Bisabolol

Unlocking the Energy of Bisabolol: Nature’s Soothing Elixir from AIHerba | Supplier & Manufacturer

1. What is Bisabolol?
Bisabolol, primarily occurring as (-)-α-bisabolol, is a naturally occurring monocyclic sesquiterpene alcohol famend for its distinctive skin-soothing, anti-irritant, and anti inflammatory properties. This bioactive compound is a prized beauty and pharmaceutical ingredient, providing a delicate but potent resolution for delicate pores and skin and numerous inflammatory circumstances. Its delicate floral aroma additional enhances its enchantment in perfumery.

2. Məhsulun Təchizatı, Kimyəvi Xüsusiyyətləri və İdentifikasiyası

• Major Natural Supply: German Chamomile (Matricaria chamomilla/recutita), particularly its important oil, is the richest pure supply of (-)-α-bisabolol. Additionally present in smaller portions in Candeia tree (Vanillosmopsis species) oil and different vegetation.

• Kimyəvi xassələri:

  • CAS Miqdarı: 515-69-5 (Usually refers back to the racemic combination; pure (-)-α-Bisabolol is 23089-26-1)

  • MF (Molekulyar Formulyasiya): C₁₅H₂₆O

  • MW (Molekulyar Çəki): 222.37 g/mol

  • EINECS: 207-454-3

  • Görünüş: Colorless to pale yellow viscous liquid.

  • Həlletmə qabiliyyəti: Soluble in alcohols and oils, insoluble in water.

  • Optical Exercise: Natural (-)-α-Bisabolol is levorotatory. Artificial variations could also be racemic.

• AIHerba Supply & Benefit: AIHerba makes use of premium German Chamomile flowers, using proprietary supercritical CO2 extraction and molecular distillation methods to yield (-)-α-Bisabolol with unparalleled purity (>98%) and stereochemical integrity, maximizing its bioactivity.

3. What is the Finest Bisabolol? Efficacy, Security & Utilization

• “Finest” Outlined: The highest efficacy is constantly attributed to pure (-)-α-Bisabolol resulting from its particular stereochemistry. AIHerba’s concentrate on ultra-high purity pure (-)-α-Bisabolol ensures superior efficiency.

• Highest Content Supply: German Chamomile important oil usually comprises the very best pure focus (as much as ~50%, although AIHerba isolates it to >98%).

• Well being & Pores and skin Benefits:

  • Potent Anti-inflammatory: Inhibits COX-2, LOX, and inflammatory cytokines (TNF-α, IL-6).

  • Soothing & Anti-irritant: Quickly calms pores and skin irritation (e.g., from surfactants, UV, chemical peels).

  • Antioksidant: Scavenges free radicals, defending pores and skin cells.

  • Wound Therapeutic & Regenerative: Stimulates fibroblast migration and promotes tissue restore.

  • Antimikrobiyal: Displays exercise towards sure micro organism and fungi.

  • Təkmilləşdirilmiş Penetrasiya: Can enhance pores and skin absorption of different actives.

  • Pores and skin Barrier Help: Contributes to a more healthy pores and skin barrier operate.

• Day by day Consumption: Bisabolol is primarily used topically (cosmetics, skincare). Oral consumption shouldn’t be frequent for bisabolol itself; security ranges depend upon the particular software (beauty, complement, pharmaceutical). Beauty use is usually thought to be secure at typical concentrations (0.2% – 2.0%).

• Wants Consideration:

  • Sensitivity: Whereas usually well-tolerated, patch testing new merchandise is at all times beneficial.

  • Oksidləşmə: Pure bisabolol can oxidize over time; formulations ought to embrace antioxidants and use acceptable packaging (e.g., airless containers, nitrogen flushing).

• Aspekt Nəticələri: Uncommon. Potential for gentle pores and skin irritation or allergic response in extremely delicate people. Natural (-)-α-Bisabolol has a wonderful security profile.

4. Introducing AIHerba: Your Trusted Bisabolol Companion
Shaanxi Zhonghong Investment Technology Co., Ltd. (AIHerba) is a premier yüksək texnologiyalı müəssisə integrating agile R&D, collaborative innovation, built-in manufacturing, and international advertising. For over 28 il, we have specialised in serving the chemical, supplies, and life sciences sectors, with core experience within the extraction, isolation, purification, and industrial software of bioactive plant constituents.

• Elmi şücaət: 5+ strategic college joint labs, 20+ patented applied sciences, and a globally distinctive xüsusi mürəkkəb kitabxana.

• Chopping-Edge High quality: HPLC (Həddindən artıq Effektiv Maye Xromatoqrafiyası), GC-MS (Benzin Xromatoqrafiyası-Kütlə Spektrometriyası), və Superconducting NMR (Nuclear Magnetic Resonance) guarantee purity requirements exceeding trade norms by 20%+.

• Dünya əldə etmək: Xidmət edir 80+ millət Asiya, Avropa və Amerika qitələrində təklif edir custom-made pure ingredient options to main multinational pharmaceutical corporations, analysis establishments, and beauty giants.

5. Product Specs: Rigorous High quality Management
AIHerba’s (-)-α-Bisabolol adheres to the strictest high quality requirements. Key specs embrace:

Desk 1: Pesticide Residue Evaluation

Desk 2: Heavy Metals Evaluation

Desk 3: Microbial Evaluation

6. Superior Manufacturing Move
AIHerba’s (-)-α-Bisabolol manufacturing exemplifies cutting-edge phytochemistry:

1. Mənbə: Premium German Chamomile flowers from licensed sustainable farms.

2. Major Extraction: Superkritik CO2 çıxarılması (SFE) – Makes use of tunable strain/temperature for selective, solvent-free isolation of volatiles, preserving delicate actives.

3. Fokus: Removing of waxes and non-target compounds.

4. Isolation & Purification: Preparative HPLC and/or Excessive-Vacuum Fractional Distillation – Achieves focused separation of (-)-α-Bisabolol from different terpenes.

5. Crystallization (Non-obligatory): For attaining highest purity grades (>99%).

6. Stabilization: Addition of synergistic antioxidants (e.g., Tocopherol).

7. Ciddi QC: HPLC-DAD/ELSD, Chiral GC/HPLC, GC-MS, NMR for identification, purity (>98%), enantiomeric extra, and residual solvent evaluation. ICP-MS for heavy metals. Microbiological testing per pharmacopeia.

8. Qablaşdırma: Underneath inert environment (Nitrogen) in light-protected, food-grade HDPE or glass containers.

7. Various Application Scenarios

• Kosmetika və Dəriyə Qulluq: Calming serums, delicate pores and skin lotions, after-sun merchandise, anti-redness remedies, child care, post-procedure formulations (laser, peels), zits remedies (mitigates irritation), pure deodorants.

• Reçeteli dərmanlar: Topical anti-inflammatory and wound therapeutic ointments/gels, mucoadhesive formulations, dental care merchandise (anti-gingivitis).

• Perfumery: Gives a tender, candy, floral notice with fixative properties.

• Qidalandırıcılar: Included into topical wellness merchandise (e.g., muscle soothing balms).

8. Complete High quality Management (QC)
AIHerba’s QC paradigm is constructed on Pharmaceutical cGMP ideas and leverages ən müasir analitik alətlər. Identification affirmation makes use of FTIR (Fourier Remodel Infrared Spectroscopy) fingerprinting and Chiral Chromatography to confirm the (-)-enantiomer. Purity is quantified by way of validated HPLC-UV/ELSD strategies calibrated towards licensed reference requirements, constantly guaranteeing >98% (-)-α-Bisabolol content material. Residual Solvent Evaluation (Headspace GC-MS) ensures compliance with ICH Q3C tips. Stabillik Araşdırması (ICH Q1A) underneath accelerated and long-term circumstances decide shelf-life and optimum storage parameters. Each batch undergoes full spectroscopic (NMR for structural elucidation if wanted), chromatographic, and microbiological testing, documented in a Certificates of Evaluation (CoA) traceable to worldwide requirements (USP, EP, CP). Our ISO 9001-certified high quality administration system ensures traceability and steady enchancment.

9. Təhlükəsiz Qablaşdırma və Dünya Logistika

• Qablaşdırma: 1kg, 5kg food-grade HDPE bottles; 25kg HDPE drums. All nitrogen flushed və aluminum bag-lined for max oxidation safety. Customized packaging obtainable.

• Yaddaş: Retailer tightly sealed in unique packaging, shielded from mild and moisture at 2-8°C (refrigerated) for long-term stability. Quick-term (<6 months) at <25°C acceptable.

• Logistika: Shipped globally by way of temperature-controlled logistics (chilly chain the place required). Compliant with all worldwide rules (REACH, FDA, COSMOS and so on.). Complete documentation offered.

10. Deep Dive: Well being Mechanisms, Purposes & Innovation

• Hərəkət mexanizmi: (-)-α-Bisabolol exerts results by way of a number of pathways:

  • Modulates NF-κB and MAPK signaling cascades, suppressing pro-inflammatory cytokine manufacturing.

  • Inhibits key enzymes: Cyclooxygenase-2 (COX-2), 5-Lipoxygenase (5-LOX).

  • Demonstrates antioxidant exercise by quenching ROS/RNS.

  • Enhances penetration by way of lipid bilayer interplay.

  • Promotes re-epithelialization and granulation tissue formation in wounds.

• Industrial Purposes & AIHerba Innovation: Past cosmetics, bisabolol enhances transdermal drug supply programs. AIHerba innovates by way of enantioselective synthesis pathways (for ultra-pure (-)-isomer), novel co-crystal formulations for enhanced stability/solubility, and sustained-release supply programs (e.g., lipid nanoparticles) built-in with our xüsusi mürəkkəb kitabxana screening for synergistic combos.

• Təhlil Sərhədləri və Çağırışlar:

  • Sərhədlər: Exploring efficacy in neuroinflammatory circumstances, gastroprotective results, anti-cancer adjunct remedy (enhancing chemo efficacy/lowering negative effects), superior biomaterials (anti-inflammatory coatings for implants).

  • Çətinliklər: Scaling sustainable cultivation of high-bisabolol chamomile strains, cost-effective large-scale chiral purification, definitive medical dose-response research for particular therapeutic endpoints, long-term stability optimization in advanced formulations.

11. Daimi Sorğulanan Suallar (FAQ)

• Q: Is pure (-)-α-Bisabolol higher than artificial?

  • A: Sure, quite a few research point out pure (-)-α-Bisabolol possesses superior anti-inflammatory and skin-soothing efficacy in comparison with artificial racemic mixtures or different isomers resulting from its particular stereochemistry.

• Q: What focus of Bisabolol is efficient in cosmetics?

  • A: Typical efficient concentrations vary from 0.2% to 2.0%. Efficacy relies on the formulation and desired impact; AIHerba gives software assist.

• Q: Is Bisabolol secure for delicate pores and skin?

  • A: Completely. Natural (-)-α-Bisabolol is famend for its distinctive tolerance and efficacy in calming delicate, irritated, and reactive pores and skin.

• Q: Does Bisabolol have any identified drug interactions?

  • A: Topical use has no vital reported interactions. Seek the advice of a doctor for potential interactions with oral medicines if used systemically (uncommon).

• Q: How ought to I retailer AIHerba Bisabolol?

  • A: For optimum long-term stability and to stop oxidation, retailer tightly sealed, shielded from mild, and refrigerated (2-8°C). See CoA for particular batch suggestions.

• Q: Is AIHerba Bisabolol compliant with worldwide requirements?

  • A: Sure. Our product meets or exceeds specs outlined in related USP/EP monographs (the place relevant), COSMOS, ISO, and is REACH/FDA compliant. Certificates obtainable.

12. The place to Purchase Premium (-)-α-Bisabolol
Supply the very best purity, naturally derived (-)-α-Bisabolol straight from the producer:

• Veb sayt: www.aiherba.com

• Əlaqə: Cənab Liao Daohai

• E-poçt: liaodaohai@gmail.com

• Sorğu: Bulk pricing, samples, technical knowledge sheets (TDS), certificates of research (CoA), and formulation assist.

13. Nəticə
(-)-α-Bisabolol stands as a cornerstone bioactive ingredient for light but highly effective soothing and anti inflammatory efficacy. AIHerba, yararlanmaq 28 years of experience in phytochemistry and superior purification applied sciences, çatdırır ultra-pure (>98%) pure (-)-α-Bisabolol. Sourced sustainably and validated by superconducting NMR, HPLC, and ICP-MS, our ingredient meets the stringent calls for of worldwide beauty, pharmaceutical, and analysis markets. Select AIHerba for unparalleled high quality, scientific assist, and a dedication to innovation in pure actives.

14. İstinadlar

1. Kamatou, G. P. P., & Viljoen, A. M. (2010). A evaluation of the applying and pharmacological properties of α-bisabolol and α-bisabolol-rich oils. Journal of the American Oil Chemists’ Society, 87(1), 1-7.

2. European Medicines Company (EMA) Evaluation Report on Matricaria recutita L., flos. (2015).

3. Cavalieri, E., et al. (2004). Professional-apoptotic exercise of α-bisabolol in preclinical fashions of major human acute leukemia cells. The Journal of Medical Investigation, 114(3).

4. Worldwide Group for Standardization (ISO). ISO 16128 – Tips on technical definitions and standards for pure and organic beauty substances.

5. United States Pharmacopeia (USP) Normal Chapters: <561> Articles of Botanical Origin, <2023> Microbiological Examination of Nonsterile Merchandise.

6. European Pharmacopoeia (Ph. Eur.) Monographs: 2.8.12 Microbiological examination of non-sterile merchandise, 2.4.8 Heavy Metals.

7. Current Analysis (e.g., search PubMed.gov for “alpha-bisabolol mechanism”, “bisabolol pores and skin”, “bisabolol wound therapeutic” – 2023/2024 publications). AIHerba Inner Analysis & Stability Information.