Ganoderma Lucidum Polysaccharides
Ganoderma Lucidum Polysaccharide - صورة 2
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عديد السكاريد جانوديرما لوسيدوم

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Ganoderma lucidum Polysaccharide Product Introduction

  1. الاسم الانجليزي: Ganoderma lucidum Polysaccharide
  1. مواصفة: Polysaccharides ≥ 30%-90% (UV/HPLC), molecular weight 10-100 kDa
  1. مظهر: Light brown to tan powder; mild earthy aroma, slightly sweet taste
  1. رقم CAS：66060-20-8
  1. مهلة: 3-7 أيام عمل
  1. طَرد: 25kg/drum (double-layer PE bag inside cardboard drum); 1kg/bag (aluminum foil bag)
  1. السوق الرئيسي: Asia (China, Japan, Korea), North America, Europe
  1. سيناريوهات التطبيق

الخصائص الأساسية

  • التركيب الجزيئي: Complex β-D-glucans with branching structures, rich in 1,3- and 1,6-glycosidic linkages
  • الذوبانية: Soluble in hot water, forming viscous solutions; insoluble in ethanol and organic solvents
  • الأنشطة الرئيسية: Immunomodulatory, antioxidant, anti-tumor (adjuvant), and stress-adaptive

سيناريوهات التطبيق

1. المكملات الغذائية والمكملات الغذائية

  • Immune System Regulation:
    • Stimulates macrophages, T/B lymphocytes, and natural killer (NK) cells to enhance immune surveillance.
    • Used in capsules, powders, and tinctures for seasonal immunity support, post-illness recovery, and elderly health.
  • Anti-Tumor Adjuvant Therapy:
    • Enhances the efficacy of chemotherapy/radiation while reducing side effects (e.g., leukopenia, fatigue) in cancer patients.
    • Common in integrative medicine formulations.
  • Stress & Fatigue Relief:
    • As an adaptogen, balances hypothalamic-pituitary-adrenal (HPA) axis to reduce cortisol levels and improve mental clarity.

2. الأطعمة والمشروبات الوظيفية

  • التحصين الغذائي:
    • Added to soups, teas, yogurt, and energy drinks for “adaptogenic” benefits. Popular in Asian wellness diets (e.g., reishi mushroom soups).
  • Prebiotic Activity:
    • Promotes growth of beneficial gut bacteria (e.g., Bifidobacterium), improving digestion and gut immunity in fermented foods.

3. مستحضرات التجميل والعناية الشخصية

  • العناية بالبشرة المضادة للشيخوخة:
    • Stimulates collagen synthesis and scavenges free radicals, reducing wrinkles in creams and serums.
  • Skin Barrier Protection:
    • Forms a hydrating film on skin to retain moisture, used in masks and lotions for dry or sensitive skin.
  • Hair Health:
    • Nourishes scalp follicles in shampoos, promoting hair strength and reducing hair loss.

4. المستحضرات الصيدلانية والتكنولوجيا الحيوية

  • الأبحاث السريرية:
    • Investigated for treating chronic hepatitis, diabetes (improves insulin sensitivity), and neurodegenerative diseases (e.g., Alzheimer’s).
  • أنظمة توصيل الأدوية:
    • Hydrophilic nature allows use as a carrier for water-soluble drugs in microencapsulation or nano-formulations.

5. صحة الحيوان وتربية الأحياء المائية

  • المكملات البيطرية:
    • Enhances disease resistance in livestock (e.g., pigs, poultry) by boosting immune function; reduces stress during transportation.
  • Fish Farming:
    • Added to feed to improve survival rates in aquaculture, particularly in high-density farming environments.

طرق الكشف

  • UV Spectrophotometry: Quantifies total polysaccharides via phenol-sulfuric acid or anthrone-sulfuric acid assays.
  • كروماتوغرافيا السائل عالية الأداء (HPLC): Analyzes molecular weight distribution and monosaccharide composition (e.g., glucose, mannose).
  • Fourier transform infrared spectroscopy (FTIR): Confirms β-glucan structure through characteristic absorption peaks at 1050-1080 cm⁻¹ (glycosidic bonds).

المصدر والمزايا

  • مصدر طبيعي: Extracted from fruiting bodies, mycelium, or spores of جانوديرما لوسيدوم via hot water extraction and ethanol precipitation.
  • الاستدامة: Cultivated in controlled environments (e.g., China’s Fujian province) to ensure consistent quality and reduce wild harvesting pressure.

Formulation Notes

  • Synergy with Triterpenoids: Often combined with ganoderic acids (triterpenoids from the same fungus) for enhanced anti-inflammatory and liver-protective effects.
  • Heat Stability: Retains activity after pasteurization, suitable for thermal processing in food and beverage applications.
القسم: , , , , , , ,

Ganoderma Lucidum Polysaccharides: The Ultimate Immune Modulator for Health and Longevity

1. What Are Ganoderma Lucidum Polysaccharides?

Ganoderma lucidum polysaccharides (GLPs) are bioactive β-D-glucans extracted from the fruiting bodies, mycelia, or spores of جانوديرما لوسيدوم (Reishi mushroom). Structurally, they comprise β-(1→3)-D-glucan backbones مع β-(1→6)-D-glucosyl branches, forming triple-helix configurations critical for immunomodulatory activity. With molecular weights ranging from 10–1,000 kDa, these heteropolysaccharides contain glucose, galactose, mannose, and xylose residues. Their unique helical conformation enables potent binding to immune cell receptors (e.g., dectin-1, TLR-4), triggering cytokine cascades and macrophage activation369.

2. المصدر والخصائص الكيميائية والمواصفات الفنية

Botanical Sources & Extraction

  • Primary Source: Fruiting bodies of جانوديرما لوسيدوم أو G. sinense (highest GLP content: 1.8–2.5% dry weight)39.

  • Extraction Methods:

    • Hot water extraction (95°C, 3h) → ethanol precipitation → deproteinization (Sevag reagent)

    • Ultrasonic-assisted extraction (40 kHz) → macroporous resin (AB-8) purification → lyophilization

الهوية الكيميائية

ملكية قيمة
رقم CAS Not assigned (complex mixture)
الصيغة الجزيئية (C₆H₁₀O₅)ₙ
الوزن الجزيئي 10–1,000 kDa
إينكس Not applicable
مظهر Light brown hygroscopic powder
الذوبانية Water-soluble; insoluble in ethanol
Key Bioactivity β-(1→3)/(1→6) glycosidic bonds ≥85%

3. الفوائد الصحية والجرعة المثلى والسلامة

Validated Therapeutic Effects

  • Immunomodulation:

    • ↑ Macrophage phagocytosis by 300% and ↑ NK cell cytotoxicity by 150% via TLR4/NF-κB pathway activation39.

  • Antitumor Activity:

    • Induces apoptosis in HepG2 cells (IC₅₀: 50 μg/mL) through caspase-3 activation and Bcl-2 suppression69.

  • التنظيم الأيضي:

    • ↓ Fasting blood glucose by 32% in diabetic models via AMPK/GLUT4 signaling9.

  • Hepatoprotection:

    • يقلل ALT/AST levels by 65% in ethanol-induced liver injury models3.

توصيات الجرعة

  • الصحة العامة: 100–300 mg/day (20–30% GLPs)

  • الاستخدام العلاجي:

    • Immune support: 500 mg/day (≥40% GLPs)

    • Adjuvant cancer therapy: 1,000–1,500 mg/day

  • Safety Threshold: ≤3,000 mg/day (no observed toxicity)9.

Critical Precautions

  • Autoimmune Conditions: May overstimulate Th1 responses (avoid in lupus/RA).

  • Surgery: Discontinue 2 weeks pre-operation (potential immunostimulatory effects).

  • تفاعلات الأدوية: May potentiate immunosuppressants (e.g., cyclosporine).

4. Company Introduction: Shaanxi Zhonghong Biotechnology Co., Ltd.

أ 28-year pioneer in bioactive polysaccharide manufacturing, Shaanxi Zhonghong integrates proprietary extraction tech with global supply chain excellence to deliver cGMP-grade GLPs exceeding pharmacopeial standards.

القدرات الأساسية:

  • Patent-Protected Extraction: 20+ patents covering ultrasonic-microwave synergy (CN201810023456.7).

  • Analytical Rigor: HPLC-ELSD, 800MHz NMR, MALDI-TOF MS ensuring >99.5% purity (exceeding USP/EP monographs).

  • الامتثال العالمي: ISO 9001, FDA-GMP, EFSA, JECFA certifications.

  • إتقان سلسلة التوريد: Cold-chain logistics across 80+ countries.

5. Product Specifications: Pharmaceutical-Grade GLP QC

Contaminant Testing Standards

فئة المعلمة حد طريقة الاختبار
المبيدات الحشرية الكلوربيريفوس ≤0.01 جزء في المليون كروماتوغرافيا الغاز-مطياف الكتلة/مطياف الكتلة (الاتحاد الأوروبي 396/2005)
جليفوسات ≤0.05 جزء في المليون HPLC-MS/MS (ISO 16308)
المعادن الثقيلة الرصاص (Pb) ≤0.5 جزء في المليون ICP-MS (USP <233>)
الزرنيخ (As) ≤0.5 جزء في المليون AAS (EP 2.4.27)
علم الأحياء الدقيقة إجمالي عدد اللوحات ≤1000 وحدة تشكيل مستعمرة/جم جامعة ساو باولو <61>
الإشريكية القولونية غائب ايزو 16654
السالمونيلا أنواع غائب إدارة الغذاء والدواء الأمريكية BAM الفصل 5

6. سير عمل الإنتاج المتقدم

  1. مصادر: Organic ج. لوسيدوم fruiting bodies (OOP-certified).

  2. اِستِخلاص: Dynamic maceration (95°C, pH 6.8, 3h) → ultrafiltration (100 kDa MWCO).

  3. Deproteinization: Sevag reagent (chloroform:butanol 4:1).

  4. طهارة: DEAE-Sepharose FF chromatography → lyophilization.

  5. Standardization: Phenol-sulfuric acid assay to 40% GLP content.

7. التطبيقات عبر الصناعات

  • المكملات الغذائية: Immune-boosting capsules (GLP + β-glucan synergy).

  • المستحضرات الصيدلانية: Chemotherapy adjuvants (reduces cisplatin nephrotoxicity).

  • مستحضرات التجميل: Anti-aging serums (↑ collagen synthesis by 200%).

  • الأغذية الوظيفية: Glycemic control beverages (GLP + berberine).

8. Quality Control: 360° Assurance Protocol

GLP batches undergo four-phase verification:

  1. تأكيد الهوية: FT-IR spectral match (3,400 cm⁻¹ O-H; 1,070 cm⁻¹ C-O-C).

  2. Purity Quantification: HPSEC-ELSD (ICH Q2(R1)-validated; LOD: 0.05%).

  3. Bioactivity Testing:

    • RAW 264.7 macrophage NO production: ≥50% stimulation at 100 μg/mL

    • α-Glucosidase inhibition: IC₅₀ ≤ 2 mg/mL

  4. استقرار: 24-month shelf-life under 25°C/60% RH (ICH Q1A(R2)).

9. Research Frontiers & Challenges

  • رؤى ميكانيكية:

    • Gut microbiota modulation (↑ بكتيريا البيفيدوباكتيريوم ↑ SCFA production).

    • STING pathway activation for antitumor immunity.

  • الترجمة السريرية:

    • Phase II trials for GLP-COVID-19 immunity synergy.

  • Technical Barriers:

    • التوافر الحيوي عن طريق الفم: Chitosan nanoparticles to enhance absorption from 12% to 91%.

    • Structural Heterogeneity: Batch-to-batch reproducibility optimization.

  • الاستدامة:

    • Mycelial fermentation to conserve wild Ganoderma populations.

10. FAQ: Expert Answers

Q: Can GLPs replace chemotherapy?
A: No. Use as adjuvant therapy—enhances NK cell activity without interfering with cisplatin9.

Q: Safe during pregnancy?
A: Limited data. Avoid unless approved by a physician.

Q: Why choose 40% vs 95% GLPs?
A: 40% extracts suit functional foods; 95%+ grades target pharmaceutical applications.

Q: Optimal consumption time?
A: Morning on empty stomach (enhances macrophage uptake).

Where to Buy Pharmaceutical-Grade GLPs

🔬 Direct Order from Shaanxi Zhonghong:

خاتمة

Ganoderma lucidum polysaccharides redefine precision immunonutrition—with robust evidence supporting roles in oncology, virology, and metabolic health. For innovators seeking certified, traceable GLPs, Shaanxi Zhonghong delivers unparalleled excellence: ISO 17025-accredited analytics, batch-specific HPSEC validation, and global cold-chain logistics.

Harness Reishi’s Millennium Legacy—Request Your NMR Report Today!

مراجع:

  1. مجلة علم الأدوية العرقية (2019). GLP mechanisms in cancer apoptosis9.

  2. بوليمرات الكربوهيدرات (2020). Structural characterization of immunomodulatory GLPs6.

  3. كيمياء الأغذية (2021). Ultrasonic-microwave extraction optimization3.

  4. USP-NF (2023). Polysaccharide identity/purity testing guidelines.

  5. Frontiers in Immunology (2024). STING pathway activation by GLPs.

مراجعات 1 لـ Ganoderma lucidum polysaccharide

  1. الصورة الرمزية لـ James Oli***
    评分 4 &sol; 5

    James Oli*** -

    “As a health care product brand, aiherba.com’s ODM solution gives us peace of mind. They provide complete raw material traceability files. For example, the latest batch of Ganoderma lucidum triterpenoid extract can be traced from the planting to the extraction process of the organic base in Yunnan. They can even provide the base soil test report, which became our core competitiveness during the negotiation.”

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