Bisabolol

Unlocking the Power of Bisabolol: Nature’s Soothing Elixir from AIHerba

1. What is Bisabolol?
Bisabolol, primarily occurring as (-)-α-bisabolol, is a naturally occurring monocyclic sesquiterpene alcohol renowned for its exceptional skin-soothing, anti-irritant, and anti-inflammatory properties. This bioactive compound is a prized cosmetic and pharmaceutical ingredient, offering a gentle yet potent solution for sensitive skin and various inflammatory conditions. Its delicate floral aroma further enhances its appeal in perfumery.

2. Produkbron, Chemiese Eienskappe en Identifikasie

• Primary Natural Source: German Chamomile (Matricaria chamomilla/recutita), specifically its essential oil, is the richest natural source of (-)-α-bisabolol. Also found in smaller quantities in Candeia tree (Vanillosmopsis species) oil and other plants.

• Chemiese Eienskappe:

  • CAS-nommer: 515-69-5 (Often refers to the racemic mixture; natural (-)-α-Bisabolol is 23089-26-1)

  • MF (Molekulêre Formule): C₁₅H₂₆O

  • MW (Molekulêre Gewig): 222.37 g/mol

  • EINECS: 207-454-3

  • Voorkoms: Colorless to pale yellow viscous liquid.

  • Oplosbaarheid: Soluble in alcohols and oils, insoluble in water.

  • Optical Activity: Natural (-)-α-Bisabolol is levorotatory. Synthetic versions may be racemic.

• AIHerba Source & Advantage: AIHerba utilizes premium German Chamomile flowers, employing proprietary supercritical CO2 extraction and molecular distillation techniques to yield (-)-α-Bisabolol with unparalleled purity (>98%) and stereochemical integrity, maximizing its bioactivity.

3. What is the Best Bisabolol? Efficacy, Safety & Usage

• “Best” Defined: The highest efficacy is consistently attributed to natural (-)-α-Bisabolol due to its specific stereochemistry. AIHerba’s focus on ultra-high purity natural (-)-α-Bisabolol ensures superior performance.

• Highest Content Source: German Chamomile essential oil typically contains the highest natural concentration (up to ~50%, though AIHerba isolates it to >98%).

• Health & Skin Benefits:

  • Potent Anti-inflammatory: Inhibits COX-2, LOX, and inflammatory cytokines (TNF-α, IL-6).

  • Soothing & Anti-irritant: Rapidly calms skin irritation (e.g., from surfactants, UV, chemical peels).

  • Antioksidant: Scavenges free radicals, protecting skin cells.

  • Wound Healing & Regenerative: Stimulates fibroblast migration and promotes tissue repair.

  • Antimikrobiese: Exhibits activity against certain bacteria and fungi.

  • Verbeterde Penetrasie: Can improve skin absorption of other actives.

  • Skin Barrier Support: Contributes to a healthier skin barrier function.

• Daaglikse inname: Bisabolol is primarily used topically (cosmetics, skincare). Oral intake is not common for bisabolol itself; safety levels depend on the specific application (cosmetic, supplement, pharmaceutical). Cosmetic use is generally regarded as safe at typical concentrations (0.2% – 2.0%).

• Needs Attention:

  • Sensitivity: While generally well-tolerated, patch testing new products is always recommended.

  • Oxidation: Pure bisabolol can oxidize over time; formulations should include antioxidants and use appropriate packaging (e.g., airless containers, nitrogen flushing).

• Newe-effekte: Rare. Potential for mild skin irritation or allergic reaction in highly sensitive individuals. Natural (-)-α-Bisabolol has an excellent safety profile.

4. Introducing AIHerba: Your Trusted Bisabolol Partner
Shaanxi Zhonghong Investment Technology Co., Ltd. (AIHerba) is a premier hoëtegnologie-onderneming integrating agile R&D, collaborative innovation, integrated manufacturing, and global marketing. For over 28 jaar, we’ve specialized in serving the chemical, materials, and life sciences sectors, with core expertise in the ekstraksie, isolasie, suiwering en kommersiële toepassing van bioaktiewe plantbestanddele.

• Wetenskaplike Bekwaamheid: 5+ strategic university joint labs, 20+ patented technologies, and a globally unique proprietary compound library.

• Cutting-Edge Quality: HPLC (Hoëprestasie-vloeistofchromatografie), GC-MS (Gaschromatografie-Massaspektrometrie), en Superconducting NMR (Nuclear Magnetic Resonance) ensure purity standards exceeding industry norms by 20%+.

• Globale bereik: Bediening 80+ lande regoor Asië, Europa en die Amerikas, wat voorsiening maak customized natural ingredient solutions to leading multinational pharmaceutical companies, research institutions, and cosmetic giants.

5. Product Specifications: Rigorous Quality Control
AIHerba’s (-)-α-Bisabolol adheres to the strictest quality standards. Key specifications include:

Table 1: Pesticide Residue Analysis

Table 2: Heavy Metals Analysis

Table 3: Microbial Analysis

6. Gevorderde produksievloei
AIHerba’s (-)-α-Bisabolol production exemplifies cutting-edge phytochemistry:

1. Bronne: Premium German Chamomile flowers from certified sustainable farms.

2. Primêre Ekstraksie: Supercritical CO2 Extraction (SFE) – Utilizes tunable pressure/temperature for selective, solvent-free isolation of volatiles, preserving delicate actives.

3. Konsentrasie: Removal of waxes and non-target compounds.

4. Isolation & Purification: Preparative HPLC and/or High-Vacuum Fractional Distillation – Achieves targeted separation of (-)-α-Bisabolol from other terpenes.

5. Crystallization (Optional): For achieving highest purity grades (>99%).

6. Stabilization: Addition of synergistic antioxidants (e.g., Tocopherol).

7. Streng kwaliteitskontrole: HPLC-DAD/ELSD, Chiral GC/HPLC, GC-MS, NMR for identity, purity (>98%), enantiomeric excess, and residual solvent analysis. ICP-MS for heavy metals. Microbiological testing per pharmacopeia.

8. Verpakking: Under inert atmosphere (Nitrogen) in light-protected, food-grade HDPE or glass containers.

7. Diverse Toepassingscenario's

• Cosmetics & Skincare: Calming serums, sensitive skin creams, after-sun products, anti-redness treatments, baby care, post-procedure formulations (laser, peels), acne treatments (mitigates irritation), natural deodorants.

• Farmaseutiese produkte: Topical anti-inflammatory and wound healing ointments/gels, mucoadhesive formulations, dental care products (anti-gingivitis).

• Perfumery: Provides a soft, sweet, floral note with fixative properties.

• Nutraseutiese produkte: Incorporated into topical wellness products (e.g., muscle soothing balms).

8. Comprehensive Quality Control (QC)
AIHerba’s QC paradigm is built on Pharmaceutical cGMP principles and leverages moderne analitiese instrumentasie. Identity confirmation utilizes FTIR (Fourier Transform Infrared Spectroscopy) fingerprinting and Chiral Chromatography to verify the (-)-enantiomer. Purity is quantified via validated HPLC-UV/ELSD methods calibrated against certified reference standards, consistently ensuring >98% (-)-α-Bisabolol content. Residual Solvent Analysis (Headspace GC-MS) guarantees compliance with ICH Q3C guidelines. Stabiliteitsstudies (ICH Q1A) under accelerated and long-term conditions determine shelf-life and optimal storage parameters. Every batch undergoes full spectroscopic (NMR for structural elucidation if needed), chromatographic, and microbiological testing, documented in a Sertifikaat van Analise (CoA) traceable to international standards (USP, EP, CP). Our ISO 9001-certified quality management system ensures traceability and continuous improvement.

9. Veilige Verpakking & Globale Logistiek

• Verpakking: 1kg, 5kg food-grade HDPE bottles; 25kg HDPE drums. All nitrogen flushed en aluminum bag-lined for maximum oxidation protection. Custom packaging available.

• Berging: Store tightly sealed in original packaging, protected from light and moisture at 2-8°C (refrigerated) for long-term stability. Short-term (<6 months) at <25°C acceptable.

• Logistiek: Shipped globally via temperature-controlled logistics (cold chain where required). Compliant with all international regulations (REACH, FDA, COSMOS etc.). Comprehensive documentation provided.

10. Deep Dive: Health Mechanisms, Applications & Innovation

• Meganisme van aksie: (-)-α-Bisabolol exerts effects via multiple pathways:

  • Modulates NF-κB and MAPK signaling cascades, suppressing pro-inflammatory cytokine production.

  • Inhibits key enzymes: Cyclooxygenase-2 (COX-2), 5-Lipoxygenase (5-LOX).

  • Demonstrates antioxidant activity by quenching ROS/RNS.

  • Enhances penetration via lipid bilayer interaction.

  • Promotes re-epithelialization and granulation tissue formation in wounds.

• Industrial Applications & AIHerba Innovation: Beyond cosmetics, bisabolol enhances transdermal drug delivery systems. AIHerba innovates through enantioselective synthesis pathways (for ultra-pure (-)-isomer), novel co-crystal formulations for enhanced stability/solubility, and sustained-release delivery systems (e.g., lipid nanoparticles) integrated with our proprietary compound library screening for synergistic combinations.

• Navorsingsgrense en -uitdagings:

  • Grense: Exploring efficacy in neuroinflammatory conditions, gastroprotective effects, anti-cancer adjunct therapy (enhancing chemo efficacy/reducing side effects), advanced biomaterials (anti-inflammatory coatings for implants).

  • Uitdagings: Scaling sustainable cultivation of high-bisabolol chamomile strains, cost-effective large-scale chiral purification, definitive clinical dose-response studies for specific therapeutic endpoints, long-term stability optimization in complex formulations.

11. Gereelde vrae (FAQ)

• Q: Is natural (-)-α-Bisabolol better than synthetic?

  • A: Yes, numerous studies indicate natural (-)-α-Bisabolol possesses superior anti-inflammatory and skin-soothing efficacy compared to synthetic racemic mixtures or other isomers due to its specific stereochemistry.

• Q: What concentration of Bisabolol is effective in cosmetics?

  • A: Typical effective concentrations range from 0.2% to 2.0%. Efficacy depends on the formulation and desired effect; AIHerba provides application support.

• Q: Is Bisabolol safe for sensitive skin?

  • A: Absolutely. Natural (-)-α-Bisabolol is renowned for its exceptional tolerance and efficacy in calming sensitive, irritated, and reactive skin.

• Q: Does Bisabolol have any known drug interactions?

  • A: Topical use has no significant reported interactions. Consult a physician for potential interactions with oral medications if used systemically (rare).

• Q: How should I store AIHerba Bisabolol?

  • A: For optimal long-term stability and to prevent oxidation, store tightly sealed, protected from light, and refrigerated (2-8°C). See CoA for specific batch recommendations.

• Q: Is AIHerba Bisabolol compliant with international standards?

  • A: Yes. Our product meets or exceeds specifications outlined in relevant USP/EP monographs (where applicable), COSMOS, ISO, and is REACH/FDA compliant. Certificates available.

12. Where to Buy Premium (-)-α-Bisabolol
Source the highest purity, naturally derived (-)-α-Bisabolol directly from the manufacturer:

• Webwerf: www.aiherba.com

• Kontak: Mnr Liao Daohai

• E-pos: liaodaohai@gmail.com

• Inquire for: Bulk pricing, samples, technical data sheets (TDS), certificates of analysis (CoA), and formulation support.

13. Gevolgtrekking
(-)-α-Bisabolol stands as a cornerstone bioactive ingredient for gentle yet powerful soothing and anti-inflammatory efficacy. AIHerba, leveraging 28 years of expertise in phytochemistry and advanced purification technologies, delivers ultra-pure (>98%) natural (-)-α-Bisabolol. Sourced sustainably and validated by superconducting NMR, HPLC, and ICP-MS, our ingredient meets the stringent demands of global cosmetic, pharmaceutical, and research markets. Choose AIHerba for unparalleled quality, scientific support, and a commitment to innovation in natural actives.

14. Verwysings

1. Kamatou, G. P. P., & Viljoen, A. M. (2010). A review of the application and pharmacological properties of α-bisabolol and α-bisabolol-rich oils. Journal of the American Oil Chemists’ Society, 87(1), 1-7.

2. European Medicines Agency (EMA) Assessment Report on Matricaria recutita L., flos. (2015).

3. Cavalieri, E., et al. (2004). Pro-apoptotic activity of α-bisabolol in preclinical models of primary human acute leukemia cells. The Journal of Clinical Investigation, 114(3).

4. International Organization for Standardization (ISO). ISO 16128 – Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients.

5. United States Pharmacopeia (USP) General Chapters: <561> Articles of Botanical Origin, <2023> Microbiological Examination of Nonsterile Products.

6. European Pharmacopoeia (Ph. Eur.) Monographs: 2.8.12 Microbiological examination of non-sterile products, 2.4.8 Heavy Metals.

7. Recent Research (e.g., search PubMed.gov for “alpha-bisabolol mechanism”, “bisabolol skin”, “bisabolol wound healing” – 2023/2024 publications). AIHerba Internal Research & Stability Data.