አልፋ-አርቡቲን
,

አልፋ-አርቡቲን

α-Arbutin supplier bulk factory Wholesale Extract factory

  1. የእንግሊዝኛ ስም: α-Arbutin,Alpha-Arbutin
  1. ዝርዝር መግለጫ
    • General Powder: α-Arbutin ≥ 99% (HPLC), optical purity ≥ 98%
    • በውሃ ውስጥ የሚሟሟ ዱቄት: α-Arbutin ≥ 98% (HPLC), with a water-soluble አቅራቢ (e.g., cyclodextrin), solubility ≥ 100 g/L at 25°C
  1. መልክ
    • General Powder: White crystalline powder, odorless
    • Water-soluble Powder: Off-white free-flowing powder
  1. CAS ቁጥር：84380-01-8
  1. የመምራት ጊዜ: 3-7 የስራ ቀናት
  1. ጥቅል
    • 1 ኪ.ግ / ቦርሳ (የአሉሚኒየም ፎይል ቦርሳ), 25 ኪ.ግ / ከበሮ (ባለ ሁለት ሽፋን PE ቦርሳ በካርቶን ከበሮ ውስጥ)
  1. ዋና ገበያ: Asia (በተለይ ውስጥ እሺ-beauty and J-beauty markets), North America, Europe
  1. የመተግበሪያ ሁኔታዎች

ዋና ባህሪያት

  • ሞለኪውላር Formula፦ ሲ₁₂H₁₆O₇
  • መሟሟት: Soluble in water, ethanol, and propylene glycol; the water-soluble formulation exhibits enhanced dissolution ፍጥነት
  • ቁልፍ አማራጮች:
    • Potent tyrosinase inhibitor, blocking melanin synthesis ተጨማሪ በተሳካ ሁኔታ than β-Arbutin (IC₅₀ = 0.2 mM)
    • Antioxidant properties, መከላከል ቀዳዳዎች እና ቆዳ from UV-induced oxidative stress
    • የተረጋጋ in acidic ሁኔታዎች (ምርጥ pH 4 – 6), ቢሆንም degrades in alkaline environments or at ከመጠን በላይ temperatures (> 60°C)

የመተግበሪያ ሁኔታዎች

1. መዋቢያዎች & የግል እንክብካቤ

  • ቀዳዳዎች እና ቆዳ መብረቅ ሸቀጣ ሸቀጦች:
    • Serums and Essences: በአጠቃላይ formulated at 2 – 5% ትኩረት, ዝቅ ማድረግ ጠቆር ያለ spots, melasma, and post-inflammatory hyperpigmentation. ሕክምና ምርምር አቅርቧል a 30% ቅናሽ in pigmentation after 8 weeks of use.
    • የፀሐይ መከላከያዎች: Added at 1 – 2% ለማቅረብ እያንዳንዱ የፀሐይ ብርሃን ደህንነት and anti-pigmentation ጥቅሞች, ማቆም UV-induced melanin ማምረት.
    • ነጭ ማድረግ ሎሽን: የተቀላቀለ ጋር የተለየ ሕያው ንጥረ ነገሮች like niacinamide and hyaluronic acid, ላይ ማተኮር አጠቃላይ ቀዳዳዎች እና ቆዳ brightening and hydration.
  • ፀረ-እያረጀ ቀመሮች:
    • Inhibits collagen degradation አመጣው free radicals, ዝቅ ማድረግ መልክዎቹ የ advantageous ውጥረት and wrinkles when included in anti-aging masks and lotions.

2. የታዘዙ መድሃኒቶች

  • የቆዳ ህክምና Therapies:
    • ውስጥ ጥቅም ላይ ውሏል prescription-strength lotions (ያህል 4% ትኩረት in some አካባቢዎች) for treating ጽንፈኛ ማቅለሚያ ችግሮች የሚያስታውስ melasma and freckles.
    • Submit-surgical and post-peel ተግባራት ለመከላከል ወይም ወደ ኋላ መመለስ post-treatment hyperpigmentation, በተለምዶ ቅልቅል with vitamin E.

3. ዓላማ ያለው ምግቦች & መጠጦች

  • የቃል የአመጋገብ ማሟያዎች:
    • Capsules or tablets containing 500 mg of α-Arbutin, በተለምዶ paired with vitamin C ለማሳደግ collagen synthesis and promote ቀዳዳዎች እና ቆዳ ደህና መሆን ከ ውስጥ.
  • Magnificence መጠጦች:
    • Added to low-calorie መጠጦች at 0.5 – 1% ትኩረት, marketed as “beauty-from-within” ሸቀጣ ሸቀጦች ለ አጠቃላይ ቀዳዳዎች እና ቆዳ brightening.

4. የኢንዱስትሪ ዓላማዎች

  • Textile Dyeing:
    • እንደ ሀ ንፁህ mordant, α-Arbutin መጠቀም ይቻላል ለመጠገን ላይ ማቅለሚያዎች ቁሳቁሶች, producing የዋህ እና የተረጋጋ coloration hues ከውጪ ጋር በመጠቀም harsh የኬሚካል ውህዶች.
  • ባዮፕስቲክስ:
    • Aqueous አማራጮች of α-Arbutin (0.1 – 0.5%) አቅርቧል ፀረ-ፈንገስ ባህሪያት, በማድረግ ተገቢ ነው። ጥቅም ላይ የሚውለው in eco-friendly agricultural pest አስተዳደር.

ማወቂያ ስልቶች

  • ከመጠን በላይ–ቅልጥፍና ፈሳሽ ክሮማቶግራፊ (HPLC):
    • አምድ፡ C18 (250 × 4.6 ሚሜ፣ 5 μm)፣ ሴሉላር ክፍል: Acetonitrile – Water (15:85, v/v), ዥረት ክስ: 1.0 mL/min, Detection Wavelength: 280 nm
  • Mass Spectrometry (ኤምኤስ):
    • Used to verify ሞለኪውላዊው ግንባታ እና ንፅህና ፣ በተለይ for pharmaceutical-grade α-Arbutin ሸቀጣ ሸቀጦች.
  • Differential Scanning Calorimetry (DSC):
    • Determines the melting level (195 – 198°C for α-Arbutin), በማገልገል ላይ ወደ ማረጋገጥ ምርት ከፍተኛ ጥራት and authenticity.

አቅርቦት & ጥቅሞች

  • ማምረት: በዋናነት synthesized በ enzymatic or chemical processes, ማቅረብ greater purity and consistency ጋር ሲነጻጸር ንፁህ ማውጣት ስልቶች.
  • ውጤታማነት: ነው። robust መከልከል ተጽዕኖ on tyrosinase ያቀርባል ፈጣን and visual ends in ቀዳዳዎች እና ቆዳ lightening, making it a በጣም የተወደደ ingredient for high-end ግርማ ሞገስ ሸቀጣ ሸቀጦች.
  • ደህንነት: በተለምዶ well-tolerated by most ቀዳዳዎች እና ቆዳ ዓይነቶች, with a መቀነስ ማስፈራሪያ of irritation ጋር ሲነጻጸር ሌላ 美白 ደላሎች.

የቁጥጥር ተገዢነት

  • ቻይና NMPA: Permitted as a ውበት ንጥረ ነገር ከ ሀ አብዛኛው ትኩረት የሁለት% (requiring ደህንነት ግምገማ ለ greater ክልሎች).
  • የአውሮፓ ህብረት ውበት ደንብ (ኢ.ሲ. 1223/2009): እውቅና ተሰጥቶታል። ጥቅም ላይ የሚውለው በመዋቢያዎች, ከኤ መገደብ of three% in leave-on ሸቀጣ ሸቀጦች.
  • የአሜሪካ ኤፍዲኤ: Tentatively labeled as an OTC ingredient for ቀዳዳዎች እና ቆዳ lightening, with ትኩረት limits ስር ግምገማ.
ምድቦች፡ ,

Alpha-Arbutin: The Gold Normal in Pores and skin Lightening and Antioxidant Safety| Supplier & Manufacturer

1. What is Alpha-Arbutin?

Alpha-arbutin is a glycosylated hydroquinone spinoff famend for its potent pores and skin – lightening properties. In contrast to its counterpart, beta – arbutin, alpha – arbutin displays a better affinity for tyrosinase, the important thing enzyme concerned in melanin synthesis. This makes it simpler at decreasing hyperpigmentation, comparable to age spots, freckles, and melasma, with out inflicting important pores and skin irritation. Extensively used within the cosmetics business, alpha – arbutin has additionally proven antioxidant and anti – inflammatory results, positioning it as a multifunctional bioactive ingredient.

Alpha-Arbutin Applications
Alpha-Arbutin Purposes

2. Product Origin and Chemical Properties

2.1 አቅርቦት

Alpha-arbutin could be extracted from varied crops, together with bearberry (Arctostaphylos uva-ursi), blueberries (Vaccinium spp.), and cranberries (Vaccinium macrocarpon). Nevertheless, as a result of low pure content material in crops, most business alpha – arbutin is produced by way of biocatalysis or chemical synthesis. At Shaanxi Zhonghong Investment Technology Co., Ltd., we make the most of superior biocatalytic processes to make sure excessive – purity, sustainable manufacturing with minimal environmental influence.

2.2 የኬሚካል መገለጫ

  • የ CAS ብዛት: 84380 – 01 – 8
  • ሞለኪውላር ፎርሙላ (ኤምኤፍ)፦ ሲ₁₂H₁₆O₇
  • ሞለኪውላር ክብደት (MW): 272.25 g/mol
  • EINECS: 282 – 776 – 3
  • Bodily State: White to off – white crystalline powder
  • መሟሟት: Soluble in water (5 – 10 g/L at 25°C), barely soluble in ethanol

3. Optimum Product, Well being Benefits, Dosage, Precautions and Aspect Results

3.1 Finest Merchandise and Content

The best – high quality alpha – arbutin merchandise sometimes have a purity of 98% or increased. Our firm leverages state – of – the – artwork purification methods, comparable to excessive – efficiency liquid chromatography (HPLC) and crystallization processes, to realize a purity stage 20% above the business common. This ensures most efficacy in pores and skin – lightening purposes and minimizes the danger of impurities inflicting antagonistic reactions.

3.2 Well being Benefits

3.2.1 Pores and skin Lightening

Alpha-arbutin inhibits tyrosinase exercise, blocking the conversion of tyrosine to melanin. By decreasing melanin manufacturing, it successfully lightens current darkish spots and prevents new pigmentation, resulting in a extra even pores and skin tone.

3.2.2 Antioxidant Safety

It acts as a free – radical scavenger, neutralizing reactive oxygen species (ROS) comparable to hydroxyl and superoxide radicals. This antioxidant property helps defend pores and skin cells from oxidative harm, which is related to untimely ageing, effective strains, and wrinkles.

3.2.3 Anti – Inflammatory Results

Alpha-arbutin can cut back the manufacturing of professional – inflammatory cytokines, soothing irritated pores and skin and selling a more healthy pores and skin barrier perform. This makes it appropriate for delicate pores and skin sorts vulnerable to irritation.

3.3 Beneficial Dosage

In beauty formulations, the standard focus of alpha – arbutin ranges from 0.5% to 2%. For direct software merchandise like serums or lotions, making use of a pea – sized quantity (roughly 1 – 2 grams) containing the suitable focus to the affected pores and skin areas a couple of times every day is widespread. Nevertheless, it is vital to comply with product – particular directions.

3.4 Precautions and Aspect Results

Alpha-arbutin is mostly nicely – tolerated. Nevertheless, in uncommon instances, it might trigger delicate pores and skin irritation, comparable to redness or itching, particularly in people with extremely delicate pores and skin. Extended publicity to daylight can cut back its effectiveness and enhance the danger of pores and skin harm, so sunscreen use is advisable when utilizing alpha – arbutin merchandise. Keep away from contact with eyes, and if unintended ingestion happens, search medical recommendation instantly.

4. Firm Introduction

With 28 years of expertise within the bioactive compound business, Shaanxi Zhonghong Investment Technology Co., Ltd. is a number one excessive – tech enterprise. Our operations span agile analysis and improvement, collaborative innovation, built-in manufacturing, and international advertising and marketing, serving the chemical, supplies, and life science sectors.
  • Analysis Edge: Our partnerships with 5 prime – tier universities by way of joint laboratories, together with over 20 patented applied sciences and a singular international compound library, drive steady innovation in alpha – arbutin manufacturing and software.
  • Technological Superiority: Outfitted with state – of – the – artwork services, together with excessive – efficiency liquid chromatography (HPLC) and superconducting nuclear magnetic resonance spectrometers, we guarantee product purity requirements 20% increased than the business common.
  • የዓለም አተያይ: Our intensive community covers greater than 80 nations throughout Asia, Europe, and the Americas. We provide custom-made uncooked materials options for multinational pharmaceutical firms, analysis establishments, and beauty producers.

5. Product Specs

ቬንቸር
ስም
አመልካች
የማወቂያ ቴክኒክ
ፀረ-ተባይ ቅሪቶች
ክሎርፒሪፎስ
<0.01 ፒፒኤም
ቤንዚን ክሮማቶግራፊ - የጅምላ ስፔክትሮሜትሪ (ጂሲ - ኤምኤስ)
ሳይፐርሜትሪን
<0.02 ፒፒኤም
ጂሲ - ኤም.ኤስ
ካርበንዳዚም
<0.05 ፒፒኤም
ከመጠን በላይ - ቅልጥፍና ፈሳሽ ክሮማቶግራፊ - የጅምላ ስፔክትሮሜትሪ (HPLC - MS/MS)
ሄቪ ብረቶች
መሪ (ፒቢ)
<0.5 ፒፒኤም
ኢንዳክቲቭ የተጣመረ ፕላዝማ – Mass Spectrometry (ICP – MS)
ሜርኩሪ (ኤችጂ)
<0.01 ፒፒኤም
ቀዝቃዛ ትነት አቶሚክ መምጠጥ ስፔክትሮስኮፒ (CVAAS)
ካድሚየም (ሲዲ)
<0.05 ፒፒኤም
አይሲፒ - ኤም.ኤስ
ጥቃቅን ብክለት
አዋጭ ሙሉ ጥገኛ
<100 CFU/ግ
መደበኛ የማይክሮባዮሎጂ ሽፋን ዘዴዎች
ኮላይ ኮላይ
የለም
Polymerase Chain ምላሽ (PCR) እና plating
ሳልሞኔላ
የለም
PCR እና plating
Listeria monocytogenes
የለም
PCR እና plating

6. የማምረት ኮርስ

  1. Uncooked Materials Preparation: For biocatalytic manufacturing, choose excessive – high quality enzymes or microorganisms with excessive exercise for alpha – arbutin synthesis. Guarantee correct cultivation and activation of those organic catalysts.
  1. Biocatalysis or Chemical Synthesis: In biocatalysis, use enzymes to catalyze the response between hydroquinone and glucose to kind alpha – arbutin. In chemical synthesis, rigorously management response situations comparable to temperature, pH, and response time to advertise the formation of alpha – arbutin whereas minimizing by – product technology.
  1. መንጻት: Make use of a number of purification steps, together with filtration, extraction, and chromatography. HPLC is used to separate alpha – arbutin from impurities, guaranteeing excessive – purity product. Crystallization processes might also be utilized to additional refine the product.
  1. Drying and Formulation: Dry the purified alpha – arbutin beneath managed situations to take away moisture. Then, formulate it into completely different varieties in keeping with buyer necessities, comparable to effective powders, granules, or pre – blended options for cosmetics.
  1. High quality Inspection: Conduct complete high quality testing on the completed product, together with purity willpower, identification, and inspection of pesticide residues, heavy metals, and microbial contamination.

7. የመተግበሪያ ሁኔታዎች

7.1 Cosmetics

  • Pores and skin – Lightening Merchandise: Alpha-arbutin is a key ingredient in serums, lotions, masks, and lotions designed to cut back hyperpigmentation and obtain a brighter, extra even complexion.
  • Anti – Growing old Formulations: Mixed with different antioxidants and anti – ageing substances, it helps fight oxidative stress and enhance pores and skin texture, decreasing the looks of effective strains and wrinkles.
  • Sunscreen and After – Solar Care: Its antioxidant properties make it appropriate for inclusion in sunscreens to boost UV safety and in after – solar merchandise to appease solar – broken pores and skin.

7.2 Prescribed drugs (Analysis – based mostly)

At the moment, alpha – arbutin is beneath investigation for potential purposes in treating pores and skin illnesses associated to irregular pigmentation, comparable to melasma and publish – inflammatory hyperpigmentation. Its anti – inflammatory and antioxidant results might also contribute to wound – therapeutic analysis.

8. ከፍተኛ ጥራት ያለው አስተዳደር

High quality management is the cornerstone of our alpha – arbutin manufacturing. On the uncooked materials stage, we conduct strict inspections on enzymes, microorganisms, or chemical precursors, verifying their purity and exercise by way of biochemical assays and spectroscopic evaluation. Through the manufacturing course of, actual – time monitoring of response parameters (temperature, pH, response time) ensures constant product high quality. Within the purification part, HPLC is used for exact separation and purity willpower, with every batch of merchandise present process a number of rounds of study to make sure the absence of impurities. For ultimate product inspection, we carry out complete exams on chemical purity, microbial security, and heavy metallic content material, adhering to strict worldwide requirements. Our high quality management laboratory is licensed to ISO 9001 and follows Good Manufacturing Follow (GMP) pointers. By implementing a multi – step high quality management system, we assure that each batch of alpha – arbutin meets the very best high quality and security necessities, offering dependable merchandise to our prospects worldwide.

9. Packaging and Logistics

  • ማሸግ: Our alpha – arbutin merchandise are packaged in air – tight, moisture – resistant containers. For small orders, we use aluminum foil luggage or amber glass bottles, whereas for bulk orders, fiber drums are utilized. Every bundle is labeled with detailed data, together with product identify, batch quantity, purity, expiration date, and storage directions.
  • ማከማቻ: Retailer in a cool, dry place, away from direct daylight, at temperatures between 2 – 8°C. Below correct storage situations, the shelf lifetime of our alpha – arbutin merchandise can attain as much as 36 months.
  • መጓጓዣ: We accomplice with dependable worldwide logistics suppliers to make sure quick and safe supply. Samples could be shipped through specific providers like DHL or FedEx inside 3 – 5 enterprise days, whereas bulk orders are transported by sea or air freight in keeping with buyer necessities.

10. Well being Efficacy Analysis, Industrial Application Innovation, and Challenges

10.1 Analysis Frontiers

  • Nano – Supply Techniques: Scientists are exploring nanoencapsulation methods to enhance the steadiness and bioavailability of alpha – arbutin, enabling higher penetration into the pores and skin and extra focused supply.
  • ድብልቅ ሕክምናዎች: Analysis is underway to research the synergistic results of alpha – arbutin when mixed with different pores and skin – lively substances, comparable to vitamin C and niacinamide, for enhanced pores and skin – lightening and anti – ageing outcomes.

10.2 ተግዳሮቶች

  • መረጋጋት: Alpha-arbutin could be unstable beneath sure situations, comparable to excessive temperature or publicity to gentle. Creating extra secure formulations with out compromising its efficacy stays a problem.
  • የቁጥጥር ተገዢነት: As a beauty ingredient, alpha – arbutin should adjust to varied worldwide rules relating to security, labeling, and efficacy claims. Guaranteeing constant compliance throughout completely different markets is essential for its widespread adoption.

11. የሚጠየቁ ጥያቄዎች

11.1 The place can I purchase Alpha-Arbutin?

  • We provide quite a lot of alpha – arbutin merchandise with completely different purity ranges and packaging choices to satisfy various buyer wants.

11.2 Is Alpha-Arbutin secure for all pores and skin sorts?

Alpha-arbutin is mostly secure for many pores and skin sorts. Nevertheless, people with extremely delicate pores and skin could expertise delicate irritation. It is advisable to carry out a patch check earlier than utilizing new merchandise containing alpha – arbutin.

11.3 Can Alpha-Arbutin be used throughout being pregnant?

There may be restricted analysis on the security of alpha – arbutin throughout being pregnant. Pregnant or nursing girls ought to seek the advice of a health care provider earlier than utilizing merchandise containing alpha – arbutin.

11.4 How lengthy does it take to see outcomes?

Seen pores and skin – lightening outcomes could take 4 – 8 weeks of constant use, because the pores and skin’s pure renewal cycle wants time to exchange pigmented cells with new, lighter – coloured ones.

12. መደምደሚያ

Alpha-arbutin stands as a revolutionary ingredient within the magnificence and skincare business, providing efficient pores and skin – lightening, antioxidant, and anti – inflammatory advantages. As a number one producer, Shaanxi Zhonghong Investment Technology Co., Ltd. is dedicated to offering excessive – high quality alpha – arbutin merchandise, backed by superior expertise, strict high quality management, and intensive international attain. Whether or not for creating modern beauty merchandise or advancing dermatological analysis, our alpha – arbutin choices set the usual for excellence.

13. ማጣቀሻዎች

  1. Kameyama, Okay., et al. (1995). Alpha – arbutin: A novel reversible tyrosinase inhibitor from the leaves of Vaccinium ashei. የግብርና እና የምግብ ኬሚስትሪ ጆርናል, 43(11), 2807 – 2810.
  1. Wang, Y., et al. (2018). Advances within the manufacturing and software of arbutin. ሞለኪውሎች, 23(6), 1461.
  1. European Fee. (2019). Beauty Substances Database (CosIng). Retrieved from [CosIng official website]

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