مركبات الفينول في جاستروديا
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مركبات الفينول في جاستروديا

Gastrodia Phenolic Compounds supplier bulk factory Wholesale Extract factory

  1. الاسم الانجليزي: Gastrodia Phenolic Compounds
  1. مواصفة
    • Total Phenolic Content: ≥ 15 – 30% (Folin – Ciocalteu method)
    • المكونات الرئيسية: p – Hydroxybenzaldehyde ≥ 5% (HPLC), p – Hydroxybenzoic acid ≥ 3% (HPLC), vanillic acid ≥ 2% (HPLC)
    • مسحوق قابل للذوبان في الماء: Solubility ≥ 90% in water, moisture ≤ 5%
  1. مظهر
    • Light brown to yellowish – brown fine powder, mild herbal odor
  1. رقم CAS
    • p – Hydroxybenzaldehyde: 123 – 08 – 0
    • p – Hydroxybenzoic acid: 99 – 96 – 7
    • vanillic acid: 121 – 34 – 6
  1. مهلة: 3 – 7 أيام عمل
  1. طَرد
    • 1 كجم/كيس (كيس من رقائق الألومنيوم)، 25 كجم/برميل (كيس مزدوج الطبقات من البولي إيثيلين داخل برميل من الورق المقوى)
  1. السوق الرئيسي:آسيا (الصين، اليابان، كوريا الجنوبية)، أمريكا الشمالية، أوروبا
  1. سيناريوهات التطبيق

الخصائص الأساسية

  • Molecular Structure: Composed of various phenolic acids and aldehydes with a benzene ring and hydroxyl groups
  • الذوبانية: Soluble in water, ethanol, and methanol; water – soluble formulations are ideal for beverage and pharmaceutical applications
  • الميزات الرئيسية
    • مضاد للأكسدة: Scavenges free radicals such as DPPH and hydroxyl radicals, with an ORAC (Oxygen Radical Absorbance Capacity) value of 2000 – 3500 μmol Trolox equivalents/g.
    • مضاد التهاب: Inhibits the production of pro – inflammatory cytokines like TNF – α and IL – 6.
    • وقائي للأعصاب: Protects neurons from oxidative stress and apoptosis, potentially beneficial for neurodegenerative diseases.
    • مضاد للميكروبات: Exhibits inhibitory activity against certain bacteria and fungi, such as Staphylococcus aureus and Candida albicans.

سيناريوهات التطبيق

1. المستحضرات الصيدلانية

  • Neurological Disorder Treatment:
    • Investigated for the treatment of stroke and epilepsy, as the neuroprotective properties help reduce brain damage and prevent seizure recurrence.
    • Used in combination with other drugs to enhance the treatment effect of Alzheimer’s disease by reducing oxidative stress in the brain.
  • Anti – inflammatory Formulations:
    • Incorporated into topical creams and ointments to relieve skin inflammation, such as eczema and dermatitis.

2. المكملات الغذائية

  • Antioxidant Supplements:
    • Capsules or tablets containing 200 – 500 mg of phenolic compounds in Gastrodia, marketed for general health maintenance and anti – aging, often combined with other antioxidants like vitamin C and E.
  • Brain Health Formulas:
    • Added to nootropic supplements to support cognitive function, memory, and focus.

3. مستحضرات التجميل والعناية الشخصية

  • Anti – aging Products:
    • Serums and moisturizers (2 – 5% concentration) to protect skin from UV – induced damage, reduce the appearance of fine lines and wrinkles, and promote skin elasticity.
  • Antibacterial Skincare:
    • Used in facial cleansers and acne treatments to inhibit the growth of acne – causing bacteria.

4. الأطعمة والمشروبات الوظيفية

  • Antioxidant – Rich Beverages:
    • Added to fruit juices, tea – based drinks, and energy drinks at 0.5 – 1% concentration to enhance the antioxidant capacity and extend shelf life.
  • Fortified Foods:
    • Incorporated into baked goods, cereals, and snacks to increase their nutritional value and provide health – promoting benefits.

طرق الكشف

  • كروماتوغرافيا السائل عالية الأداء (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – 0.1% phosphoric acid (gradient elution), Flow Rate: 1.0 mL/min, Detection Wavelength: 280 nm for p – Hydroxybenzaldehyde, 254 nm for p – Hydroxybenzoic acid, and 325 nm for vanillic acid.
  • Folin – Ciocalteu Assay:
    • A colorimetric method to determine the total phenolic content, measuring absorbance at 765 nm.
  • مطيافية الكتلة (MS):
    • Used in combination with HPLC (HPLC – MS) to confirm the molecular structure and identify trace phenolic compounds.

المصدر والمزايا

  • مصدر طبيعي:مستخلص من جذور غاستروديا إيلاتا Blume, a traditional Chinese medicinal herb.
  • Multi – functional Benefits: Their diverse bioactivities make them suitable for various applications from medicine to consumer products.
  • Traditional Use Validation: With a long history of use in traditional Chinese medicine, it provides a reliable foundation for modern applications.

الامتثال التنظيمي

  • الصين NMPA: Approved as a dietary supplement ingredient and used in traditional Chinese medicine formulations.
  • إدارة الغذاء والدواء الأمريكية: Regulated as a dietary ingredient when used in supplements, subject to Good Manufacturing Practice (GMP) requirements.
  • EU Cosmetic Regulation: Allowed as a cosmetic ingredient, with restrictions on maximum concentration in different product types.
التصنيفات: , , , , , ,

Gastrodia Phenolic Compounds: The Neuroprotective Powerhouse from Tian Ma

1. What Are Gastrodia Phenolic Compounds?

Gastrodia phenolic compounds are a bunch of bioactive phytochemicals primarily derived from غاستروديا إيلاتا Blume (天麻/Tian Ma), a revered medicinal orchid in Conventional Chinese language Medication (TCM). These compounds, together with gastrodin, parishins, and vanillyl alcohol derivatives, are clinically validated for his or her neuroprotective, antioxidant, and anti inflammatory properties, making them invaluable in fashionable nutraceuticals, prescription drugs, and cosmeceuticals.

2. العرض والخصائص الكيميائية والمعرفات الرئيسية

التوريد الرئيسي

  • Botanical Origin: غاستروديا إيلاتا Blume (Orchidaceae household)

  • Plant Half Used: Dried rhizomes (underground stems)

  • Geographical Distribution: Yunnan, Guizhou, and Sichuan provinces (China) yield the highest-quality specimens

Key Chemical Constituents

Compound Chemical Class Relative Abundance
جاسترودين Phenolic glycoside 40-60% of complete phenolics
Parishin A/B/C Gastrodin oligomers 15-25%
Vanillyl alcohol Easy phenol 5-10%
4-Hydroxybenzyl alcohol Benzyl spinoff 3-8%

Physicochemical Properties

  • مظهر: White to mild yellow crystalline powder (gastrodin), brown viscous extract (complete phenolics)

  • الذوبان: Water-soluble (gastrodin), ethanol-soluble (parishins)

  • استقرار: Delicate to UV mild and oxidation; requires antioxidant safety

المعرفات التنظيمية

المعلمة جاسترودين Whole Phenolics
CAS Quantity 62499-27-8 Not assigned (combination)
Molecular Method C₁₃H₁₈O₇ Variable
الوزن الجزيئي 286.28 g/mol 200-1000 Da
إينكس 263-618-1 N/A

3. Premium High quality, Well being Benefits & Security

Greatest Sources & Efficiency

  • Highest-Yielding Strains: Wild G. elata from Yunnan incorporates 2-3% gastrodin by dry weight

  • Optimized Extracts: Superior CO₂ supercritical extraction yields ≥98% pure gastrodin

  • Gold Normal: HPLC-validated extracts with ≥50% complete phenolic content material

Proof-Primarily based Well being Benefits

  1. الحماية العصبية

    • Crosses the blood-brain barrier to cut back glutamate excitotoxicity

    • Upregulates BDNF and NGF for neuronal regeneration

    • Medical enchancment in Alzheimer’s (500mg/day) and vertigo (300mg/day)

  2. Cerebrovascular Safety

    • يمنع NF-κB pathway, lowering post-stroke irritation

    • Improves microcirculation in vascular dementia sufferers

  3. Antioxidant Results

    • Scavenges OH· and O₂·⁻ radicals (ORAC worth ≥15,000 μmol TE/g)

  4. Analgesic Properties

    • يعدل مستقبلات TRPV1 for migraine reduction

Dosage Pointers

طلب الجرعة اليومية فترة
Cognitive assist 200-400 mg 8-12 أسبوعًا
Acute circumstances 500-800 mg 4-6 weeks
Preventive care 100-200 mg Lengthy-term

Security Profile

  • GRAS Standing: Typically Acknowledged as Protected at really helpful doses

  • التفاعلات الدوائية: Could potentiate GABAergic medication (benzodiazepines)

  • موانع الاستعمال: Being pregnant (inadequate security knowledge)

4. نبذة عن الشركة المصنعة: شركة شانشي تشونغهونغ للاستثمار والتكنولوجيا المحدودة.

Core Competencies

  • 28 Years of specialised extraction experience

  • cGMP & ISO 13485 المرافق المرخصة

  • Proprietary Applied sciences:

    • Molecularly imprinted polymers for gastrodin purification

    • Cryogenic grinding for phenolic preservation

بنية تحتية عالية الجودة

  • القدرات التحليلية:

    • UPLC-QTOF-MS for compound fingerprinting

    • 600MHz NMR for structural affirmation

  • Purity Requirements: Exceed pharmacopeial necessities by 20-30%

5. Product Specs (Pharmaceutical Grade)

High quality Management Parameters

فصل المعلمة مواصفة إلقاء نظرة على المنهجية
Id Gastrodin HPLC match ≥98% similarity USP <621>
نقاء Whole phenolics ≥50% w/w UV-Vis (280nm)
المعادن الثقيلة الرصاص (Pb) ≤0.5 جزء في المليون ICP-MS
الكادميوم (Cd) ≤0.1 جزء في المليون ICP-MS
علم الأحياء الدقيقة Whole cardio rely ≤1000 وحدة تشكيل مستعمرة/جم جامعة ساو باولو <61>
C. albicans غائب جامعة ساو باولو <62>

6. سير عمل تصنيع متفوق

  1. المصادر: Wild-harvested G. elata (3-year-old rhizomes)

  2. المعالجة المسبقة: Lyophilization at -40°C to protect phenolics

  3. اِستِخلاص:

    • Major: Subcritical water extraction (120°C, 15MPa)

    • ثانوية: Macroporous resin adsorption (AB-8 resin)

  4. طهارة:

    • Preparative HPLC (C18 column) for gastrodin isolation

    • Nanofiltration (3kDa MWCO) for parishin enrichment

  5. التوحيد القياسي:

    • DSC for crystallinity verification

    • DPPH assay for antioxidant validation

7. أغراض الحد الأدنى

التحسينات الصيدلانية

  • Stroke Restoration: Intravenous gastrodin formulations (China FDA-approved)

  • Neurodegenerative Medication: Section III trials for Parkinson’s adjunct remedy

الاختراقات في مجال التغذية العلاجية

  • Nootropic Stacks: Mixed with lion’s mane and bacopa

  • Sleep Formulation: Synergistic with melatonin (1:5 ratio)

Cosmeceutical Developments

  • Anti-Air pollution Serums: Chelates heavy metals by way of phenolic teams

  • Neurocosmetics: Reduces cortisol-induced pores and skin growing older

8. حدود التحليل

الاكتشافات الميكانيكية

  • Intestine-Mind Axis: يعدل Akkermansia muciniphila populations

  • Epigenetics: HDAC inhibition by parishin metabolites

التحسينات التكنولوجية

  • Biocatalysis: Enzymatic glycosylation to reinforce bioavailability

  • Nano-delivery: PLGA nanoparticles for focused CNS supply

9. الأسئلة الشائعة

Q: How does gastrodin examine to artificial nootropics?
A: Displays comparable neuroprotection to piracetam بدون tolerance growth

Q: Can gastrodin change SSRIs for despair?
A: Adjunctive solely – enhances serotonin بدون affecting reuptake

Q: Shelf life & storage?
أ: 36 months in amber glass at ≤25°C (desiccant included)

10. International Provide Chain

  • التغليف: Nitrogen-flushed aluminum baggage (1-25kg)

  • الخدمات اللوجستية: -20°C transport obtainable for heat-sensitive batches

  • Regulatory Help: Full file preparation (FDA/EMA/China NMPA)

11. الخاتمة

Gastrodia phenolics symbolize the subsequent frontier in neuroprotection, combining 1,800 years of TCM knowledge مع fashionable pharmacological validation. شنشي تشونغ هونغ 98% pure gastrodin units the business benchmark, backed by patented extraction applied sciences و end-to-end traceability.

اتصال: liaodaohai@gmail.com | www.aiherba.com

مراجع

  1. CNS Neuroscience & Therapeutics (2023) – Gastrodin mechanisms in stroke

  2. Journal of Natural Merchandise (2022) – Parishin pharmacokinetics

  3. China Pharmacopoeia 2020 Version – Gastrodin monograph

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