গেষ্ট্ৰ’ডিয়া ফেনলিক যৌগ
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গেষ্ট্ৰ’ডিয়া ফেনলিক যৌগ

Gastrodia Phenolic Compounds supplier bulk factory Wholesale Extract factory

  1. ইংৰাজী নাম: Gastrodia Phenolic Compounds
  1. নিৰ্দিষ্টকৰণ
    • Total Phenolic Content: ≥ 15 – 30% (Folin – Ciocalteu method)
    • Major Components: p – Hydroxybenzaldehyde ≥ 5% (HPLC), p – Hydroxybenzoic acid ≥ 3% (HPLC), vanillic acid ≥ 2% (HPLC)
    • Water – soluble Powder: Solubility ≥ 90% in water, moisture ≤ 5%
  1. ৰূপ
    • Light brown to yellowish – brown fine powder, mild herbal odor
  1. CAS NO.
    • p – Hydroxybenzaldehyde: 123 – 08 – 0
    • p – Hydroxybenzoic acid: 99 – 96 – 7
    • vanillic acid: 121 – 34 – 6
  1. লিড টাইম: ৩ – ৭ কৰ্মদিন
  1. পেকেজ
    • ১ কিলোগ্ৰাম/বেগ (এলুমিনিয়াম ফয়েল বেগ), ২৫ কিলোগ্ৰাম/ড্ৰাম (ডাবল – কাৰ্ডবৰ্ড ড্ৰামৰ ভিতৰত স্তৰ পিই বেগ)
  1. মূল বজাৰ: এছিয়া (চীন, জাপান, দক্ষিণ কোৰিয়া), উত্তৰ আমেৰিকা, ইউৰোপ
  1. প্ৰয়োগৰ পৰিস্থিতি

মূল বৈশিষ্ট্যসমূহ

  • আণৱিক গঠন: Composed of various phenolic acids and aldehydes with a benzene ring and hydroxyl groups
  • দ্ৰৱণীয়তা: Soluble in water, ethanol, and methanol; water – soluble formulations are ideal for beverage and pharmaceutical applications
  • মূল বৈশিষ্ট্যসমূহ
    • এন্টিঅক্সিডেন্ট: Scavenges free radicals such as DPPH and hydroxyl radicals, with an ORAC (Oxygen Radical Absorbance Capacity) value of 2000 – 3500 μmol Trolox equivalents/g.
    • এন্টি – প্ৰদাহজনিত: Inhibits the production of pro – inflammatory cytokines like TNF – α and IL – 6.
    • স্নায়ুৰক্ষাকাৰী: Protects neurons from oxidative stress and apoptosis, potentially beneficial for neurodegenerative diseases.
    • এন্টিমাইক্ৰ’বিয়াল: Exhibits inhibitory activity against certain bacteria and fungi, such as Staphylococcus aureus and Candida albicans.

প্ৰয়োগৰ পৰিস্থিতি

1. ফাৰ্মাচিউটিকেলছ

  • Neurological Disorder Treatment:
    • Investigated for the treatment of stroke and epilepsy, as the neuroprotective properties help reduce brain damage and prevent seizure recurrence.
    • Used in combination with other drugs to enhance the treatment effect of Alzheimer’s disease by reducing oxidative stress in the brain.
  • Anti – inflammatory Formulations:
    • Incorporated into topical creams and ointments to relieve skin inflammation, such as eczema and dermatitis.

2. খাদ্য পৰিপূৰক

  • Antioxidant Supplements:
    • Capsules or tablets containing 200 – 500 mg of phenolic compounds in Gastrodia, marketed for general health maintenance and anti – aging, often combined with other antioxidants like vitamin C and E.
  • Brain Health Formulas:
    • Added to nootropic supplements to support cognitive function, memory, and focus.

3. প্ৰসাধন সামগ্ৰী আৰু ব্যক্তিগত যত্ন

  • Anti – aging Products:
    • Serums and moisturizers (2 – 5% concentration) to protect skin from UV – induced damage, reduce the appearance of fine lines and wrinkles, and promote skin elasticity.
  • Antibacterial Skincare:
    • Used in facial cleansers and acne treatments to inhibit the growth of acne – causing bacteria.

4. কাৰ্য্যকৰী খাদ্য আৰু পানীয়

  • Antioxidant – Rich Beverages:
    • Added to fruit juices, tea – based drinks, and energy drinks at 0.5 – 1% concentration to enhance the antioxidant capacity and extend shelf life.
  • Fortified Foods:
    • Incorporated into baked goods, cereals, and snacks to increase their nutritional value and provide health – promoting benefits.

ধৰা পেলোৱাৰ পদ্ধতি

  • উচ্চ – কাৰ্য্যক্ষমতা লিকুইড ক্ৰ'মাট'গ্ৰাফী (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – 0.1% phosphoric acid (gradient elution), Flow Rate: 1.0 mL/min, Detection Wavelength: 280 nm for p – Hydroxybenzaldehyde, 254 nm for p – Hydroxybenzoic acid, and 325 nm for vanillic acid.
  • Folin – Ciocalteu Assay:
    • A colorimetric method to determine the total phenolic content, measuring absorbance at 765 nm.
  • গণ বৰ্ণালীবিজ্ঞান (MS):
    • Used in combination with HPLC (HPLC – MS) to confirm the molecular structure and identify trace phenolic compounds.

উৎস আৰু সুবিধা

  • প্ৰাকৃতিক উৎস: ৰ ৰাইজমৰ পৰা উলিওৱা হয় গেষ্ট্ৰ’ডিয়া ইলাটা Blume, a traditional Chinese medicinal herb.
  • Multi – functional Benefits: Their diverse bioactivities make them suitable for various applications from medicine to consumer products.
  • Traditional Use Validation: With a long history of use in traditional Chinese medicine, it provides a reliable foundation for modern applications.

নিয়ন্ত্ৰণমূলক অনুসৰণ

  • চীন এনএমপিএ: Approved as a dietary supplement ingredient and used in traditional Chinese medicine formulations.
  • আমেৰিকাৰ এফ ডি এ: Regulated as a dietary ingredient when used in supplements, subject to Good Manufacturing Practice (GMP) requirements.
  • EU Cosmetic Regulation: Allowed as a cosmetic ingredient, with restrictions on maximum concentration in different product types.
বিভাগসমূহ: , , , , , ,

Gastrodia Phenolic Compounds: The Neuroprotective Powerhouse from Tian Ma

1. What Are Gastrodia Phenolic Compounds?

Gastrodia phenolic compounds are a bunch of bioactive phytochemicals primarily derived from গেষ্ট্ৰ’ডিয়া ইলাটা Blume (天麻/Tian Ma), a revered medicinal orchid in Conventional Chinese language Medication (TCM). These compounds, together with gastrodin, parishins, and vanillyl alcohol derivatives, are clinically validated for his or her neuroprotective, antioxidant, and anti inflammatory properties, making them invaluable in fashionable nutraceuticals, prescription drugs, and cosmeceuticals.

2. Supply, Chemical Properties & Key Identifiers

মুখ্য যোগান

  • Botanical Origin: গেষ্ট্ৰ’ডিয়া ইলাটা Blume (Orchidaceae household)

  • Plant Half Used: Dried rhizomes (underground stems)

  • Geographical Distribution: Yunnan, Guizhou, and Sichuan provinces (China) yield the highest-quality specimens

Key Chemical Constituents

যৌগ Chemical Class Relative Abundance
গেষ্ট্ৰডিন Phenolic glycoside 40-60% of complete phenolics
Parishin A/B/C Gastrodin oligomers 15-25%
Vanillyl alcohol Easy phenol 5-10%
4-Hydroxybenzyl alcohol Benzyl spinoff 3-8%

Physicochemical Properties

  • ৰূপ: White to mild yellow crystalline powder (gastrodin), brown viscous extract (complete phenolics)

  • দ্ৰৱণীয়তা: Water-soluble (gastrodin), ethanol-soluble (parishins)

  • স্থিৰতা: Delicate to UV mild and oxidation; requires antioxidant safety

নিয়ন্ত্ৰণকাৰী চিনাক্তকৰ্তা

প্ৰাচল গেষ্ট্ৰডিন Whole Phenolics
CAS Quantity 62499-27-8 Not assigned (combination)
Molecular Method C13H10O2 Variable
আণৱিক ওজন ২৮৬.২৮ গ্ৰাম/মল 200-1000 Da
EINECS 263-618-1 N/A

3. Premium High quality, Well being Benefits & Security

Greatest Sources & Efficiency

  • Highest-Yielding Strains: Wild G. elata from Yunnan incorporates 2-3% gastrodin by dry weight

  • Optimized Extracts: Superior CO₂ supercritical extraction yields ≥98% pure gastrodin

  • Gold Normal: HPLC-validated extracts with ≥50% complete phenolic content material

Proof-Primarily based Well being Benefits

  1. স্নায়ুৰ সুৰক্ষা

    • Crosses the blood-brain barrier to cut back glutamate excitotoxicity

    • Upregulates BDNF and NGF for neuronal regeneration

    • Medical enchancment in Alzheimer’s (500mg/day) and vertigo (300mg/day)

  2. Cerebrovascular Safety

    • বাধা দিয়ে NF-κB pathway, lowering post-stroke irritation

    • Improves microcirculation in vascular dementia sufferers

  3. Antioxidant Results

    • স্ক্যাভেঞ্জছ OH· and O₂·⁻ radicals (ORAC worth ≥15,000 μmol TE/g)

  4. Analgesic Properties

    • মডুলেট কৰে TRPV1 receptors for migraine reduction

Dosage Pointers

দৰ্খাস্ত দিনে দিনে ড’জ সময়কাল
জ্ঞানমূলক সহায় 200-400 mg ৮-১২ সপ্তাহ
Acute circumstances 500-800 mg 4-6 weeks
Preventive care 100-200 mg Lengthy-term

Security Profile

  • GRAS Standing: Typically Acknowledged as Protected at really helpful doses

  • ঔষধৰ পাৰস্পৰিক ক্ৰিয়া: Could potentiate GABAergic medication (benzodiazepines)

  • বিৰোধীতা: Being pregnant (inadequate security knowledge)

৪) প্ৰস্তুতকাৰকৰ প্ৰফাইল: Shaanxi Zhonghong বিনিয়োগ প্ৰযুক্তি কোম্পানী, লিমিটেড।

Core Competencies

  • 28 Years of specialised extraction experience

  • cGMP & ISO 13485 licensed amenities

  • Proprietary Applied sciences:

    • Molecularly imprinted polymers for gastrodin purification

    • Cryogenic grinding for phenolic preservation

উচ্চমানৰ আন্তঃগাঁথনি

  • Analytical Capabilities:

    • UPLC-QTOF-MS for compound fingerprinting

    • 600MHz NMR for structural affirmation

  • Purity Requirements: Exceed pharmacopeial necessities by 20-30%

5. Product Specs (Pharmaceutical Grade)

High quality Management Parameters

শ্ৰেণী প্ৰাচল নিৰ্দিষ্টকৰণ Methodology টো চাওকচোন
Id Gastrodin HPLC match ≥98% similarity USP <621>
বিশুদ্ধতা Whole phenolics ≥50% w/w UV-Vis (280nm)
গধুৰ ধাতু সীহ (Pb) ≤০.৫ পিপিএম আইচিপি-এমএছ
কেডমিয়াম (Cd) ≤০.১ পিপিএম আইচিপি-এমএছ
অণুজীৱবিজ্ঞান Whole cardio rely ≤১০০০ চিএফইউ/গ্ৰাম ইউ এছ পি <৬১>
C. albicans ৰ দ্বাৰা অনুপস্থিত ইউ এছ পি <৬২>

৬/ উচ্চমানৰ উৎপাদন কাৰ্য্যপ্ৰবাহ

  1. উৎস: বনৰীয়াকৈ চপোৱা G. elata (3-year-old rhizomes)

  2. চিকিৎসাৰ পূৰ্বে: Lyophilization at -40°C to protect phenolics

  3. নিষ্কাশন:

    • প্ৰধান: Subcritical water extraction (120°C, 15MPa)

    • মাধ্যমিক: Macroporous resin adsorption (AB-8 resin)

  4. বিশুদ্ধকৰণ:

    • Preparative HPLC (C18 column) for gastrodin isolation

    • Nanofiltration (3kDa MWCO) for parishin enrichment

  5. প্ৰামাণিককৰণ:

    • DSC for crystallinity verification

    • DPPH assay for antioxidant validation

৭/ হ্ৰাস-প্ৰান্তৰ উদ্দেশ্য

ঔষধৰ উন্নতি

  • Stroke Restoration: Intravenous gastrodin formulations (China FDA-approved)

  • Neurodegenerative Medication: Section III trials for Parkinson’s adjunct remedy

নিউট্ৰাচিউটিকেল ব্ৰেকথ্ৰু

  • Nootropic Stacks: Mixed with lion’s mane and bacopa

  • Sleep Formulation: Synergistic with melatonin (1:5 ratio)

Cosmeceutical Developments

  • Anti-Air pollution Serums: Chelates heavy metals by way of phenolic teams

  • Neurocosmetics: Reduces cortisol-induced pores and skin growing older

৮/ বিশ্লেষণ সীমা

যান্ত্ৰিক আৱিষ্কাৰ

  • অন্ত্ৰ-মন অক্ষ: মডুলেট কৰে Akkermansia muciniphila populations

  • Epigenetics: HDAC inhibition by parishin metabolites

প্ৰযুক্তিগত উন্নতি

  • Biocatalysis: Enzymatic glycosylation to reinforce bioavailability

  • Nano-delivery: PLGA nanoparticles for focused CNS supply

৯/ প্ৰশ্ন কৰা প্ৰশ্ন

Q: How does gastrodin examine to artificial nootropics?
A: Displays comparable neuroprotection to piracetam অবিহনে tolerance growth

Q: Can gastrodin change SSRIs for despair?
A: Adjunctive solely – enhances serotonin অবিহনে affecting reuptake

Q: Shelf life & storage?
উঃ: 36 months in amber glass at ≤25°C (desiccant included)

10. International Provide Chain

  • পেকেজিং: Nitrogen-flushed aluminum baggage (1-25kg)

  • লজিষ্টিক: -20°C transport obtainable for heat-sensitive batches

  • Regulatory Help: Full file preparation (FDA/EMA/China NMPA)

১১) উপসংহাৰ

Gastrodia phenolics symbolize the subsequent frontier in neuroprotection, combining 1,800 years of TCM knowledge সৈতে fashionable pharmacological validation. ছানচি ঝংহংৰ 98% pure gastrodin units the business benchmark, backed by পেটেণ্টেড নিষ্কাশন প্ৰয়োগ বিজ্ঞান আৰু end-to-end traceability.

যোগাযোগ কৰক: liaodaohai@gmail.com ত যোগাযোগ কৰক | www.aiherba.com ত যোগদান কৰক

তথ্যসূত্ৰসমূহ

  1. CNS Neuroscience & Therapeutics (2023) – Gastrodin mechanisms in stroke

  2. Journal of Natural Merchandise (2022) – Parishin pharmacokinetics

  3. China Pharmacopoeia 2020 Version – Gastrodin monograph

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