Gastrodia fenol birləşmələri
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Gastrodia fenol birləşmələri

Gastrodia Phenolic Compounds supplier bulk factory Wholesale Extract factory

  1. İngilis adı: Gastrodia Phenolic Compounds
  1. Spesifikasiya
    • Total Phenolic Content: ≥ 15 – 30% (Folin – Ciocalteu method)
    • Major Components: p – Hydroxybenzaldehyde ≥ 5% (HPLC), p – Hydroxybenzoic acid ≥ 3% (HPLC), vanillic acid ≥ 2% (HPLC)
    • Water – soluble Powder: Solubility ≥ 90% in water, moisture ≤ 5%
  1. Görünüş
    • Light brown to yellowish – brown fine powder, mild herbal odor
  1. CAS NO.
    • p – Hydroxybenzaldehyde: 123 – 08 – 0
    • p – Hydroxybenzoic acid: 99 – 96 – 7
    • vanillic acid: 121 – 34 – 6
  1. Təqdimat vaxtı: 3 – 7 İş Günü
  1. Paket
    • 1 kq/çanta (alüminium folqa torbası), 25 kq/baraban (karton baraban içərisində iki qatlı PE torba)
  1. Əsas bazar: Asiya (Çin, Yaponiya, Cənubi Koreya), Şimali Amerika, Avropa
  1. Tətbiq Ssenariləri

Əsas Xüsusiyyətlər

  • Molecular Structure: Composed of various phenolic acids and aldehydes with a benzene ring and hydroxyl groups
  • Həlledicilik: Soluble in water, ethanol, and methanol; water – soluble formulations are ideal for beverage and pharmaceutical applications
  • Əsas Xüsusiyyətlər
    • Antioksidant: Scavenges free radicals such as DPPH and hydroxyl radicals, with an ORAC (Oxygen Radical Absorbance Capacity) value of 2000 – 3500 μmol Trolox equivalents/g.
    • İltihab əleyhinə: Inhibits the production of pro – inflammatory cytokines like TNF – α and IL – 6.
    • Neyroprotektiv: Protects neurons from oxidative stress and apoptosis, potentially beneficial for neurodegenerative diseases.
    • Antimikrobiyal: Exhibits inhibitory activity against certain bacteria and fungi, such as Staphylococcus aureus and Candida albicans.

Tətbiq Ssenariləri

1. Əczaçılıq

  • Neurological Disorder Treatment:
    • Investigated for the treatment of stroke and epilepsy, as the neuroprotective properties help reduce brain damage and prevent seizure recurrence.
    • Used in combination with other drugs to enhance the treatment effect of Alzheimer’s disease by reducing oxidative stress in the brain.
  • Anti – inflammatory Formulations:
    • Incorporated into topical creams and ointments to relieve skin inflammation, such as eczema and dermatitis.

2. Pəhriz əlavələri

  • Antioxidant Supplements:
    • Capsules or tablets containing 200 – 500 mg of phenolic compounds in Gastrodia, marketed for general health maintenance and anti – aging, often combined with other antioxidants like vitamin C and E.
  • Brain Health Formulas:
    • Added to nootropic supplements to support cognitive function, memory, and focus.

3. Kosmetika və Şəxsi Qulluq

  • Anti – aging Products:
    • Serums and moisturizers (2 – 5% concentration) to protect skin from UV – induced damage, reduce the appearance of fine lines and wrinkles, and promote skin elasticity.
  • Antibacterial Skincare:
    • Used in facial cleansers and acne treatments to inhibit the growth of acne – causing bacteria.

4. Funksional Qida və İçkilər

  • Antioxidant – Rich Beverages:
    • Added to fruit juices, tea – based drinks, and energy drinks at 0.5 – 1% concentration to enhance the antioxidant capacity and extend shelf life.
  • Gücləndirilmiş Qidalar:
    • Incorporated into baked goods, cereals, and snacks to increase their nutritional value and provide health – promoting benefits.

Aşkarlama üsulları

  • Yüksək Performanslı Maye Xromatoqrafiyası (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – 0.1% phosphoric acid (gradient elution), Flow Rate: 1.0 mL/min, Detection Wavelength: 280 nm for p – Hydroxybenzaldehyde, 254 nm for p – Hydroxybenzoic acid, and 325 nm for vanillic acid.
  • Folin – Ciocalteu Assay:
    • A colorimetric method to determine the total phenolic content, measuring absorbance at 765 nm.
  • Kütləvi Spektrometriya (MS):
    • Used in combination with HPLC (HPLC – MS) to confirm the molecular structure and identify trace phenolic compounds.

Mənbə və Üstünlüklər

  • Təbii Mənbə: rizomlarından çıxarılır Gastrodia elata Blume, a traditional Chinese medicinal herb.
  • Multi – functional Benefits: Their diverse bioactivities make them suitable for various applications from medicine to consumer products.
  • Traditional Use Validation: With a long history of use in traditional Chinese medicine, it provides a reliable foundation for modern applications.

Tənzimləmə Uyğunluğu

  • Çin NMPA: Approved as a dietary supplement ingredient and used in traditional Chinese medicine formulations.
  • ABŞ FDA: Regulated as a dietary ingredient when used in supplements, subject to Good Manufacturing Practice (GMP) requirements.
  • EU Cosmetic Regulation: Allowed as a cosmetic ingredient, with restrictions on maximum concentration in different product types.
Kateqoriyalar: , , , , , ,

Gastrodia Phenolic Compounds: The Neuroprotective Powerhouse from Tian Ma

1. What Are Gastrodia Phenolic Compounds?

Gastrodia phenolic compounds are a bunch of bioactive phytochemicals primarily derived from Gastrodia elata Blume (天麻/Tian Ma), a revered medicinal orchid in Conventional Chinese language Medication (TCM). These compounds, together with gastrodin, parishins, and vanillyl alcohol derivatives, are clinically validated for his or her neuroprotective, antioxidant, and anti inflammatory properties, making them invaluable in fashionable nutraceuticals, prescription drugs, and cosmeceuticals.

2. Təchizat, Kimyəvi Xüsusiyyətlər və Əsas İdentifikatorlar

Əsas Təchizat

  • Botanical Origin: Gastrodia elata Blume (Orchidaceae household)

  • Plant Half Used: Dried rhizomes (underground stems)

  • Geographical Distribution: Yunnan, Guizhou, and Sichuan provinces (China) yield the highest-quality specimens

Key Chemical Constituents

Qarışıq Chemical Class Relative Abundance
Qastrodin Phenolic glycoside 40-60% of complete phenolics
Parishin A/B/C Gastrodin oligomers 15-25%
Vanillyl alcohol Easy phenol 5-10%
4-Hydroxybenzyl alcohol Benzyl spinoff 3-8%

Physicochemical Properties

  • Görünüş: White to mild yellow crystalline powder (gastrodin), brown viscous extract (complete phenolics)

  • Həlledicilik: Water-soluble (gastrodin), ethanol-soluble (parishins)

  • Sabitlik: Delicate to UV mild and oxidation; requires antioxidant safety

Tənzimləyici identifikatorlar

Parametr Qastrodin Whole Phenolics
CAS miqdarı 62499-27-8 Not assigned (combination)
Molecular Method C₁₃H₁₈O₇ Variable
Molekulyar Çəki 286,28 q/mol 200-1000 Da
EINECS 263-618-1 Yoxdur

3. Premium High quality, Well being Benefits & Security

Greatest Sources & Efficiency

  • Highest-Yielding Strains: Wild G. elata from Yunnan incorporates 2-3% gastrodin by dry weight

  • Optimized Extracts: Superior CO₂ supercritical extraction yields ≥98% pure gastrodin

  • Gold Normal: HPLC-validated extracts with ≥50% complete phenolic content material

Proof-Primarily based Well being Benefits

  1. Neyroproteksiya

    • Crosses the blood-brain barrier to cut back glutamate excitotoxicity

    • Upregulates BDNF and NGF for neuronal regeneration

    • Medical enchancment in Alzheimer’s (500mg/day) and vertigo (300mg/day)

  2. Cerebrovascular Safety

    • Mane olur NF-κB pathway, lowering post-stroke irritation

    • Improves microcirculation in vascular dementia sufferers

  3. Antioxidant Results

    • Scavenges OH· and O₂·⁻ radicals (ORAC worth ≥15,000 μmol TE/g)

  4. Analgesic Properties

    • Modulyasiya edir TRPV1 receptors for migraine reduction

Dosage Pointers

Ərizə Gündən-günə Doza Dövr
Koqnitiv yardım 200-400 mq 8-12 həftə
Acute circumstances 500-800 mg 4-6 weeks
Preventive care 100-200 mg Lengthy-term

Security Profile

  • GRAS dayanır: Typically Acknowledged as Protected at really helpful doses

  • Dərman qarşılıqlı təsiri: Could potentiate GABAergic medication (benzodiazepines)

  • Əks göstərişlər: Being pregnant (inadequate security knowledge)

4. İstehsalçı Profili: Shaanxi Zhonghong Investment Technology Co., Ltd.

Əsas Bacarıqlar

  • 28 Years of specialised extraction experience

  • cGMP & ISO 13485 licensed amenities

  • Proprietary Applied sciences:

    • Molecularly imprinted polymers for gastrodin purification

    • Cryogenic grinding for phenolic preservation

Yüksək keyfiyyətli infrastruktur

  • Analitik imkanlar:

    • UPLC-QTOF-MS for compound fingerprinting

    • 600MHz NMR for structural affirmation

  • Purity Requirements: Exceed pharmacopeial necessities by 20-30%

5. Product Specs (Pharmaceutical Grade)

High quality Management Parameters

Sinif Parametr Spesifikasiya Metodologiyaya nəzər salın
İd Gastrodin HPLC match ≥98% similarity USP <621>
Saflıq Whole phenolics ≥50% w/w UV-Vis (280nm)
Ağır metallar Qurğuşun (Pb) ≤0,5 ppm ICP-MS
Kadmium (Cd) ≤0,1 ppm ICP-MS
Mikrobiologiya Whole cardio rely ≤1000 KFU/q USP <61>
C. albicans Yoxdur USP <62>

6. Üstün İstehsalat İş Akışı

  1. Mənbə: Wild-harvested G. elata (3-year-old rhizomes)

  2. Əvvəlcədən müalicə: Lyophilization at -40°C to protect phenolics

  3. Çıxarış:

    • Major: Subcritical water extraction (120°C, 15MPa)

    • İkinci dərəcəli: Macroporous resin adsorption (AB-8 resin)

  4. Təmizləmə:

    • Preparative HPLC (C18 column) for gastrodin isolation

    • Nanofiltration (3kDa MWCO) for parishin enrichment

  5. Standartlaşdırma:

    • DSC for crystallinity verification

    • DPPH assay for antioxidant validation

7. Kənarın Azaldılması Məqsədləri

Əczaçılıq Təkmilləşdirmələri

  • Stroke Restoration: Intravenous gastrodin formulations (China FDA-approved)

  • Neurodegenerative Medication: Section III trials for Parkinson’s adjunct remedy

Nutraceutical sıçrayışlar

  • Nootropic Stacks: Mixed with lion’s mane and bacopa

  • Sleep Formulation: Synergistic with melatonin (1:5 ratio)

Cosmeceutical Developments

  • Anti-Air pollution Serums: Chelates heavy metals by way of phenolic teams

  • Neurocosmetics: Reduces cortisol-induced pores and skin growing older

8. Sərhədlərin təhlili

Mexanik kəşflər

  • Intestine-Mind Axis: Modulyasiya edir Akkermansia muciniphila əhali

  • Epigenetics: HDAC inhibition by parishin metabolites

Texnoloji Təkmilləşdirmələr

  • Biocatalysis: Enzymatic glycosylation to reinforce bioavailability

  • Nano-delivery: PLGA nanoparticles for focused CNS supply

9. FAQ

Q: How does gastrodin examine to artificial nootropics?
A: Displays comparable neuroprotection to piracetam ilə tolerance growth

Q: Can gastrodin change SSRIs for despair?
A: Adjunctive solely – enhances serotonin ilə affecting reuptake

Q: Shelf life & storage?
A: 36 months in amber glass at ≤25°C (desiccant included)

10. International Provide Chain

  • Qablaşdırma: Nitrogen-flushed aluminum baggage (1-25kg)

  • Logistika: -20°C transport obtainable for heat-sensitive batches

  • Regulatory Help: Full file preparation (FDA/EMA/China NMPA)

11. Nəticə

Gastrodia phenolics symbolize the subsequent frontier in neuroprotection, birləşdirən 1,800 years of TCM knowledge ilə fashionable pharmacological validation. Shaanxi Zhonghong's 98% pure gastrodin units the business benchmark, backed by patented extraction applied sciences və end-to-end traceability.

Əlaqə: liaodaohai@gmail.com | www.aiherba.com

İstinadlar

  1. CNS Neuroscience & Therapeutics (2023) – Gastrodin mechanisms in stroke

  2. Təbii mallar jurnalı (2022) – Parishin pharmacokinetics

  3. China Pharmacopoeia 2020 Version – Gastrodin monograph

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