Camptothecin – High-Purity Bioactive Extract for Pharmaceutical R&D and Advanced Formulations

كامبتوثيسين (CPT) هو naturally occurring alkaloid originally isolated from كامبتوثيكا أكوميناتا. Today, it remains a critical precursor for the synthesis of topoisomerase-I inhibitor drugs such as irinotecan و topotecan, widely researched in oncology and cellular biology.
في AIHerba® (شركة شنشي تشونغ هونغ لتكنولوجيا الاستثمار المحدودة), we manufacture high-purity camptothecin تحت GMP-aligned standards, serving pharmaceutical companies, research institutes, nutraceutical developers, and biotechnology innovators.

---

1. نظرة عامة على المنتج

• اسم المنتج: كامبتوثيسين

• رقم CAS: 7689-03-4

• المصدر النباتي: كامبتوثيكا أكوميناتا (Happy Tree)

• مواصفة: 95% / 98% HPLC

• مظهر: مسحوق بلوري أصفر

• أصل: الصين

• Supply Form: Bulk powder for industrial, pharmaceutical & research use

• الحد الأدنى لكمية الطلب: 1–5 kg (bulk orders negotiable)

Our factory operates with أكثر من 28 عامًا من الخبرة في الاستخراج, using استخلاص ثاني أكسيد الكربون فوق الحرج, precision purification, and low-temperature crystallization to protect the molecule’s stability.

---

2. Key Benefits & Functional Properties

Expert Review – Dr. L. Meng, PhD, Natural Products Chemistry (quoted with permission)
“Camptothecin’s unique lactone ring makes it one of the most studied plant-derived compounds in cancer biology. High purity is essential for consistent activity, and only GMP-controlled extraction can achieve pharmaceutical-grade reliability.”

الخصائص الأساسية

1. Topoisomerase-I Inhibition
   Widely used as a reference compound in oncology research (NIH, PubMed: PMID 2684270).

2. Supports Drug Development Pipelines
   Essential precursor for semi-synthetic clinical drugs including irinotecan (CPT-11) and topotecan.

3. Cellular Stress Response Studies
   Extensively used in apoptosis, DNA repair, and cell-cycle disruption research (NIH, PMID 2153155).

4. High Purity = Stability
   Residual solvent control and crystalline structure guarantee better assay performance.

---

3. Health-Related Research Insights

While Camptothecin is not a dietary supplement, it is one of the most influential natural products in anti-tumor drug discovery.
Research suggests potential roles in:

• DNA replication interference

• Anti-proliferative activity

• In vitro anti-tumor mechanism modeling

• Precision oncology tool compound applications

(References linked below.)

---

4. Traditional Botanical Background

Camptotheca acuminata has been referenced in traditional Chinese medicine literature as far back as the 17th century, used historically for “heat-clearing” and detoxifying functions—long before scientists isolated camptothecin in 1966.

---

5. Recommended Usage (For Industrial & Research Applications Only)

• البحث والتطوير الصيدلاني: 95–98% HPLC

• Reference Standard: 98%

• Formulation Input: For precursor synthesis only

• Cosmetic R&D: Typically micro-dosed in high-tech anti-aging prototypes (not consumer-facing due to regulations)

Not intended for direct consumption.

---

6. Best Formulation Guidelines

• الذوبان: Poor water solubility; dissolve in DMSO, ethanol, or formulated carriers

• استقرار: Protect lactone ring—avoid high pH

• التوافق: Sensitive to oxidation

• Ideal Use: Oncology model systems, biosimilar pathway research, early-stage drug formulation

---

7. COA-Style Quality Specification Table

A. General Specifications

---

B. Pesticide Residues

---

ج. المعادن الثقيلة

---

د. الاختبارات الميكروبيولوجية

---

8. Manufacturing Process (Summary)

Step-by-Step Flow

1. Raw Material Harvesting – Sustainably cultivated كامبتوثيكا أكوميناتا

2. التجفيف والطحن – Low-temperature handling to preserve alkaloids

3. الاستخلاص بالمذيبات (Ethanol/water or SC-CO₂)

4. التركيز والترشيح

5. طهارة (Resin column → crystallization)

6. HPLC Standardization

7. Drying & Micronization

8. Final QC Testing

9. Packaging in GMP Workshops

This process ensures إمكانية التتبع, نقاء عالي، و lot-to-lot consistency — essential for pharmaceutical buyers.

---

9. التخزين ومدة الصلاحية

• تخزين: Store at 2–8°C, sealed, protected from light and humidity

• مدة الصلاحية: 24–36 months unopened

• التغليف:

  • كيس من رقائق الألومنيوم 1 كجم

  • 25 kg drum

  • Customized packaging available

---

10. Sample Policy, MOQ & Logistics

• عينة مجانية من مستخلص الأعشاب: 10–20 g for QC testing

• الحد الأدنى لكمية الطلب: 1 kg (research), 5–25 kg (bulk manufacturing)

• مهلة: 3–5 days for stock items

• الخدمات اللوجستية: International express, air freight, and temperature-controlled shipping available

• شروط التجارة: EXW, FOB, CIF

---

11. الصناعات المطبقة وحالات الاستخدام

Camptothecin is typically used in:

البحث والتطوير الصيدلاني

• Oncology drug precursor

• Reference standard

• Topoisomerase inhibitor studies

Biotechnology & Laboratory Research

• Cell-death pathway modeling

• Antitumor screening

• DNA repair studies

Cosmetic R&D

• Advanced anti-aging experimental formulas
  (Only for مستخلص نباتي معتمد من GMP لمستحضرات التجميل research groups.)

Functional Food Developers

Not for ingestion, but relevant for الشركة المصنعة للمواد الخام للمكملات الغذائية R&D departments.

---

12. Why Choose AIHerba® as Your Camptothecin Supplier

1. الشركة المصنعة الحاصلة على شهادة GMP with 28+ years experience

2. Factory-direct price and traceable raw material base

3. Bulk supply with consistent purity and stable batches

4. Strict QC + third-party testing upon request

5. Custom extraction services ل مستخلص عشبي مخصص projects

6. Global shipping with regulatory support

We serve hundreds of clients across pharmaceuticals, biotechnology, cosmetics, and academic research.

---

13. الأسئلة الشائعة

Q1. Is your Camptothecin suitable for pharmaceutical manufacturing?
Yes. Our 98% grade is produced in GMP facilities and suitable for precursor synthesis.

Q2. Do you offer technical documents?
COA, HPLC chromatograms, MSDS, and process documentation can be provided.

Q3. Can I buy small research quantities?
Yes. MOQ begins at 1 kg with عينات مجانية متاح.

Q4. Can you support custom purity levels?
We can adjust specs for OEM/ODM partners and research institutions.

Q5. Do you provide wholesale pricing?
نعم. Wholesale and bulk price tiers are available depending on quantity.

---

14. المراجع العلمية

(PubMed / NIH / FDA official sources)

1. Wall ME et al. علوم, 1966 — Discovery of camptothecin. (PubMed: 5916656)

2. Hsiang YH et al. Topoisomerase-I inhibition mechanism. (PubMed: 2684270)

3. Pommier Y. DNA repair pathways in CPT action. (PubMed: 2153155)

4. FDA Orange Book – Camptothecin derivatives regulatory data.

---

Contact & Ordering

ايه هيربا® | شنشي Zhonghong شركة تكنولوجيا الاستثمار المحدودة.
📧 sales@aiherba.com | info@aiherba.com | liaodaohai@gmail.com
🌐 www.aiherba.com
حاصل على شهادة GMP مزود, الشركة المصنعة، و مصنع of high-purity plant extracts.