কুৱেৰচেটিন
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কুৱেৰচেটিন পৰিপূৰক

Quercetin Supplements​ – High-Purity Flavonoid Compound

  1. ইংৰাজী নাম: Quercetin
  1. নিৰ্দিষ্টকৰণ
    • বিশুদ্ধতা: Quercetin ≥ 98% (HPLC)
    • Water-soluble Form: Quercetin glycosides (e.g., rutin) or nanoemulsion – based formulations, solubility enhanced up to 10 g/L through encapsulation
    • কণিকাৰ আকাৰ: Standard powder ≤100 μm; micronized versions ≤5 μm for better bioavailability
  1. ৰূপ
    • Powder: Yellow to orange – yellow crystalline powder, odorless, slightly bitter taste
  1. CAS NO.：117-39-5
  1. লিড টাইম: ৩ – ৭ কৰ্মদিন
  1. পেকেজ
    • 1 kg/bag (aluminum foil bag), 25 kg/drum (double – layer PE bag inside cardboard drum)
  1. মূল বজাৰ: North America, Europe, Asia, South America
  1. প্ৰয়োগৰ পৰিস্থিতি

মূল বৈশিষ্ট্যসমূহ

  • আণৱিক সূত্ৰ: C₁₅H₁₀O₇
  • দ্ৰৱণীয়তা: Sparingly soluble in water (0.1 g/L at 25°C); soluble in ethanol, DMSO; water – soluble derivatives improve usability in aqueous systems
  • মূল বৈশিষ্ট্যসমূহ
    • Potent Antioxidant: Scavenges free radicals (e.g., hydroxyl, superoxide), with an ORAC value of ~5000 μmol Trolox equivalents/g.
    • এন্টি – প্ৰদাহজনিত: Inhibits pro – inflammatory enzymes (COX – 2, iNOS) and cytokines (TNF – α, IL – 6).
    • Phytoestrogenic Activity: Weak estrogen – like effects, beneficial for menopausal symptom management.
    • এন্টিমাইক্ৰ’বিয়াল: Exhibits activity against bacteria (e.g., ষ্টেফাইলোককাচ অৰেয়াছ) and fungi (e.g., কেণ্ডিডা এলবিকেন্স).

প্ৰয়োগৰ পৰিস্থিতি

1. খাদ্য পৰিপূৰক

  • General Health Formulas:
    • Capsules or tablets (250 – 500 mg per serving) sold as antioxidant and immune – boosting supplements.
    • Often combined with vitamin C and zinc for enhanced efficacy during cold and flu seasons.
  • Specialty Health Products:
    • Joint health supplements (500 – 1000 mg/day) to reduce inflammation in arthritis patients.
    • Cardiovascular support formulas, as it may help lower blood pressure and cholesterol levels.

2. কাৰ্য্যকৰী খাদ্য আৰু পানীয়

  • Antioxidant – Fortified Products:
    • Added to juices, teas, and energy drinks at 50 – 100 mg/L to increase antioxidant content.
    • Used in “clean – label” snacks (e.g., granola bars) as a natural preservative and nutrient enhancer.
  • Plant – Based Meat Alternatives:
    • Inhibits lipid oxidation, extending the shelf – life of plant – based proteins and improving flavor stability.

3. প্ৰসাধন সামগ্ৰী আৰু ব্যক্তিগত যত্ন

  • Anti – aging Skincare:
    • Serums and creams (0.5 – 2% concentration) to protect against UV – induced damage, reduce wrinkles, and promote collagen synthesis.
    • Soothing formulations for sensitive skin, leveraging its anti – inflammatory properties.
  • চুলিৰ যত্ন:
    • Shampoos and conditioners to strengthen hair follicles and reduce dandruff by combating scalp inflammation.

4. ফাৰ্মাচিউটিকেলছ

  • Investigational Therapies:
    • Studied for its potential in treating neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s) due to neuroprotective effects.
    • Investigated as an adjuvant in cancer treatment, enhancing the efficacy of chemotherapy while reducing side effects.
  • অভাৰ – দ্য – কাউণ্টাৰ (OTC) ঔষধ:
    • Used in topical creams for mild skin irritations and allergies, providing anti – inflammatory and antioxidant relief.

5. Animal Health

  • Livestock Feed Additives:
    • Added to poultry and swine feed (100 – 500 ppm) to improve growth performance, reduce oxidative stress, and enhance meat quality.
  • Pet Supplements:
    • Formulated in chewable tablets for dogs and cats to support joint health and immune function.

ধৰা পেলোৱাৰ পদ্ধতি

  • উচ্চ – কাৰ্য্যক্ষমতা লিকুইড ক্ৰ'মাট'গ্ৰাফী (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – 0.1% phosphoric acid (35:65 v/v), Flow Rate: 1.0 mL/min, Detection Wavelength: 360 nm.
  • গণ বৰ্ণালীবিজ্ঞান (MS):
    • Used in combination with HPLC (HPLC – MS) to confirm molecular structure and detect trace impurities.
  • FTIR স্পেকট্ৰস্কপি:
    • Identifies characteristic functional groups (e.g., hydroxyl, carbonyl) to verify product identity.

উৎস আৰু সুবিধা

  • প্ৰাকৃতিক উৎস: Extracted from various plants, including Sophora japonica flowers, onions, apples, and grapes.
  • স্থিৰতা: Can be sourced from agricultural by – products (e.g., onion skins), reducing waste.
  • Multi – functional: Its diverse bioactivities make it suitable for applications across multiple industries.

নিয়ন্ত্ৰণমূলক অনুসৰণ

  • আমেৰিকাৰ এফ ডি এ: Regulated as a dietary supplement ingredient under DSHEA (Dietary Supplement Health and Education Act).
  • ইউৰোপীয় ইউনিয়নৰ নিয়ন্ত্ৰণ: Permitted as a food additive and dietary supplement ingredient, subject to safety evaluations.
  • চীন এনএমপিএ: Approved for use in functional foods and dietary supplements, with specific usage limits.
বিভাগসমূহ: , , , , ,

Quercetin Supplements​: The Premier Flavonoid Powerhouse – Ultimate Guide & Premium Source

১/ কুৱেৰচেটিন কি?
কুৱেৰচেটিন হৈছে ক খাদ্যৰ ফ্লেভনল belonging to the polyphenolic compounds subclass. As a potent plant pigment, it serves critical roles in UV protection and stress response in botanicals. In human physiology, it exhibits multifunctional bioactivity, acting as a master antioxidant, anti-inflammatory agent, আৰু cellular signaling modulator. Its unique catechol structure আৰু α,β-unsaturated carbonyl group enable exceptional free radical scavenging and metal chelation capabilities.

২/ উৎস, ৰাসায়নিক ধৰ্ম আৰু চিনাক্তকৰণ

  • Primary Natural Sources (Highest Concentrations):

    • Sophora japonica Buds: Richest source (up to 20% dry weight)

    • Onion Skins (Allium cepa): Particularly red onions (1-1.5%)

    • Ginkgo biloba Leaves: Standardized extracts (22-26%)

    • Apple Peel (Malus domestica): Key source of quercetin glycosides

    • Other Sources: Capers, lovage, elderberries, buckwheat, tea

  • ৰাসায়নিক ধৰ্ম:

    • CAS নম্বৰ: 117-39-5

    • আণৱিক সূত্ৰ: C15H1O2

    • আণৱিক ওজন: ৩০২.২৪ গ্ৰাম/মল

    • EINECS নম্বৰ: 204-187-1

    • ৰূপ: হালধীয়া স্ফটিকীয় গুড়ি

    • দ্ৰৱণীয়তা: Insoluble in water; soluble in ethanol, DMSO, lipids (when complexed)

    • স্থিৰতা: Sensitive to UV light and alkaline conditions; degrades above 160°C

3. Benefits, Efficacy, Dosage & Safety

  • Optimal Sources & Bioavailability: Sophora japonica extracts deliver the highest natural concentrations (95-98% purity). Bioavailability is enhanced through phospholipid complexation (Quercetin Phytosome®) or liposomal encapsulation, increasing absorption by 5-20x vs. standard powder.

  • Validated Health Benefits & Mechanisms:

    • Systemic Antioxidant Defense: মডুলেট কৰে Nrf2/ARE পথ, upregulating glutathione synthesis আৰু superoxide dismutase (SOD)

    • Anti-Inflammatory Action: বাধা দিয়ে COX-2, LOX, আৰু NF-κB signaling pathways, reducing pro-inflammatory cytokines (TNF-α, IL-6)

    • ইমিউন মডুলেচন: Stabilizes mast cells, reduces histamine release via cAMP phosphodiesterase inhibition

    • Cardiometabolic Support: Improves endothelial function through eNOS activation, inhibits LDL oxidation

    • Viral Defense: Demonstrated 3CL protease inhibition against coronaviruses in vitro

  • Clinical Dosage:

    Formulationদৈনিক ড’জসময়কাল
    Standard Powder500-1000 mg৮-১২ সপ্তাহ
    Phytosome®250-500 mgঅবিৰত
    Acute Immune SupportUp to 3000 mg≤5 days

  • Safety Profile:

    • GRAS status (FDA)

    • Avoid concomitant use with CYP3A4 substrates (cyclosporine, warfarin)

    • Potential renal toxicity at >5g/day

    • Pregnancy Category C

4. Shaanxi Zhonghong: Quercetin Excellence
Leveraging 28 years in bioactive phytochemistry, Shaanxi Zhonghong Investment Technology Co., Ltd. pioneers quercetin production through:

  • Core Innovations:

    • Glycoside-to-Aglycone Conversion: Patented enzymatic hydrolysis for >98% aglycone purity

    • Nanocrystallization Technology: 200nm particle size for enhanced solubility

    • Phytosome® Manufacturing: Validated complexation with sunflower phospholipids

  • Quality Infrastructure:

    • ইউপিএলচি-কিউটিঅ’এফ-এমএছ for isomer profiling

    • cGMP আৰু ISO 22000 certified facilities

    • Batch traceability via blockchain technology

5. Product Specification (Pharmaceutical Grade)

শ্ৰেণীপ্ৰাচলনিৰ্দিষ্টকৰণপৰীক্ষাৰ পদ্ধতি
বিশুদ্ধতাQuercetin Aglycone≥98.0%HPLC-DAD (EP 10.0)
গধুৰ ধাতুসীহ (Pb)≤1.0 ppmআইচিপি-এমএছ (ইউএছপি <২৩৩>)
কেডমিয়াম (Cd)≤0.5 ppmআইচিপি-এমএছ
আৰ্ছেনিক (As)≤1.0 ppmআইচিপি-এমএছ
কীটনাশকক্লৰপাইৰিফছ≤০.০১ পিপিএমজিচি-এমএছ/এমএছ
চাইপাৰমেথ্ৰিন≤০.০২ পিপিএমজিচি-এমএছ/এমএছ
মুঠ ১৮৬ টা কীটনাশকঋণাত্মকEU SANTE/11813/2017
অণুজীৱবিজ্ঞানমুঠ এৰোবিক গণনা≤1000 CFU/gইউ এছ পি <৬১>
ঈষ্ট আৰু ছাঁচ≤১০০ চিএফইউ/গ্ৰামইউ এছ পি <৬১>
EnterobacteriaceaeAbsent/10gISO 21528-2

6. উন্নত উৎপাদন কাৰ্য্যপ্ৰবাহ

  1. Botanical Sourcing: DNA-authenticated Sophora japonica buds

  2. Multistage Extraction: Ethanol/water (70:30) at 45°C with microwave assistance

  3. Macroporous Resin Chromatography: AB-8 resin for flavonoid isolation

  4. Enzymatic Bioconversion: β-glucosidase treatment (45°C, pH 5.0)

  5. Crystallization Control: Anti-solvent precipitation at 4°C

  6. Nanomilling: Wet-milling to D90 < 250nm

  7. Phospholipid Complexation (Optional): 1:1 ratio with phosphatidylcholine

  8. লাইঅ'ফিলাইজেচন: -40°C primary drying

7. Application Matrix

IndustryFormulation ExamplesFunctional Role
নিউট্ৰাচিউটিকেলছImmune complexes, sports formulasOxidative stress reduction
ফাৰ্মাচিউটিকেলছAntiviral adjuvants, cardioprotectivesEndothelial function modulation
প্ৰসাধন সামগ্ৰীAnti-pollution serums, UV protectantsMMP inhibition
কাৰ্য্যক্ষম খাদ্যStability-enhanced beveragesShelf-life extension

8. Mechanism & Clinical Evidence

  • মাইট'কণ্ড্ৰিয়াল বায়'জেনেছিছ: Activates SIRT1/PGC-1α পথ (5-15% increase in ATP production)

  • Senescence Modulation: হ্ৰাস কৰে p16INK4a expression in human fibroblasts

  • Viral Inhibition: IC₅₀ = 7.6 μM against SARS-CoV-2 3CL protease

  • Cardiometabolic Effects: 12% LDL reduction in hyperlipidemic patients (500mg/day, 8 weeks)

9. Technological Frontiers

  • Bioavailability Solutions:

    • Quercetin-β-cyclodextrin complexes (water solubility: 35 mg/mL)

    • Solid lipid nanoparticles (90% oral bioavailability)

  • Green Chemistry:

    • উপজটিল পানী নিষ্কাশন (SWE) at 120°C/50 bar

    • Enzyme-assisted deep eutectic solvent systems

10. Research Challenges

  • Pharmacokinetics: Short plasma half-life (3-4 hours)

  • ক্লিনিকেল অনুবাদ: Limited Phase III trials for immune claims

  • Regulatory Status: Novel Food authorization required in EU

১১) প্ৰশ্ন কৰা প্ৰশ্ন

  1. Q: Why choose Sophora japonica-derived quercetin?
    উঃ: Superior concentration profile (98% vs. 70% in onion extracts) and lower pesticide risk.

  2. Q: How to overcome bioavailability limitations?
    উঃ: Our phytosome technology achieves Cₘₐₓ 4.3x higher than standard powder.

  3. Q: Validated immune support dosage?
    উঃ: 500-1000mg/day prophylactic; 3000mg/day acute phase (max 5 days).

  4. Q: Stability in formulations?
    উঃ: Nanoencapsulated form retains >90% potency at 25°C/60% RH for 24 months.

  5. Q: GMP compliance?
    উঃ: Manufactured under ICH Q7 guidelines with ISO 17025 accredited QC.

12. Procurement Information

১৩) উপসংহাৰ
কুৱেৰচেটিনে প্ৰতিনিধিত্ব কৰে apex of flavonoid bioactivity with clinically validated impacts on immune competence, বিপাকীয় স্বাস্থ্য, আৰু oxidative resilience. Shaanxi Zhonghong’s vertically integrated production—from DNA-verified Sophora japonica লৈ nanoparticle-enhanced delivery systems—ensures unprecedented purity (≥98%) and bioavailability. Our patented enzymatic conversion technology and cGMP-compliant manufacturing deliver benchmark material compliant with USP, EP, and JP monographs. Partner with our ২৮ বছৰীয়া বিশেষজ্ঞতা for quercetin solutions powering next-generation nutraceuticals, pharmaceuticals, and functional foods.

১৪) তথ্যসূত্ৰ

  1. Li Y, et al. (2021). অণু. 26(9):2507. [Bioavailability]

  2. Colunga Biancatelli RML, et al. (2020). ফ্ৰন্ট ইমিউনল. 11:1451. [Antiviral]

  3. EFSA Panel (2020). ই এফ এছ এ জাৰ্নেল. 18(1):e05993.

  4. Anand David AV, et al. (2016). J Food Sci. 81(10):R2501. [Metabolism]

  5. Zhonghong Technical Dossier QRC-2024. aiherba.com/docs/QRC-Spec

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