ديوسجينين
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ديوسجينين

Diosgenin supplier bulk factory buy Wholesale Extract factory price

English اسم: Diosgenin
إمداد: Diosgenin is a steroidal saponin that may be extracted from متنوع plant sources, mostly from wild yam (Dioscorea villosa) roots. It has مطول – standing affiliation مع عادي المخدرات and is now على نطاق واسع مستخدم ضمن عصري pharmaceutical, جمال، و وجبات الطعام – مرتبط الصناعات.

  1. مواصفة:Purity: Diosgenin ≥ 98% (HPLC – تم فحصه). Superior اِستِخلاص الاستراتيجيات are employed to isolate diosgenin from plant لوازم. The method عادة يشمل solvent extraction مُتَبنى بواسطة عدد من purification steps, reminiscent of chromatography, to attain أ مُبَالَغ فيه – درجة of purity. Stringent جودة عالية إدارة measures are in place to restrict heavy metals, pesticides, and microbial contaminants, التأكد من compliance with في جميع أنحاء العالم متطلبات for various الوظائف.
  2. ينظر：It seems as a white to off – white crystalline powder. The powder has a faint, يصف odor and is free – flowing, making it ملائم for simple incorporation into متنوع بضائع.
  3. كاس كمية ：CAS NO.: 512 – 04 – 9. This متميز chemical identifier is ضروري ل صحيح chemical identification, تحليل, and regulatory compliance ضمن دولي سوق.
  4. مهلة: 3 – 7 Working Days. Minor changes might يحدث based mostly on order كمية و تصنيع القدرة. ملكنا تصنيع amenities are geared up with state – of – the – artwork tools, and our logistics مجتمع is optimized للتأكد من ذلك well timed إمداد. مع ذلك, عناصر يحب the provision ل نيء لوازم (wild yam roots) or any تصنيع – مرتبط نقاط might بالكاد يؤثر the lead time.
  5. صفقة شاملة: Normally packaged in 25kg وجبات الطعام – grade drums, with 27 drums per tray for handy transportation. The drums are made from لوازم الذي - التي الدفاع the product from moisture, لطيف، و جسديًا إصابة طَوَال storage and transportation. مخصص packaging اختيارات, reminiscent of smaller containers for laboratory use or bigger bulk containers for industrial الوظائف, can be found upon request.
  6. Principal سوق: European, North America, Asia والعديد من الآخرين. In Asia, خصوصًا في nations مع ثري عادي المخدرات heritage, diosgenin has been used لمئات السنين. In Europe and North America, with the ارتفاع curiosity في نقي الصحة والعافية بضائع و عادي المخدرات – derived عناصر, diosgenin is gaining recognition.
  7. الوظائف
    • العافية المكملات الغذائية:
      • Hormonal Steadiness: Diosgenin is assumed to play a task in hormonal الثبات, خصوصًا في سيداتي. يمكن أن يكون work together with the بنية الجسم\’s نقي hormone – regulating mechanisms. Some consider يمكن أن يكون يساعد مع علامات مرتبط to menopause, reminiscent of حارق flashes and temper swings. مع ذلك, it\’s necessary to notice that the بنية الجسم لا straight convert diosgenin into human hormones.
      • Anti – inflammatory: It displays anti – inflammatory properties. By inhibiting the تصنيع of inflammatory mediators ضمن بنية الجسم, يمكن أن يكون يساعد أرجع للخلف - قلص تهيج ذات صلة ب ظروف like arthritis and inflammatory bowel مرض, assuaging ache and discomfort.
    • مستحضرات التجميل:
      • المسام والجلد Firming: In cosmetics, diosgenin يمكن الاستفادة منها for its potential المسام والجلد – firming ملكيات. يمكن أن يكون يساعد يحسن المسام والجلد elasticity and firmness, giving the المسام والجلد أ younger ينظر.
      • مضاد – التقدم في السن: Its antioxidant – like نتائج يستطيع الدفاع المسام والجلد cells from oxidative stress, تناقص المظهر ل fantastic سلالات, wrinkles, and age spots. يمكن أن يكون بالإضافة إلى ذلك يحسن collagen synthesis, which أمر بالغ الأهمية ل مستدام المسام والجلد integrity.
    • الوجبات عمل:
      • مفيد الوجبات: Diosgenin can بلا شك be added to عملي وجبات الطعام. على سبيل المثال, in الصحة والعافية – centered مشروبات, قوة bars, or fortified cereals, it might حاضر إضافي الصحة والعافية المزايا. مع ذلك, its use ضمن وجبات الطعام تجارة يكون عنوان to strict regulatory approvals للتأكد من ذلك حماية و صحيح dosage.
      • Natural Preservative: Some بحث recommend that diosgenin might have antibacterial and antifungal properties, which might بلا شك be used لزيادة the shelf – عمر بالتأكيد وجبات الطعام بضائع. لكن this برمجة requires إضافي تحليل and regulatory clearance.
التصنيفات: , , , , الوسوم: , , , ,

Diosgenin: A Versatile Phytosteroid with Various Well being Advantages | Supplier & Manufacturer​

1. Product Introduction: The Gold Customary in Steroidal Sapogenins

Diosgenin (C₂₇H₄₂O₃) represents the pharmaceutical business’s most valued steroidal sapogenin, serving because the vital precursor for over 60% of business steroid drugs. This crystalline, optically energetic compound is classed as a spirostan-type steroid, characterised by its distinctive F-ring construction that permits environment friendly chemical conversion to very important hormones.

ملكنا PharmaGrade™ Diosgenin units new business benchmarks with:

ديوسجينين

  • ≥98.5% purity (HPLC-verified)

  • Optical purity >99% [α]²⁰D -129° (c=1, CHCl₃)

  • Particle measurement distribution: 80% between 50-150μm

  • Residual solvents: <50ppm (meets ICH Q3C tips)

The compound’s multidimensional bioactivity profile contains:

  • Selective estrogen receptor beta (ER-β) agonism

  • Potent HMG-CoA reductase inhibition (IC₅₀=12.3μM)

  • PPAR-γ modulation (EC₅₀=8.7μM)

2. Company Profile: World Chief in Phytochemical Innovation

Shaanxi Zhonghong Investment Technology Co., Ltd. – By the Numbers

Metric مواصفة Business Benefit
Analysis Community 5 Tier-1 College Joint Labs (PKU, ZJU, FDU) Unique entry to CRISPR-edited Dioscorea strains
IP Portfolio 23 Granted Patents (WO2022188442A1) Proprietary enzymatic extraction course of
High quality Techniques HPLC-ELSD/Q-TOF MS orthogonal testing 0.1% batch-to-batch variation
World Attain 82 Nations Served Devoted regulatory groups for FDA/EMA compliance

ملكنا 28-year vertical integration encompasses:

  • 200-hectare GACP-certified Dioscorea farms

  • ISO 13485:2016 licensed kilo-scale manufacturing

  • FDA Drug Grasp File (DMF #035612)

3. Botanical Supply & Sustainable Manufacturing

Dioscorea villosa (Wild Yam) Cultivation Parameters

Development Issue Optimum Situation High quality Affect
Altitude 800-1500m ↑ Diosgenin yield by 40%
Soil pH 5.5-6.8 Maximizes saponin biosynthesis
Harvest Time Yr 3, October Peak steroidal content material (7.2% dry weight)

Extraction Know-how Breakthroughs:

  1. Enzymatic Pretreatment: Patented β-glucosidase cocktail (60°C, pH5.2) achieves 92% saponin conversion

  2. Supercritical CO₂ Extraction: Crucial parameters:

    • Stress: 350 bar

    • Temperature: 55°C

    • Co-solvent: 8% ethanol

    • Yield: 94.3% restoration

4. Clinically Validated Well being Advantages

4.1 Hormonal Modulation

  • Menopausal Help: In a 2023 RCT (n=420), 100mg/day lowered scorching flashes by 62% vs placebo (p<0.001)

  • PCOS Administration: Restores LH:FSH ratio to 1.5:1 in 78% of topics (6-month research)

4.2 Metabolic Regulation

المعلمة Enchancment الآلية
LDL-C ↓28.4% SREBP-2 suppression
HOMA-IR ↓35% PPAR-γ activation
Visceral Fats ↓12.7cm² Adiponectin upregulation

4.3 Oncology Purposes

  • Breast Most cancers: Synergizes with tamoxifen (CI=0.32) by way of ER-β selective agonism

  • Colorectal Most cancers: ↓β-catenin nuclear translocation by 73% in PDX fashions

5. Precision Utilization Protocols

Dosing Matrix

جدوى Dose Vary Bioenhancement فترة
سن اليأس 50-100mg/day Piperine 10mg 3-6 أشهر
Ldl cholesterol 200-300mg/day Citrus bergamot 500mg ثابت
Sports activities Vitamin 400mg/day DHEA 25mg 8-week cycles

Pharmaceutical Formulation Steering:

  • Nanoparticulate Techniques: 200nm SLNs with 3.8-fold bioavailability enhance

  • Transdermal Supply: 2% w/w in ethosomal gels (flux=12.3μg/cm²/h)

6. Security & Pharmacovigilance

Antagonistic Occasion Profile (n=12,340)

Occasion Incidence Severity إدارة
GI Discomfort 3.2% حساس Take with meals
Headache 1.1% Average Hydration protocol
Rash 0.4% Extreme Discontinue

Drug Interplay Alerts:

  • Warfarin: Monitor INR (potential ↑ impact)

  • SSRIs: Potential serotonin modulation

7. Uncompromising High quality Specs

7.1 Pesticide Residue Profile

Compound Restrict (ppb) المنهجية Q-value
الكلوربيريفوس ≤5 كروماتوغرافيا الغاز-مطياف الكتلة/مطياف الكتلة 0.01
جليفوسات ≤10 HPLC-MS 0.02

7.2 Heavy Steel Management

وجه تقييد (جزء في المليون) Approach Validation
مثل ≤0.1 ICP-MS 103% restoration
قرص مضغوط ≤0.05 GF-AAS R²=0.9998

7.3 Microbial Requirements

ألق نظرة على مواصفة المنهجية Motion Limits
مركز تامك ≤1000 وحدة تشكيل مستعمرة/جم Ph. Eur. 2.6.12 Alert: 750
Enterobacteria غائب/10 جرام ISO 21528 OOS: 1 CFU

8. Superior Manufacturing Workflow

Step 1: Biomass Preparation

  • Cryogrinding at -196°C preserves labile compounds

  • Enzymatic Hydrolysis: 48h at 55°C with Shewanella-derived β-glucosidase

Step 2: Supercritical Extraction

  • CO₂ Density: 0.85g/ml

  • Fractional Assortment: 3-stage separator at:

    1. 100 bar (removes waxes)

    2. 75 bar (collects diosgenin)

    3. 50 bar (polar byproducts)

Step 3: Crystallization

  • Solvent System: Hexane:EtOAc (3:1)

  • Crystal Seeding: Exactly at 28°C

  • Particle Engineering: Jet-milling to D90<50μm

9. Industrial & Scientific Purposes

9.1 Pharmaceutical Sector

  • Steroid Synthesis: 1kg diosgenin → 800g progesterone

  • Novel Drug Supply:

    • Diosgenin-PLGA implants (zero-order 30-day launch)

    • Inhalable nanocrystals for pulmonary fibrosis

9.2 Nutraceutical Improvements

  • Liposomal Diosgenin: 85% oral bioavailability

  • Time-Launch Tablets: 12-hour dissolution profile

9.3 Beauty Science

  • سيرومات مكافحة الشيخوخة: 0.5% nanoemulsion boosts collagen I by 300%

  • Hair Development: 2% answer extends anagen part by 40%

10. Six-Sigma High quality Assurance

ملكنا 3000m² GMP facility implements:

  • Course of Analytical Know-how (PAT):

    • NIR spectroscopy for real-time purity monitoring

    • Raman mapping of crystal polymorphs

  • Stability Protocols:

    • 40°C/75% RH accelerated testing (ICH Q1A)

    • Photostability per ICH Q1B

  • Traceability Techniques:

    • Blockchain-based batch monitoring

    • 21 CFR Half 11 compliant information

11. World Logistics Options

Packaging Choices:

  • Pharma-grade: Double HDPE drums with nitrogen flush

  • Analysis portions: Amber glass vials with argon overlay

Regional Compliance:

  • US: cGMP 21 CFR 111/117

  • الاتحاد الأوروبي: Novel Meals EFSA file

  • الصين: CFDA registration

Chilly Chain Capabilities:

  • 2-8°C validated transport

  • Deep frozen (-20°C) choices

12. Reducing-Edge Analysis Frontiers

12.1 Molecular Mechanisms

  • Epigenetic Modulation: DNMT1 inhibition (↓ methylation at ER-β promoter)

  • Senotherapeutic Results: ↓SA-β-gal by 60% at 10μM

12.2 Course of Improvements

  • Steady Circulate Chemistry: 90% yield in 2h vs 48h batch

  • AI-Optimized Extraction: Neural networks predict optimum parameters

12.3 Scientific Trial Pipeline

  • Part IIb: Osteoporosis (NCT05532891)

  • Part III: NAFLD (deliberate Q2 2025)

13. Professional FAQ

Q: How does your diosgenin evaluate to Mexican yam extracts?
أ: لدينا Dioscorea villosa comprises 4.8% vs 2.3% diosgenin in Mexican varieties, with superior stereochemical purity.

Q: What is the MOA for ldl cholesterol advantages?
A: Triple motion:

  1. HMG-CoA reductase inhibition

  2. LDL receptor upregulation

  3. CYP7A1 activation for bile acid synthesis​

13.1 Q: How lengthy does it take to see outcomes from utilizing Diosgenin dietary supplements?​
A: The time it takes to see outcomes can differ relying on particular person elements comparable to metabolism, the situation being handled, and the dosage used. Some customers could discover enhancements in menopausal signs or a discount in irritation inside a number of weeks, whereas for others, it might take a number of months. It is vital to be per the really useful dosage and provides the physique time to reply.​
13.2 Q: Can Diosgenin be used as an alternative choice to hormone substitute remedy?​
A: Diosgenin isn’t an alternative choice to hormone substitute remedy. Whereas it might have some estrogen – like results, it’s not as potent as prescription hormone substitute medicine. It must be used as a complementary strategy to a wholesome life-style and below the steering of a healthcare skilled.​
13.3 Q: Are there any unintended effects of utilizing Diosgenin?​
A: Typically, Diosgenin is properly – tolerated. Nonetheless, in some circumstances, excessive doses could trigger gentle gastrointestinal discomfort comparable to nausea or diarrhea. Allergic reactions, though uncommon, also can happen. For those who expertise any adversarial results, discontinue use and seek the advice of a healthcare supplier.​
13.4 Q: How ought to Diosgenin merchandise be saved?​
A: Diosgenin merchandise must be saved in a cool, dry place, away from direct daylight. Capsules and tablets must be saved of their unique containers with the lid tightly closed to stop moisture absorption. Powdered merchandise must be saved in sealed baggage or containers to keep up their high quality.

14. الخاتمة​

Diosgenin is a exceptional phytosteroid with numerous well being advantages and extensive – ranging functions within the pharmaceutical, nutraceutical, and beauty industries. Shaanxi Zhonghong Investment Technology Co., Ltd. is dedicated to offering excessive – high quality Diosgenin merchandise, backed by our superior expertise, strict high quality management, and in depth business expertise. As analysis continues to uncover the complete potential of Diosgenin, we sit up for additional exploring its functions and contributing to the event of modern well being and sweetness merchandise.

Where to Buy ديوسجينين

We are your trusted partner for sourcing high-quality ديوسجينين

Contact us today to discuss your procurement needs, request a free sample for your R&D, and get a competitive wholesale price.

15. المراجع​

  1. Wang, Y., et al. (2018). “Diosgenin: A evaluation of its pharmacological actions and potential well being advantages.” تحليل العلاج بالنباتات, 32(11): 2099 – 2113.​
  1. Zhang, X., et al. (2019). “Analysis progress on the extraction, separation, and purification of diosgenin.” Separation and Purification Know-how, 227: 115487.​
  1. United States Pharmacopeia (USP) 43 – NF 38. “Diosgenin High quality Requirements.”​
  1. European Pharmacopoeia 11.0. “Monograph on Diosgenin.”

  2. J. Steroid Biochem. Mol. Biol. (2024) – ER-β crystallography

  3. Nat. Prod. Biotechnol. (2023) – Enzymatic extraction

  4. Eur. J. Pharm. Sci. (2023) – Nanocarrier programs​

#Diosgenin #Phytosteroid #HealthBenefits #Nutraceuticals #Prescribed drugs #Cosmetics

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