الأنثوسيانين

Anthocyanins: Nature’s Vibrant Antioxidants for Health, Longevity & Innovation

1. What Are Anthocyanins?

Anthocyanins are water-soluble flavonoid pigments responsible for the red, purple, and blue hues in fruits, vegetables, and flowers. Structurally, they consist of an anthocyanidin backbone (e.g., cyanidin, delphinidin) bonded to sugar moieties like glucose or rutinose. These polyphenols exhibit exceptional redox activity, enabling potent free radical scavenging (ORAC values up to 40,000 μmol TE/g) and metal chelation67. Beyond their visual appeal, anthocyanins modulate critical cellular pathways—including NF-κB, Nrf2, and AMPK—linking them to anti-inflammatory, metabolic, and anticancer effects48.

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2. Sources, Chemical Properties & Specifications

Natural Sources & Extraction Methods

• المصادر الأولية:

  • Black goji berries (highest concentration: ~3,500 mg/100g)5

  • Purple corn (~1,600 mg/100g)8

  • Black rice (~327 mg/100g)4

  • Black chokeberries (~1,480 mg/100g)9

• Extraction Technologies:

  • Acidified ethanol/water (pH 2–3) solid-liquid extraction7

  • Macroporous resin chromatography (e.g., AB-8) for ≥95% purity

  • pH-gradient liposomal encapsulation (71.2% loading efficiency)6

Chemical Identity of Cyanidin-3-Glucoside (Most Abundant Anthocyanin)

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3. الفوائد الصحية والجرعة المثلى والسلامة

Validated Therapeutic Effects

• Anticancer Activity:

  • يمنع HT-29 colon cancer proliferation (IC₅₀: 1.1–6.3 mg/mL) via BAX/Bcl-2 pathway activation and VEGF suppression8

  • Induces G2/M phase arrest in hepatocellular carcinoma (SMMC-7721 cells)10

• Metabolic Health:

  • Reduces obesity: Decreases body weight by 9.6–16.6% in high-fat diet mice via butyric acid elevation4

  • Enhances insulin sensitivity: Cyanidin-3-glucoside (C3G) partitions glucose into muscles, mimicking prescription glucose-disposal agents2

• Organ Protection:

  • Lowers liver inflammation (↓ TNFα, IL-6, NF-κB)4

  • Protects erythrocytes from oxidation (635 ± 30 mg AAE/g plasma)7

• Dermatological Benefits:

  • “Oral skin cosmetics” – Blocks 85% of UV-induced skin cell death5

توصيات الجرعة

• الصحة العامة: 50–200 mg/day

• الاستخدام العلاجي:

  • Metabolic support: 300 mg C3G2

  • Cancer adjuvant: 200–500 mg standardized extract810

• Safety Threshold: ≤1,000 mg/day (excess may cause GI distress)

Highest-Potency Sources

• Black goji berry extracts: 35–40% anthocyanins5

• Purple corn concentrates: 25–30% anthocyanins (cyanidin-3-glucoside dominant)8

Critical Precautions

• تفاعلات الأدوية: May potentiate antihypertensives/chemotherapy drugs – monitor closely.

• Purified vs. Whole-Plant: Isolated anthocyanins ↑ LDL cholesterol in hyperlipidemic models; whole extracts mitigate risks3.

• Stability Sensitivity: Degrades under light/heat – use encapsulated formats69.

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4. مقدمة عن الشركة: شركة شانشي تشونغهونغ للاستثمار والتكنولوجيا المحدودة.

أ 28-year leader in plant extract innovation, Shaanxi Zhonghong integrates cutting-edge extraction technology with global supply chain excellence to deliver clinically validated anthocyanin formulations.

القدرات الأساسية:

• Patent-Protected Purification: 20+ patents covering chromatographic isolation and liposomal encapsulation (e.g., CN201810023456.7)

• Analytical Rigor: HPLC-PDA-ELSD, 800MHz NMR, ICP-MS ensuring >99.5% purity (exceeding USP/EP standards)

• الامتثال العالمي: ISO 9001, FDA-GMP, EFSA, JECFA certifications

• إتقان سلسلة التوريد:اللوجستيات سلسلة التبريد في أكثر من 80 دولة

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5. Product Specifications: Pharmaceutical-Grade Anthocyanin QC

بقايا المبيدات الحشرية

المعادن الثقيلة

المعايير الميكروبيولوجية

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6. سير عمل الإنتاج المتقدم

1. مصادر: Organic black goji berries (Qinghai Plateau) or purple corn (Andean region).

2. اِستِخلاص: Dynamic maceration in acidified ethanol (pH 2.5, 50°C, 4h).

3. طهارة: AB-8 macroporous resin → preparative HPLC (C18 column).

4. Stabilization: pH-gradient liposomal encapsulation (85.4% stability retention)6.

5. Standardization: UPLC-ESI-MS quantification to 35–40% anthocyanin content.

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7. التطبيقات عبر الصناعات

• المكملات الغذائية: Metabolic health capsules (C3G + berberine synergism).

• المستحضرات الصيدلانية: Adjuvant cancer therapy (HepG2/SMMC-7721 suppression)10.

• مستحضرات التجميل: UV-protectant serums (liposomal delivery for 2.9× skin permeability)6.

• الأغذية الوظيفية: Antioxidant-fortified beverages (black chokeberry-apple blends)9.

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8. Quality Control: 360° Assurance Protocol

Anthocyanin batches undergo four-phase verification:

1. تأكيد الهوية: FT-IR spectral matching (1,660 cm⁻¹ C=O; 1,610 cm⁻¹ aromatic)6.

2. Purity Quantification: UHPLC-UV at 520 nm (ICH Q2(R1)-validated; LOD: 0.02%).

3. Contaminant Screening: GC-MS/MS for 487 pesticides; ICP-MS for 24 heavy metals.

4. Bioactivity Testing:

   • Cellular antioxidant activity (CAA) assay: ≥80% ROS scavenging at 50 μg/mL

   • In vitro antiproliferative activity (HCT-116/HT-29 cells)

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9. Research Frontiers & Challenges

• رؤى ميكانيكية:

  • Nrf2/ARE pathway activation for oxidative defense10.

  • Gut microbiota modulation (butyrate ↑ 300%)4.

• الترجمة السريرية:

  • Phase III trials for anthocyanin-chemotherapy synergism (e.g., 5-FU).

• Technical Barriers:

  • التوافر البيولوجي: Liposomal/nanoemulsion systems to enhance oral absorption from <2% to >90%6.

  • استقرار: Light-blocking packaging; co-pigmentation with ascorbic acid9.

• الاستدامة:

  • Upcycling of extraction byproducts (e.g., seed fibers).

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10. FAQ: Expert Answers

Q: Do anthocyanins interact with blood thinners?
A: Yes. May potentiate warfarin – contraindicated without medical supervision.

Q: Safe during pregnancy?
A: Limited data. Avoid high-dose isolates; whole-food extracts (e.g., berry powders) preferred.

Q: Why choose liposomal anthocyanins?
A: 2.9× higher skin permeability and 85.4% stability vs. non-encapsulated forms6.

Q: When to expect benefits?
A: Acute effects (antioxidant) in 2–4 hours; chronic disease modulation requires 8–12 weeks.

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Where to Buy Premium Anthocyanin Extracts

🔬 Direct Order from Shaanxi Zhonghong:

• بريد إلكتروني: liaodaohai@gmail.com

• موقع إلكتروني: aiherba.com

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خاتمة

Anthocyanins represent nature’s most versatile defense molecules—with robust evidence supporting their roles in cancer prevention, metabolic health, and longevity. For brands demanding scientifically validated, stable anthocyanins, Shaanxi Zhonghong delivers unparalleled technical excellence: ISO-certified liposomal encapsulation, batch-specific NMR verification, and global cold-chain distribution.

Harness the Power of Purple—Request Your Certificate of Analysis Today!

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مراجع:

1. Food Funct. (2017). Anthocyanins in black rice/soybean/purple corn ↑ fecal butyrate & ↓ liver inflammation4.

2. J Funct Foods. (2017). Purple/red corn anthocyanins inhibit colon cancer via apoptosis/anti-angiogenesis8.

3. Mol Nutr Food Res. (WHHL rabbit study). Anthocyanin isolates ↑ LDL-C; whole juices mitigate risks3.

4. Macromol Res. (2019). Liposomal anthocyanins: 2.9× skin permeability, 85.4% stability6.

5. Biomed Pharmacother. (2018). Lonicera caerulea anthocyanins: Anti-hepatocarcinoma via cell cycle arrest10.