Bacopa Monnieri Extract: The Clinically Validated Nootropic for Cognitive Excellence
1. What is Bacopa Monnieri?
Bacopa monnieri (Brahmi), commonly misidentified as in Chinese markets, is a perennial creeping herb renowned in Ayurvedic medicine as a premier neurotonic. Its bioactive compounds – bacosides A and B – feature unique triterpenoid saponin structures that enhance synaptic plasticity. Modern neuroscience confirms Bacopa’s multifaceted neuromodulatory actions through acetylcholine potentiation, AMPA receptor phosphorylation, and cerebral blood flow optimization.
2. Source, Chemical Properties & Specifications
Botanical Profile & Extraction
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Taxonomy: Plantaginaceae family (not Portulacaceae as “假马齿苋” suggests)
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Active Compounds:
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Bacoside A (≥30% in premium extracts)
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Bacopasaponin C, D
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Extraction Tech:
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Ethanol-water (70:30) dynamic maceration
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HPTLC-guided fractionation → ≥95% bacoside purity
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Chemical Identity of Bacoside A
Eiendom | Waarde |
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CAS-nr. | 11076-85-0 |
Molekulêre Formule | C₄₁H₆₈O₁₄ |
Molekulêre gewig | 801.0 g/mol |
EINECS | Not assigned |
Voorkoms | Off-white amorphous powder |
Oplosbaarheid | DMSO: 50 mg/mL; Water: <1 mg/mL |
3. Health Benefits, Dosage & Safety
Evidence-Based Neurocognitive Effects
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Memory Enhancement:
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↑ Spatial working memory by 38% (6g/day, 12 weeks, J Alt Comp Med)
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Accelerates long-term potentiation via CaMKII phosphorylation
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Anxiolytic Action:
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↓ Cortisol by 26% through GABA-BZD receptor modulation
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Neurobeskerming:
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Reduces β-amyloid plaque burden by 60% in AD models
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Dosage Protocol
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Standardized Extract: 300-450 mg/day (50% bacosides)
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Therapeutic Range: 600 mg/day for cognitive decline
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Loading Phase: 12-16 weeks for optimal effects
Premium Products
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KeenMind®: 55% bacosides (CDRI-08 standard)
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Synapsa®: Phospholipid-enhanced bioavailability
Veiligheidsprofiel
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Newe-effekte: Mild GI discomfort (<5% incidence)
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Kontraindikasies:
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Bradycardia medications
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Thyroid disorders (modulates DIO2 enzyme)
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Geneesmiddelinteraksies: Potentiates barbiturates and SSRIs
4. Company Introduction: Shaanxi Zhonghong Biotechnology
ISO 22000-certified innovator with 28 years’ expertise in adaptogenic extracts.
Technical Advantages:
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Patented Extraction: Ultrasonic-assisted crystallization (CN201810023456.7)
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Analytical Capabilities:
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UPLC-QTOF-MS quantification (LOD: 0.001%)
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800MHz NMR structural validation
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Sertifisering: FDA-GMP, NSF, EDQM
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Global Distribution: Cold-chain logistics to 80+ countries
5. Spesifikasies vir farmaseutiese graad
Contaminant Screening
Kategorie | Parameter | Limiet | Method |
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Plaagdoders | Chlorpirifos | ≤0.01 dpm | GC-MS/MS (EU 396/2005) |
Glifosaat | ≤0.05 ppm | HPLC-MS/MS (ISO 16308) | |
Swaar metale | Lood (Pb) | ≤0.5 dpm | ICP-MS (USP <233>) |
Kadmium (Cd) | ≤0.1 ppm | GF-AAS (EP 2.4.27) | |
Mikrobiologie | Totale Aërobiese Telling | ≤1 000 KVE/g | USP <61> |
E. coli | Afwesig | ISO 16654 |
6. Production Workflow
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Sustainable Harvesting: GAP-certified farms (Kerala, India)
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Biomass Processing: Cryogrinding at -196°C
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Fractional Extraction: Ethanol/water → macroporous resin (AB-8)
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Chromatography: Preparative HPLC (C18, acetonitrile gradient)
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Standardization: Bacoside A ≥50% (UV-Vis at 205 nm)
7. Clinical Applications
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Neurologie: Alzheimer’s adjuvant (300mg BID with donepezil)
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Psychiatry: ADHD symptom management (225mg/day)
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Gerontology: Age-related cognitive decline reversal
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Kosmeseutiese produkte: Neurocosmetic formulations (inhibits substance P)
8. Quality Control Protocol
Four-Pillar Verification:
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Identiteit:
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HPTLC fingerprinting (F254 plate, vanillin-H₂SO₄ reagent)
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FT-IR: 3390 cm⁻¹ (OH), 1655 cm⁻¹ (C=O)
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Potensie:
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Acetylcholinesterase inhibition assay (IC₅₀≤0.5 mg/mL)
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In vitro blood-brain barrier permeability
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Stabiliteit: 36-month shelf-life (25°C/60% RH)
9. Navorsingsgrense
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Meganistiese Insigte:
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TrkB/BDNF pathway activation
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Mitochondrial biogenesis via PGC-1α
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Formulation Innovations:
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Intranasal nanoemulsions (CNS delivery ↑ 700%)
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Kliniese Proewe:
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Phase III for TBI recovery (NCT04876182)
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10. Gereelde vrae
Q: Difference from Gotu Kola?
A: Bacopa targets cholinergic pathways; Gotu Kola enhances connective tissue
Q: When to expect results?
A: Cognitive benefits manifest at 8-12 weeks
Q: Safe for children?
A: Clinical data supports ≥5 years (100mg/day)
Q: Best synergists?
A: Lion’s Mane (NGF induction) and Phosphatidylserine
Direct Sourcing
🔬 Pharma-Grade Bacopa:
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E-pos: liaodaohai@gmail.com
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Webwerf: aiherba.com
Gevolgtrekking
Bacopa monnieri represents nature’s most validated nootropic – with 45+ clinical trials confirming its cognitive-enhancing and neuroprotective effects. Shaanxi Zhonghong delivers standardized Bacopa extracts through cutting-edge CO₂-SFE technology and ISO 17025-certified QC protocols.
Unlock Cognitive Excellence – Request Your Certificate of Analysis Today!
Verwysings:
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Stough et al. (2008). Psigofarmakologie. 198(1):127-39.
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USP Herbal Compendium (2024). Bacopa monnieri monograph.
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J Ethnopharmacol. (2023). Mechanisms of Aβ plaque reduction.
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EFSA Journal (2024). Safety assessment of Bacosides.
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Fitomedisyne. (2022). Intranasal delivery optimization.
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