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Withanolide: Nature’s Potent Adaptogen | Science-Backed Benefits & Premium Sources

1. What is Withanolide?

Withanolides are a crucial class of naturally occurring steroidal lactones, primarily identified within the Solanaceae plant family. Structurally, they feature an ergostane skeleton modified by a six-membered lactone ring (delta-lactone) at C-22 and C-26. These bioactive phytochemicals serve as the key markers for the efficacy of adaptogenic herbs, most notably Withania somnifera (Ashwagandha). Their complex molecular architecture underpins their diverse and potent physiological activities.

২/ পণ্যৰ উৎস, ৰাসায়নিক ধৰ্ম আৰু চিনাক্তকৰ্তা

• Primary Botanical Source: Withania somnifera (L.) Dunal (Ashwagandha) roots and leaves are the predominant commercial sources. Other Withania species and select Solanaceae plants may contain varying withanolide profiles.

• ৰাসায়নিক ধৰ্ম:

  • Chemical Class: Steroidal Lactones (C28 ergostane-type framework)

  • দ্ৰৱণীয়তা: Generally lipophilic, soluble in organic solvents (e.g., methanol, ethanol, chloroform, DMSO); poorly soluble in water. Often formulated as standardized extracts or in delivery systems for bioavailability.

  • স্থিৰতা: Sensitive to light, heat, pH extremes, and oxidation. Requires optimized storage conditions (cool, dark, dry) and often stabilization in final products.

• মূল চিনাক্তকৰ্তাসমূহ:

  • CAS পঞ্জীয়ন নম্বৰ: 5119-48-2 (commonly cited for Withaferin A, a major withanolide; specific CAS varies per compound as over 300 exist).

  • আণৱিক সূত্ৰ (MF): Varies per specific withanolide (e.g., Withaferin A: C₂₈H₃₈O₆).

  • আণৱিক ওজন (MW): Varies (e.g., Withaferin A: 470.60 g/mol).

  • EINECS: Not typically listed as a single entity due to the diversity of specific compounds.

3. Potency, Health Benefits, Dosage & Safety

• “Best” & Highest Content: Defining “best” depends on the intended application. Withanolide glycosides (like Withanoside IV/V) are often highlighted for neuroprotective effects, while Withaferin A is studied for potent anti-inflammatory and potential anti-cancer properties. Reputable suppliers like Shaanxi Zhonghong offer extracts standardized to specific withanolide concentrations (e.g., 1.5%, 2.5%, 5%, or even higher % total withanolides). The “highest content” commercially viable depends on extraction tech and cost; 5-10% is common for high-potency extracts.

• Health Benefits (Supported by Traditional Use & Emerging Research):

  • Adaptogenic: Modulates stress response via HPA axis regulation, reducing cortisol levels, combating fatigue, enhancing resilience.

  • Neuroprotective: Supports cognitive function (memory, focus), exhibits anxiolytic and mild antidepressant effects, promotes neurite outgrowth. Potential in neurodegenerative conditions.

  • Immunomodulatory: Enhances immune cell activity (macrophages, lymphocytes, NK cells) while reducing excessive inflammation (via inhibition of NF-κB, COX-2, etc.).

  • এন্টি-ইনফ্লেমেটৰী আৰু এন্টিঅক্সিডেন্ট: Potently scavenges free radicals and downregulates pro-inflammatory cytokines and enzymes.

  • Endocrine Support: May support thyroid function and healthy testosterone levels.

  • Musculoskeletal Health: Potential to increase muscle mass, strength, and recovery; supports joint health.

• সাধাৰণ দৈনিক গ্ৰহণ: Dosage varies significantly based on extract standardization, form, and purpose. Common ranges for Ashwagandha root extract (standardized to 1.5-5% withanolides) are 250mg to 600mg daily, often divided into two doses. Always follow product-specific guidelines or consult a healthcare professional.

• সাৱধানতা আৰু পাৰ্শ্বক্ৰিয়া:

  • Generally well-tolerated at recommended doses. Mild GI upset (nausea, diarrhea) possible.

  • বিৰোধীতা: Pregnancy, breastfeeding (insufficient safety data). Theoretical risk with hyperthyroidism or autoimmune conditions – consult physician.

  • ঔষধৰ পাৰস্পৰিক ক্ৰিয়া: Potential interaction with sedatives (CNS depressants), immunosuppressants, thyroid hormone medication, and drugs metabolized by CYP450 enzymes (e.g., 3A4). Crucial to consult a doctor before use if taking medication or managing a health condition.

  • Quality Matters: Risk of contamination (heavy metals, pesticides) or adulteration with inferior sources underscores the need for premium suppliers like Shaanxi Zhonghong.

4. Premium Supplier: Shaanxi Zhonghong Investment Technology Co., Ltd.
Shaanxi Zhonghong বিনিয়োগ প্ৰযুক্তি কোম্পানী, লিমিটেড. লিডিং হিচাপে থিয় দিছে high-technology enterprise deeply integrated across the chemical, materials, and life science value chains. With 28 years of specialized expertise in bioactive compounds, the company excels in the advanced extraction, isolation, and purification of potent plant constituents like Withanolides.

• মূল দক্ষতাসমূহ:

  • Agile R&D & Innovation: ৰক্ষণাবেক্ষণ কৰে joint laboratories with 5 premier universities, driving cutting-edge phytochemistry and process optimization.

  • মালিকানাধীন প্ৰযুক্তি: ধৰি ৰাখে ২০+ পেটেণ্ট and curates a বিশ্বব্যাপী একচেটিয়া যৌগ লাইব্ৰেৰী, ensuring unique product offerings and significant scientific differentiation.

  • Advanced Manufacturing: ব্যৱহাৰ কৰে অত্যাধুনিক বিশ্লেষণাত্মক যন্ত্ৰপাতি সাঙুৰি উচ্চ-কাৰ্য্যক্ষম তৰল ক্ৰ'মাট'গ্ৰাফী (HPLC), Ultra-conducting Nuclear Magnetic Resonance (NMR), and GC-MS. This enables 20%+ ৰ দ্বাৰা উদ্যোগৰ নীতি অতিক্ৰম কৰা বিশুদ্ধতাৰ মানদণ্ড, guaranteeing batch-to-batch consistency and premium quality.

  • গ্ল'বেল ৰিচ: যোগান কাষ্টমাইজড উদ্ভিদ উপাদানৰ সমাধান to multinational pharmaceutical corporations, nutraceutical brands, research institutions, and cosmetic formulators across ৮০+ দেশ এছিয়া, ইউৰোপ আৰু আমেৰিকাত।

• Product Focus: High-purity Withanolide extracts (various standardizations), natural plant extracts, cosmetic actives, nutraceutical/API ingredients, natural pigments, and plant-based sweeteners.

5. Withanolide Benefits Recap
Withanolides offer a scientifically compelling profile as potent adaptogens আৰু multi-target therapeutic agents. Key benefits supported by research include significant stress resilience enhancement, cognitive function support, robust anti-inflammatory and antioxidant activity, immune system modulation, and potential benefits for muscle strength, recovery, and endocrine balance.

6. ব্যৱহাৰৰ নিৰ্দেশনা

• Primarily used in খাদ্য পৰিপূৰক (capsules, tablets, powders), functional foods/beverages, আৰু cosmeceuticals.

• Follow manufacturer dosage recommendations based on extract standardization.

• Optimal timing is often with meals to enhance absorption of lipophilic compounds.

• Consult a healthcare provider for personalized advice, especially concerning pre-existing conditions or medications.

৭/ জটিল সাৱধানতা

• Avoid during pregnancy and lactation.

• Consult physician before use if: Taking sedatives, thyroid medication, immunosuppressants, or drugs metabolized by CYP3A4/CYP2C19; diagnosed with autoimmune disorders or hyperthyroidism.

• Source Quality: Prioritize suppliers with stringent GMP compliance, transparent বিশ্লেষণৰ প্ৰমাণপত্ৰ (CoA), and advanced testing capabilities (like Shaanxi Zhonghong) to mitigate contamination risks.

8. Product Specification & Quality Control

Table 1: Rigorous Quality Specifications for Withanolide Extract (Example – Shaanxi Zhonghong Standard)

৯/ উন্নত উৎপাদন প্ৰক্ৰিয়া
Shaanxi Zhonghong employs a vertically integrated, cGMP-সঙ্গতিপূৰ্ণ process:

1. উৎস আৰু প্ৰমাণীকৰণ: প্ৰিমিয়াম Withania somnifera roots/leaves, botanically verified (morphology, DNA barcoding).

2. প্ৰি-প্ৰচেছিং: Washing, drying (lyophilization or controlled air-drying), milling.

3. নিৰ্বাচিত নিষ্কাশন: অনুকূলিত কৰা হৈছে দ্রাৱক নিষ্কাশন (e.g., hydroalcoholic) using temperature/pressure control, or advanced techniques like Supercritical Fluid Extraction (SFE-CO2) for enhanced purity and solvent-free profiles.

4. ঘনত্ব: Vacuum evaporation or membrane filtration (UF/NF).

5. বিশুদ্ধকৰণ: Multi-stage chromatographic techniques (যেনে, প্ৰস্তুতিমূলক এইচ পি এল চি, adsorption chromatography) for selective withanolide isolation and enrichment.

6. প্ৰামাণিককৰণ: Precise blending or further concentration to achieve specified withanolide potency (e.g., 5% total withanolides).

7. Stabilization & Drying: Spray drying, freeze drying, or formulation into liquid concentrates with stabilizers.

8. Rigorous QC: বিশ্লেষণৰ বেচ-নিৰ্দিষ্ট প্ৰমাণপত্ৰ (CoA) generated via HPLC-UV/DAD, UPLC-MS/MS, জিচি-এমএছ, আইচিপি-এমএছ, and microbiological assays against stringent internal specs exceeding pharmacopoeial standards.

১০) বৈচিত্ৰময় প্ৰয়োগৰ পৰিস্থিতি

• নিউট্ৰাচিউটিকেলছ আৰু খাদ্য পৰিপূৰক: Stress relief formulas, cognitive enhancers, immune support blends, sports nutrition products, general wellness capsules/tablets.

• কাৰ্য্যকৰী খাদ্য আৰু পানীয়: Fortified juices, health bars, teas, powdered drink mixes.

• প্ৰসাধন সামগ্ৰী: Anti-aging serums/creams (antioxidant, collagen protection), soothing lotions (anti-inflammatory), hair growth serums.

• ঔষধৰ মধ্যৱৰ্তী পদাৰ্থ: High-purity Withaferin A or specific withanolides for drug discovery and development.

• Veterinary Applications: Pet calming supplements, animal health support.

11. Comprehensive Quality Control (QC)
Quality is paramount. Shaanxi Zhonghong ৰূপায়ণ ক বহু-স্তৰীয় QC কৌশল grounded in আই এছ অ’ ৯০০১ আৰু cGMP principles:

• Incoming Raw Material Control: Strict botanical identification (macroscopic, microscopic, HPTLC, DNA), pesticide/heavy metal screening.

• প্ৰক্ৰিয়াৰ ভিতৰত নিয়ন্ত্ৰণ (IPC): Monitoring critical parameters (pH, temp, solvent conc., intermediate purity via TLC/HPLC) at every unit operation to ensure consistency and prevent deviations.

• Finished Product Testing: Exhaustive analysis per Table 1 specifications. Stability Studies (ICH Q1A) determine shelf-life under various conditions (temp, humidity). Method Validation (ICH Q2) ensures accuracy, precision, specificity, linearity, range, LOD/LOQ for all analytical procedures.

• ট্ৰেচেবিলিটি আৰু নথিপত্ৰ: Full batch record traceability from raw material to finished product. Electronic data capture (LIMS) ensures data integrity (ALCOA+ principles). Regular internal audits and readiness for external audits (regulatory, client).

• উন্নত বিশ্লেষণ: Utilization of ইউপিএলচি-কিউটিঅ’এফ-এমএছ for comprehensive metabolite profiling and impurity identification, এন এম আৰ for structural confirmation, আইচিপি-এমএছ for ultra-trace elemental analysis.

১২) পেকেজিং আৰু লজিষ্টিক

• পেকেজিং: Food-grade, light-resistant materials: Double polyethylene bags inside sealed foil-lined fiber drums (25kg typical); smaller quantities in HDPE bottles or zip-lock bags within cartons. Custom packaging available (blister packs, sachets for finished goods).

• সংৰক্ষণ: ষ্ট'ৰ কৰক ক cool, dry place (<25°C), protected from light and moisture. Maintain controlled warehouse conditions.

• লজিষ্টিক: Efficient global shipping via air freight (DHL, FedEx) or sea freight (FCL/LCL). Expertise in customs clearance and regulatory documentation (CoA, MSDS, Certificate of Origin, Phytosanitary Certificates where required) for seamless international delivery.

13. Deep Dive: Health Mechanisms, Applications & Research

• স্বাস্থ্য ব্যৱস্থা:

  • HPA Axis Modulation: Reduces cortisol synthesis and blunts stress response via effects on CRH, ACTH.

  • Neuroprotection: Enhances GABAergic activity, promotes acetylcholine synthesis, reduces glutamate excitotoxicity, stimulates neuritogenesis (via ERK, PI3K/Akt pathways), modulates BDNF.

  • Immunomodulation: Activates macrophages (phagocytosis, NO production), enhances Th1 response, suppresses pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) via NF-κB, MAPK inhibition.

  • Antioxidant: Direct ROS scavenging, upregulation of endogenous antioxidants (SOD, GSH, catalase).

  • Anti-cancer (Withaferin A Focus): Induces apoptosis (ROS-mediated, p53 activation), inhibits angiogenesis (VEGF), anti-metastatic (MMP inhibition, EMT reversal), proteasome inhibition.

• Industrial Applications & Tech Innovation:

  • বৰ্ধিত জৈৱ উপলব্ধতা: Development of nanoemulsions, liposomes, phospholipid complexes (Phytosome®), and cyclodextrin inclusion complexes.

  • Sustainable Extraction: Optimization of green chemistry techniques (SFE-CO2, subcritical water extraction, enzyme-assisted extraction) reducing solvent use and energy consumption.

  • কৃত্ৰিম জীৱবিজ্ঞান: Exploring heterologous production of key withanolides in microbial hosts (yeast, bacteria) for sustainability and scalability.

  • High-Throughput Screening: Utilizing Shaanxi Zhonghong’s exclusive compound library for drug discovery against novel targets.

• গৱেষণাৰ সীমা আৰু প্ৰত্যাহ্বানসমূহ:

  • সীমান্ত: Clinical validation of specific withanolides for neurological disorders (AD, PD), cancer chemoprevention/adjuvant therapy, metabolic syndrome; deciphering structure-activity relationships (SAR) for targeted drug design; understanding gut microbiome interactions.

  • প্ৰত্যাহ্বানসমূহ: Complexity of the withanolide metabolome (>300 compounds); bioavailability limitations of major constituents; need for large-scale, long-term human clinical trials; standardization complexity across diverse extracts; sustainable sourcing and cultivation practices.

১৪) সঘনাই সোধা প্ৰশ্ন (FAQ)

• Q: What is Withanolide good for?

  • উঃ: Primarily known for stress reduction, enhancing cognitive function, boosting immunity, reducing inflammation, supporting muscle health, and providing antioxidant protection. Research explores wider applications.

• Q: Is Withanolide safe?

  • উঃ: Generally safe at recommended doses for most adults. Crucial contraindications: Pregnancy, breastfeeding. Consult a doctor if taking medications (sedatives, thyroid, immunosuppressants) or have autoimmune/hormonal conditions. Source high-quality products.

• Q: How much Withanolide should I take daily?

  • উঃ: Dosage depends on the extract standardization. For Ashwagandha root extract (standardized to 1.5-5% withanolides), typical doses range from 250mg to 600mg daily, often split. Always follow the specific product label.

• Q: What makes Shaanxi Zhonghong’s Withanolide superior?

  • উঃ: 28 years expertise, university partnerships (5 joint labs), 20+ patents, exclusive compound library, cutting-edge HPLC/NMR analytics ensuring purity >20% above industry norms, stringent GMP-compliant QC (see Table 1), global supply chain reliability.

• Q: Where can I buy high-quality Withanolide extract?

  • উঃ: Shaanxi Zhonghong বিনিয়োগ প্ৰযুক্তি কোম্পানী, লিমিটেড. supplies premium Withanolide extracts globally. Contact via email: liaodaohai@gmail.com ত যোগাযোগ কৰক or visit our website: aiherba.com.

15. Conclusion: Harness Nature’s Adaptogenic Power
Withanolides represent a pinnacle of botanical bioactivity, offering profound adaptogenic, neuroprotective, immunomodulatory, and anti-inflammatory benefits backed by increasing scientific validation. Choosing a premium source like Shaanxi Zhonghong বিনিয়োগ প্ৰযুক্তি কোম্পানী, লিমিটেড. is essential to access the full potential of these remarkable compounds. Leveraging advanced extraction technology, unparalleled QC rigor (purity exceeding industry standards by 20%), and 28 years of specialized expertise, Shaanxi Zhonghong delivers research-grade, highly efficacious Withanolide extracts for nutraceutical, cosmeceutical, and pharmaceutical applications worldwide.

Experience the Zhonghong difference. Source superior Withanolide today:

• ইমেইল: liaodaohai@gmail.com ত যোগাযোগ কৰক

• ৱেবছাইট: aiherba.com

16. References (Illustrative – Use Primary Sources)

1. Mirjalili, M.H., et al. (2009). Steroidal lactones from Withania somnifera, an ancient plant for novel medicine. অণু, *14*(7), 2373-2393.

2. Singh, N., et al. (2011). An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda. African Journal of Traditional, Complementary and Alternative Medicines, *8*(5S), 208-213.

3. Dar, N.J., et al. (2015). Pharmacologic overview of Withanolides. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease, 297-305.

4. Gupta, G.L., & Rana, A.C. (2007). Withania somnifera (Ashwagandha): A review. Pharmacognosy Reviews, *1*(1), 129-136.

5. White, P.T., et al. (2016). Natural Withanolides in the Functional Modulation of Cancer, Inflammation, and Immunity. Progress in the Chemistry of Organic Natural Products, 102.

6. ICH Q2(R1) Validation of Analytical Procedures: Text and Methodology.

7. USP-NF General Chapters: <61> Microbiological Examination…, <467> Residual Solvents, etc.

8. European Pharmacopoeia (Ph. Eur.) Monographs and General Chapters. (Note: Always cite specific, relevant research papers and pharmacopoeial standards used for actual product specs).