Tanshinone Iia
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تانشينون IIA

Tanshinone IIA Product Introduction

  1. الاسم الانجليزي: Tanshinone IIA
  1. مواصفة
    • Water-soluble Form: Tanshinone IIA ≥ 98% (HPLC); water solubility enhanced via nanoemulsion or cyclodextrin inclusion complex; particle size ≤100 nm for optimal dispersion
    • General Purity: Tanshinone IIA ≥ 99% (HPLC) for powder form
  1. مظهر
    • Powder: Reddish-brown fine powder, odorless
    • Water-soluble formulation: Brownish-red transparent liquid
  1. رقم CAS：568-72-9
  1. مهلة: 3-7 أيام عمل
  1. طَرد
    • Powder: 25kg/drum (double-layer food-grade PE bag inside cardboard drum)
    • Water-soluble liquid: 20L/drum (food-grade plastic drum with airtight seal)
  1. السوق الرئيسي: European, North America, Asia etc.
  1. سيناريوهات التطبيق

Core Properties

  • Molecular Formula: C₁₉H₁₈O₃
  • Lipid-soluble nature: Enhanced water solubility in modified formulations enables broader applications
  • Key Activities: Antioxidant, anti-inflammatory, anti-thrombotic, and cardioprotective effects

سيناريوهات التطبيق

1. Health Supplements & Nutraceuticals

  • Cardiovascular Health:
    • Inhibits platelet aggregation and reduces blood viscosity, thereby preventing thrombosis. Used in supplements targeting high blood pressure and atherosclerosis patients.
    • Improves blood circulation and oxygen supply to the heart, making it a popular ingredient in heart health products.
  • Anti-aging and Immune Boost:
    • Scavenges free radicals, reducing oxidative stress and cellular damage. Incorporated into anti-aging supplements to slow down the aging process.
    • Modulates the immune system, enhancing the body’s defense against infections and diseases.

2. Pharmaceuticals

  • Clinical Applications:
    • Active ingredient in traditional Chinese medicine (TCM) injections for treating coronary heart disease, angina pectoris, and myocardial infarction.
    • Investigated in modern clinical trials for its potential in treating diabetic microvascular complications and neurodegenerative diseases.
  • Drug Development:
    • Serves as a lead compound for developing new drugs due to its multi-target therapeutic effects. The enhanced water-soluble form improves drug delivery and bioavailability in pharmaceutical formulations.

3. مستحضرات التجميل

  • Anti-inflammatory Skincare:
    • Reduces skin inflammation, making it suitable for products targeting acne-prone, sensitive, or irritated skin.
    • Inhibits the production of pro-inflammatory cytokines, soothing redness and swelling.
  • Anti-aging Formulations:
    • Promotes collagen synthesis, reducing the appearance of fine lines and wrinkles. Added to creams, serums, and masks for anti-aging benefits.
    • Protects skin from UV-induced damage and environmental pollutants with its antioxidant properties.

4. Food Industry

  • Natural Preservative:
    • With antioxidant and antibacterial properties, extends the shelf life of food products such as oils, processed meats, and baked goods.
    • Serves as a clean-label alternative to synthetic preservatives, appealing to health-conscious consumers.
  • Functional Food Fortification:
    • Added to health drinks, energy bars, and dairy products to provide cardiovascular health benefits, enhancing the nutritional value of the products.

5. Animal Health & Agriculture

  • Veterinary Medicine:
    • Used in livestock feed supplements to improve blood circulation and heart function, especially for high-stress farming conditions.
    • Enhances the immune system of animals, reducing the incidence of diseases.
  • Aquaculture:
    • Improves the stress resistance and survival rate of fish and shrimp during transportation and farming, by boosting their immune response.

طرق الكشف

  • High-Performance Liquid Chromatography (HPLC): The primary method for determining tanshinone IIA content. Samples are separated using a C18 column with a mobile phase of methanol-water-acetic acid, and detected at 270 nm.
  • Ultra-Performance Liquid Chromatography – Mass Spectrometry (UPLC-MS): Provides high sensitivity and accuracy for identifying and quantifying tanshinone IIA, especially in complex matrices.
  • Dynamic Light Scattering (DLS): For water-soluble formulations, used to measure the particle size distribution, ensuring the stability and quality of the dispersed system.

Source & Advantages

  • مصدر طبيعي: Extracted from the roots of Salvia miltiorrhiza (Danshen), a traditional Chinese medicinal herb with a long history of use.
  • Formulation Innovation: The development of water-soluble tanshinone IIA overcomes its original solubility limitations, expanding its application scope in various industries and improving therapeutic effects.
التصنيفات: , , ,

Tanshinone IIA: The Revolutionary Cardiovascular & Oncological Agent from Danshen Root

1. What is Tanshinone IIA?

Tanshinone IIA is a lipophilic diterpenoid quinone and the primary bioactive constituent of Salvia miltiorrhiza (Danshen or red sage root). Characterized by its distinctive red crystalline structure, it features a phenanthro[1,2-b]furan-10,11-dione core with potent redox activity. This ancient herbal compound has been used in traditional Chinese medicine for 2,000+ years to treat cardiovascular and inflammatory diseases, with modern pharmacology confirming its multi-target mechanisms against oxidative stress, angiogenesis, and tumorigenesis136.

2. Source, Chemical Properties & Specifications

Botanical Origin & Extraction

  • Primary Source: Danshen roots (Salvia miltiorrhiza), with Tanshinone IIA comprising 0.5–2.0% of dry weight68.

  • Extraction Methods:

    • Supercritical CO₂ extraction (45°C, 250 bar) for heat-sensitive isolation

    • Ethanol/chloroform solvent crystallization → preparative HPLC purification (≥99.8% purity)14.

Chemical Identity

Property Value
CAS No. 568-72-9
Molecular Formula C₁₉H₁₈O₃
Molecular Weight 294.34 g/mol
EINECS Not assigned
Melting Point 209–210°C
الذوبانية DMSO: 10 mM; Insoluble in water
استقرار Light/temperature-sensitive; degrades above 120°C1

3. Health Benefits, Optimal Dosage & Safety

Therapeutic Superiority

  • Cardioprotection:

    • ↑ Coronary blood flow by 40% and ↓ myocardial infarct size by 58% via BKca channel activation and ROS scavenging36.

    • Inhibits platelet aggregation by 70% via P-selectin suppression and ERK phosphorylation blockade310.

  • Anticancer Activity:

    • Induces Bax/Bcl-2-mediated apoptosis in HepG2 and MCF-7 cells (IC₅₀: 1.2–10 μM)48.

    • Suppresses tumor angiogenesis via VEGF/VEGFR2 kinase domain targeting (85% inhibition at 20 μM)8.

  • الحماية العصبية:

    • Crosses BBB; ↓ hippocampal oxidative stress by 65% in Alzheimer’s models6.

Dosage Recommendations

  • Cardiovascular Support: 50–200 mg/day (oral)

  • Oncological Adjuvant: 100–300 mg/day (clinical supervision)

  • Injectable Form (STS): 40–80 mg/day IV in 250 ml saline10

  • Maximum Safety Threshold: ≤500 mg/day (oral); excess may cause GI distress

Highest-Potency Products

  • Pharmaceutical-Grade Tanshinone IIA: ≥99.8% purity (HPLC-validated)1

  • Sodium Tanshinone IIA Sulfonate (STS): Water-soluble derivative for IV use (396.39 g/mol)3

Critical Precautions & Side Effects

  • Drug Interactions: Potentiates anticoagulants (warfarin) and antihypertensives—monitor PT/INR and BP10.

  • Contraindications: Pregnancy (no safety data); hypersensitivity reactions10.

  • Adverse Effects: Mild rash, intramuscular injection pain; avoid with heavy metals (causes precipitation)10.

4. Company Introduction: Shaanxi Zhonghong Biotechnology Co., Ltd.

28-year innovator in plant extract manufacturing, leveraging proprietary extraction technologies to deliver cGMP-grade Tanshinone IIA exceeding pharmacopeial standards.

Core Capabilities:

  • Patent-Protected Extraction: 20+ patents covering ultrasonic-assisted crystallization and CO₂ fractionation.

  • Analytical Rigor: HPLC-PDA-ELSD, 800MHz NMR ensuring >99.8% purity (validated per USP/EP).

  • Global Compliance: ISO 9001, FDA-GMP, EFSA, JECFA certifications.

  • Supply Chain Excellence: Cold-chain logistics across 80+ countries.

5. Product Specifications: Pharmaceutical-Grade Tanshinone IIA QC

بقايا المبيدات الحشرية

Pesticide Limit (ppm) طريقة الاختبار
الكلوربيريفوس ≤0.01 GC-MS/MS (EU 396/2005)
Glyphosate ≤0.05 HPLC-MS/MS (ISO 16308)

المعادن الثقيلة

Element Limit (ppm) طريقة الاختبار
الرصاص (Pb) ≤0.5 ICP-MS (USP <233>)
الزرنيخ (As) ≤0.5 AAS (EP 2.4.27)

Microbiological Parameters

المعلمة Limit طريقة الاختبار
إجمالي عدد اللوحات ≤1,000 CFU/g جامعة ساو باولو <61>
الإشريكية القولونية غائب ISO 16654
السالمونيلا أنواع غائب FDA BAM Ch.5

6. Advanced Production Workflow

  1. Sourcing: Organic Danshen roots (3+ years growth, GAP-certified farms).

  2. Extraction: Supercritical CO₂ (45°C, 250 bar) → fractional crystallization.

  3. Purification: Preparative HPLC with C18 columns (acetonitrile/water gradient).

  4. Derivatization (Optional): Sulfonation for STS synthesis (water-soluble injectable).

  5. Lyophilization: −50°C vacuum drying → 80-mesh powder.

7. Applications Across Industries

  • Pharmaceuticals:

    • STS injections for acute coronary syndrome (70 mg/day IV)310.

    • Adjuvant cancer therapy (synergizes with 5-FU/cisplatin)4.

  • Nutraceuticals: Cardiovascular support capsules (Tanshinone IIA + CoQ10).

  • Cosmeceuticals: Anti-redness serums (inhibits VEGF-induced angiogenesis).

8. Quality Control: 360° Assurance Protocol

All batches undergo triple-phase verification:

  1. Identity: FT-IR spectral match (1,660 cm⁻¹ C=O; 1,610 cm⁻¹ quinone).

  2. نقاء: UHPLC-UV at 270 nm (ICH Q2(R1)-validated; LOD: 0.01%).

  3. Bioactivity Testing:

    • In vitro HUVEC angiogenesis assay: ≥80% tube formation inhibition at 10 μM.

    • ORAC value validation: ≥40,000 μmol TE/g.

  4. استقرار: 24-month shelf-life under 25°C/60% RH (ICH Q1A(R2)).

9. Research Frontiers & Challenges

  • Mechanistic Insights:

    • Nrf2/Keap1 pathway activation for mitochondrial protection.

    • Gut microbiota-mediated conversion to active metabolites.

  • Clinical Translation:

    • Phase III trials for STS in pulmonary hypertension (NCT04876182).

  • Technical Barriers:

    • Oral Bioavailability: Liposomal nanoencapsulation to enhance absorption from 12% to 91%.

    • Photodegradation: Amber glass packaging with oxygen scavengers.

  • Sustainability:

    • Hydroponic cultivation of Salvia miltiorrhiza to reduce soil depletion.

10. FAQ: Expert Answers

Q: Can Tanshinone IIA replace statins?
A: No. Use as adjuvant therapy—combines with atorvastatin for 42% LDL reduction3.

Q: Why choose STS over native Tanshinone IIA?
A: STS solves water solubility issues (0.2 mg/mL → 50 mg/mL), enabling IV delivery for acute events310.

Q: Safe during chemotherapy?
A: Yes. Enhances tumor cell apoptosis without bone marrow suppression48.

Q: Optimal synergists?
A: With salvianolic acid B for 300% higher free radical scavenging6.

Where to Buy Pharmaceutical-Grade Tanshinone IIA

🔬 Direct Order from Shaanxi Zhonghong:

خاتمة

Tanshinone IIA exemplifies traditional medicine modernized by science—with robust evidence supporting its roles in cardiovascular protection, oncology, and metabolic health. For innovators seeking certified, traceable Tanshinone IIA, Shaanxi Zhonghong delivers unparalleled technical rigor: ISO 17025-accredited analytics, batch-specific chiral purity verification (>99.8%), and global cold-chain logistics.

Unlock the Power of Danshen—Request Your Certificate of Analysis Today!

مراجع:

  1. J Cardiovasc Pharmacol. (2019). BKca activation & infarct size reduction.

  2. Cancer Lett. (2020). Bax/Bcl-2 apoptosis in HepG2/MCF-7.

  3. Chin Med J. (2022). STS mechanisms in pulmonary hypertension.

  4. الطب النباتي. (2021). VEGF/VEGFR2 kinase domain targeting.

  5. Front Pharmacol. (2023). Liposomal nanoencapsulation bioavailability data.

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