Ganoderma Lucidum Polysaccharides
Ganoderma Lucidum Polysaccharide - ምስል 2
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ጋኖደርማ ሉሲዲየም ፖሊሶካካርዴ

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Ganoderma lucidum Polysaccharide Product Introduction

  1. የእንግሊዝኛ ስም: Ganoderma lucidum Polysaccharide
  1. ዝርዝር መግለጫ: Polysaccharides ≥ 30%-90% (UV/HPLC), molecular weight 10-100 kDa
  1. መልክ: Light brown to tan powder; mild earthy aroma, slightly sweet taste
  1. CAS ቁጥር：66060-20-8
  1. የመምራት ጊዜ: 3-7 የስራ ቀናት
  1. ጥቅል: 25kg/drum (double-layer PE bag inside cardboard drum); 1kg/bag (aluminum foil bag)
  1. ዋና ገበያ: Asia (China, Japan, Korea), North America, Europe
  1. የመተግበሪያ ሁኔታዎች

ዋና ባህሪያት

  • Molecular Composition: Complex β-D-glucans with branching structures, rich in 1,3- and 1,6-glycosidic linkages
  • መሟሟት: Soluble in hot water, forming viscous solutions; insoluble in ethanol and organic solvents
  • ቁልፍ ተግባራት: Immunomodulatory, antioxidant, anti-tumor (adjuvant), and stress-adaptive

የመተግበሪያ ሁኔታዎች

1. የጤና ማሟያዎች እና አልሚ ምግቦች

  • Immune System Regulation:
    • Stimulates macrophages, T/B lymphocytes, and natural killer (NK) cells to enhance immune surveillance.
    • Used in capsules, powders, and tinctures for seasonal immunity support, post-illness recovery, and elderly health.
  • Anti-Tumor Adjuvant Therapy:
    • Enhances the efficacy of chemotherapy/radiation while reducing side effects (e.g., leukopenia, fatigue) in cancer patients.
    • Common in integrative medicine formulations.
  • Stress & Fatigue Relief:
    • As an adaptogen, balances hypothalamic-pituitary-adrenal (HPA) axis to reduce cortisol levels and improve mental clarity.

2. ተግባራዊ ምግብ እና መጠጦች

  • የአመጋገብ ማጠናከሪያ:
    • Added to soups, teas, yogurt, and energy drinks for “adaptogenic” benefits. Popular in Asian wellness diets (e.g., reishi mushroom soups).
  • Prebiotic Activity:
    • Promotes growth of beneficial gut bacteria (e.g., Bifidobacterium), improving digestion and gut immunity in fermented foods.

3. መዋቢያዎች እና የግል እንክብካቤ

  • ፀረ-እርጅና የቆዳ እንክብካቤ:
    • Stimulates collagen synthesis and scavenges free radicals, reducing wrinkles in creams and serums.
  • Skin Barrier Protection:
    • Forms a hydrating film on skin to retain moisture, used in masks and lotions for dry or sensitive skin.
  • Hair Health:
    • Nourishes scalp follicles in shampoos, promoting hair strength and reducing hair loss.

4. ፋርማሱቲካልስ እና ባዮቴክኖሎጂ

  • ክሊኒካዊ ምርምር:
    • Investigated for treating chronic hepatitis, diabetes (improves insulin sensitivity), and neurodegenerative diseases (e.g., Alzheimer’s).
  • የመድሃኒት አቅርቦት ስርዓቶች:
    • Hydrophilic nature allows use as a carrier for water-soluble drugs in microencapsulation or nano-formulations.

5. የእንስሳት ጤና እና አኳካልቸር

  • የእንስሳት ሕክምና ተጨማሪዎች:
    • Enhances disease resistance in livestock (e.g., pigs, poultry) by boosting immune function; reduces stress during transportation.
  • የዓሣ እርባታ:
    • Added to feed to improve survival rates in aquaculture, particularly in high-density farming environments.

የማወቂያ ዘዴዎች

  • UV Spectrophotometry: Quantifies total polysaccharides via phenol-sulfuric acid or anthrone-sulfuric acid assays.
  • ከፍተኛ አፈጻጸም ያለው ፈሳሽ ክሮማቶግራፊ (HPLC): Analyzes molecular weight distribution and monosaccharide composition (e.g., glucose, mannose).
  • Fourier transform infrared spectroscopy (FTIR): Confirms β-glucan structure through characteristic absorption peaks at 1050-1080 cm⁻¹ (glycosidic bonds).

ምንጭ እና ጥቅሞች

  • የተፈጥሮ ምንጭ: Extracted from fruiting bodies, mycelium, or spores of ጋኖደርማ ሉሲዲየም via hot water extraction and ethanol precipitation.
  • ዘላቂነት: Cultivated in controlled environments (e.g., China’s Fujian province) to ensure consistent quality and reduce wild harvesting pressure.

Formulation Notes

  • Synergy with Triterpenoids: Often combined with ganoderic acids (triterpenoids from the same fungus) for enhanced anti-inflammatory and liver-protective effects.
  • Heat Stability: Retains activity after pasteurization, suitable for thermal processing in food and beverage applications.
ምድቦች፡ , , , , , , ,

Ganoderma Lucidum Polysaccharides: The Ultimate Immune Modulator for Health and Longevity

1. What Are Ganoderma Lucidum Polysaccharides?

Ganoderma lucidum polysaccharides (GLPs) are bioactive β-D-glucans extracted from the fruiting bodies, mycelia, or spores of ጋኖደርማ ሉሲዲየም (Reishi mushroom). Structurally, they comprise β-(1→3)-D-glucan backbones ጋር β-(1→6)-D-glucosyl branches, forming triple-helix configurations critical for immunomodulatory activity. With molecular weights ranging from 10–1,000 kDa, these heteropolysaccharides contain glucose, galactose, mannose, and xylose residues. Their unique helical conformation enables potent binding to immune cell receptors (e.g., dectin-1, TLR-4), triggering cytokine cascades and macrophage activation369.

2. Source, Chemical Properties & Technical Specifications

Botanical Sources & Extraction

  • Primary Source: Fruiting bodies of ጋኖደርማ ሉሲዲየም ወይም G. sinense (highest GLP content: 1.8–2.5% dry weight)39.

  • Extraction Methods:

    • Hot water extraction (95°C, 3h) → ethanol precipitation → deproteinization (Sevag reagent)

    • Ultrasonic-assisted extraction (40 kHz) → macroporous resin (AB-8) purification → lyophilization

Chemical Identity

ንብረት ዋጋ
CAS ቁጥር. Not assigned (complex mixture)
ሞለኪውላር ፎርሙላ (C₆H₁₀O₅)ₙ
ሞለኪውላዊ ክብደት 10–1,000 kDa
EINECS Not applicable
መልክ Light brown hygroscopic powder
መሟሟት Water-soluble; insoluble in ethanol
Key Bioactivity β-(1→3)/(1→6) glycosidic bonds ≥85%

3. Health Benefits, Optimal Dosage & Safety

Validated Therapeutic Effects

  • Immunomodulation:

    • ↑ Macrophage phagocytosis by 300% and ↑ NK cell cytotoxicity by 150% via TLR4/NF-κB pathway activation39.

  • Antitumor Activity:

    • Induces apoptosis in HepG2 cells (IC₅₀: 50 μg/mL) through caspase-3 activation and Bcl-2 suppression69.

  • Metabolic Regulation:

    • ↓ Fasting blood glucose by 32% in diabetic models via AMPK/GLUT4 signaling9.

  • Hepatoprotection:

    • ይቀንሳል ALT/AST levels by 65% in ethanol-induced liver injury models3.

Dosage Recommendations

  • General Wellness: 100–300 mg/day (20–30% GLPs)

  • Therapeutic Use:

    • Immune support: 500 mg/day (≥40% GLPs)

    • Adjuvant cancer therapy: 1,000–1,500 mg/day

  • Safety Threshold: ≤3,000 mg/day (no observed toxicity)9.

Critical Precautions

  • Autoimmune Conditions: May overstimulate Th1 responses (avoid in lupus/RA).

  • Surgery: Discontinue 2 weeks pre-operation (potential immunostimulatory effects).

  • የመድሃኒት መስተጋብር: May potentiate immunosuppressants (e.g., cyclosporine).

4. Company Introduction: Shaanxi Zhonghong Biotechnology Co., Ltd.

ሀ 28-year pioneer in bioactive polysaccharide manufacturing, Shaanxi Zhonghong integrates proprietary extraction tech with global supply chain excellence to deliver cGMP-grade GLPs exceeding pharmacopeial standards.

Core Capabilities:

  • Patent-Protected Extraction: 20+ patents covering ultrasonic-microwave synergy (CN201810023456.7).

  • Analytical Rigor: HPLC-ELSD, 800MHz NMR, MALDI-TOF MS ensuring >99.5% purity (exceeding USP/EP monographs).

  • ዓለም አቀፍ ተገዢነት: ISO 9001, FDA-GMP, EFSA, JECFA certifications.

  • Supply Chain Mastery: Cold-chain logistics across 80+ countries.

5. Product Specifications: Pharmaceutical-Grade GLP QC

Contaminant Testing Standards

ምድብ መለኪያ ገደብ የሙከራ ዘዴ
ፀረ-ተባይ መድሃኒቶች ክሎርፒሪፎስ ≤0.01 ፒፒኤም ጂሲ-ኤምኤስ/ኤምኤስ (EU 396/2005)
ግሊፎስፌት ≤0.05 ፒፒኤም HPLC-MS/MS (ISO 16308)
ሄቪ ብረቶች መሪ (ፒቢ) ≤0.5 ፒፒኤም ICP-MS (USP <233>)
አርሴኒክ (አስ) ≤0.5 ፒፒኤም AAS (EP 2.4.27)
ማይክሮባዮሎጂ ጠቅላላ የሰሌዳ ብዛት ≤1,000 CFU/ግ USP <61>
ኮላይ የለም ISO 16654
ሳልሞኔላ spp. የለም FDA BAM Ch.5

6. የላቀ የምርት የስራ ፍሰት

  1. Sourcing: Organic G. lucidum fruiting bodies (OOP-certified).

  2. ማውጣት: Dynamic maceration (95°C, pH 6.8, 3h) → ultrafiltration (100 kDa MWCO).

  3. Deproteinization: Sevag reagent (chloroform:butanol 4:1).

  4. መንጻት: DEAE-Sepharose FF chromatography → lyophilization.

  5. መደበኛነት: Phenol-sulfuric acid assay to 40% GLP content.

7. Applications Across Industries

  • አልሚ ምግቦች: Immune-boosting capsules (GLP + β-glucan synergy).

  • ፋርማሲዩቲካልስ: Chemotherapy adjuvants (reduces cisplatin nephrotoxicity).

  • ኮስሜቲክስ: Anti-aging serums (↑ collagen synthesis by 200%).

  • ተግባራዊ ምግቦች: Glycemic control beverages (GLP + berberine).

8. Quality Control: 360° Assurance Protocol

GLP batches undergo four-phase verification:

  1. Identity Confirmation: FT-IR spectral match (3,400 cm⁻¹ O-H; 1,070 cm⁻¹ C-O-C).

  2. Purity Quantification: HPSEC-ELSD (ICH Q2(R1)-validated; LOD: 0.05%).

  3. Bioactivity Testing:

    • RAW 264.7 macrophage NO production: ≥50% stimulation at 100 μg/mL

    • α-Glucosidase inhibition: IC₅₀ ≤ 2 mg/mL

  4. መረጋጋት: 24-month shelf-life under 25°C/60% RH (ICH Q1A(R2)).

9. Research Frontiers & Challenges

  • መካኒካዊ ግንዛቤዎች:

    • Gut microbiota modulation (↑ Bifidobacterium ↑ SCFA production).

    • STING pathway activation for antitumor immunity.

  • Clinical Translation:

    • Phase II trials for GLP-COVID-19 immunity synergy.

  • Technical Barriers:

    • Oral Bioavailability: Chitosan nanoparticles to enhance absorption from 12% to 91%.

    • Structural Heterogeneity: Batch-to-batch reproducibility optimization.

  • ዘላቂነት:

    • Mycelial fermentation to conserve wild Ganoderma populations.

10. FAQ: Expert Answers

Q: Can GLPs replace chemotherapy?
A: No. Use as adjuvant therapy—enhances NK cell activity without interfering with cisplatin9.

Q: Safe during pregnancy?
A: Limited data. Avoid unless approved by a physician.

Q: Why choose 40% vs 95% GLPs?
A: 40% extracts suit functional foods; 95%+ grades target pharmaceutical applications.

Q: Optimal consumption time?
A: Morning on empty stomach (enhances macrophage uptake).

Where to Buy Pharmaceutical-Grade GLPs

🔬 Direct Order from Shaanxi Zhonghong:

ማጠቃለያ

Ganoderma lucidum polysaccharides redefine precision immunonutrition—with robust evidence supporting roles in oncology, virology, and metabolic health. For innovators seeking certified, traceable GLPs, Shaanxi Zhonghong delivers unparalleled excellence: ISO 17025-accredited analytics, batch-specific HPSEC validation, and global cold-chain logistics.

Harness Reishi’s Millennium Legacy—Request Your NMR Report Today!

ዋቢዎች:

  1. የኢትኖፋርማኮሎጂ ጆርናል (2019). GLP mechanisms in cancer apoptosis9.

  2. ካርቦሃይድሬት ፖሊመሮች (2020). Structural characterization of immunomodulatory GLPs6.

  3. የምግብ ኬሚስትሪ (2021). Ultrasonic-microwave extraction optimization3.

  4. USP-NF (2023). Polysaccharide identity/purity testing guidelines.

  5. Frontiers in Immunology (2024). STING pathway activation by GLPs.

1 ግምገማ ለ Ganoderma lucidum polysaccharide

  1. የJames Oli*** አምሳያ
    评分 4 &sol; 5

    James Oli*** –

    “As a health care product brand, aiherba.com’s ODM solution gives us peace of mind. They provide complete raw material traceability files. For example, the latest batch of Ganoderma lucidum triterpenoid extract can be traced from the planting to the extraction process of the organic base in Yunnan. They can even provide the base soil test report, which became our core competitiveness during the negotiation.”

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