Mulberry Leaf Extract: The Clinically Validated Solution for Metabolic Health & Longevity

1. What is Mulberry Leaf Extract?

Mulberry leaf extract is a potent bioactive concentrate derived from Morus alba leaves, standardized to contain ≥1.5% 1-deoxynojirimycin (DNJ) – a potent α-glucosidase inhibitor. This extract features a unique polyhydroxylated alkaloid profile that modulates glucose metabolism through dual AMPK activation and carbohydrate-digesting enzyme inhibition. With 2,000+ years of traditional use and modern clinical validation, it represents the gold standard for natural glycemic control.

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২) উৎস, ৰাসায়নিক ধৰ্ম আৰু কাৰিকৰী নিৰ্দিষ্টকৰণ

Botanical & Production Profile

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৩/ স্বাস্থ্য উপকাৰীতা, অনুকূল মাত্ৰা আৰু সুৰক্ষা

Clinically Validated Effects

• Glycemic Control:

  • ↓ Postprandial glucose by 27% (IC₅₀=0.12 mg/mL for α-glucosidase)

  • ↑ Insulin sensitivity via IRS-1/PI3K pathway activation

• কাৰ্ডিঅ’মেটাবলিক সুৰক্ষা:

  • ↓ LDL oxidation by 35%

  • ↓ Systolic BP by 7.5 mmHg (RCT, J Ethnopharmacol)

• স্নায়ুৰ সুৰক্ষা:

  • Inhibits MAO-B (IC₅₀=2.8 μM) → ↑ dopamine levels

মাত্ৰাৰ পৰামৰ্শ

সুৰক্ষা প্ৰফাইল

• Potential Side Effects:

  • Mild GI discomfort (<5% incidence)

  • Hypoglycemia risk with antidiabetic drugs

• বিৰোধিতা:

  • Pregnancy (limited safety data)

  • Scheduled surgery (bleeding risk)

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4. Company Introduction: Shaanxi Zhonghong Biotechnology

২৮ বছৰীয়া উদ্ভাৱক in metabolic health ingredients with GMP-certified manufacturing facilities.

মূল ক্ষমতাসমূহ:

• পেটেণ্ট পৰ্টফলিঅ': CN202310654321 (DNJ enrichment technology)

• বিশ্লেষণাত্মক নিখুঁততা:

  • UPLC-ELSD (DNJ quantification)

  • 800MHz NMR structural verification

• Global Certifications:

  • ISO 22000, FDA DMF #34621, HALAL

• Supply Chain:

  • Cold-chain logistics to 80+ countries

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৫/ ফাৰ্মাচিউটিকেল-গ্ৰেড স্পেচিফিকেশন

Quality Control Standards

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6. উন্নত উৎপাদন কাৰ্য্যপ্ৰবাহ

1. Sustainable Harvesting:

   • Organic-certified mulberry leaves (June collection)

2. নিষ্কাশন:

   • Dynamic maceration (70°C, ethanol:water=7:3, 3h)

3. বিশুদ্ধকৰণ:

   • AB-8 macroporous resin chromatography

   • Nanofiltration (500 Da MWCO)

4. Concentration:

   • Vacuum evaporation → spray drying

5. Standardization:

   • DNJ ≥1.5%, flavonoids ≥10%

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7. Clinical Applications

• নিউট্ৰাচিউটিকেলছ:

  • Blood sugar management formulas

  • Metabolic syndrome supplements

• কাৰ্য্যক্ষম খাদ্য:

  • Glycemic control beverages

  • Healthy snack bars

• প্ৰসাধন সামগ্ৰী:

  • Anti-glycation skincare serums

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8. Quality Assurance Protocol

Four-Dimensional Verification:

1. পৰিচয়:

   • FT-IR: 3380 cm⁻¹ (O-H), 1650 cm⁻¹ (C=O)

   • TLC fingerprinting (n-butanol:acetic acid:water=4:1:1)

2. বিশুদ্ধতা:

   • UPLC-DAD at 210 nm (DNJ quantification)

   • Heavy metal panel analysis

3. Bioactivity:

   • α-Glucosidase inhibition assay (IC₅₀≤0.2 mg/mL)

   • Glucose uptake test in C2C12 myotubes

4. স্থিৰতা:

   • 24-month shelf-life at 25°C/60% RH

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৯/ গৱেষণাৰ সীমা

Mechanistic Advances

• AMPK/SIRT1/PGC-1α pathway activation

• Gut microbiota modulation (↑ Akkermansia)

Innovations

• Delivery Systems:

  • Phospholipid complexes (↑ DNJ bioavailability 3.2×)

• ছিনাৰ্জিষ্টিক ফৰ্মুলেচন:

  • Berberine + mulberry extract (↑ efficacy 40%)

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১০) প্ৰশ্ন কৰা প্ৰশ্ন

Q: Can it replace diabetes medication?
A: No – use as adjuvant therapy under medical supervision

Q: Optimal consumption time?
A: 10-15 minutes before carbohydrate-rich meals

Q: Difference between 1.5% and 3% DNJ?
A: 3% extracts allow lower dosing (500mg vs 1000mg)

Q: Safe for long-term use?
A: Clinical studies confirm safety for ≤12 months

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Direct Sourcing

🔬 Pharmaceutical-Grade Mulberry Extract:

• ইমেইল: liaodaohai@gmail.com ত যোগাযোগ কৰক

• ৱেবছাইট: aiherba.com

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উপসংহাৰ

Mulberry leaf extract represents nature’s most effective solution for metabolic health – clinically proven to regulate blood sugar, improve lipid profiles, and support weight management. Shaanxi Zhonghong delivers standardized DNJ-rich extract through proprietary enrichment technology and pharmaceutical-grade manufacturing exceeding USP/EP standards.

Transform Metabolic Health – Request Certificate of Analysis Today!

white mulberry leaf extract 1000 mg,Mulberry leaf extract 1.5% DNJ, blood sugar support, natural alpha-glucosidase inhibitor, metabolic health supplement, DNJ standardized extract, Shaanxi Zhonghong.

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তথ্যসূত্ৰসমূহ:

1. Mudra et al. (2007). Diabetes Care. 30(7):1862-4.

2. Sheng et al. (2021). J Ethnopharmacol. 265:113303.

3. EFSA Panel (2024). Safety Evaluation of DNJ.

4. USP-NF (2024). Botanical Extracts Monographs.

5. পুষ্টিকৰ উপাদান. (2023). AMPK Activation Mechanisms.

6. Food Chem Toxicol. (2022). 12-Month Safety Study.