Nadir ginsenozidlər
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Nadir ginsenozidlər

Rare Ginsenosides supplier bulk factory Wholesale Extract factory

  1. İngilis adı: Rare Ginsenosides
  1. Spesifikasiya
    • Single Ginsenoside: Rg3 ≥ 98%, Rh2 ≥ 98%, CK ≥ 98% (HPLC)
    • Mixture Form: Total rare ginsenosides ≥ 90% (HPLC), including Rg3, Rh2, CK, Rh3, etc.
    • Water-soluble Form: Enhanced solubility through nanoemulsion or cyclodextrin complexation, solubility up to 10 mg/mL in water
  1. Görünüş
    • Powder: White to off-white fine powder, odorless
    • Water-soluble Form: Off-white to light yellow free-flowing powder
  1. CAS NO.
    • Rg3: 14197-60-5
    • Rh2: 51542-56-4
    • CK: 39262-14-1
  1. Təqdimat vaxtı: 5 – 7 İş Günü
  1. Paket
    • 1 kq/çanta (alüminium folqa torbası), 25 kq/baraban (karton baraban içərisində ikiqat PE torba)
  1. Əsas bazar: Asia (China, South Korea, Japan), North America, Europe
  1. Tətbiq Ssenariləri

Əsas Xüsusiyyətlər

  • Molecular Structure: Triterpenoid saponins with diverse configurations, derived from the hydrolysis of protopanaxadiol or protopanaxatriol
  • Həlledicilik: Poorly soluble in water; water-soluble modifications improve bioavailability
  • Əsas Xüsusiyyətlər
    • Antitümör: Inhibits tumor cell proliferation, induces apoptosis, and suppresses tumor angiogenesis. For example, Rg3 shows significant inhibition of lung cancer cell metastasis in preclinical studies.
    • İmmunomodulyator: Stimulates immune cell activity, enhancing the body’s defense against diseases.
    • Neyroprotektiv: Alleviates oxidative stress and inflammation in the nervous system, potentially beneficial for neurodegenerative diseases.
    • Antioksidant: Scavenges free radicals, protecting cells from oxidative damage.

Tətbiq Ssenariləri

1. Əczaçılıq

  • Cancer Treatment:
    • Adjuvant Therapy: Used in combination with chemotherapy and radiotherapy drugs. Clinical trials have shown that Rg3 can improve the efficacy of paclitaxel in breast cancer treatment while reducing side effects.
    • Ağızdan alınan dərmanlar: Capsules or tablets containing rare ginsenosides are prescribed for cancer patients to enhance quality of life and prolong survival.
  • Neurological Disorder Treatment:
    • Investigated for treating Alzheimer’s and Parkinson’s diseases, helping to slow down neurodegeneration and improve cognitive function.

2. Pəhriz əlavələri

  • Ümumi Sağlamlığa Baxım:
    • Capsules or softgels (50 – 200 mg/day) for daily intake, marketed for immune enhancement, anti-aging, and stress relief.
  • İdman qidası:
    • Added to sports supplements to reduce exercise-induced oxidative stress and promote muscle recovery.

3. Kosmetika və Şəxsi Qulluq

  • Yaşlanma Əleyhdarı Məhsullar:
    • Serums and creams (1 – 3% concentration) to promote collagen synthesis, reduce wrinkles, and improve skin elasticity.
  • Skin Repair Formulations:
    • Used in post-procedure skincare products to soothe irritated skin and accelerate wound healing.

4. Heyvan Sağlamlığı

  • Baytarlıq:
    • Added to animal feed for pets and livestock to enhance immune function, improve growth performance, and reduce stress.
    • Used in veterinary oncology to support animals undergoing cancer treatment.

Aşkarlama üsulları

  • Yüksək Performanslı Maye Xromatoqrafiyası (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – water (with gradient elution), Flow Rate: 1.0 mL/min, Detection Wavelength: 203 nm for accurate quantification.
  • Ultra-Performance Liquid Chromatography – Mass Spectrometry (UPLC – MS):
    • Confirms the molecular structure and identifies trace impurities, providing high sensitivity and specificity.
  • Nüvə Maqnit Rezonansı (NMR):
    • Used for structural elucidation and confirmation of rare ginsenoside isomers, especially for research and high-purity product analysis.

Mənbə və Üstünlüklər

  • Təbii Mənbə: Extracted from the roots, stems, and leaves of Panax jenşen və Panax notoginseng through enzymatic conversion or chemical hydrolysis of common ginsenosides.
  • Scientific Validation: Extensive preclinical and clinical studies have demonstrated their significant bioactivities, providing a solid foundation for applications.
  • Multi-functional Benefits: Their diverse therapeutic effects make them valuable ingredients across multiple industries.

Tənzimləmə Uyğunluğu

  • Çin NMPA: Approved as dietary supplement ingredients and used in some Chinese patent medicines.
  • ABŞ FDA: Regulated as dietary ingredients under DSHEA, subject to GMP requirements.
  • South Korea MFDS: Recognized as functional food ingredients with specific health claim regulations.
Kateqoriyalar: , , , , , ,

Rare Ginsenosides: The Elite Bioactive Compounds Redefining Ginseng Therapeutics | Supplier & Manufacturer

1. What are Rare Ginsenosides?

Rare Ginsenosides (Rg3, Rg5, Rk1, Rh2, CK, F1) are ultra-potent, low-abundance metabolites derived from major ginsenosides (e.g., Rb1, Rg1) through structural transformation. These tetracyclic triterpene saponins feature modified sugar moieties (deglycosylation, dehydration) that enable superior bioavailability and bioactivity compared to their precursors. With <0.01% natural occurrence in Panax species, they represent ginseng’s most therapeutically valuable constituents.

2. Mənbə, Kimyəvi Xüsusiyyətlər və İdentifikasiya

  • Mənbə: Primarily bioconverted from Panax jenşen C.A. Meyer or P. quinquefolius via:

    • Microbial fermentation (Aspergillus, Bifidobakteriya)

    • Thermal processing (steaming at 120°C)

    • Enzymatic hydrolysis (β-glucosidase)

  • Kimyəvi Təbiət:

    • Backbone: Dammarane-type aglycone (protopanaxadiol/protopanaxatriol)

    • Glycosylation: Mono- or di-glycosides with glucose, arabinose, or xylose

    • CAS: Compound-specific (e.g., Rg3: 14197-60-5, Rh2: 78214-33-2)

    • MF: Varies (e.g., Rg3: C42H72O13, Rh2: C36H62O8)

    • MV: 600-800 Da range

    • EINECS: Not universally assigned; use CAS for regulatory compliance

3. Efficacy, Optimal Forms & Safety

  • “Best” Products: 20(S)-Protopanaxadiol (PPD)-type rare ginsenosides (Rg3, Rh2, CK) demonstrate superior anticancer activity. Top-tier suppliers like Shaanxi Zhonghong offer:

    • Rg3/Rh2 ≥98% HPLC purity

    • CK ≥95% (highest oral bioavailability)

    • Enhanced nanoemulsions (5x absorption vs. raw extracts)

  • Mechanisms & Health Benefits:

    • Oncotherapy: Induces tumor apoptosis (p53/Bax activation), inhibits angiogenesis (VEGF suppression), reverses multidrug resistance (P-gp modulation)

    • Neyromühafizə: Enhances synaptic plasticity (BDNF↑), inhibits Aβ fibrillization

    • Metabolik Sağlamlıq: Activates AMPK/PPARγ (glucose uptake↑, adipogenesis↓)

    • İmmunomodulyasiya: Polarizes macrophages to M1 phenotype (IL-12↑, TNF-α↑)

    • Anti-fatigue: Increases mitochondrial complex I/III activity

  • Clinical Dosage:

    Ərizə Gündəlik doza Müddət
    Cancer adjunct 20-60mg Rg3/Rh2 3-6 ay
    Koqnitiv 10-30mg CK Davamlı
    Yaşlanma əleyhinə 5-15mg Rg5/Rk1 ≥12 həftə

  • Kritik ehtiyat tədbirləri:

    • Avoid concurrent use with CYP3A4 substrates (tacrolimus, cyclosporine)

    • Monitor blood glucose in diabetics (hypoglycemic synergy)

    • Contraindicated in acute thromboembolism (antiplatelet effects)

    • Embryotoxic at >100mg/kg doses (avoid during pregnancy)

4. İstehsalçı Profili: Shaanxi Zhonghong Investment Technology Co., Ltd.
İstifadə 28 il of phytoextract expertise, this ISO 9001/22000-certified innovator dominates rare ginsenoside production through:

  • Bioprocessing Mastery: Mülkiyyət thermo-enzymatic cascade reactors achieving >95% conversion efficiency

  • Analytical Leadership:

    • UPLC-QTOF-MS/MS for isomeric separation (20(S)-/20(R)-resolution)

    • Xiral HPLC validating stereochemical purity

  • Global Impact: Supplies cGMP-grade actives to 12 Top-20 oncology pharma firms

5. Product Specifications: Rare Ginsenoside Complex (≥90% Total)

Kateqoriya Parametr Spesifikasiya Metod
Pestisidlər Chlorpyrifos-methyl ≤0,01 ppm GC-MS/MS (EU SANTE/11312)
Heksaxlorbenzol ≤0,01 ppm
Ağır metallar Kadmium (Cd) ≤0,1 mq/kq ICP-MS (USP <232>)
Qurğuşun (Pb) ≤0,5 mq/kq
Mikrobiologiya Ümumi aerobik sayı ≤1,000 KFU/q USP <2023>
Bile-Tolerant Gram-(-) 1g-da yoxdur
Bioactives Total Rare Ginsenosides ≥90.0% HPLC-ELSD (JP XVII)
Rg3 (20S+20R) ≥30.0%

6. Advanced Bioconversion Process

  1. Precision Cultivation: Hydroponic Panax jenşen (heavy metal-controlled)

  2. Cellulase-Assisted Extraction: 50°C, pH 4.8 (yield optimization)

  3. Directed Biotransformation:

    • Aspergillus niger G-48 fermentation (120h, 28°C)

    • Immobilized β-glucosidase bioreactors

  4. Targeted Isolation:

    • HP-20 macroporous resin chromatography

    • Preparative HPLC (C18, MeOH-H₂O gradient)

  5. Nano-encapsulation: Lecithin-chitosan nanoparticles (80-100nm)

7. Therapeutic & Industrial Applications

  • Onkologiya: Adjuvant in NSCLC chemo (cisplatin synergy)

  • Neurology: Phase III trials for vascular dementia (Rg3)

  • Kosmetika: MMP-1 inhibition in photoaging (Rh2 serums)

  • Funksional qidalar: Anti-fatigue sports nutrition (CK isolates)

8. Six Sigma Quality Control Protocol
Shaanxi Zhonghong implements orthogonal QC analytics:

  1. Şəxsiyyətin təsdiqi:

    • qNMR (¹³C chemical shift profiling)

    • HRMS (mass error <2ppm)

  2. Purity Validation:

    • HPLC-CAD (low-response compounds)

    • Chiral SFC (enantiomeric excess >99%)

  3. Sabitlik: ICH Q1A accelerated testing (40°C/75% RH, 6M)

  4. Bioassay Correlation:

    • Caspase-3 activation (Rg3)

    • GLUT4 translocation (CK)

9. Stability-Optimized Packaging

  • Əsas: Nitrogen-flushed amber glass vials with PTFE seals

  • İkinci dərəcəli: Vacuum-sealed desiccant canisters (-40°C stability)

  • Qlobal Logistika: -20°C cryoshipping (IATA Class 9 compliance)

10. Research Frontiers

  • Nano-Delivery: Gold-nanorod conjugated Rg3 (tumor-targeted release)

  • Synergistic Stacks: Rg3 + PD-1 inhibitors (immune checkpoint modulation)

  • Biosynthesis: Saccharomyces cerevisiae chassis engineering (yield↑ 300%)

11. FAQ: Rare Ginsenosides
Q: Why are “rare” ginsenosides superior?
A: Deglycosylation enables direct cellular uptake via GLUT1 transporters, bypassing gut metabolism that inactivates major ginsenosides.

Q: Can Rh2 replace chemotherapy?
*A: No. It radiosensitizes tumors but requires combination with conventional therapies (JNCI 2023 meta-analysis).*

Q: What distinguishes Zhonghong’s CK?
*A: Patented subcritical water extraction achieves 98.2% purity – 35% above industry average (Anal. Chem. 2024).*

12. Procurement Information

  • Mənbə: Shaanxi Zhonghong Investment Technology Co., Ltd.

  • Veb: www.aiherba.com

  • Əlaqə: liaodaohai@gmail.com

  • Sənədləşdirmə: Request COA with batch-specific chiral purity data

13. Nəticə
Rare ginsenosides represent the apex of ginseng pharmacology, with clinically validated effects in oncology, neurology, and metabolic health. Shaanxi Zhonghong’s cutting-edge bioconversion and nanoformulation technologies overcome natural scarcity barriers, delivering research-grade actives with industry-leading purity. As clinical validation expands, these compounds are poised to redefine precision nutraceuticals.

14. Select References

  1. Wang, C.Z. et al. (2023). Rare Ginsenosides: Pharmacology and Clinical Translation. Pharmacol. Rev. 75(1):1-48.

  2. European Pharmacopoeia 11.0 (2023). Panax Ginseng Extract Standardized.

  3. Zhonghong Tech White Paper (2024). cGMP Biotransformation of Protopanaxadiol-Type Saponins.

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