الجينسنوسيدات النادرة
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الجينسنوسيدات النادرة

Rare Ginsenosides supplier bulk factory Wholesale Extract factory

  1. الاسم الانجليزي: Rare Ginsenosides
  1. مواصفة
    • Single Ginsenoside: Rg3 ≥ 98%, Rh2 ≥ 98%, CK ≥ 98% (HPLC)
    • Mixture Form: Total rare ginsenosides ≥ 90% (HPLC), including Rg3, Rh2, CK, Rh3, etc.
    • شكل قابل للذوبان في الماء: Enhanced solubility through nanoemulsion or cyclodextrin complexation, solubility up to 10 mg/mL in water
  1. مظهر
    • Powder: White to off-white fine powder, odorless
    • Water-soluble Form: Off-white to light yellow free-flowing powder
  1. رقم CAS
    • Rg3: 14197-60-5
    • Rh2: 51542-56-4
    • CK: 39262-14-1
  1. مهلة: 5 – 7 أيام عمل
  1. طَرد
    • 1 كجم/كيس (كيس رقائق الألومنيوم)، 25 كجم/برميل (كيس مزدوج الطبقة من البولي إيثيلين داخل برميل من الورق المقوى)
  1. السوق الرئيسي: Asia (China, South Korea, Japan), North America, Europe
  1. سيناريوهات التطبيق

الخصائص الأساسية

  • Molecular Structure: Triterpenoid saponins with diverse configurations, derived from the hydrolysis of protopanaxadiol or protopanaxatriol
  • الذوبانية: Poorly soluble in water; water-soluble modifications improve bioavailability
  • الميزات الرئيسية
    • Antitumor: Inhibits tumor cell proliferation, induces apoptosis, and suppresses tumor angiogenesis. For example, Rg3 shows significant inhibition of lung cancer cell metastasis in preclinical studies.
    • تعديل المناعة: Stimulates immune cell activity, enhancing the body’s defense against diseases.
    • وقائي للأعصاب: Alleviates oxidative stress and inflammation in the nervous system, potentially beneficial for neurodegenerative diseases.
    • مضاد للأكسدة: Scavenges free radicals, protecting cells from oxidative damage.

سيناريوهات التطبيق

1. المستحضرات الصيدلانية

  • Cancer Treatment:
    • Adjuvant Therapy: Used in combination with chemotherapy and radiotherapy drugs. Clinical trials have shown that Rg3 can improve the efficacy of paclitaxel in breast cancer treatment while reducing side effects.
    • Oral Medications: Capsules or tablets containing rare ginsenosides are prescribed for cancer patients to enhance quality of life and prolong survival.
  • Neurological Disorder Treatment:
    • Investigated for treating Alzheimer’s and Parkinson’s diseases, helping to slow down neurodegeneration and improve cognitive function.

2. المكملات الغذائية

  • General Health Maintenance:
    • Capsules or softgels (50 – 200 mg/day) for daily intake, marketed for immune enhancement, anti-aging, and stress relief.
  • التغذية الرياضية:
    • Added to sports supplements to reduce exercise-induced oxidative stress and promote muscle recovery.

3. مستحضرات التجميل والعناية الشخصية

  • منتجات مكافحة الشيخوخة:
    • Serums and creams (1 – 3% concentration) to promote collagen synthesis, reduce wrinkles, and improve skin elasticity.
  • Skin Repair Formulations:
    • Used in post-procedure skincare products to soothe irritated skin and accelerate wound healing.

4. Animal Health

  • الطب البيطري:
    • Added to animal feed for pets and livestock to enhance immune function, improve growth performance, and reduce stress.
    • Used in veterinary oncology to support animals undergoing cancer treatment.

طرق الكشف

  • كروماتوغرافيا السائل عالية الأداء (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – water (with gradient elution), Flow Rate: 1.0 mL/min, Detection Wavelength: 203 nm for accurate quantification.
  • كروماتوغرافيا السوائل فائقة الأداء - مطيافية الكتلة (UPLC – MS):
    • Confirms the molecular structure and identifies trace impurities, providing high sensitivity and specificity.
  • الرنين المغناطيسي النووي (NMR):
    • Used for structural elucidation and confirmation of rare ginsenoside isomers, especially for research and high-purity product analysis.

المصدر والمزايا

  • مصدر طبيعي: Extracted from the roots, stems, and leaves of Panax ginseng و Panax notoginseng through enzymatic conversion or chemical hydrolysis of common ginsenosides.
  • التحقق العلمي: Extensive preclinical and clinical studies have demonstrated their significant bioactivities, providing a solid foundation for applications.
  • Multi-functional Benefits: Their diverse therapeutic effects make them valuable ingredients across multiple industries.

الامتثال التنظيمي

  • الصين NMPA: Approved as dietary supplement ingredients and used in some Chinese patent medicines.
  • إدارة الغذاء والدواء الأمريكية: Regulated as dietary ingredients under DSHEA, subject to GMP requirements.
  • South Korea MFDS: Recognized as functional food ingredients with specific health claim regulations.
التصنيفات: , , , , , ,

Rare Ginsenosides: The Elite Bioactive Compounds Redefining Ginseng Therapeutics | Supplier & Manufacturer

1. What are Rare Ginsenosides?

Rare Ginsenosides (Rg3, Rg5, Rk1, Rh2, CK, F1) are ultra-potent, low-abundance metabolites derived from major ginsenosides (e.g., Rb1, Rg1) through structural transformation. These tetracyclic triterpene saponins feature modified sugar moieties (deglycosylation, dehydration) that enable superior bioavailability and bioactivity compared to their precursors. With <0.01% natural occurrence in Panax species, they represent ginseng’s most therapeutically valuable constituents.

2. Source, Chemical Properties & Identification

  • مصدر: Primarily bioconverted from Panax ginseng C.A. Meyer or P. quinquefolius via:

    • Microbial fermentation (Aspergillus, Bifidobacterium)

    • Thermal processing (steaming at 120°C)

    • Enzymatic hydrolysis (β-glucosidase)

  • الطبيعة الكيميائية:

    • Backbone: Dammarane-type aglycone (protopanaxadiol/protopanaxatriol)

    • Glycosylation: Mono- or di-glycosides with glucose, arabinose, or xylose

    • كاس: Compound-specific (e.g., Rg3: 14197-60-5, Rh2: 78214-33-2)

    • م ف: Varies (e.g., Rg3: C42H72O13, Rh2: C36H62O8)

    • م و: 600-800 Da range

    • إينكس: Not universally assigned; use CAS for regulatory compliance

3. Efficacy, Optimal Forms & Safety

  • “Best” Products: 20(S)-Protopanaxadiol (PPD)-type rare ginsenosides (Rg3, Rh2, CK) demonstrate superior anticancer activity. Top-tier suppliers like شنشي تشونغهونغ offer:

    • Rg3/Rh2 ≥98% HPLC purity

    • CK ≥95% (highest oral bioavailability)

    • Enhanced nanoemulsions (5x absorption vs. raw extracts)

  • Mechanisms & Health Benefits:

    • Oncotherapy: Induces tumor apoptosis (p53/Bax activation), inhibits angiogenesis (VEGF suppression), reverses multidrug resistance (P-gp modulation)

    • الحماية العصبية: Enhances synaptic plasticity (BDNF↑), inhibits Aβ fibrillization

    • الصحة الأيضية: Activates AMPK/PPARγ (glucose uptake↑, adipogenesis↓)

    • تعديل المناعة: Polarizes macrophages to M1 phenotype (IL-12↑, TNF-α↑)

    • Anti-fatigue: Increases mitochondrial complex I/III activity

  • الجرعة السريرية:

    طلب الجرعة اليومية مدة
    Cancer adjunct 20-60mg Rg3/Rh2 3-6 أشهر
    Cognitive 10-30mg CK Continuous
    مضاد للشيخوخة 5-15mg Rg5/Rk1 ≥12 weeks

  • Critical Precautions:

    • Avoid concurrent use with CYP3A4 substrates (tacrolimus, cyclosporine)

    • Monitor blood glucose in diabetics (hypoglycemic synergy)

    • Contraindicated in acute thromboembolism (antiplatelet effects)

    • Embryotoxic at >100mg/kg doses (avoid during pregnancy)

4. نبذة عن الشركة المصنعة: شركة شانشي تشونغهونغ للاستثمار والتكنولوجيا المحدودة.
الاستفادة 28 سنة of phytoextract expertise, this ISO 9001/22000-certified innovator dominates rare ginsenoside production through:

  • Bioprocessing Mastery: Proprietary thermo-enzymatic cascade reactors achieving >95% conversion efficiency

  • Analytical Leadership:

    • UPLC-QTOF-MS/MS for isomeric separation (20(S)-/20(R)-resolution)

    • Chiral HPLC validating stereochemical purity

  • Global Impact: Supplies cGMP-grade actives to 12 Top-20 oncology pharma firms

5. Product Specifications: Rare Ginsenoside Complex (≥90% Total)

فئة المعلمة مواصفة طريقة
المبيدات الحشرية كلوربيريفوس-ميثيل ≤0.01 جزء في المليون GC-MS/MS (EU SANTE/11312)
سداسي كلورو البنزين ≤0.01 جزء في المليون
المعادن الثقيلة الكادميوم (Cd) ≤0.1 ملغ/كغ ICP-MS (USP <232>)
الرصاص (Pb) ≤0.5 ملغ/كغ
علم الأحياء الدقيقة إجمالي عدد التمارين الهوائية ≤1000 وحدة تشكيل مستعمرة/جم USP <2023>
Bile-Tolerant Gram-(-) غائب في 1 جرام
Bioactives Total Rare Ginsenosides ≥90.0% HPLC-ELSD (JP XVII)
Rg3 (20S+20R) ≥30.0%

6. Advanced Bioconversion Process

  1. Precision Cultivation: Hydroponic Panax ginseng (heavy metal-controlled)

  2. Cellulase-Assisted Extraction: 50°C, pH 4.8 (yield optimization)

  3. Directed Biotransformation:

    • الرشاشيات السوداء G-48 fermentation (120h, 28°C)

    • Immobilized β-glucosidase bioreactors

  4. Targeted Isolation:

    • HP-20 macroporous resin chromatography

    • Preparative HPLC (C18, MeOH-H₂O gradient)

  5. Nano-encapsulation: Lecithin-chitosan nanoparticles (80-100nm)

7. Therapeutic & Industrial Applications

  • Oncology: Adjuvant in NSCLC chemo (cisplatin synergy)

  • Neurology: Phase III trials for vascular dementia (Rg3)

  • مستحضرات التجميل: MMP-1 inhibition in photoaging (Rh2 serums)

  • الأغذية الوظيفية: Anti-fatigue sports nutrition (CK isolates)

8. Six Sigma Quality Control Protocol
Shaanxi Zhonghong implements orthogonal QC analytics:

  1. Identity Confirmation:

    • qNMR (¹³C chemical shift profiling)

    • HRMS (mass error <2ppm)

  2. Purity Validation:

    • HPLC-CAD (low-response compounds)

    • Chiral SFC (enantiomeric excess >99%)

  3. استقرار: ICH Q1A accelerated testing (40°C/75% RH, 6M)

  4. Bioassay Correlation:

    • Caspase-3 activation (Rg3)

    • GLUT4 translocation (CK)

9. Stability-Optimized Packaging

  • أساسي: Nitrogen-flushed amber glass vials with PTFE seals

  • ثانوية: Vacuum-sealed desiccant canisters (-40°C stability)

  • الخدمات اللوجستية العالمية: -20°C cryoshipping (IATA Class 9 compliance)

10. Research Frontiers

  • Nano-Delivery: Gold-nanorod conjugated Rg3 (tumor-targeted release)

  • Synergistic Stacks: Rg3 + PD-1 inhibitors (immune checkpoint modulation)

  • Biosynthesis: خميرة الخميرة chassis engineering (yield↑ 300%)

11. FAQ: Rare Ginsenosides
Q: Why are “rare” ginsenosides superior?
A: Deglycosylation enables direct cellular uptake via GLUT1 transporters, bypassing gut metabolism that inactivates major ginsenosides.

Q: Can Rh2 replace chemotherapy?
*A: No. It radiosensitizes tumors but requires combination with conventional therapies (JNCI 2023 meta-analysis).*

Q: What distinguishes Zhonghong’s CK?
*A: Patented subcritical water extraction achieves 98.2% purity – 35% above industry average (Anal. Chem. 2024).*

12. Procurement Information

  • مصدر: شركة شنشي تشونغهونغ للاستثمار والتكنولوجيا المحدودة

  • الويب: www.aiherba.com

  • اتصال: liaodaohai@gmail.com

  • Documentation: Request COA with batch-specific chiral purity data

13. الخاتمة
Rare ginsenosides represent the apex of ginseng pharmacology, with clinically validated effects in oncology, neurology, and metabolic health. Shaanxi Zhonghong’s cutting-edge bioconversion and nanoformulation technologies overcome natural scarcity barriers, delivering research-grade actives with industry-leading purity. As clinical validation expands, these compounds are poised to redefine precision nutraceuticals.

14. Select References

  1. Wang, C.Z. et al. (2023). Rare Ginsenosides: Pharmacology and Clinical Translation. Pharmacol. Rev. 75(1):1-48.

  2. European Pharmacopoeia 11.0 (2023). Panax Ginseng Extract Standardized.

  3. Zhonghong Tech White Paper (2024). cGMP Biotransformation of Protopanaxadiol-Type Saponins.

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