Which β-Amyloid variants are available?

We offer Aβ1–40, Aβ1–42, and custom fragments such as Aβ25–35, Aβ1–28, and Aβ1–43. Purity options include ≥95%, ≥98%, and custom >99%.

Can I order β-Amyloid peptides in bulk?

Yes. We provide GMP-level bulk supply with COA, MSDS, and global shipping. Contact sales@aiherba.com for quotation.

How should β-Amyloid be stored?

Store lyophilized β-Amyloid at −20°C or below, protected from moisture and light. Reconstituted solutions should be aliquoted and used promptly.

What are the main applications of β-Amyloid?

Applications include Alzheimer’s disease modeling, neurotoxicity assays, aggregation studies, and pharmaceutical drug screening.

1. What Is β-Amyloid (Aβ)?

β-Amyloid (Aβ) is a short peptide derived from amyloid precursor protein (APP) via enzymatic cleavage. Depending on processing pathways, it commonly appears as Aβ1–40, Aβ1–42, or other fragment variants. These peptides are central to research on:

Alzheimer’s disease (AD) pathology
Amyloid fibril formation
Neurodegenerative mechanisms
Pharmaceutical drug target validation
In vitro neurotoxicity and inflammation models

Aβ’s biochemical properties—particularly its aggregation behavior—make it essential for mechanistic neuroscience, biopharmaceutical development, and diagnostic innovation.

2. Mechanisms & Biological Functions

Name: β-Amyloid Peptide (Aβ1–40, Aβ1–42)
Brand: AIHERBA
SKU: Beta-Amyloid
Availability: InStock

2.1 Aggregation & Plaque Formation

Aβ peptides readily aggregate into oligomers, protofibrils, and amyloid plaques. These structures are key pathological markers of Alzheimer’s disease.

2.2 Neurotoxicity in Preclinical Models

Soluble Aβ oligomers are widely studied for their role in:

Synaptic impairment
Oxidative stress
Neuroinflammation
Mitochondrial dysfunction

These actions help validate disease models and drug candidates.

2.3 Role in Drug Discovery

Researchers use Aβ peptides to:

Screen anti-aggregation compounds
Develop targeted antibody therapeutics
Evaluate neuroprotective mechanisms
Validate biomarkers for clinical diagnosis

3. Types of β-Amyloid Peptides Available

We provide commercially relevant grades tailored for research, diagnostics, and biopharmaceutical development:

✔ Aβ1–40

Most commonly used; stable and widely applied in aggregation models.

✔ Aβ1–42

More aggregation-prone and neurotoxic; ideal for Alzheimer’s pathology research.

✔ Custom Fragment Lengths

Aβ25–35, Aβ1–28, Aβ1–43, and additional variants available upon request.

✔ Purity Grades

≥95% HPLC
≥98% premium purity
Custom >99% for critical R&D applications

Each batch includes COA, MSDS, HPLC/LC-MS data for quality verification.

4. Key Applications in Science & Industry

4.1 Neuroscience Research

Aβ peptides enable researchers to build in vitro and in vivo models of:

Cognitive decline
Oxidative neuronal injury
Amyloid aggregation
Synaptic loss

They are standard components in both academic and industrial research pipelines.

4.2 Pharmaceutical Development

Pharma R&D uses Aβ peptides to test:

Immunotherapies (anti-Aβ antibodies)
β-secretase and γ-secretase inhibitors
Aggregation blockers
Neuroprotective drug candidates

4.3 Diagnostics & Biomarkers

Aβ levels and ratios (Aβ1–40 / Aβ1–42) serve as important biomarkers in:

CSF testing
PET imaging research
Neurological disease assessment

5. Quality Requirements for β-Amyloid in B2B Procurement

High-purity peptide sourcing is critical for experimental repeatability. Buyers—especially biotech labs, CROs, pharmaceutical companies—typically require:

✔ Strict purity (≥95–98%)

Ensures aggregation behavior and toxicity remain consistent.

✔ GMP-aligned production

Stable quality, traceable batches, regulatory-friendly documentation.

✔ COA / MSDS / HPLC documentation

For compliance and experimental verification.

✔ Global shipping stability

Lyophilized powder ensures long-term transport safety.

✔ Customization

Length, purity, modified structures (FITC-labeled, biotinylated, etc.)

6. How to Store & Handle β-Amyloid (Lab-ready Guide)

Storage Conditions

−20°C or below (lyophilized form)
Avoid moisture and light
Use inert gas packaging if possible

Reconstitution

Use ultrapure water or DMSO
Prepare aliquots to avoid freeze–thaw cycles
Work quickly with solutions—Aβ aggregates rapidly

Aggregation Preparation Tips

For consistent experiments, researchers often use:

HFIP pre-treatment
Freshly dissolved peptides
Standardized monomerization steps

7. Why Choose Shaanxi Zhonghong (AIHERBA) as Your β-Amyloid Supplier?

✔ GMP-Level Factory

Modern facility with peptide synthesis and purification capabilities.

✔ High Purity

95–98% standard, 99% custom purification on request.

✔ Full Documentation

COA, MSDS, HPLC/LC-MS available for every batch.

✔ Global B2B Export Experience

Long-term partners in biotech labs, CROs, pharmaceutical research, and universities.

✔ Custom Synthesis Available

Aβ fragments, labeled peptides, high-purity custom specifications.

📧 Contact Sales
sales@aiherba.com
info@aiherba.com
liaodaohai@gmail.com

8. Frequently Asked Questions (FAQ)

1) What purity is recommended for neuroscience research?

≥95% is standard; ≥98% is recommended for high-sensitivity assays.

2) Do you accept bulk and customized orders?

Yes. We supply bulk quantities and offer custom peptide synthesis.

3) Can Aβ peptides be shipped internationally?

Yes. Lyophilized powders ship safely under controlled temperature conditions.

4) What documentation is included?

COA, MSDS, HPLC, LC-MS test results.

5) Is β-Amyloid suitable for pharmaceutical development?

Yes. High-purity peptides are used in preclinical studies, mechanism exploration, and formulation development.

9. References

NIH: https://www.nih.gov
NIA Alzheimer’s disease information: https://www.nia.nih.gov
PubMed Aβ research index: https://pubmed.ncbi.nlm.nih.gov
Alzheimer’s Association research resources: https://www.alz.org