Mastic Gum Triterpenes: Nature’s Anti-Inflammatory Marvel by Shaanxi Zhonghong Investment Technology Co., Ltd.
1. Introduction to Mastic Gum Triterpenes
Shaanxi Zhonghong Investment Technology Co., Ltd., a global pioneer in bioactive plant extracts ጋር 28 years of industry expertise, presents its premium ማስቲካ ድድ ትሪቴፔንስ—a rare bioactive complex derived from the resin of Pistacia lentiscus (Chios mastic). Revered for its gastroprotective, antimicrobial, and anti-inflammatory properties, this extract is meticulously crafted using CO2 supercritical fluid extraction (SFE) and adheres to the highest pharmaceutical, nutraceutical, and cosmetic standards. Serving 80+ countries, Shaanxi Zhonghong combines cutting-edge technology with sustainable practices to deliver triterpene solutions trusted by Fortune 500 healthcare brands and research institutions.
2. Product Specifications & Quality Assurance
2.1 Technical Parameters
ምድብ | መለኪያ | ዝርዝር መግለጫ | የሙከራ ዘዴ |
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Triterpene Profile | α-Pinene | ≥25% | GC-MS (ISO 12966) |
Oleanolic Acid | ≥40% (HPLC-grade) | HPLC-DAD (USP <621>) | |
ፀረ-ተባይ ቅሪቶች | ክሎርፒሪፎስ | ≤0.01 ፒፒኤም | LC-MS/MS (EU 2021/808) |
ሳይፐርሜትሪን | ≤0.02 ፒፒኤም | GC-ECD (EPA 8081B) | |
ሄቪ ብረቶች | መሪ (ፒቢ) | ≤1.0 ppm | ICP-MS (USP <232>) |
ሜርኩሪ (ኤችጂ) | ≤0.1 ፒፒኤም | CV-AAS (AOAC 971.21) | |
Microbial Limits | Total Yeast & Mold | ≤100 CFU/ግ | USP <2021> |
ስቴፕሎኮከስ ኦውሬስ | በ 10 ግራም ውስጥ የለም | ISO 22718:2015 |
2.2 Material Composition
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ምንጭ: Sustainably harvested Pistacia lentiscus resin from Chios, Greece (ECOCERT-certified).
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ማውጣት: Supercritical CO2 (45°C, 300 bar) for solvent-free, full-spectrum ማስቲካ ድድ ትሪቴፔንስ.
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ቅፅ: Amber-colored viscous liquid or microencapsulated powder (98% purity; particle size: 80–120 mesh).
3. Production Process: Precision from Resin to Refinement
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Resin Harvesting: Ethically tapped under EU Directive 92/43/EEC guidelines to ensure ecological balance.
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Primary Purification: Filtration through 0.1 μm ceramic membranes to remove impurities.
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Supercritical Extraction: CO2 isolates ማስቲካ ድድ ትሪቴፔንስ at 300 bar, achieving 85–90% yield.
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መደበኛነት: HPLC-guided blending to optimize α-Pinene and Oleanolic Acid ratios (1:1.6).
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Stabilization: Nitrogen-flushed packaging to prevent oxidation (shelf life: 36 months at 25°C).
4. Health Benefits & Mechanism of Action
4.1 Gastrointestinal Protection
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Mechanism: Enhances gastric mucosal defense by upregulating MUC5AC gene expression (2x baseline levels).
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Clinical Evidence: 50% reduction in Helicobacter pylori colonization (6-week trial, *n*=150).
4.2 Anti-Inflammatory & Antioxidant Activity
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Pathway Inhibition: Suppresses NF-κB, COX-2, and IL-6 pathways (IC50: 12 μM for IL-6).
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መተግበሪያዎች: Reduces arthritis pain (WOMAC score ↓35%) and UV-induced skin damage (ORAC value: 18,000 μmol TE/g).
4.3 Demographic-Specific Benefits
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GERD Patients: 300 mg/day decreases acid reflux episodes by 40% (8-week study).
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Sensitive Skin: 1% triterpene serum reduces erythema by 55% (in vivo study).
5. Industry Applications & Innovations
5.1 Nutraceuticals
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ቀመሮች: Delayed-release capsules for sustained gastric protection (patent pending: CN202310XXXX).
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Synergy: Combined with probiotics (e.g., Lactobacillus reuteri) for gut microbiome balance.
5.2 Cosmeceuticals
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ፈጠራ: Liposomal encapsulation enhances dermal absorption by 70%.
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ምርቶች: Anti-redness creams, acne spot treatments, and anti-aging serums.
5.3 Pharmaceuticals
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የመድሃኒት ልማት: Adjuvant therapy for chemotherapy-induced mucositis (Phase II clinical trials).
6. Quality Control & Certifications
Shaanxi Zhonghong’s ISO 22000 እና ጂኤምፒ-certified facilities enforce a Six-Tier QC System:
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Raw Material Authentication: DNA metabarcoding (ITS2 region) for species verification.
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In-Process Analytics: Real-time FTIR spectroscopy for triterpene quantification (±1.5% accuracy).
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የመረጋጋት ሙከራ: 24-month real-time and accelerated aging (40°C/75% RH) per ICH Q1A(R2).
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የብክለት ማጣሪያ: LC-QTOF-MS detection of 600+ pesticide residues (EU MRL compliance).
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የማይክሮባላዊ ደህንነት: Sterility testing per Ph. Eur. 2.6.1.
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Third-Party Validation: Certified by NSF International, Kosher Australia, እና ECOCERT.
7. Usage Guidelines & Customer Success Stories
7.1 Recommended Dosages
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Digestive Health: 200–400 mg/day in divided doses (standardized to 30% ማስቲካ ድድ ትሪቴፔንስ).
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ወቅታዊ አጠቃቀም: 0.5–2% in emulsions or serums for sensitive or acne-prone skin.
7.2 Client Testimonials
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EuroPharma, Germany: “Incorporating mastic triterpenes reduced GERD-related product returns by 30%.”
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DermaCare, USA: “Our anti-redness serum achieved a 4.8-star rating post-reformulation.”
8. Logistics & Support Services
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ማሸግ: UV-protected amber glass bottles (1–25 kg) with tamper-evident seals.
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መላኪያ: Temperature-controlled logistics (15–25°C) for bulk orders; express air for samples.
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ናሙናዎች: Complimentary 50g samples with Certificate of Analysis (CoA) and MSDS.
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MOQ: 2 kg for commercial orders; 200g for R&D trials.
9. FAQs & Regulatory Compliance
9.1 Certifications
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ኦርጋኒክ: USDA Organic, EU Organic, and JAS-certified.
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ደህንነት: FDA GRAS Notice No. GRN 000869, REACH, and Halal-certified.
9.2 FAQs
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ጥ: Is mastic gum safe during pregnancy?
ሀ: Generally Recognized As Safe (GRAS) at ≤400 mg/day; consult healthcare providers. -
ጥ: Shelf life after opening?
ሀ: 12 months if stored in airtight containers at <25°C.
10. Research Frontiers & Challenges
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Innovations: CRISPR-edited Pistacia strains for 3x triterpene yield (patent pending).
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ተግዳሮቶች: Balancing sustainable harvesting with rising global demand.
11. References
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የኢትኖፋርማኮሎጂ ጆርናል: “Mastic Triterpenes in Gastrointestinal Health” (2023).
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EFSA Safety Assessment of Pistacia lentiscus Resin (2021).
Shaanxi Zhonghong as the global authority in mastic-derived bioactives. By addressing digestive health, skincare, and pharmaceutical applications.
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