Kwersetien
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Quercetin-aanvullings

Kwersetien Dieetaanvullings​ – Oormatige-Purity Flavonoid Compound supplier bulk vervaardigingseenheid Wholesale Extract vervaardigingseenheid

  1. Engelse Naam: Quercetin
  1. Spesifikasie
    • Suiwerheid: Quercetin ≥ 98% (HPLC)
    • Wateroplosbaar Soortgelyk: Quercetin glycosides (e.g., rutin) or nanoemulsion – hoofsaaklik gebaseer formulations, solubility enhanced soveel as 10 g/L by wyse van encapsulation
    • Deeltjie Dimensie: Alledaags powder ≤100 μm; micronized variasies ≤5 μm for hoër biobeskikbaarheid
  1. Voorkoms
    • Powder: Yellow to orange – yellow crystalline powder, odorless, skaars bitter styl
  1. CAS-nr.：117-39-5
  1. Leweringstyd: 3 – 7 Werksdae
  1. Pakket
    • 1 kg/sak (aluminiumfoeliesak), 25 kg/drom (dubbellaag PE-sak binne kartondrom)
  1. Hoofmark: North America, Europe, Asia, South America
  1. Toepassingscenario's

Kern Eienskappe

  • Molekulêre Komponente: C₁₅H₁₀O₇
  • Oplosbaarheid: Sparingly soluble in water (0.1 g/L at 25°C); soluble in ethanol, DMSO; water – soluble derivatives verbeter usability in aqueous programme
  • Sleutel Opsies
    • Potent Antioxidant: Scavenges free radicals (e.g., hydroxyl, superoxide), with an ORAC werd of ~5000 μmol Trolox equivalents/g.
    • Anti-inflammatorieseInhibeer professioneel – inflammatory enzymes (COX – 2, iNOS) and cytokines (TNF – α, IL – 6).
    • Phytoestrogenic Oefening: Weak estrogen – like resultate, nuttig for menopausal symptom administrasie.
    • Antimikrobiese: Skerms oefening na mikro-organisme (bv., Staphylococcus aureus) en swamme (bv. Candida albicans).

Toepassingscenario's

1. Dieet Dieetaanvullings

  • Basies Welstand Formulering:
    • Capsules or tablets (250 – 500 mg per serving) bought as antioxidant and immune – boosting dieetaanvullings.
    • Gewoonlik gemeng with vitamin C and zinc for enhanced efficacy dwarsdeur koud and flu seasons.
  • Specialty Welstand Handelsware:
    • Gewrig welstand dieetaanvullings (500 – 1000 mg/day) om terug te sny irritasie in arthritis lyers.
    • Kardiovaskulêr hulp formulering, as dit kon bystaan afname bloed stres en vlakke van cholesterol.

2. Prakties Maaltye en Drankies

  • Antioxidant – Fortified Handelsware:
    • Added to juices, teas, and vitaliteit drinks at 50 – 100 mg/L om uit te brei antioksidant inhoudsmateriaal.
    • Gebruik in “duidelik – label” snacks (e.g., granola bars) as a suiwer preservative and nutrient enhancer.
  • Plant – Meestal gebaseer Meat Alternatiewe opsies:
    • Inhibits lipid oxidation, extending the shelf – leeftyd van plant – hoofsaaklik gebaseer proteïene en verbetering smaak stabiliteit.

3. Skoonheidsmiddels & Privaat Sorg

  • Anti- ouer word Velversorging:
    • Serums en lotions (0.5 – 2% fokus) om te bewaak na UV – induced skade, sny terug wrinkles, and promote collagen synthesis.
    • Soothing formulations for delikaat porieë en vel, leveraging its anti – inflammatory properties.
  • Haarversorging:
    • Shampoos and conditioners to strengthen hair follicles and sny terug dandruff by combating scalp irritasie.

4. Voorgeskrewe medisyne

  • Investigational Therapies:
    • Studied for its potential in treating neurodegenerative siektes (e.g., Alzheimer’s, Parkinson’s) as gevolg van neurobeskermend resultate.
    • Investigated as an adjuvant in meeste kankers terapie, enhancing the efficacy of chemotherapy terwyl verlaging ongewenste newe-effekte.
  • Oor-die-toonbank (OTC) Medisynes:
    • Gebruik in aktueel lotions vir sagmoedig porieë en vel irritations and allergie simptome, aanbod anti – inflammatory and antioxidant hulp.

5. Dier Welstand

  • Veevoer Komponente:
    • Added to poultry and swine feed (100 – 500 ppm) om te verbeter ontwikkeling doeltreffendheid, sny terug oxidative stress, and verbeter meat hoë gehalte.
  • Troeteldier Dieetaanvullings:
    • Formulated in chewable tablets for honde and cats to hulp gewrig welstand en immuun uitvoer.

Opsporing Strategieë

  • Oormatige – Doeltreffendheid Vloeistofchromatografie (HPLC):
    • Kolom: C18 (250 × 4.6 mm, 5 μm), Sel Afdeling: Acetonitrile – 0.1% phosphoric acid (35:65 v/v), Sirkulasie Fooi: 1.0 mL/min, Detection Wavelength: 360 nm.
  • Massaspektrometrie (MS):
    • Gebruik in mengsel with HPLC (HPLC – MS) to substantiate molecular konstruksie and detect wenk impurities.
  • FTIR Spektroskopie:
    • Identifies kenmerk doelgerig spanne (e.g., hydroxyl, carbonyl) to bevestig produk identification.

Voorsiening en Voordele

  • Natuurlik Voorsiening: Uittreksel uit talle plantegroei, saam met Sophora japonica flowers, onions, apples, and grapes.
  • Volhoubaarheid: Might be sourced from agricultural by – handelsware (e.g., onion skins), verlaging afval.
  • Multi – doelgerig: Sy verskeie bioactivities make it gepas vir funksies dwarsdeur 'n aantal nywerhede.

Regulatoriese Nakoming

  • Amerikaanse FDA: Regulated as a dietary komplement bestanddeel onder DSHEA (Dietary Komplement Welstand en Training Act).
  • EU-verordening: Permitted as a maaltye additive and dietary komplement ingredient, onderwerp om sekuriteit evaluations.
  • China NMPA: Permitted om gebruik te word in doelgerig maaltye en dieetkundige dieetaanvullings, met besonder benutting limits.
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Quercetin Dietary supplements​: The Premier Flavonoid Powerhouse – Final Information & Premium Supply| Supplier & Manufacturer

1. Wat is Quercetin?
Quercetin is 'n dieet flavonol belonging to the polyphenolic compounds subclass. As a potent plant pigment, it serves vital roles in UV safety and stress response in botanicals. In human physiology, it displays multifunctional bioactivity, appearing as a grasp antioxidant, anti-inflammatory agent, en mobile signaling modulator. Its distinctive catechol construction en α,β-unsaturated carbonyl group allow distinctive free radical scavenging and metallic chelation capabilities.

2. Voorsiening, Chemiese Eienskappe en Identifikasie

  • Main Natural Sources (Highest Concentrations):

    • Sophora japonica Buds: Richest supply (as much as 20% dry weight)

    • Onion Skins (Allium cepa): Significantly purple onions (1-1.5%)

    • Ginkgo biloba Leaves: Standardized extracts (22-26%)

    • Apple Peel (Malus domestica): Key supply of quercetin glycosides

    • Different Sources: Capers, lovage, elderberries, buckwheat, tea

  • Chemiese Eienskappe:

    • CAS Hoeveelheid: 117-39-5

    • Molekulêre Komponente: C₁₅H₁₀O⇇

    • Molekulêre gewig: 302.24 g/mol

    • EINECS Hoeveelheid: 204-187-1

    • Voorkoms: Geel kristallyne poeier

    • Oplosbaarheid: Insoluble in water; soluble in ethanol, DMSO, lipids (when complexed)

    • Stabiliteit: Delicate to UV mild and alkaline circumstances; degrades above 160°C

3. Benefits, Efficacy, Dosage & Security

  • Optimum Sources & Bioavailability: Sophora japonica extracts ship the very best pure concentrations (95-98% purity). Bioavailability is enhanced by phospholipid complexation (Quercetin Phytosome®) or liposomal encapsulation, growing absorption by 5-20x vs. commonplace powder.

  • Validated Well being Benefits & Mechanisms:

    • Systemic Antioxidant Protection: Moduleer Nrf2/ARE-roete, upregulating glutathione synthesis en superoxide dismutase (SOD)

    • Anti-Inflammatory Motion: Inhibeer COX-2, LOX, en NF-κB signaling pathways, decreasing pro-inflammatory cytokines (TNF-α, IL-6)

    • Immuunmodulasie: Stabilizes mast cells, reduces histamine launch through cAMP phosphodiesterase inhibition

    • Cardiometabolic Assist: Improves endothelial perform by eNOS activation, inhibits LDL oxidation

    • Viral Protection: Demonstrated 3CL protease inhibition in opposition to coronaviruses in vitro

  • Medical Dosage:

    Formulering Each day Dose Lengte
    Commonplace Powder 500-1000 mg 8-12 weke
    Phytosome® 250-500 mg Bestendig
    Acute Immune Assist As much as 3000 mg ≤5 days

  • Sekuriteitsprofiel:

    • GRAS standing (FDA)

    • Keep away from concomitant use with CYP3A4 substrates (cyclosporine, warfarin)

    • Potential renal toxicity at >5g/day

    • Being pregnant Class C

4. Shaanxi Zhonghong: Quercetin Excellence
Hefboomwerking 28 years in bioactive phytochemistry, Shaanxi Zhonghong Investment Technology Co., Ltd. pioneers quercetin manufacturing by:

  • Core Improvements:

    • Glycoside-to-Aglycone Conversion: Patented enzymatic hydrolysis for >98% aglycone purity

    • Nanocrystallization Know-how: 200nm particle measurement for enhanced solubility

    • Phytosome® Manufacturing: Validated complexation with sunflower phospholipids

  • Hoë kwaliteit infrastruktuur:

    • UPLC-QTOF-MS for isomer profiling

    • cGMP en ISO 22000 licensed amenities

    • Batch traceability through blockchain expertise

5. Product Specification (Pharmaceutical Grade)

Klas Parameter Spesifikasie Kontroleer Tegniek
Suiwerheid Quercetin Aglycone ≥98.0% HPLC-DAD (EP 10.0)
Swaar metale Lood (Pb) ≤1.0 ppm ICP-MS (USP <233>)
Kadmium (Cd) ≤0.5 dpm ICP-MS
Arseen (As) ≤1.0 ppm ICP-MS
Plaagdoders Chlorpirifos ≤0.01 dpm GC-MS/MS
Sipermetrien ≤0.02 dpm GC-MS/MS
Complete 186 Pesticides Detrimental EU SANTE/11813/2017
Mikrobiologie Volledige Kardio-afhanklikheid ≤1000 KVE/g USP <61>
Gis en skimmel ≤100 KVE/g USP <61>
Enterobacteriaceae Afwesig/10g ISO 21528-2

6. Superieure Vervaardigingswerkvloei

  1. Botanical Sourcing: DNA-authenticated Sophora japonica buds

  2. Multistage Extraction: Ethanol/water (70:30) at 45°C with microwave help

  3. Macroporous Resin Chromatography: AB-8 resin for flavonoid isolation

  4. Enzymatic Bioconversion: β-glucosidase remedy (45°C, pH 5.0)

  5. Crystallization Management: Anti-solvent precipitation at 4°C

  6. Nanomilling: Moist-milling to D90 < 250nm

  7. Phospholipid Complexation (Optionally available): 1:1 ratio with phosphatidylcholine

  8. Lyofilisasie: -40°C main drying

7. Application Matrix

Besigheid Formulation Examples Useful Position
Nutraseutiese produkte Immune complexes, sports activities formulation Oxidative stress discount
Voorskrifmedisyne Antiviral adjuvants, cardioprotectives Endothelial perform modulation
Kosmeseutiese produkte Anti-pollution serums, UV protectants MMP inhibition
Useful Meals Stability-enhanced drinks Shelf-life extension

8. Mechanism & Medical Proof

  • Mitochondriale Biogenese: Aanwysings SIRT1/PGC-1α-roete (5-15% improve in ATP manufacturing)

  • Senescence Modulation: Verminder p16INK4a expression in human fibroblasts

  • Viral Inhibition: IC₅₀ = 7.6 μM in opposition to SARS-CoV-2 3CL protease

  • Cardiometabolic Results: 12% LDL discount in hyperlipidemic sufferers (500mg/day, 8 weeks)

9. Technological Frontiers

  • Bioavailability Options:

    • Quercetin-β-cyclodextrin complexes (water solubility: 35 mg/mL)

    • Strong lipid nanoparticles (90% oral bioavailability)

  • Onervare Chemie:

    • Subkritiese wateronttrekking (SWE) at 120°C/50 bar

    • Enzyme-assisted deep eutectic solvent tegnieke

10. Analysis Challenges

  • Pharmacokinetics: Quick plasma half-life (3-4 hours)

  • Mediese vertaling: Restricted Part III trials for immune claims

  • Regulatoriese Status: Novel Meals authorization required in EU

11. Gereelde vrae

  1. Q: Why select Sophora japonica-derived quercetin?
    A: Superior focus profile (98% vs. 70% in onion extracts) and decrease pesticide danger.

  2. Q: The best way to overcome bioavailability limitations?
    A: Our phytosome expertise achieves Cₘₐₓ 4.3x greater than commonplace powder.

  3. Q: Validated immune help dosage?
    A: 500-1000mg/day prophylactic; 3000mg/day acute part (max 5 days).

  4. V: Stabiliteit in formulerings?
    A: Nanoencapsulated type retains >90% efficiency at 25°C/60% RH for twenty-four months.

  5. Q: GMP compliance?
    A: Manufactured underneath ICH Q7 pointers with ISO 17025 accredited QC.

12. Procurement Info

  • Technical Dossiers: liaodaohai@gmail.com

  • Order Portal: aiherba.com/quercetin

  • MOQ: 1kg (R&D), 10kg (business)

  • Logistiek: -20°C validated chilly chain transport

13. Gevolgtrekking
Quercetin verteenwoordig die apex of flavonoid bioactivity with clinically validated impacts on immune competence, metaboliese welstand, en oxidative resilience. Shaanxi Zhonghong’s vertikaal ingeboude vervaardiging—from DNA-verified Sophora japonica om nanoparticle-enhanced supply techniques—ensures unprecedented purity (≥98%) and bioavailability. Our patented enzymatic conversion expertise and cGMP-voldoenende vervaardiging ship benchmark materials compliant with USP, EP, and JP monographs. Accomplice with our 28 jaar ondervinding for quercetin options powering next-generation nutraceuticals, prescription drugs, and useful meals.

14. Verwysings

  1. Li Y, et al. (2021). Molekules. 26(9):2507. [Bioavailability]

  2. Colunga Biancatelli RML, et al. (2020). Entrance Immunol. 11:1451. [Antiviral]

  3. EFSA Panel (2020). EFSA-joernaal. 18(1):e05993.

  4. Anand David AV, et al. (2016). J Meals Sci. 81(10):R2501. [Metabolism]

  5. Zhonghong Technical File QRC-2024. aiherba.com/docs/QRC-Spec

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