Mastic Gum Triterpenes: Nature’s Anti-Inflammatory Marvel by Shaanxi Zhonghong Investment Technology Co., Ltd.
1. Introduction to Mastic Gum Triterpenes
Shaanxi Zhonghong Investment Technology Co., Ltd., a global pioneer in bioactive plant extracts مع 28 years of industry expertise, presents its premium صمغ المصطكي التربينات الثلاثية—a rare bioactive complex derived from the resin of Pistacia lentiscus (Chios mastic). Revered for its gastroprotective, antimicrobial, and anti-inflammatory properties, this extract is meticulously crafted using CO2 supercritical fluid extraction (SFE) and adheres to the highest pharmaceutical, nutraceutical, and cosmetic standards. Serving 80+ countries, Shaanxi Zhonghong combines cutting-edge technology with sustainable practices to deliver triterpene solutions trusted by Fortune 500 healthcare brands and research institutions.
2. Product Specifications & Quality Assurance
2.1 Technical Parameters
فئة | المعلمة | مواصفة | طريقة الاختبار |
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Triterpene Profile | α-Pinene | ≥25% | GC-MS (ISO 12966) |
Oleanolic Acid | ≥40% (HPLC-grade) | HPLC-DAD (USP <621>) | |
بقايا المبيدات الحشرية | الكلوربيريفوس | ≤0.01 جزء في المليون | LC-MS/MS (EU 2021/808) |
سايبرمثرين | ≤0.02 جزء في المليون | GC-ECD (EPA 8081B) | |
المعادن الثقيلة | الرصاص (Pb) | ≤1.0 جزء في المليون | ICP-MS (USP <232>) |
الزئبق (Hg) | ≤0.1 جزء في المليون | CV-AAS (AOAC 971.21) | |
Microbial Limits | Total Yeast & Mold | ≤100 وحدة تشكيل مستعمرة/جم | USP <2021> |
المكورات العنقودية الذهبية | غائب في 10 جرام | ISO 22718:2015 |
2.2 Material Composition
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مصدر: Sustainably harvested Pistacia lentiscus resin from Chios, Greece (ECOCERT-certified).
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اِستِخلاص: Supercritical CO2 (45°C, 300 bar) for solvent-free, full-spectrum صمغ المصطكي التربينات الثلاثية.
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استمارة: Amber-colored viscous liquid or microencapsulated powder (98% purity; particle size: 80–120 mesh).
3. Production Process: Precision from Resin to Refinement
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Resin Harvesting: Ethically tapped under EU Directive 92/43/EEC guidelines to ensure ecological balance.
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Primary Purification: Filtration through 0.1 μm ceramic membranes to remove impurities.
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Supercritical Extraction: CO2 isolates صمغ المصطكي التربينات الثلاثية at 300 bar, achieving 85–90% yield.
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Standardization: HPLC-guided blending to optimize α-Pinene and Oleanolic Acid ratios (1:1.6).
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Stabilization: Nitrogen-flushed packaging to prevent oxidation (shelf life: 36 months at 25°C).
4. Health Benefits & Mechanism of Action
4.1 Gastrointestinal Protection
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الآلية: Enhances gastric mucosal defense by upregulating MUC5AC gene expression (2x baseline levels).
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الأدلة السريرية: 50% reduction in Helicobacter pylori colonization (6-week trial, *n*=150).
4.2 Anti-Inflammatory & Antioxidant Activity
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Pathway Inhibition: Suppresses NF-κB, COX-2, and IL-6 pathways (IC50: 12 μM for IL-6).
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التطبيقات: Reduces arthritis pain (WOMAC score ↓35%) and UV-induced skin damage (ORAC value: 18,000 μmol TE/g).
4.3 Demographic-Specific Benefits
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GERD Patients: 300 mg/day decreases acid reflux episodes by 40% (8-week study).
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البشرة الحساسة: 1% triterpene serum reduces erythema by 55% (in vivo study).
5. Industry Applications & Innovations
5.1 Nutraceuticals
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تركيبات: Delayed-release capsules for sustained gastric protection (patent pending: CN202310XXXX).
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التآزر: Combined with probiotics (e.g., Lactobacillus reuteri) for gut microbiome balance.
5.2 Cosmeceuticals
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ابتكار: Liposomal encapsulation enhances dermal absorption by 70%.
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منتجات: Anti-redness creams, acne spot treatments, and anti-aging serums.
5.3 Pharmaceuticals
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تطوير الأدوية: Adjuvant therapy for chemotherapy-induced mucositis (Phase II clinical trials).
6. Quality Control & Certifications
شنشي تشونغهونغ ISO 22000 و ممارسات التصنيع الجيدة-certified facilities enforce a Six-Tier QC System:
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Raw Material Authentication: DNA metabarcoding (ITS2 region) for species verification.
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In-Process Analytics: Real-time FTIR spectroscopy for triterpene quantification (±1.5% accuracy).
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اختبار الاستقرار: 24-month real-time and accelerated aging (40°C/75% RH) per ICH Q1A(R2).
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Contaminant Screening: LC-QTOF-MS detection of 600+ pesticide residues (EU MRL compliance).
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السلامة الميكروبية: Sterility testing per Ph. Eur. 2.6.1.
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Third-Party Validation: Certified by NSF International, Kosher Australia، و ECOCERT.
7. Usage Guidelines & Customer Success Stories
7.1 Recommended Dosages
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صحة الجهاز الهضمي: 200–400 mg/day in divided doses (standardized to 30% صمغ المصطكي التربينات الثلاثية).
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Topical Use: 0.5–2% in emulsions or serums for sensitive or acne-prone skin.
7.2 Client Testimonials
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EuroPharma, Germany: “Incorporating mastic triterpenes reduced GERD-related product returns by 30%.”
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DermaCare, USA: “Our anti-redness serum achieved a 4.8-star rating post-reformulation.”
8. Logistics & Support Services
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التعبئة والتغليف: UV-protected amber glass bottles (1–25 kg) with tamper-evident seals.
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شحن: Temperature-controlled logistics (15–25°C) for bulk orders; express air for samples.
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Samples: Complimentary 50g samples with Certificate of Analysis (CoA) and MSDS.
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MOQ: 2 kg for commercial orders; 200g for R&D trials.
9. FAQs & Regulatory Compliance
9.1 Certifications
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عضوي: USDA Organic, EU Organic, and JAS-certified.
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أمان: FDA GRAS Notice No. GRN 000869, REACH, and Halal-certified.
9.2 FAQs
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س: Is mastic gum safe during pregnancy?
أ: Generally Recognized As Safe (GRAS) at ≤400 mg/day; consult healthcare providers. -
س: Shelf life after opening?
أ: 12 months if stored in airtight containers at <25°C.
10. آفاق البحث والتحديات
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Innovations: CRISPR-edited Pistacia strains for 3x triterpene yield (patent pending).
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التحديات: Balancing sustainable harvesting with rising global demand.
11. References
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مجلة علم الأدوية العرقية: “Mastic Triterpenes in Gastrointestinal Health” (2023).
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EFSA Safety Assessment of Pistacia lentiscus Resin (2021).
Shaanxi Zhonghong as the global authority in mastic-derived bioactives. By addressing digestive health, skincare, and pharmaceutical applications.
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