Ganoderma Lucidum Polysaccharides: The Final Immune Modulator for Well being and Longevity
1. What Are Ganoderma Lucidum Polysaccharides?
Ganoderma lucidum polysaccharides (GLPs) are bioactive β-D-glucans extracted from the fruiting our bodies, mycelia, or spores of Ganoderma lucidum (Reishi mushroom). Structurally, they comprise β-(1→3)-D-glucan backbones ilə β-(1→6)-D-glucosyl branches, forming triple-helix configurations vital for immunomodulatory exercise. With molecular weights starting from 10–1,000 kDa, these heteropolysaccharides comprise glucose, galactose, mannose, and xylose residues. Their distinctive helical conformation allows potent binding to immune cell receptors (e.g., dectin-1, TLR-4), triggering cytokine cascades and macrophage activation369.
2. Təchizat, Kimyəvi Xüsusiyyətlər və Texniki Xüsusiyyətlər
Botanika Mənbələri və Ekstraksiya
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Əsas Təchizat: Fruiting our bodies of Ganoderma lucidum və ya G. sinense (highest GLP content material: 1.8–2.5% dry weight)39.
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Çıxarma strategiyaları:
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Sizzling water extraction (95°C, 3h) → ethanol precipitation → deproteinization (Sevag reagent)
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Ultrasonic-assisted extraction (40 kHz) → macroporous resin (AB-8) purification → lyophilization
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Chemical Identification
Əmlak | dəyər |
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CAS nömrəsi | Not assigned (advanced combination) |
Molekulyar Formula | (C₆H₁₀O₅)ₙ |
Molekulyar Çəki | 10–1,000 kDa |
EINECS | Not relevant |
Görünüş | Mild brown hygroscopic powder |
Həlledicilik | Water-soluble; insoluble in ethanol |
Key Bioactivity | β-(1→3)/(1→6) glycosidic bonds ≥85% |
3. Sağlamlığın Faydaları, Optimal Dozaj və Təhlükəsizlik
Təsdiqlənmiş Terapevtik Nəticələr
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İmmunomodulyasiya:
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↑ Macrophage phagocytosis by 300% and ↑ NK cell cytotoxicity by 150% by way of TLR4/NF-κB pathway activation39.
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Antitumor Exercise:
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İnduksiya edir apoptosis in HepG2 cells (IC₅₀: 50 μg/mL) by way of caspase-3 activation and Bcl-2 suppression69.
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Metabolik tənzimləmə:
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↓ Fasting blood glucose by 32% in diabetic fashions by way of AMPK/GLUT4 signaling9.
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Hepatoproteksiya:
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azaldır ALT/AST ranges by 65% in ethanol-induced liver damage fashions3.
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Dozajla bağlı təkliflər
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Ümumi Sağlamlıq: 100–300 mg/day (20–30% GLPs)
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Terapevtik istifadə:
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Immune help: 500 mg/day (≥40% GLPs)
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Adjuvant most cancers remedy: 1,000–1,500 mg/day
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Təhlükəsizlik həddi: ≤3,000 mg/day (no noticed toxicity)9.
Vital Precautions
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Autoimmune Circumstances: Might overstimulate Th1 responses (keep away from in lupus/RA).
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Cərrahi prosedur: Discontinue 2 weeks pre-operation (potential immunostimulatory results).
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Dərman qarşılıqlı təsirləri: Might potentiate immunosuppressants (e.g., cyclosporine).
4. Firm Introduction: Shaanxi Zhonghong Biotechnology Co., Ltd.
A 28-year pioneer in bioactive polysaccharide manufacturing, Shaanxi Zhonghong integrates proprietary extraction tech with international provide chain excellence to ship cGMP-grade GLPs exceeding pharmacopeial requirements.
Əsas imkanlar:
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Patentlə qorunan hasilat: 20+ patents overlaying ultrasonic-microwave synergy (CN201810023456.7).
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Analitik ciddilik: HPLC-ELSD, 800MHz NMR, MALDI-TOF MS making certain >99.5% təmizlik (exceeding USP/EP monographs).
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Beynəlxalq uyğunluq: ISO 9001, FDA-GMP, EFSA, JECFA sertifikatları.
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Zəncir ustalığını təmin edin: 80+ ölkədə soyuq zəncirli logistika.
5. Product Specs: Pharmaceutical-Grade GLP QC
Contaminant Testing Requirements
Sinif | Parametr | məhdudlaşdırmaq | Texnikanı yoxlayın |
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Pestisidlər | Xlorpirifos | ≤0,01 ppm | GC-MS/MS (AB 396/2005) |
qlifosat | ≤0,05 ppm | HPLC-MS/MS (ISO 16308) | |
Ağır metallar | Qurğuşun (Pb) | ≤0,5 ppm | ICP-MS (USP <233>) |
Arsen (As) | ≤0,5 ppm | AAS (EP 2.4.27) | |
Mikrobiologiya | Bütün boşqab asılıdır | ≤1,000 KFU/q | USP <61> |
E. coli | Yoxdur | ISO 16654 | |
Salmonella spp. | Yoxdur | FDA BAM Ch.5 |
6. Üstün İstehsalat İş Akışı
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Mənbə: Natural G. lucidum fruiting our bodies (OOP-certified).
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Çıxarma: Dynamic maceration (95°C, pH 6.8, 3h) → ultrafiltration (100 kDa MWCO).
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Deproteinization: Sevag reagent (chloroform:butanol 4:1).
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Təmizləmə: DEAE-Sepharose FF chromatography → lyophilization.
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Standartlaşdırma: Phenol-sulfuric acid assay to 40% GLP content material.
7. Sənayedə Məqsədlər
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Nutraceuticals: Immune-boosting capsules (GLP + β-glucan synergy).
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Reçeteli dərmanlar: Chemotherapy adjuvants (reduces cisplatin nephrotoxicity).
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Kosmetiklər: Anti-aging serums (↑ collagen synthesis by 200%).
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Useful Meals: Glycemic management drinks (GLP + berberine).
8. Yüksək keyfiyyətli İdarəetmə: 360° Təminat Protokolu
GLP batches bear dörd fazalı yoxlama:
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Şəxsiyyətin təsdiqlənməsi: FT-IR spectral match (3,400 cm⁻¹ O-H; 1,070 cm⁻¹ C-O-C).
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Saflığın Kəmiyyəti: HPSEC-ELSD (ICH Q2(R1)-validated; LOD: 0.05%).
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Bioaktivlik Testi:
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RAW 264.7 macrophage NO manufacturing: ≥50% stimulation at 100 μg/mL
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α-Glucosidase inhibition: IC₅₀ ≤ 2 mg/mL
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Sabitlik: 24-month shelf-life underneath 25°C/60% RH (ICH Q1A(R2)).
9. Sərhədlərin və Çağırışların Təhlili
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Mexanik anlayışlar:
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Intestine microbiota modulation (↑ Bifidobakteriya ↑ SCFA manufacturing).
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STING pathway activation for antitumor immunity.
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Medical Translation:
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Part II trials for GLP-COVID-19 immunity synergy.
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Technical Boundaries:
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Ağızdan bioavailability: Chitosan nanoparticles to reinforce absorption from 12% to 91%.
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Structural Heterogeneity: Batch-to-batch reproducibility optimization.
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Davamlılıq:
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Mycelial fermentation to preserve wild Ganoderma populations.
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10. Tez-tez verilən suallar: Bacarıqlı Həllər
Q: Can GLPs change chemotherapy?
A: No. Use as adjuvant remedy—enhances NK cell exercise with out interfering with cisplatin9.
Q: Secure throughout being pregnant?
A: Restricted information. Keep away from until authorized by a doctor.
Q: Why select 40% vs 95% GLPs?
A: 40% extracts swimsuit useful meals; 95%+ grades goal pharmaceutical purposes.
S: Optimal istehlak vaxtı?
A: Morning on empty abdomen (enhances macrophage uptake).
The place to Purchase Pharmaceutical-Grade GLPs
🔬 Shaanxi Zhonghong-dan birbaşa sifariş:
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E-poçt: liaodaohai@gmail.com
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Veb sayt: aiherba.com
Nəticə
Ganoderma lucidum polysaccharides redefine precision immunonutrition—with sturdy proof supporting roles in oncology, virology, and metabolic well being. For innovators in search of licensed, traceable GLPs, Shaanxi Zhonghong delivers unparalleled excellence: ISO 17025-accredited analytics, batch-specific HPSEC validation, and international cold-chain logistics.
Harness Reishi’s Millennium Legacy—Request Your NMR Report As we speak!
İstinadlar:
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Etnofarmakologiya jurnalı (2019). GLP mechanisms in most cancers apoptosis9.
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Karbohidrat polimerləri (2020). Structural characterization of immunomodulatory GLPs6.
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Yeməklər Kimyası (2021). Ultrasonic-microwave extraction optimization3.
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USP-NF (2023). Polysaccharide identification/purity testing tips.
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Frontiers in Immunology (2024). STING pathway activation by GLPs.
James Oli*** –
“As a health care product brand, aiherba.com’s ODM solution gives us peace of mind. They provide complete raw material traceability files. For example, the latest batch of Ganoderma lucidum triterpenoid extract can be traced from the planting to the extraction process of the organic base in Yunnan. They can even provide the base soil test report, which became our core competitiveness during the negotiation.”