መጠጥ መጨመር, ኮስሜቲክስ እና የግል እንክብካቤ, የምግብ ተጨማሪዎች, የተፈጥሮ እፅዋት ማከሚያዎች

ትሬሃሎዝ

እንግሊዝኛ ስምትሬሃሎዝ

ዝርዝር መግለጫ

- ንጽህና: ≥ 99% (HPLC)

- መሟሟት: ከፍተኛ በውሃ ውስጥ የሚሟሟ (68.9 ግ / 100 ሚሊ በ 25 ° ሴ) ፣ በጭንቅ soluble in ethanol, insoluble in most organic solvents

- መልክ – የተያያዘ: Loss on drying ≤ 0.5%, Heavy metals ≤ 5 ppm, Residual solvents ≤ 0.2%

- ማቅለጥ ደረጃ: 210 – 218°C (decomposes)

መልክ

- White crystalline powder or colorless crystals, odorless, with a ከረሜላ ዘይቤ (about 45% as ከረሜላ as sucrose), not የተያያዘ to chocolate in ቀለም ወይም መዓዛ

CAS ቁጥር：6138 – 23 – 4

የመምራት ጊዜ: 3-7 የስራ ቀናት

የጥቅል ስምምነት

- 25 kg/drum (polyethylene bag inside cardboard drum), 1000 kg/bulk bag

Predominant ገበያ

- አለም ገበያ, ጋር አስፈላጊ demand in North America, Europe, Asia, በዋናነት ጥቅም ላይ የዋለ ውስጥ ምግቦች and beverage, cosmetics, በሐኪም የታዘዙ መድሃኒቶች, agriculture, and biotechnology industries

መገልገያ ውሎ አድሮ

ዋና ባህሪያት

ኬሚካል ግንባታ: A non – ዝቅ ማድረግ disaccharide composed of two glucose እቃዎች joined by an α,α – 1,1 – glucosidic bond. Its የተለየ ግንባታ endows it with glorious stability and ጥበቃ ማድረግ ንብረቶች.

ቁልፍ አማራጮች

- Thermostability and Chemical Stability: Immune to ከመጠን በላይ temperatures, acids, and alkalis, ማቆየት የእሱ ግንባታ and properties በታች harsh ሁኔታዎች. ይህ ያደርገዋል ተገቢ ነው። ለ የተለያዩ processing environments.

- እርጥበት ማቆየት: Can strongly bind water molecules, በተሳካ ሁኔታ ማቆም ሸቀጣ ሸቀጦች from drying out and ማቆየት moisture የይዘት ቁሳቁስ, የሚረዳው ማራዘም the shelf የህይወት ዘመን ሸቀጣ ሸቀጦች.

- Cell and Protein ደህንነት: Stabilizes cell membranes and proteins, መከላከል them from denaturation and ጉዳት አመጣው ንጥረ ነገሮች ጋር ሊወዳደር ይችላል። dehydration, warmth, and freezing. This property is አስፈላጊ በብዙ ኦርጋኒክ and industrial ዓላማዎች.

- Antioxidant – like ተጽዕኖ: Not directly reduces oxidative stress by መከላከል cells and biomolecules, contributing to the general stability and ከፍተኛ ጥራት የ ሸቀጣ ሸቀጦች.

መገልገያ ውሎ አድሮ

1. ምግቦች እና መጠጥ ንግድ

Preservative and Shelf – Life Extender

- Added to baked እቃዎች like bread, muffins, and pastries (0.5 – 2% ትኩረት) ለመከላከል መቆንጠጥ፣ መጠበቅ moisture, and ማራዘም the shelf life. ለምሳሌ, in frozen bread, trehalose helps maintain the feel comfortable እና recent በመላው ረጅም – የጊዜ ወቅት storage.

- ውስጥ ጥቅም ላይ ውሏል የወተት ተዋጽኦዎች ሸቀጣ ሸቀጦች ጋር ሊወዳደር ይችላል። yogurt and ice cream ለማሻሻል texture, ተወ ice crystal formation, and ማሻሻል ቅመሱ መረጋጋት.

Taste Enhancer and Sweetener

- እንደ a gentle sweetener, it may be used alone or blended with የተለየ sweeteners in መጠጦች, confectionery, and jams to regulate sweetness and ማሻሻል አጠቃላይ ቅመሱ. Its low – glycemic index በተጨማሪ makes it engaging for sugar – free or low – calorie product formulations.

Freeze – Drying መርዳት

- ውስጥ ማምረት of freeze – dried ምግቦች (ጋር ሊወዳደር ይችላል። ፍራፍሬዎች, አረንጓዴዎች, እና prompt ኤስፕሬሶ), trehalose protects the ግንባታ እና ቅመሱ of the ንጥረ ነገሮች through the drying ኮርስ የ, ዋስትና መስጠት ከመጠን በላይ – ከፍተኛ ጥራት rehydration.

2. መዋቢያዎች እና የግል እንክብካቤ

Moisturizer and ቀዳዳዎች እና ቆዳ Protectant

- ታክሏል። lotions, lotions, and serums (1 – 5% ትኩረት) to retain ቀዳዳዎች እና ቆዳ moisture, ተወ dryness, and መከላከል የ ቀዳዳዎች እና ቆዳ from environmental stressors. It helps መጠበቅ the integrity of the ቀዳዳዎች እና ቆዳ barrier and improves ቀዳዳዎች እና ቆዳ texture.

Stabilizer for ሕያው አካላት

- ይጠብቃል። the steadiness የ ስስ ንጥረ ነገሮች እንደ የአመጋገብ ቫይታሚኖች, enzymes, and plant extracts in cosmetics, ማቆም their degradation and ዋስትና መስጠት product efficacy over time.

3. ፋርማሲዩቲካል ንግድ

Drug Excipient

- Used as an excipient in tablets, capsules, and injectable formulations ለማሻሻል the steadiness of medicine, በተለይ for warmth – ስስ or moisture – ስስ መድሃኒቶች. It might መከላከል የ ጉልበት ያለው ፋርማሲዩቲካል ንጥረ ነገሮች በመላው storage and ማሻሻል drug አቅርቦት.

Freeze – Drying of Biopharmaceuticals

- ውስጥ ማምረት of biopharmaceuticals ጋር ሊወዳደር ይችላል። vaccines, antibodies, and enzymes, trehalose stabilizes the ኦርጋኒክ የአካል ብቃት እንቅስቃሴ ማድረግ ከእነዚህ ውስጥ ሸቀጣ ሸቀጦች በመላው freeze – drying and ረጅም – የጊዜ ወቅት storage, ዋስትና መስጠት their effectiveness.

4. Agriculture and Biotechnology

Plant Stress Resistance

- ጥቅም ላይ ውሏል to crops as a foliar spray or soil መድሃኒት ለማሳደግ plant tolerance to abiotic stresses ጋር ሊወዳደር ይችላል። drought, warmth, እና ቀዝቃዛ. Trehalose helps መከላከል plant cells and መጠበቅ ፊዚዮሎጂያዊ ባህሪያት በታች worrying ሁኔታዎች, ማሻሻል crop yield and ከፍተኛ ጥራት.

Microorganism Preservation

- Used ውስጥ preservation of microorganisms (ጋር ሊወዳደር ይችላል። probiotics, yeast, and ረቂቅ ተሕዋስያን) for industrial fermentation processes. It protects the viability ከእነዚህ ውስጥ microorganisms በመላው storage and transportation, ዋስትና መስጠት የማያቋርጥ ቅልጥፍና ውስጥ ዓላማዎች እንደ ምግቦች fermentation and biofuel ማምረት.

ማወቂያ ስልቶች

ከመጠን በላይ – ቅልጥፍና ፈሳሽ ክሮማቶግራፊ (HPLC)

- Column: Sugar – በተለይ column (e.g., Aminex HPX – 87H), ሴሉላር ክፍል- 5 ሚሜ ሰልፈሪክ አሲድ; እንቅስቃሴ ክስ: 0.6 mL/min, Detection Wavelength: Refractive index detector. This ቴክኒክ በትክክል quantifies trehalose የይዘት ቁሳቁስ ውስጥ የተለያዩ samples.

Enzymatic Assay

- ይጠቀማል በተለይ enzymes (ጋር ሊወዳደር ይችላል። trehalase) ለማቋረጥ down trehalose into glucose, which may then be measured colorimetrically or በ መንገድ የተለየ analytical ዘዴዎች. ይህ ቴክኒክ ነው። ተገቢ ነው። ለ ፈጣን እና ቀላል detection, በተለይ ውስጥ ምግቦች ከፍተኛ ጥራት አስተዳደር.

ቀጭን - ንብርብር ክሮማቶግራፊ (TLC)

- A preliminary screening ቴክኒክ ለ ማወቅ trehalose in samples. It separates trehalose from የተለየ sugars በአብዛኛው የተመሰረተ on their ፍጹም የተለየ migration ክፍያዎች on a chromatographic plate, ማደጎ by visualization መጠቀም የሚተገበር reagents.

አቅርቦት & ጥቅሞች

ማምረት ስልቶች

- በዋናነት produced by fermentation መጠቀም genetically engineered microorganisms or enzymatic synthesis from starch – በአብዛኛው የተመሰረተ ያልበሰለ አቅርቦቶች. እነዚህ ስልቶች ዋስትና ከመጠን በላይ – yield and value – ውጤታማ ማምረት.

ሁለገብ ተግባራት

- የእሱ የተለየ properties make it relevant በመላው ቁጥር industries, ስብሰባ ብዙ ይፈልጋል from product preservation to ኦርጋኒክ ደህንነት፣ በማቅረብ ላይ አስፈላጊ ድርጅት አማራጮች.

ደንበኛ አስማት

- እንደ ሀ ንፁህ – occurring sugar, it’s በጥሩ ሁኔታ – obtained በ ደንበኞች, በተለይ ውስጥ ምግቦች and cosmetics industries, ቦታው there’s a መነሳት ምኞት ለ ግልጽ - መለያ እና ንፁህ ንጥረ ነገሮች.

የቁጥጥር ተቀባይነት

- አብዛኛውን ጊዜ እውቅና ሰጥቷል እንደ አስተማማኝ (GRAS) በብዙ ዓለም አቀፍ ቦታዎች እና አካባቢዎች, with clear laws ለአጠቃቀሙ in numerous industries, facilitating its widespread መገልገያ.

ምድቦች፡ መጠጥ መጨመር, ኮስሜቲክስ እና የግል እንክብካቤ, የምግብ ተጨማሪዎች, የተፈጥሮ እፅዋት ማከሚያዎች

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Trehalose: Nature’s Protective Sugar – Ultimate Guide by Zhonghong Tech

1. Trehalose ምንድን ነው?
Trehalose (α-D-glucopyranosyl α-D-glucopyranoside) is a naturally occurring, non-reducing disaccharide sugar composed of two glucose molecules. Renowned for its exceptional stabilizing properties, it acts as a bioprotectant for cells and biomolecules under stress conditions like dehydration, heat, and freezing. Its unique glycosidic bond (1,1-alpha linkage) confers high stability and low reactivity.

2. የምርት ምንጭ, ኬሚካዊ ባህሪያት እና መለያዎች

ምንጭ፡- Primarily derived through enzymatic hydrolysis of starch (from corn, tapioca, potatoes) using trehalose synthase. Also found naturally in mushrooms, honey, algae, and yeast.
ኬሚካላዊ ቀመር፡ C₁₂H₂ ኦ
CAS ቁጥር፡- 99-20-7
ሞለኪውላር ፎርሙላ (ኤምኤፍ)፡- C12H22O11
ሞለኪውላዊ ክብደት (MW): 342.30 ግ / ሞል
EINECS ቁጥር፡- 202-739-6
ቁልፍ ባህሪያት፡
- ነጭ ክሪስታል ዱቄት
- Mild sweet taste (~45% sweetness of sucrose)
- High glass transition temperature (Tg)
- Low hygroscopicity
- Excellent chemical & thermal stability
- Non-reducing sugar (Maillard reaction inert)
- High water retention capacity

3. What is the Best Trehalose? Key Considerations
The “best” trehalose prioritizes purity, origin, compliance, and intended application. Zhonghong Tech sets the benchmark:

ቁልፍ ንጥረ ነገር: High-Purity Anhydrous Trehalose (C12H22O11)
Primary Efficacy & Health Benefits (Compliant):
- Biostabilization: Protects proteins, enzymes, cells, and lipids from denaturation during drying, freezing, and heating (crucial for pharmaceuticals & diagnostics).
- Dental Health: Non-cariogenic – does not promote tooth decay (EFSA, FDA approved).
- የኃይል ምንጭ፡- Provides sustained glucose release (4 kcal/g) with a low glycemic index (~70% of glucose).
- Osmoprotection: Helps cells maintain integrity under osmotic stress.
- የቆዳ እርጥበት; Used in cosmetics for moisturizing and protecting skin barrier function.
- Shelf-life Extension: Stabilizes flavors, colors, textures, and biologics in food & pharma.
መነሻ፡- Globally sourced non-GMO starch (e.g., EU corn, Asian tapioca), processed in China under GMP.
አጠቃቀም፡ Food additive (baked goods, beverages, confectionery), Pharmaceutical excipient (lyophilization, biotherapeutics), Cosmetics (serums, creams), Research reagent. Typical incorporation: 1-10% w/w depending on application.
የዒላማ ታዳሚዎች፡- Food & Beverage Manufacturers, Cosmetic Formulators, Pharmaceutical Developers, Biotech Researchers, Nutraceutical Brands.
ዕለታዊ ቅበላ እና ደህንነት፡ Recognized as safe (GRAS by FDA, approved by EFSA, JECFA). No established ADI. Typical consumption is safe; high doses (>50g/day) may cause mild gastrointestinal discomfort in sensitive individuals.
ወሳኝ ጉዳዮች፡-
- ንጽህና፡ Essential for sensitive applications (e.g., diagnostics, injectables). Zhonghong guarantees >99.5%.
- Specification Compliance: Must meet relevant pharmacopoeia (USP/Ph.Eur/JP) or food grade standards.
- Residual Solvents/Enzymes: Rigorous control needed, especially for pharma.
- Allergens: Ensure processing avoids major allergens if required (e.g., gluten-free).
የጎንዮሽ ጉዳቶች: Extremely rare at typical usage levels. Potential for mild laxative effect only with very high acute intake.

4. Zhonghong Investment Technology Co., Ltd.: Pioneering Bioactive Compounds
Shaanxi Zhonghong Investment Technology Co., Ltd. is a premier high-tech enterprise integrating agile R&D, collaborative innovation, integrated manufacturing, and global marketing. For 28 years, we’ve specialized in the extraction, isolation, purification, and application of potent plant-derived compounds, serving the chemical, material science, and life science sectors.

ዋና ዕውቀት፡- Advanced extraction & purification of Natural Plant Extracts, Cosmetic Actives, Nutraceutical & Pharmaceutical Ingredients, Natural Pigments, and Plant-Based Sweeteners (like Trehalose).
ሳይንሳዊ ችሎታ (R&D እንቅፋቶች)፡-
- Strategic alliances with 5 elite universities via Joint Research Labs.
- Proprietary IP portfolio: 20+ patents in separation science and stabilization.
- Globally unique natural compound library for discovery.
የማምረት ብቃት፡-
- State-of-the-art analytics: U/HPLC, GC-MS, 600MHz Superconducting NMR, ICP-MS.
- Purity standards exceeding industry norms by 20%+.
- Strict adherence to cGMP, ISO 9001, ISO 22000 (food grade), and ICH Q7 (pharma grade) where applicable.
ዓለም አቀፍ ተደራሽነት Trusted supplier network spanning 80+ countries across Asia, Europe, and the Americas. Provides bespoke ingredient solutions to multinational pharmaceutical corporations, leading research institutions, and innovative FMCG brands.

5. Trehalose: Health Benefits & Applications

Health Benefits Mechanism:
- Cellular Stress Resistance: Mimics natural anhydrobiosis, stabilizing biomolecules by replacing water hydrogen bonds (“water replacement theory”) and forming vitrified matrices.
- Metabolic Pathway: Hydrolyzed slowly by trehalase enzyme in the small intestine, providing sustained glucose release.
- የራስ-ፋጂ ማስተካከያ; Emerging research suggests potential roles in cellular cleanup processes (preclinical focus).
Application Scenarios:
- Food Tech: Cryoprotectant (surimi, ice cream), Texture enhancer (baked goods, rice), Flavor/aroma stabilizer (dried fruits, beverages), Natural humectant.
- Pharma/Biotech: Critical lyoprotectant for vaccines, antibodies, enzymes, and diagnostic reagents in freeze-drying (lyophilization). Stabilizer for liquid formulations.
- ኮስሜቲክስ፡ Moisturizing agent, Enhancer of skin barrier function, Stabilizer for sensitive actives (Vit C, peptides).
- ግብርና፡- Seed coating protectant, Biopesticide stabilizer.
- Diagnostics: Stabilizer for enzymes and antibodies in test kits.

6. Production Process: Precision Purification
Zhonghong’s high-purity trehalose production involves:

የኢንዛይም ለውጥ; Starch slurry → Maltooligosaccharides → ትሬሃሎዝ (using specific trehalose synthase).
Decolorization & Deionization: Removal of pigments, ions, and proteins via activated carbon and ion-exchange resins.
ክሪስታላይዜሽን፡ Controlled crystallization for uniform particle size distribution.
Ultrafiltration/Nanofiltration: Advanced membrane separation for precise molecular weight cut-off.
Spray Drying/Crystallization: Final drying under strict humidity control to yield anhydrous crystals.
ማጥራት Sieving to ensure consistent mesh size (e.g., 80-100 mesh).

7. Rigorous Quality Control (QC)
Zhonghong implements a multi-tiered QC strategy exceeding pharmacopeial standards:

Identity & Assay: Confirmed via HPLC-ELSD/RID (USP/Ph.Eur.) and FTIR. Purity guaranteed >99.5%.
Specific Rotation: Measured using polarimetry.
ቀሪ ፈሳሾች፡- Monitored by Headspace GC-MS according to ICH Q3C guidelines.
Advanced Impurity Profiling: UPLC-QTOF-ኤምኤስ for trace-level unknown identification.
የመረጋጋት ጥናቶች; Accelerated (40°C/75% RH) and long-term (25°C/60% RH) testing per ICH Q1A(R2).
ሙሉ ክትትል; Batch-specific documentation from raw material to finished product.

8. የምርት ዝርዝር እና የትንታኔ የምስክር ወረቀት (COA)

Table 1: Comprehensive COA Specifications for Zhonghong Trehalose

ምድብ	ንጥል	ዝርዝር መግለጫ	የሙከራ ዘዴ
ንጽህና	Trehalose (Anhydrous)	≥ 99.5%	USP/Ph.Eur. HPLC
	ተዛማጅ ንጥረ ነገሮች	Meet USP/Ph.Eur.	HPLC
	በማድረቅ ላይ ኪሳራ	≤ 1.5%	USP <731>
	Specific Rotation [α]20D	+197° to +201°	USP <781>
ሄቪ ብረቶች	አርሴኒክ (አስ)	≤ 0.5 ፒፒኤም	ICP-MS (USP <232>/ICH Q3D)
	መሪ (ፒቢ)	≤ 0.5 ፒፒኤም	ICP-MS (USP <232>/ICH Q3D)
	ካድሚየም (ሲዲ)	≤ 0.5 ፒፒኤም	ICP-MS (USP <232>/ICH Q3D)
	ሜርኩሪ (ኤችጂ)	≤ 0.1 ፒፒኤም	ICP-MS (USP <232>/ICH Q3D)
ፀረ-ተባይ መድሃኒቶች	ጠቅላላ ፀረ-ተባይ	≤ 0.01 ppm (Individual)	GC-MS/MS, LC-MS/MS (EU 396/2005)
		≤ 0.05 ppm (Sum)
ማይክሮባዮሎጂ	ጠቅላላ የኤሮቢክ ብዛት	≤ 1000 CFU/ግ	USP <61>፣ EP 2.6.12
	እርሾ እና ሻጋታዎች	≤ 100 CFU/ግ	USP <61>፣ EP 2.6.12
	ኮላይ	በ 10 ግራም ውስጥ የለም	USP <62>፣ EP 2.6.13
	ሳልሞኔላ spp.	በ 25 ግራም ውስጥ የለም	USP <62>፣ EP 2.6.13
	ስቴፕ አውሬስ	በ 1 ግራም ውስጥ የለም	USP <62>
ሌላ	የሰልፌት አመድ	≤ 0.1%	USP <281>
	መልክ	ነጭ ክሪስታል ዱቄት	የእይታ
	Solubility (10% soln.)	Clear, colorless solution	የእይታ
	ፒኤች (10% soln.)	5.0 – 7.0	USP <791>

9. ማሸግ እና ሎጅስቲክስ

ዋና፡ Food-grade polyethylene liners.
ሁለተኛ ደረጃ፡ Robust 25kg fiber drums or kraft paper bags. Custom packaging available (e.g., vacuum-sealed foil bags for hygroscopic grades).
ሎጂስቲክስ፡ Shipped globally via air/sea freight under controlled conditions (cool, dry). Compliant with IMDG/IATA regulations. MOQ typically 25kg; samples available.

10. Research Frontiers & Challenges

ድንበር፡ Exploring trehalose’s role in autophagy induction for neurodegenerative diseases, enhancing bioavailability of poorly soluble drugs (cocrystallization), next-gen mRNA vaccine stabilization, and novel biomaterial preservation.
ተግዳሮቶች፡- Cost-effective large-scale enzymatic production optimization, demonstrating clinical efficacy for novel therapeutic claims, regulatory pathways for new high-value applications.

11. ተዘውትረው የሚጠየቁ ጥያቄዎች (FAQ)

Q: Is trehalose natural? A: Yes, it occurs naturally. Commercial trehalose is typically produced enzymatically from starch.
Q: Is trehalose safe? A: Yes, it has GRAS status (FDA) and is approved globally (EFSA, JECFA) for food use. It’s well-tolerated.
Q: Does trehalose spike blood sugar? A: It has a lower Glycemic Index (~70) than glucose (100) and sucrose (65), causing a slower, more sustained rise.
Q: Why use trehalose instead of sucrose? A: Superior stability, lower reactivity (non-reducing), better cryo/lyoprotection, lower cariogenicity, and mild sweetness.
Q: Can trehalose be used in vegan products? A: Absolutely, as it’s derived from plant starch and produced enzymatically.
Q: How does trehalose stabilize proteins? A: Primarily through the “Water Replacement Hypothesis,” forming hydrogen bonds with biomolecules, and vitrification during drying.
ጥ፡ የመደርደሪያው ሕይወት ምንድን ነው? A: Typically 3 years when stored sealed in a cool, dry place (<25°C, <65% RH).

12. የት እንደሚገዙ እና ናሙናዎችን ይጠይቁ
Source premium, high-purity Trehalose directly from the manufacturer:

ድህረገፅ፥ Explore our full product portfolio at aiherba.com
Contact for Quotes & FREE Samples: Reach our technical sales team at liaodaohai@gmail.com for competitive pricing, technical data sheets (TDS), and sample requests tailored to your application (Food, Pharma, Cosmetic, Research).

13. መደምደሚያ
Trehalose stands as a versatile and scientifically validated biomolecule, offering unparalleled stabilization benefits across food, pharmaceutical, cosmetic, and research industries. Its natural origin, safety profile, and unique physicochemical properties make it an indispensable tool. Shaanxi Zhonghong Investment Technology Co., Ltd., leveraging 28 years of expertise, cutting-edge purification technology (validated by እጅግ የላቀ ኤን.ኤም.አር እና UPLC-QTOF-ኤምኤስ), and stringent quality control exceeding pharmacopeial standards, delivers trehalose of exceptional purity (>99.5%) and consistency. Partner with Zhonghong for reliable, high-performance trehalose solutions backed by deep technical support and a global supply chain. Contact us today via liaodaohai@gmail.com ወይም ይጎብኙ aiherba.com for samples and specifications.

14. ማጣቀሻዎች

International Trehalose Association. (n.d.). Scientific Resources. [Link]
European Food Safety Authority (EFSA). (2011). Scientific Opinion on the substantiation of health claims related to trehalose… EFSA ጆርናል, 9(4), 2073.
Ohtake, S., & Wang, Y. J. (2011). Trehalose: current use and future applications. የመድኃኒት ሳይንስ ጆርናል, 100(6), 2020-2053.
Chen, A., & Tait, A. R. (2019). Trehalose as a promising therapeutic candidate for neurodegenerative disorders. Translational Neurodegeneration, 8(1), 1-10.
USP-NF. (2024). Monograph: Trehalose. United States Pharmacopeial Convention.
European Pharmacopoeia (Ph. Eur.) 11th Edition. (2024). Monograph 01/2024:0000.
Zhonghong Tech. (2024). Internal Quality Control Protocols & Analytical Reports. Shaanxi, China.

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