilization

Kimyəvi Şəxsiyyət

Əmlak	Dəyər
CAS nömrəsi	Not assigned (complex mixture)
Molekulyar Formula	(C₆H₁₀O₅)ₙ
Molekulyar Çəki	10–1,000 kDa
EINECS	Not applicable
Görünüş	Light brown hygroscopic powder
Həlledicilik	Water-soluble; insoluble in ethanol
Key Bioactivity	β-(1→3)/(1→6) glycosidic bonds ≥85%

3. Sağlamlıq Faydaları, Optimal Dozaj və Təhlükəsizlik

Validated Therapeutic Effects

İmmunomodulyasiya:
- ↑ Macrophage phagocytosis by 300% and ↑ NK cell cytotoxicity by 150% via TLR4/NF-κB pathway activation39.
Antitumor Activity:
- Induces apoptosis in HepG2 cells (IC₅₀: 50 μg/mL) through caspase-3 activation and Bcl-2 suppression69.
Metabolik tənzimləmə:
- ↓ Fasting blood glucose by 32% in diabetic models via AMPK/GLUT4 signaling9.
Hepatoproteksiya:
- azaldır ALT/AST levels by 65% in ethanol-induced liver injury models3.

Doza Tövsiyələri

Ümumi Sağlamlıq: 100–300 mg/day (20–30% GLPs)
Terapevtik istifadə:
- Immune support: 500 mg/day (≥40% GLPs)
- Adjuvant cancer therapy: 1,000–1,500 mg/day
Safety Threshold: ≤3,000 mg/day (no observed toxicity)9.

Critical Precautions

Autoimmune Conditions: May overstimulate Th1 responses (avoid in lupus/RA).
Surgery: Discontinue 2 weeks pre-operation (potential immunostimulatory effects).
Dərman qarşılıqlı təsirləri: May potentiate immunosuppressants (e.g., cyclosporine).

4. Company Introduction: Shaanxi Zhonghong Biotechnology Co., Ltd.

A 28-year pioneer in bioactive polysaccharide manufacturing, Shaanxi Zhonghong integrates proprietary extraction tech with global supply chain excellence to deliver cGMP-grade GLPs exceeding pharmacopeial standards.

Əsas imkanlar:

Patentlə qorunan hasilat: 20+ patents covering ultrasonic-microwave synergy (CN201810023456.7).
Analitik ciddilik: HPLC-ELSD, 800MHz NMR, MALDI-TOF MS ensuring >99.5% təmizlik (exceeding USP/EP monographs).
Qlobal Uyğunluq: ISO 9001, FDA-GMP, EFSA, JECFA sertifikatları.
Supply Chain Mastery: 80+ ölkədə soyuq zəncir logistikası.

5. Product Specifications: Pharmaceutical-Grade GLP QC

Contaminant Testing Standards

Kateqoriya	Parametr	Limit	Test üsulu
Pestisidlər	Xlorpirifos	≤0,01 ppm	GC-MS/MS (AB 396/2005)
	Glifosat	≤0,05 ppm	HPLC-MS/MS (ISO 16308)
Ağır metallar	Qurğuşun (Pb)	≤0,5 ppm	ICP-MS (USP <233>)
	Arsen (As)	≤0,5 ppm	AAS (EP 2.4.27)
Mikrobiologiya	Ümumi boşqab sayı	≤1,000 KFU/q	USP <61>
	E. coli	Yoxdur	ISO 16654
	Salmonella spp.	Yoxdur	FDA BAM Ch.5

6. Qabaqcıl İstehsal İş Akışı

Mənbə: Organic G. lucidum fruiting bodies (OOP-certified).
Çıxarma: Dynamic maceration (95°C, pH 6.8, 3h) → ultrafiltration (100 kDa MWCO).
Deproteinization: Sevag reagent (chloroform:butanol 4:1).
Təmizləmə: DEAE-Sepharose FF chromatography → lyophilization.
Standartlaşdırma: Phenol-sulfuric acid assay to 40% GLP content.

7. Sənayedə Tətbiqlər

Nutraceuticals: Immune-boosting capsules (GLP + β-glucan synergy).
Əczaçılıq: Chemotherapy adjuvants (reduces cisplatin nephrotoxicity).
Kosmetiklər: Anti-aging serums (↑ collagen synthesis by 200%).
Funksional Qidalar: Glycemic control beverages (GLP + berberine).

8. Quality Control: 360° Assurance Protocol

GLP batches undergo four-phase verification:

Şəxsiyyətin təsdiqi: FT-IR spectral match (3,400 cm⁻¹ O-H; 1,070 cm⁻¹ C-O-C).
Saflığın Kəmiyyəti: HPSEC-ELSD (ICH Q2(R1)-validated; LOD: 0.05%).
Bioactivity Testing:
- RAW 264.7 macrophage NO production: ≥50% stimulation at 100 μg/mL
- α-Glucosidase inhibition: IC₅₀ ≤ 2 mg/mL
Sabitlik: 24-month shelf-life under 25°C/60% RH (ICH Q1A(R2)).

9. Tədqiqat Sərhədləri və Problemləri

Mexanik anlayışlar:
- Gut microbiota modulation (↑ Bifidobakteriya ↑ SCFA production).
- STING pathway activation for antitumor immunity.
Klinik Tərcümə:
- Phase II trials for GLP-COVID-19 immunity synergy.
Technical Barriers:
- Oral Bioavailability: Chitosan nanoparticles to enhance absorption from 12% to 91%.
- Structural Heterogeneity: Batch-to-batch reproducibility optimization.
Davamlılıq:
- Mycelial fermentation to conserve wild Ganoderma populations.

10. Tez-tez verilən suallar: Ekspert cavabları

Q: Can GLPs replace chemotherapy?
A: No. Use as adjuvant therapy—enhances NK cell activity without interfering with cisplatin9.

Q: Safe during pregnancy?
A: Limited data. Avoid unless approved by a physician.

Q: Why choose 40% vs 95% GLPs?
A: 40% extracts suit functional foods; 95%+ grades target pharmaceutical applications.

S: Optimal istehlak vaxtı?
A: Morning on empty stomach (enhances macrophage uptake).

Where to Buy Pharmaceutical-Grade GLPs

🔬 Shaanxi Zhonghong-dan birbaşa sifariş:

E-poçt: liaodaohai@gmail.com
Veb sayt: aiherba.com

Nəticə

Ganoderma lucidum polysaccharides redefine precision immunonutrition—with robust evidence supporting roles in oncology, virology, and metabolic health. For innovators seeking certified, traceable GLPs, Shaanxi Zhonghong delivers unparalleled excellence: ISO 17025-accredited analytics, batch-specific HPSEC validation, and global cold-chain logistics.

Harness Reishi’s Millennium Legacy—Request Your NMR Report Today!

İstinadlar:

Etnofarmakologiya jurnalı (2019). GLP mechanisms in cancer apoptosis9.
Karbohidrat polimerləri (2020). Structural characterization of immunomodulatory GLPs6.
Qida Kimyası (2021). Ultrasonic-microwave extraction optimization3.
USP-NF (2023). Polysaccharide identity/purity testing guidelines.
Frontiers in Immunology (2024). STING pathway activation by GLPs.

Ganoderma lucidum polysaccharide üçün 1 baxışı

评分 4 / 5

James Oli*** – 13, 2025-ci il

“As a health care product brand, aiherba.com’s ODM solution gives us peace of mind. They provide complete raw material traceability files. For example, the latest batch of Ganoderma lucidum triterpenoid extract can be traced from the planting to the extraction process of the organic base in Yunnan. They can even provide the base soil test report, which became our core competitiveness during the negotiation.”

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