ራፓማይሲን

ራፓማይሲን

Rapamycin factory supplier bulk Wholesale Extract factory

  1. የእንግሊዝኛ ስም: Rapamycin (also known by its brand name Sirolimus—pronounced “ray-puh-MY-sin”; it’s a prescription-only medication, not a supplement!)
  1. ዝርዝር መግለጫ
    • ንጽህና: ≥ 99.5% (HPLC tested—pharmaceutical grade, critical for consistent medical effects)
    • ቅፅ: Available as oral tablets (0.5mg, 1mg, 2mg), oral solution (1mg/mL), or injectable for research use
    • መሟሟት: Insoluble in water; dissolves well in ethanol, DMSO, and vegetable oils (formulated into tablets/solutions for medical use)
    • ቆሻሻዎች: ≤ 0.1% (strict pharmaceutical standards—no harmful byproducts)
    • Storage Stability: Stable for 2+ years when stored at 2–8°C (refrigerated, away from light/moisture)
  1. መልክ: White to off-white crystalline powder (pure form) or white/cream tablets (pharmaceutical form). It has a mild, neutral aroma—በእርግጠኝነት no chocolate aroma! Odorless in tablet form, so it’s easy to take as prescribed.
  1. CAS ቁጥር: 53123-88-9 (this is the official CAS for rapamycin—critical for pharmaceutical labeling and regulatory compliance)
  1. የመምራት ጊዜ: 3–7 Working Days (for pharmaceutical distributors; research-grade versions also in stock, but note: prescription-only for medical use)
  1. ጥቅል:
    • Pharmaceutical: Blister packs (10 tablets/ pack) or amber glass bottles (oral solution) to protect from light
    • Research-grade: 1g/10g amber glass vials (light-resistant, airtight) or 25kg sealed pharmaceutical drums (for bulk medical manufacturing)
  1. ዋና ገበያ: Global (Europe, North America, Asia)—used in hospitals and clinics for organ transplants, cancer treatment, and rare diseases. Research-grade versions are popular in biotech labs.
  1. የመተግበሪያ ሁኔታዎች (Critical Note: Rapamycin is a prescription drug—must be used under medical supervision)

Key Features (Medical Focus)

  • Immunosuppressant Power: Slows the immune system to prevent organ rejection (e.g., kidney, liver transplants)—saves lives post-transplant
  • Anti-Cancer Effects: Inhibits cell growth—used to treat rare cancers (e.g., renal cell carcinoma, mantle cell lymphoma)
  • Targeted Action: Works on the mTOR pathway (a key cell growth regulator)—fewer off-target side effects than older immunosuppressants
  • Pharmaceutical Grade Only: No over-the-counter versions—requires a doctor’s prescription to ensure safe dosing
  • Research Potential: Studied for age-related diseases (e.g., Alzheimer’s) in labs, but these uses are not yet approved for medical practice

Industry Applications (Medical & Research Only)

  1. Organ Transplant Medicine
    • Kidney/Liver Transplants: Prescribed daily (0.5–2mg) to prevent immune rejection—often combined with other immunosuppressants (e.g., tacrolimus) for better results
    • Heart/Lung Transplants: Used in select cases to support long-term graft survival (dosing adjusted for patient weight/health)
  1. Oncology (Cancer Treatment)
    • Rare Cancers: Prescribed for advanced renal cell carcinoma (kidney cancer) or mantle cell lymphoma—slows tumor growth by blocking mTOR
    • Kaposi’s Sarcoma: Used to treat this AIDS-related cancer in patients who can’t tolerate other treatments
  1. Rare Disease Treatment
    • Tuberous Sclerosis Complex (TSC): Approved for treating seizures and kidney tumors in adults/children with TSC—targets abnormal cell growth caused by TSC mutations
    • Lymphangioleiomyomatosis (LAM): A rare lung disease—reduces lung lesions and improves breathing in affected patients
  1. Biotech Research
    • Age-Related Disease Studies: Used in labs to study mTOR’s role in aging, Alzheimer’s, and Parkinson’s—no approved medical use for these yet
    • Cell Biology: A tool for researching cell growth and survival pathways (common in academic and pharmaceutical labs)
  1. Veterinary Medicine (Specialized)
    • Pet Organ Transplants: Rarely used in dogs/cats post-kidney transplants (veterinarian-prescribed, adjusted for animal size)

Critical Safety Note

Rapamycin has serious side effects (e.g., increased infection risk, high cholesterol, kidney issues) and interacts with many drugs. It is not a supplement—do not use without a doctor’s prescription and close medical monitoring.
ምድብ፡

Rapamycin: Pharmaceutical-Grade mTOR Inhibitor for Research & Medical Applications – Manufacturer & Exporter Guide

1. What is Rapamycin?
For research institutions and pharmaceutical companies exploring longevity and immune modulation, Rapamycin (Sirolimus) represents one of the most significant discoveries in molecular biology. This macrocyclic lactone compound, originally isolated from Streptomyces hygroscopicus found in Easter Island soil, has revolutionized our understanding of cellular metabolism and aging processes. As a potent mTOR (mechanistic target of rapamycin) inhibitor, it serves as a critical tool for research into aging, cancer, and autoimmune disorders. While primarily used as an immunosuppressant drug in transplant medicine, its research applications continue to expand into novel therapeutic areas.

2. ምንጭ፣ ኬሚስትሪ እና ዝርዝር መግለጫዎች

  • ምንጭ፡- Fermentation product of Streptomyces hygroscopicus

  • ኬሚካዊ ማንነት (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone

  • የኬሚካል መገለጫ

    • CAS ቁጥር፡- 53123-88-9

    • ኤምኤፍ፡ C₅₁H₇₉NO₁₃

    • MW 914.17 g/mol

    • ኢይነክስ፡ 610-535-3

  • መልክ፡ ከነጭ-ከነጭ-ነጭ ክሪስታል ዱቄት

  • መሟሟት; Soluble in DMSO, ethanol; insoluble in water

3. Research and Pharmaceutical Applications
Important Notice: Rapamycin is a prescription drug with significant side effects and must be used only under medical supervision. This information is for research purposes only.

  • Key Mechanism: Potent and specific inhibitor of mTOR pathway

  • Research Applications:

    • Longevity Research: Investigating effects on lifespan extension

    • Oncology Research: Studying tumor suppression mechanisms

    • Immunology Research: Exploring immune system modulation

    • Metabolic Studies: Researching metabolic pathway regulation

  • Pharmaceutical Grade: ≥98% purity for research applications

  • Storage Requirements: -20°C protected from light

  • አያያዝ፡ Requires specialized handling and containment procedures

4. Zhonghong Biotech: Your Research Compound Partner
Sourcing high-purity rapamycin requires pharmaceutical-grade expertise.Shaanxi Zhonghong ኢንቨስትመንት ቴክኖሎጂ Co., Ltd. brings 28 years of experience in advanced compound production to serve the global research community.

  • የቴክኒክ ችሎታዎች፡-

    • Fermentation Expertise: Advanced fermentation technology for consistent production

    • Purification Technology: Chromatographic purification to pharmaceutical standards

    • የጥራት ማረጋገጫ፡ Comprehensive analytical testing and characterization

  • የቁጥጥር ተገዢነት፡- Meets ISO 9001 and cGMP standards

5. Scientific Significance: mTOR Inhibition Mechanism
Rapamycin’s research value stems from its unique mechanism:

  • Forms complex with FKBP12 protein

  • Binds to and inhibits mTORC1 specifically

  • Modulates protein synthesis and cell growth

  • Influences autophagy and metabolic processes

6. የፋርማሲዩቲካል-ደረጃ ጥራት ማረጋገጫ
Our rigorous quality control ensures research-ready material:

Certificate of Analysis (COA) Summary – Rapamycin (Research Grade)

ምድብ መለኪያ ዝርዝር መግለጫ የሙከራ ዘዴ
ማንነት HPLC Retention ተዛማጆች ማጣቀሻ HPLC-UV
አስይ Rapamycin Content ≥ 98.0% HPLC-UV
ንጽህና ተዛማጅ ንጥረ ነገሮች ≤ 2.0% HPLC-UV
ደህንነት ሄቪ ብረቶች ≤ 10 ፒፒኤም ICP-MS
ቀሪ ፈሳሾች Meet ICH Guidelines ጂሲ-ኤም.ኤስ
ማይክሮባዮሎጂ Endotoxin <0.5 EU/mg የኤልኤል ሙከራ
መካንነት Sterile Membrane ማጣሪያ

7. የላቀ የማምረት ሂደት
Our pharmaceutical-grade production ensures highest quality:

  1. መፍላት፡ Controlled fermentation of Streptomyces hygroscopicus

  2. ማውጣት፡ Solvent extraction of crude product

  3. መንጻት፡ Multi-stage chromatographic purification

  4. ክሪስታላይዜሽን፡ Controlled crystallization process

  5. ሊዮፊላይዜሽን; Freeze-drying for stability

  6. የጥራት ቁጥጥር፡- አጠቃላይ ትንታኔ

8. Research Applications

  • የአካዳሚክ ጥናት; University and institutional research programs

  • ፋርማሲዩቲካል R&D፡ Drug discovery and development

  • Biotech Research: Molecular biology and biochemistry studies

  • Medical Research: Translational medicine investigations

9. Specialized Handling & Logistics

  • ማሸግ፡ Sealed vials with argon atmosphere

  • ማከማቻ፡ -20°C protected from light and moisture

  • መላኪያ፡ Cold chain logistics with temperature monitoring

  • ሰነድ፡ Comprehensive research-use documentation

10. Research Partnership Opportunities
እናቀርባለን፡-

  • Research-grade materials for scientific investigation

  • Technical documentation for research applications

  • Custom quantities for research programs

  • Analytical support for research projects

Contact Our Scientific Team:

11. Research FAQ

  • Q: What purity grade do you offer?
    A: We provide research-grade rapamycin with ≥98% purity

  • Q: Do you provide analytical data?
    A: Yes, comprehensive COA and characterization data provided

  • Q: What’s the minimum order quantity?
    A: MOQ varies based on research requirements

  • Q: Do you offer custom synthesis?
    A: We offer custom quantities and specialized packaging

  • Q: What documentation is provided?
    A: Full analytical data, MSDS, and research-use documentation

12. Important Disclaimer
Rapamycin is a potent pharmaceutical compound with significant side effects. It must be used only by qualified researchers in appropriate facilities following all safety guidelines. This product is for research use only and not for human consumption.

ማጠቃለያ
Rapamycin remains a cornerstone compound in molecular biology research and pharmaceutical development. Zhonghong’s pharmaceutical-grade manufacturing capabilities ensure consistent, high-quality material for research applications. Our commitment to quality and technical excellence makes us a reliable partner for the research community.

Contact us for research inquiries and availability.

ዋቢዎች፡-

  1. Brown, E.J., et al. (1994). A mammalian protein targeted by G1-arresting rapamycin. Nature

  2. Sabatini, D.M., et al. (1994). RAFT1: A mammalian protein that binds to FKBP12. ሕዋስ

  3. Blagosklonny, M.V., et al. (2019). Rapamycin for longevity. እርጅና

  4. US Pharmacopeia. (2023). Sirolimus monograph. USP-NF

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