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Adrenochrome: The Hemostatic Compound with Evolving Therapeutic Potential | Supplier & Manufacturer

1. What is Adrenochrome?
Adrenochrome (CAS 54-06-8) is the oxidation product of adrenaline (epinephrine), characterised by its distinct indole-5,6-quinone construction. Biochemically, it kinds spontaneously when adrenaline is uncovered to oxidizing brokers or gentle. Whereas traditionally related to cytotoxic properties in leukocyte-mediated bacterial killing 14, its significance in fashionable science lies in two domains: as a analysis device learning neurodegenerative pathways እና ኦክሳይድ ውጥረት 10, and because the precursor to the broadly used hemostatic drug carbazochrome (adrenochrome monohydrazone) 28. Not like adrenaline, adrenochrome lacks important pressor results, making its derivatives clinically priceless for vascular integrity modulation with out impacting coronary heart charge or blood strain 58.

2. አቅርቦት, ኬሚካላዊ ባህሪያት እና ዝርዝሮች

• አቅርቦት፡ Primarily synthesized through the chemical oxidation of epinephrine. Natural enzymatic formation happens in vivo however is unstable and never commercially viable for extraction 1410.

• Chemical Identification & Properties:

  • CAS No: 54-06-8

  • ሞለኪውላዊ ዘዴ; C₉H₉NO₃

  • ሞለኪውላዊ ክብደት; 179.17 g/mol

  • ኢይነክስ፡ 200-192-8

  • መልክ፡ Crimson crystalline powder

  • መሟሟት; Soluble in water (with attribute absorbance maxima at 299-304 nm and 485-490 nm) and alcohols; insoluble in non-polar solvents 1410.

  • መረጋጋት፡ Mild- and air-sensitive; requires storage at -20 ° ሴ in hermetic containers 110.

3. Therapeutic Spinoff: Carbazochrome (The “Greatest” Clinically Used Type)

Whereas pure adrenochrome is primarily a analysis chemical, its stabilized by-product, carbazochrome (adrenochrome monosemicarbazone sodium salicylate), is the dominant clinically related type resulting from enhanced stability and security.

• Highest Content & Purity: Pharmaceutical-grade carbazochrome targets >95% purity (HPLC assay). Respected producers obtain this through ክሮማቶግራፊክ ማጽዳት (e.g., preparative HPLC). No “pure” supply gives larger concentrations than artificial derivation 258.

• የጤንነት ጥቅሞች እና ዘዴዎች:

  • Hemostasis: ይጨምራል capillary endothelial resistance, stabilizes perivascular acidic mucopolysaccharides, and promotes contraction of broken capillary ends. Inhibits prostaglandin E1 (PGE1) synthesis/launch, decreasing vascular permeability and exudation 258.

  • Major Functions: Efficient for bleeding resulting from elevated capillary fragility (e.g., idiopathic thrombocytopenic purpura, retinal hemorrhage, continual pulmonary hemorrhage, GI bleeding, epistaxis, metrorrhagia, hematuria) 28.

• Each day Consumption & Dosage (Carbazochrome):

  • ጓልማሶች፥ Oral: 2.5-5 mg, 2-3 instances each day; Extreme instances: 5-10 mg each 2-4 hours. IM: 5-10 mg, 2-3 instances each day; Extreme: 10-20 mg each 2-3 hours. IV use is contraindicated.

  • ልጆች፡ Oral: 1.25-2.5 mg (≤5 yrs), 2.5-5 mg (>5 yrs). IM: 2.5-5 mg (≤5 yrs), 5-10 mg (>5 yrs) 258.
    No established RDI exists for pure adrenochrome; its use is restricted to analysis.

• Precautions & Aspect Results (Carbazochrome):

  • ተቃውሞዎች፡- Hypersensitivity to carbazochrome or salicylates.

  • Opposed Results: Salicylate-like reactions – nausea, vomiting, dizziness, tinnitus, imaginative and prescient disturbances. Excessive doses could trigger neuropsychiatric results (psychological disturbances, irregular EEG, decreased efficacy of antipsychotics/antiepileptics) 258.

  • Warnings: Use cautiously in sufferers with epilepsy or psychiatric historical past. Keep away from concurrent use with antihistamines/anticholinergics (could scale back efficacy) and tetracyclines (incompatibility) 58.

4. Shaanxi Zhonghong Investment Technology Co., Ltd.: Your Trusted Supply for Premium Bioactives

Shaanxi Zhonghong እንደ ፕሪሚየር ይቆማል ከፍተኛ የቴክኖሎጂ ድርጅት (ISO 9001, ISO 22000, FDA-registered facility) with የ 28 ዓመታት ልምድ within the analysis, growth, and large-scale manufacturing of high-purity bioactive compounds for the pharmaceutical, nutraceutical, and life science industries. We specialize within the ማውጣት, ማግለል እና ማጽዳት of complicated plant-derived and artificial molecules, together with research-grade adrenochrome and associated hemostatic intermediates 9.

• ዋና ብቃቶች፡-

  • ሳይንሳዊ ችሎታ; Joint laboratories with 5 main universities, 20+ የባለቤትነት መብት የተሰጣቸው የተግባር ሳይንስ, and a proprietary international compound library enabling novel discovery and course of optimization.

  • የማምረት ብቃት፡- State-of-the-art GMP-compliant services geared up with እጅግ በጣም ወሳኝ CO2 ማውጣት, preparative HPLC/UHPLC, እና lyophilization capabilities.

  • Analytical Supremacy: Extremely-conducting NMR spectrometers, HR-MS (Excessive-Decision Mass Spectrometry), እና validated HPLC-DAD/ELSD strategies guarantee purity requirements exceeding trade norms by >20%. Our QC protocols rigorously adhere to USP/EP/ICH pointers 9.

  • የዓለም አተያይ፡ Provides tailor-made, cGMP የሚያከብር elements to multinational pharmaceutical companies and analysis establishments throughout 80+ ብሄሮች በእስያ, በአውሮፓ እና በአሜሪካ.

5. Rigorous Product Specs (Carbazochrome Instance)

Specs are batch-specific; full particulars supplied on the Certificates of Evaluation (CoA).

6. Superior Manufacturing & High quality Management

• Synthesis & Purification Course of:

  1. Oxidation: Managed oxidation of pharmaceutical-grade epinephrine below inert ambiance and optimized pH/temperature.

  2. Derivatization (For Carbazochrome): Response with semicarbazide adopted by salicylate salt formation.

  3. መንጻት፡ ባለብዙ ደረጃ ክሮማቶግራፊክ ማጽዳት (Adsorption Chromatography → የዝግጅት HPLC) removes course of impurities and associated substances.

  4. ክሪስታላይዜሽን እና ማግለል Managed crystallization for particle dimension distribution.

  5. ማድረቅ፡ Vacuum Tray Drying ወይም ሊዮፊላይዜሽን ensures stability and low residual moisture (<5%).

  6. Strict QC Launch Testing: Each batch undergoes full id affirmation (FT-IR, NMR), assay (HPLC-UV), impurity profiling (UHPLC-MS), residual solvent evaluation (HS-GC-MS), ከባድ ብረቶች (ICP-MS), microbiological testing (USP <61>/<62>), እና pesticide screening (GC-MS/MS/LC-MS/MS) 9.

• High quality Management Philosophy :
  Shaanxi Zhonghong ተግባራዊ ያደርጋል quality-by-design (QbD) strategy built-in with cGMP ሀሳቦች all through the manufacturing lifecycle. Our multi-layered QC system ያረጋግጣል id, purity, efficiency, and security:

  • ያልበሰሉ እቃዎች አስተዳደር; Rigorous qualification of beginning supplies (epinephrine) towards pharmacopeial requirements (USP/EP).

  • የቁጥጥር ኮርስ (አይፒሲ)፡- Actual-time monitoring of vital course of parameters (CPPs – e.g., response pH/Temp, solvent ratios, intermediate purity through UHPLC) ensures consistency and facilitates early deviation correction.

  • Stability-Indicating Strategies: Validated HPLC/UHPLC strategies able to resolving adrenochrome, carbazochrome, and potential degradation merchandise (e.g., adrenolutin, additional oxidation merchandise). Compelled degradation research (ICH Q1A(R2)) below acid/base, oxidative, thermal, and photolytic stress verify methodology specificity.

  • Hint Contaminant Evaluation: State-of-the-art ICP-MS ensures heavy metals meet ICH Q3D/ USP <232> limits. Residue Evaluation ይቀጥራል LC-QTOF-MS እና GC-QqQ-MS/MS platforms screening for >500 pesticides per EU MRLs.

  • Microbiological Assurance: Testing per USP <61> (enumeration) and USP <62> (specified pathogens) in ISO Class 7 cleanrooms.

  • Stability & Shelf-Life: Actual-time እና accelerated stability research decide shelf-life (usually 24 months at -20°C for adrenochrome, 36 months for carbazochrome salts at managed room temperature).

  • Information Integrity: Adherence to ALCOA+ ideas ጋር Digital Batch Data (EBR) እና LIMS (Laboratory Data Administration System). Complete CoAs present full traceability 9.

7. Application Scenarios & Analysis Frontiers

• Present Functions:

  • የታዘዙ መድሃኒቶች; Lively ingredient in hemostatic medication (e.g., Carbazochrome salicylate injections and tablets for capillary hemorrhage).

  • Analysis Reagents: Excessive-purity adrenochrome (>98%, HPLC) is vital for learning ኦክሳይድ ውጥረት in neuronal/cardiac cells 410, COMT (Catechol-O-Methyltransferase) inhibition10, and potential roles in neurodegenerative fashions (e.g., Parkinson’s, Alzheimer’s).

  • Radiation Safety: Derivatives like Adrenochrome monoguanylhydrazone methanesulfonate (S-Adchnone) present efficacy in defending hematopoietic organs from radiation harm 7.

• የትንታኔ ድንበሮች እና ተግዳሮቶች፡-

  • Neuroinflammation & Neuroprotection: Investigating adrenochrome’s twin function as a neurotoxin (through quinone-mediated oxidative stress) and potential protecting mechanisms at low concentrations or by way of particular derivatives.

  • የላቀ የመድኃኒት አቅርቦት; በማደግ ላይ nanoparticle-encapsulated ወይም transdermal patch formulations of carbazochrome for sustained launch and enhanced bioavailability.

  • Novel Therapeutic Indications: Exploring potential in sepsis-associated coagulopathy, diabetic microangiopathy, and as an adjunct in chemotherapy-induced thrombocytopenia.

  • ተግዳሮቶች፡- Overcoming adrenochrome’s inherent chemical instability, elucidating exact molecular targets past TRP channels/PGE1 inhibition, establishing sturdy scientific proof for brand spanking new indications, and navigating regulatory pathways for novel derivatives.

8. Packaging, Logistics & Ordering Data

• ማሸግ፡

  • Analysis Grade Adrenochrome: Amber glass vials with butyl rubber stoppers (1mg, 5mg, 25mg, 250mg), below inert gasoline (N₂/Ar), filled with desiccants.

  • Bulk Carbazochrome/Carbazochrome Salts: Meals-grade HDPE drums with double LDPE liners (1kg, 5kg, 25kg). Consists of desiccant packs and COA.

• ማከማቻ፡ -20°C ± 5°C, protected against gentle and moisture.

• የመደርደሪያ ሕይወት; 24 months (Adrenochrome), 36 months (Carbazochrome Salts) when saved accurately.

• የአለም ሎጂስቲክስ፡ Shipped on dry ice (analysis portions) or through climate-controlled freight (bulk). Experience in international customs clearance, together with documentation for DGR (Harmful Items) if relevant and GDP compliance for APIs.

የሚገዛበት ቦታ፡-

• Contact E mail: liaodaohai@gmail.com

• Firm Web site: https://www.aiherba.com

• Inquiries: For present pricing, bulk quotes (>1kg), pattern requests (R&D), Technical Dossiers (TDS), Certificates of Evaluation (CoA), and customized synthesis choices.

9. Continuously Requested Questions (FAQ)

• Q: Is adrenochrome secure for human consumption?
  A: Pure adrenochrome is not permitted for direct human consumption and is strictly a analysis chemical. Its stabilized by-product, carbazochrome (e.g., Adrenobazone, Adrenosin), is a clinically permitted and secure hemostatic drug when used in response to prescribing pointers 258.

• Q: What is the distinction between Adrenochrome and Carbazochrome?
  A: Carbazochrome is a semi-synthetic stabilized by-product (adrenochrome monosemicarbazone sodium salicylate salt) developed for pharmaceutical use. It retains the hemostatic exercise of adrenochrome whereas providing superior chemical stability, decreased uncomfortable side effects, and predictable pharmacokinetics 28.

• Q: Can adrenochrome trigger psychiatric results?
  መ፡ ከመጠን በላይ መጠኖች of carbazochrome derivatives have been related to neuropsychiatric uncomfortable side effects (e.g., psychological disturbances, EEG abnormalities) and may intrude with antipsychotic/antiepileptic medication 58. Pure adrenochrome’s function in psychiatric problems stays a analysis speculation, not a longtime scientific truth.

• Q: What purity grades do you provide?
  A: Shaanxi Zhonghong provides:

  • Analysis Grade: ≥95% (HPLC), very best for in vitro research.

  • Excessive Purity Grade: ≥98% (HPLC), appropriate for analytical requirements and superior analysis.

  • Pharmaceutical Grade (Carbazochrome Salts): Conforms to USP/EP monographs, ≥95% assay, full GMP documentation.

• Q: Do you provide customized synthesis or derivatization?
  A: Sure. Our joint college labs እና የባለቤትነት ግቢ ቤተ መጻሕፍት allow customized synthesis of adrenochrome analogs (e.g., S-Adchnone 7) and scale-up below cGMP. Contact R&D through liaodaohai@gmail.com for mission proposals.

10. Conclusion

Adrenochrome (CAS 54-06-8), significantly in its stabilized pharmaceutical type carbazochrome, represents an important hemostatic agent focusing on capillary fragility. Its mechanism—enhancing endothelial resistance and inhibiting PGE1-mediated permeability—gives a singular strategy to managing microvascular bleeding with out cardiovascular results. Shaanxi Zhonghong ኢንቨስትመንት ቴክኖሎጂ Co., Ltd. መጠቀሚያዎች 28 years of bioactive compound experience, cutting-edge chromatographic purification (prep-HPLC, SFC), እና rigorous cGMP/QbD-compliant QC (NMR, ICP-MS, UHPLC-MS/MS) to provide the worldwide analysis and pharmaceutical markets with ultra-high-purity adrenochrome and carbazochrome. Our dedication to scientific innovation (20+ patents, college JVs), የትንታኔ የላቀ, እና customized synthesis capabilities positions us because the premier accomplice for growing and manufacturing vital hemostatic brokers and novel adrenochrome derivatives. Contact us right this moment to debate your particular uncooked materials or analysis compound wants.

11. References

1. Sigma-Aldrich. Adrenochrome Product Data (CAS 54-06-8). http://www.chemdict.com/brand_sigma-aldrich/prodt280112.html

2. Chemsrc. *Adrenochrome (CAS 54-06-8) – Chemical Supply*. https://www.chemsrc.com/baike/1189877.html

3. Santa Cruz Biotechnology. *Adrenochrome (CAS 54-06-8) – Inhibitor*. https://www.scbt.com/zh/p/adrenochrome-54-06-8

4. TargetMol. *Adrenochrome monoguanylhydrazone methanesulfonate (S-Adchnone, T89273)*. https://www.targetmol.cn/compound/adrenochrome_monoguanylhydrazone_methanesulfonate

5. PCBShop. Shaanxi Zhonghong Investment Technology Co., Ltd. Profile. https://www.pcbshop.org/cn/supplier/profile.asp?SupID=7102

6. Harley-Mason, J. (1950). Adrenochrome. Journal of the Chemical Society (Resumed), 1276.

7. Hoffer, A., & Osmond, H. (1967). The Hallucinogens. Tutorial Press. (Word: Represents the largely discredited adrenochrome speculation).

8. Worldwide Council for Harmonisation (ICH) Tips: Q2(R1) Validation of Analytical Procedures, Q1A(R2) Stability Testing.

9. United States Pharmacopeia (USP) Basic Chapters: <61> Microbiological Examination of Nonsterile Merchandise, <62> Microbiological Procedures for Absence of Specified Microorganisms, <561> Articles of Botanical Origin.

10. European Pharmacopoeia (Ph. Eur.) Basic Strategies.

11. Instance Analysis on Authentic Plant Actives (Substitute with particular compound analysis): Aggarwal, B. B., & Harikumar, Ok. B. (2009). Potential therapeutic results of curcumin, the anti-inflammatory agent, towards neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic illnesses. The worldwide journal of biochemistry & cell biology, 41(1), 40–59.